Clinical characteristics of neonatal and infant osteomyelitis and septic arthritis: a multicenter retrospective study
CONCLUSION: Distinct differences were found between neonatal and infants with osteoarticular infections. Future studies should focus on improving diagnosis and subsequent treatment regimens for younger age groups.PMID:38642591 | DOI:10.1016/j.jped.2024.03.003 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - April 20, 2024 Category: Pediatrics Authors: Keming Sun Chunxu Zhang Ziwen Mao Chen Wang Hua Zhu Huiqing Sun Kang Wang Weyland Cheng Source Type: research
Disrupting B and T cell Collaboration in Autoimmune Disease: T cell engagers versus CAR T cell therapy?
Clin Exp Immunol. 2024 Apr 20:uxae031. doi: 10.1093/cei/uxae031. Online ahead of print.ABSTRACTB and T cells collaborate to drive autoimmune disease (AID). Historically, B and T cell (B-T cell) co-interaction was targeted through different pathways such as alemtuzumab, abatacept, and dapirolizumab with variable impact on B cell depletion (BCD), whereas the majority of patients with AID including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and organ transplantation benefit from targeted BCD with anti-CD20 monoclonal antibodies such as rituximab, ocrelizumab or ofatumumab. Refractory AID is a signi...
Source: Clinical and Developmental Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Kavina Shah Maria Leandro Mark Cragg Florian Kollert Franz Schuler Christian Klein Venkat Reddy Source Type: research
Predictors of quality of life, functional status, depression and fatigue in early arthritis: comparison between clinically suspect arthralgia, unclassified arthritis and rheumatoid arthritis
This study assessed ... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - April 20, 2024 Category: Orthopaedics Authors: Barbara Torlinska, Karim Raza, Andrew Filer, Gurpreet Jutley, Ilfita Sahbudin, Ruchir Singh, Paola de Pablo, Elizabeth Rankin, Benjamin Rhodes, Nicole Amft, Elizabeth Justice, Catherine McGrath, Sangeetha Baskar, Jeanette Trickey, Melanie Calvert and Mari Tags: Research Source Type: research
CD20 + T lymphocytes in isolated Hashimoto’s thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study
ConclusionsThese preliminary findings indicate that CD8+CD20+ T cells are activated in patients with autoimmune thyroiditis and may behave differently according to the presence of poly-autoimmunity and hypothyroidism. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - April 20, 2024 Category: Endocrinology Source Type: research
Psoriatic arthropathy in patients with previous neoplasia: a case series of four patients treated with secukinumab and literature review
CONCLUSIONS: In conclusion, our case series, consisting of four PsA patients with concurrent neoplasia treated with secukinumab, showed no evidence of cancer progression and represents the first case of PsA described in the literature treated during active oncological disease, lending support to the safety of secukinumab for the treatment of patients with PsA and concomitant neoplasia.PMID:38639525 | DOI:10.26355/eurrev_202404_35919 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: U G Massafra F Giovannangeli A Migliore Source Type: research
Programmed cell death in autoimmune diseases: ferroptosis
Ann Biol Clin (Paris). 2024 Apr 19;82(1):33-42. doi: 10.1684/abc.2024.1866.ABSTRACTFerroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseas...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Jiantao Sun Lujuan Huang Jiawei Wang Yelang Hu Wenmin Wang Haihong Zhu Source Type: research
Orthopedic Articular and Periarticular Joint Infections
Emerg Med Clin North Am. 2024 May;42(2):249-265. doi: 10.1016/j.emc.2024.01.002. Epub 2024 Mar 2.ABSTRACTAcute nontraumatic joint pain has an extensive differential. Emergency physicians must be adept at identifying limb and potentially life-threatening infection. Chief among these is septic arthritis. In addition to knowing how these joint infections typically present, clinicians need to be aware of host and pathogen factors that can lead to more insidious presentations and how these factors impact the interpretation of diagnostic tests.PMID:38641390 | DOI:10.1016/j.emc.2024.01.002 (Source: The Medical Clinics of North America)
Source: The Medical Clinics of North America - April 19, 2024 Category: General Medicine Authors: Pim Jetanalin Yanint Raksadawan Pholaphat Charles Inboriboon Source Type: research
Programmed cell death in autoimmune diseases: ferroptosis
Ann Biol Clin (Paris). 2024 Apr 19;82(1):33-42. doi: 10.1684/abc.2024.1866.ABSTRACTFerroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseas...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: Jiantao Sun Lujuan Huang Jiawei Wang Yelang Hu Wenmin Wang Haihong Zhu Source Type: research
