Inborn Errors of Immunity: How to diagnose them?
CONCLUSIONS: The diagnostic investigation of Inborn Errors of Immunity should be guided by the clinical characterization of patients, aiming to optimize the use of complementary tests. Many diagnoses are attained only through genetic tests, which are not always available. However, the absence of a diagnosis of certainty should never delay the implementation of therapeutic measures that preserve patient life and health. PMID: 33400918 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - January 2, 2021 Category: Pediatrics Authors: Grumach AS, Goudouris ES Tags: J Pediatr (Rio J) Source Type: research

Association between interleukin-10 polymorphisms and CD4+CD25+FOXP3+ T cells in asthmatic children.
CONCLUSIONS: Our results suggest that moderate asthma is associated with a higher frequency of the T allele in the SNP rs3024491. In addition, the variant rs3024491 (TT) was associated with a reduction in IL-10 production and an increased percentage of Tregs cells, suggesting possible mechanisms that influence asthma severity. PMID: 33400919 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - January 2, 2021 Category: Pediatrics Authors: Mocellin M, de Azeredo Leitão LA, de Araújo PD, Jones MH, Stein RT, Pitrez PM, de Souza APD, Pinto LA Tags: J Pediatr (Rio J) Source Type: research

Biomarkers of renal function in preterm neonates at 72  h and 3 weeks of life.
CONCLUSION: The elevation of molecules related to glomerular function indicates an increase of glomerular filtration rate from 72 h up until 3 weeks of life, which was not clearly detected with the measurement of cystatin C. PMID: 33358961 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 23, 2020 Category: Pediatrics Authors: Correa LP, Marzano ACS, Silva Filha R, Magalhães RC, Silva ACSE Tags: J Pediatr (Rio J) Source Type: research

Hemodynamic effects of increased intra-abdominal pressure in critically ill children.
CONCLUSION: The ACM significantly increases IAP, causing severe reversible impairment in the cardiovascular system and is effective in distending the LIJV in just over half of the subjects. Even low levels of HIA can result in significant cardiac dysfunction in children. Therefore, health professionals should be aware of the negative hemodynamic repercussions caused by the increased IAP. PMID: 33358965 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 21, 2020 Category: Pediatrics Authors: Silveira LGT, Brocca IC, Moraes ES, Brandão MB, de Souza TH Tags: J Pediatr (Rio J) Source Type: research

Accuracy of neck circumference for diagnosing overweight in six- and seven-year-old children.
Abstract OBJECTIVE: To estimate the accuracy of neck circumference measurement as a method of diagnosing excess weight of six and seven-year-old children. METHODS: 1026 six and seven-year-old children were included and anthropometric data were collected using cut-off points for the Body Mass Index (BMI) Z-score, in addition to the measurement of their neck circumference in centimeters. Pearson's correlation coefficient was used to assess the correlation between neck circumference and BMI. Sensitivity, specificity, positive and negative predictive values were calculated. The Receiver Operating Characteristic c...
Source: Jornal de Pediatria - December 21, 2020 Category: Pediatrics Authors: Mucelin E, Traebert J, Zaidan MA, Piovezan AP, Nunes RD, Traebert E Tags: J Pediatr (Rio J) Source Type: research

End-of-life practices in patients admitted to pediatric intensive care units in Brazil: A retrospective study.
CONCLUSIONS: LSLs were associated with older and more severely ill patients, with a high prevalence of family participation in this process. The historical comparison showed an increase in LSL and in the withdrawal of life support. PMID: 33358967 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 21, 2020 Category: Pediatrics Authors: Furtado RA, Tonial CT, Costa CAD, Andrades GRH, Crestani F, Bruno F, Fiori HH, Piva JP, Garcia PCR Tags: J Pediatr (Rio J) Source Type: research

Primary immunodeficiencies: a diagnostic challenge?
te; D PMID: 33352110 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 19, 2020 Category: Pediatrics Authors: Solé D Tags: J Pediatr (Rio J) Source Type: research

The critical function of miR-1323/Il6 axis in children with Mycoplasma pneumoniae pneumonia.
CONCLUSION: In conclusion, miR-1323 targets the mRNA of Il6 and inhibits the expression of Il6. The pathogenesis of MPP inhibits the expression of miR-1323 in macrophages, triggers the overexpression of Il6, and enhances inflammation response. PMID: 33347836 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 18, 2020 Category: Pediatrics Authors: Yin L, Ma Y, Wang W, Zhu Y Tags: J Pediatr (Rio J) Source Type: research

Inborn errors of immunity associated with characteristic phenotypes ϯ.
CONCLUSIONS: Immunological defects can present with very different characteristics; however, the occurrence of infectious processes, autoimmune disorders and progression to malignancy may suggest diagnostic research. In the case of diseases with gene mutations, family history is of utmost importance. PMID: 33347837 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 18, 2020 Category: Pediatrics Authors: Bardou MLD, Henriques MT, Grumach AS Tags: J Pediatr (Rio J) Source Type: research

Impact of chronic kidney disease on health-related quality of life in the pediatric population: meta-analysis.
CONCLUSION: The findings of this study show that pediatric patients have lower health-related quality of life in all the evaluated dimensions, with the "school" dimension being the most affected and the "emotional" one the least. In this sense, we suggest monitoring the health-related quality of life of pediatric patients with chronic kidney disease so that interventions can be oriented to strengthen the affected dimensions, including adjustments to daily life and prevention of complications related to the disease. PMID: 33340460 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 16, 2020 Category: Pediatrics Authors: Ruidiaz-Gómez KS, Higuita-Gutiérrez LF Tags: J Pediatr (Rio J) Source Type: research

Combined immunodeficiencies.
CONCLUSIONS: The CIDs or IEI constitute a complex group of genetic diseases with T-cell involvement. Neonatal screening for these diseases has improved the prognosis of these patients, especially in severe ones, known as SCIDs. PMID: 33340461 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 16, 2020 Category: Pediatrics Authors: Aranda CS, Guimarães RR, de Gouveia-Pereira Pimentel M Tags: J Pediatr (Rio J) Source Type: research

Translation and cross-cultural adaptation of the Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ)1.
Abstract OBJECTIVE: To translate and cross-culturally adapt the Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) for use in Brazilian Portuguese. The CBBDQ is an 18-item tool covering 10 bladder and 8 bowel symptoms that was developed for use with children of 5-12 years of age with bowel and bladder dysfunction (BBD). The instrument has already been validated for use in Dutch and English. METHOD: In the process of translation and cultural adaptation from English to Portuguese, the CBBDQ was submitted to undergo the required steps as established by the international methodological criteria: forwar...
Source: Jornal de Pediatria - December 16, 2020 Category: Pediatrics Authors: Bernardes RP, Barroso U, Cordeiro DB, Scremim C, Lonkhuyzen MLVE, de Bie RA Tags: J Pediatr (Rio J) Source Type: research

Answer to the Letter "An illustration of how harmful the degree of freedom of the researcher is using the article entitled "Reliability and validity of the Brazilian version of the Pittsburgh Sleep Quality Index in adolescents" as an example".
Answer to the Letter "An illustration of how harmful the degree of freedom of the researcher is using the article entitled "Reliability and validity of the Brazilian version of the Pittsburgh Sleep Quality Index in adolescents" as an example". J Pediatr (Rio J). 2020 Dec 12;: Authors: Rodrigo Cappato de A PMID: 33321091 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 12, 2020 Category: Pediatrics Authors: Rodrigo Cappato de A Tags: J Pediatr (Rio J) Source Type: research