Psoriatic arthropathy in patients with previous neoplasia: a case series of four patients treated with secukinumab and literature review
CONCLUSIONS: In conclusion, our case series, consisting of four PsA patients with concurrent neoplasia treated with secukinumab, showed no evidence of cancer progression and represents the first case of PsA described in the literature treated during active oncological disease, lending support to the safety of secukinumab for the treatment of patients with PsA and concomitant neoplasia.PMID:38639525 | DOI:10.26355/eurrev_202404_35919 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 19, 2024 Category: Drugs & Pharmacology Authors: U G Massafra F Giovannangeli A Migliore Source Type: research
Orthopedic Articular and Periarticular Joint Infections
Emerg Med Clin North Am. 2024 May;42(2):249-265. doi: 10.1016/j.emc.2024.01.002. Epub 2024 Mar 2.ABSTRACTAcute nontraumatic joint pain has an extensive differential. Emergency physicians must be adept at identifying limb and potentially life-threatening infection. Chief among these is septic arthritis. In addition to knowing how these joint infections typically present, clinicians need to be aware of host and pathogen factors that can lead to more insidious presentations and how these factors impact the interpretation of diagnostic tests.PMID:38641390 | DOI:10.1016/j.emc.2024.01.002 (Source: The Medical Clinics of North America)
Source: The Medical Clinics of North America - April 19, 2024 Category: General Medicine Authors: Pim Jetanalin Yanint Raksadawan Pholaphat Charles Inboriboon Source Type: research
Psoriatic arthropathy in patients with previous neoplasia: a case series of four patients treated with secukinumab and literature review
CONCLUSIONS: In conclusion, our case series, consisting of four PsA patients with concurrent neoplasia treated with secukinumab, showed no evidence of cancer progression and represents the first case of PsA described in the literature treated during active oncological disease, lending support to the safety of secukinumab for the treatment of patients with PsA and concomitant neoplasia.PMID:38639525 | DOI:10.26355/eurrev_202404_35919 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 19, 2024 Category: Drugs & Pharmacology Authors: U G Massafra F Giovannangeli A Migliore Source Type: research
A single chain variable fragment antibody (Tn 64) cognate to fibronectin type III repeats promotes corneal wound healing by inhibiting fibrosis
We examined corneal epithelial as well as stromal wound healing through Tn64 binding to Tn fn 3-5, using a human corneal epithelial cell (HCEC) line, primary cultures of human corneal fibroblasts (HCFs), and an ex-vivo corneal organ culture model. Tn64 enhanced proliferation and adhesion of corneal epithelial cells, while inhibiting the migration of corneal fibroblasts and myofibroblasts. Tn64 appears to attenuate inflammation through downregulation of TNF-α, prevent corneal fibrosis by limiting fibronectin polymerization, and promote regeneration of corneal epithelia and stroma, suggesting that it could be developed as a...
Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Ashu Shukla Vyshak Suresh Parul Chawla Gupta Maryada Sharma Uma Nahar Saikia Jagat Ram Manni Luthra-Guptasarma Source Type: research
Bone health and physical activity in adolescents with juvenile idiopathic arthritis: a cross-sectional case-control study
Adolescents with juvenile idiopathic arthritis (JIA) tend to engage in less physical activity than their typically developing peers. Physical activity is essential for bone development and reduced physical act... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - April 19, 2024 Category: Rheumatology Authors: Egi Vasil, Colleen M. Nesbitt, Clodagh Toomey, Gregor Kuntze, Shane Esau, Carolyn A. Emery and Leigh Gabel Tags: Research article Source Type: research
Retraction Note: Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4+CCR6+ Th/Treg cell subset imbalance in ankylosing spondylitis
(Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 19, 2024 Category: Rheumatology Authors: Yanfeng Wu, Mingliang Ren, Rui Yang, Xinjun Liang, Yuanchen Ma, Yong Tang, Lin Huang, Jichao Ye, Keng Chen, Peng Wang and Huiyong Shen Tags: Retraction Note Source Type: research
Measuring synovial thickness on knee MRI in pediatric patients with arthritis: is contrast necessary?
ConclusionUnenhanced knee MRI is equivalent to contrast-enhanced MRI in assessment of synovial thickness using conventional MRI sequences. Contrast material helped improve inter-reader reliability.Graphical abstract (Source: Pediatric Radiology)
Source: Pediatric Radiology - April 19, 2024 Category: Radiology Source Type: research