An illustration of how harmful the degree of freedom of the researcher is using the article entitled "Reliability and validity of the Brazilian version of the Pittsburgh Sleep Quality Index in adolescents" as an example.
An illustration of how harmful the degree of freedom of the researcher is using the article entitled "Reliability and validity of the Brazilian version of the Pittsburgh Sleep Quality Index in adolescents" as an example. J Pediatr (Rio J). 2020 Dec 12;: Authors: Santos MS PMID: 33321092 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 12, 2020 Category: Pediatrics Authors: Santos MS Tags: J Pediatr (Rio J) Source Type: research

Birth weight, life course factors and excess weight among schoolchildren in Niter ói, Rio de Janeiro, Brazil in 2010.
CONCLUSIONS: Although some of the secondary associations were statistically significant, we could not identify a significant association between birthweight and excess weight in adolescents. PMID: 33290734 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 5, 2020 Category: Pediatrics Authors: Noronha GA, Kale PL, Torres TZG, Vasconcelos JCPL, Kuschnir MCC, Cavalcanti MLT, Costa AJL, Szklo M Tags: J Pediatr (Rio J) Source Type: research

Hereditary angioedema: a disease seldom diagnosed by pediatricians.
CONCLUSIONS: Hereditary angioedema is little known by pediatricians due to the significant delay in diagnosis of this condition, whose onset usually begins in childhood. The presence of recurrent angioedema that does not respond to treatment with antihistamines, corticosteroids and adrenaline should increase the diagnostic suspicion. PMID: 33271064 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 30, 2020 Category: Pediatrics Authors: Campos RA, Valle SOR, Toledo EC Tags: J Pediatr (Rio J) Source Type: research

Human Inborn Errors of Immunity (HIEI): predominantly antibody deficiencies (PADs): if you suspect it, you can detect it.
CONCLUSION: Bruton (1952) used clinical expertise and protein electrophoresis to identify XLA. The IUIS (2020) committee used immunoglobulins and B lymphocyte to characterize PADs. Pediatricians should suspect it to detect it and prevent morbidities that can have an astonishing and irreversible impact on the child's life. PMID: 33245895 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 24, 2020 Category: Pediatrics Authors: Vilela MMDS Tags: J Pediatr (Rio J) Source Type: research

Merging Pediatric Index of Mortality (a physiologic instability measure), lactate, and Systemic Inflammation Mortality Risk to better predict outcome in Pediatric sepsis.
PMID: 33242412 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 23, 2020 Category: Pediatrics Authors: Horvat C, Simon DW, Aldewereld Z, Evans I, Aneja R, Carcillo JA Tags: J Pediatr (Rio J) Source Type: research

Immunological deficiencies: more frequent than they seem to be.
CONCLUSIONS: Considering this scenario, immunity disorders should be part of the investigation carried out by the general pediatrician, whether they are the innate errors of immunity (primary immunodeficiencies) or secondary immunodeficiencies, so that the diagnosis is attained as early as possible and therapeutic measures are implemented, reducing the morbidity and mortality of these patients. PMID: 33238140 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 22, 2020 Category: Pediatrics Authors: Barreto ICDP, Barreto BAP, Cavalcante EGDN, Condino Neto A Tags: J Pediatr (Rio J) Source Type: research

Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study.
CONCLUSIONS: Most characteristics of the present MIS-C patients were similar to that of other cohorts. The present results may contribute to a broader understanding of SARS-CoV-2 infection in children and its short-term consequences. Long-term multidisciplinary follow-up is needed, since it is not known whether these patients will have chronic cardiac impairment or other sequelae. PMID: 33186512 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 9, 2020 Category: Pediatrics Authors: Lima-Setta F, Magalhães-Barbosa MC, Rodrigues-Santos G, Figueiredo EADN, Jacques ML, Zeitel RS, Sapolnik R, Borges CTDS, Lanziotti VS, Castro REV, Bellinat APN, Silva TPD, Oliveira FRC, Reis BCSD, Castro NAASR, Macedo JHGC, Scarlato ACCP, Riveiro PM, Mot Tags: J Pediatr (Rio J) Source Type: research

Immune system: Development and acquisition of immunological competence.
CONCLUSIONS: In-depth knowledge of the development of the immune system and of the adaptive mechanisms that allow a safer transition to the extrauterine environment are fundamental components of optimizing maternal and young infant vaccination, as well as the strategies associated with full postnatal development, and the early diagnosis and treatment of innate errors of immunity. PMID: 33181111 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 9, 2020 Category: Pediatrics Authors: de Moraes-Pinto MI, Suano-Souza F, Aranda CS Tags: J Pediatr (Rio J) Source Type: research

Treatment of patients with immunodeficiency: Medication, gene therapy, and transplantation.
CONCLUSIONS: Immunoglobulin replacement therapy remains the main therapeutic tool. Precision medicine with specific drugs for altered immune pathways is already a reality for several immune defects. Advances in the management of HSCT and gene therapy have expanded the capacity for curative treatments in patients with primary immunodeficiencies. PMID: 33181112 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 9, 2020 Category: Pediatrics Authors: Segundo GRS, Condino Neto A Tags: J Pediatr (Rio J) Source Type: research

Immunodeficiencies: non-infectious manifestations.
CONCLUSIONS: Not only infectious conditions should raise the suspicion of immunodeficiencies, but also manifestations of allergy, inflammation, autoimmunity, lymphoproliferation, or cancer, especially if they are recurrent, associated to each other, affecting young patients, or in severe and/or difficult to treat conditions. PMID: 33176164 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 8, 2020 Category: Pediatrics Authors: Goudouris ES Tags: J Pediatr (Rio J) Source Type: research

Failure of immunological competence: when to suspect?
CONCLUSIONS: This article highlights the importance of considering this group of diseases even in the face of patients with non-infectious manifestations. Disclosure of innate errors of immunity diseases, especially to non-specialists, is essential for early diagnosis and, consequently, for the reduction of these patients' morbidity and mortality. PMID: 33176165 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 8, 2020 Category: Pediatrics Authors: Mariz FP Tags: J Pediatr (Rio J) Source Type: research

Cardiomyopathy and cardiac function in fetuses and newborns of diabetic mothers.
CONCLUSION: A decrease in the rate of myocardial hypertrophy and changes in cardiac function parameters were observed in the fetal and neonatal periods. PMID: 33176166 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - November 8, 2020 Category: Pediatrics Authors: Bogo MA, Pabis JS, Bonchoski AB, Santos DCD, Pinto TJF, Simões MA, Silva JC, Pabis FC Tags: J Pediatr (Rio J) Source Type: research

The general movement checklist: A guide to the assessment of general movements during preterm and term age.
Abstract OBJECTIVES: To develop a checklist describing features of normal and abnormal general movements (GMs) in order to guide General Movement Assessment (GMA) novices through the assessment procedure, to provide a quantification of GMA; and to demonstrate that normal and abnormal GMs can be distinguished on the basis of a metric checklist score. METHODS: Three examiners used GMA and the newly developed GM checklist to assess 20 videos of 16 infants (seven males) recorded at 31-45 weeks postmenstrual age (writhing GMs). Inter- and intra-scorer agreement was determined for GMA (nominal data; Kappa values) a...
Source: Jornal de Pediatria - November 1, 2020 Category: Pediatrics Authors: Aizawa CYP, Einspieler C, Genovesi FF, Ibidi SM, Hasue RH Tags: J Pediatr (Rio J) Source Type: research

Improvement of 1st-hour bundle compliance and sepsis mortality in pediatrics after the implementation of the surviving sepsis campaign guidelines.
osa A Abstract OBJECTIVES: To study the impact of the implementation of the Pediatric Surviving Sepsis Campaign (SSC) protocol on early recognition of sepsis, 1 -h treatment bundle and mortality. METHODS: Retrospective, single-center study, before and after the implementation of the sepsis protocol. OUTCOMES: sepsis recognition, compliance with the 1 -h bundle (fluid resuscitation, blood culture, antibiotics), time interval to fluid resuscitation and antibiotics administration, and mortality. Patients with febrile neutropenia were excluded. The comparisons between the periods were performed using non...
Source: Jornal de Pediatria - October 26, 2020 Category: Pediatrics Authors: Rodrigues-Santos G, de Magalhães-Barbosa MC, Raymundo CE, Lima-Setta F, da Cunha AJLA, Prata-Barbosa A Tags: J Pediatr (Rio J) Source Type: research

Genetic-molecular characterization in the diagnosis of primary immunodeficiencies.
CONCLUSIONS: There are many evident benefits of genetic analysis, such as the definitive diagnosis of the disease, family genetic counseling, and the possibility of a more adequate and accurate management. Cost, access and interpretation of genetic test results are limitations that need continuous improvement. The understanding of the benefits and limits of the several genetic assessment methodologies related to primary immunodeficiencies is essential to obtain more effective results from the sequencing. PMID: 33121930 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - October 26, 2020 Category: Pediatrics Authors: Segundo GRS Tags: J Pediatr (Rio J) Source Type: research

Predicting mortality in pediatric sepsis: A laudable but elusive goal.
PMID: 33115631 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - October 25, 2020 Category: Pediatrics Authors: Kortz TB, Kissoon N Tags: J Pediatr (Rio J) Source Type: research

✰Prevalence and diagnostic accuracy of microcephaly in a pediatric cohort in Brazil: A retrospective cross-sectional study.
CONCLUSIONS: Microcephaly prevalence was 4.1% in this study. Cutoff values determined by the World Health Organization had the highest sensitivity and specificity in relation to the standard IG curve. The main reason for microcephaly was intrauterine growth restriction. All possible causes of microcephaly must be investigated to allow the best development of an affected baby. PMID: 33086050 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - October 18, 2020 Category: Pediatrics Authors: Bertozzi APAP, Gazeta RE, Fajardo TCG, Moron AF, Soriano-Arandes A, Alarcon A, Garcia-Alix A, Silva ABD, Filho NF, Sarmento SGP, Witkin SS, Passos SD Tags: J Pediatr (Rio J) Source Type: research

The effectiveness of early parental coaching in the autism spectrum disorder.
CONCLUSIONS: The learning rate for comprehensive development skills in the ESDM checklist, such as receptive communication, expressive communication, social capacity, imitation, cognition, games, fine motor skills, gross motor skills, behavior, and personal independence was significantly higher in the SG, as well as the strategies and the quality of interaction between parents and children. Thus, Parental Coaching presents as a possibility of early intervention in children with Autism Spectrum Disorder. PMID: 33069667 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - October 15, 2020 Category: Pediatrics Authors: Malucelli ERS, Antoniuk SA, Carvalho NO Tags: J Pediatr (Rio J) Source Type: research

Late vitamin K deficiency bleeding in infants: Five-year prospective study.
CONCLUSION: Secondary late VKDB is more common than the primary subtypes, and late VKDB is still a serious disease in developing countries, including Iraq, when vitamin K prophylaxis isn't routinely used at birth. PMID: 33064995 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - October 13, 2020 Category: Pediatrics Authors: Al-Zuhairy SH Tags: J Pediatr (Rio J) Source Type: research

Cord blood bilirubin and prediction of neonatal hyperbilirubinemia and perinatal infection in newborns at risk of hemolysis.
CONCLUSIONS: A positive correlation was found between umbilical cord bilirubin and hyperbilirubinemia in the first 48 h of life. Umbilical cord bilirubin is a poor marker for predicting neonatal infection. PMID: 33049218 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - October 10, 2020 Category: Pediatrics Authors: Kardum D, Serdarušić I, Biljan B, Šantić K, Živković V, Kos M Tags: J Pediatr (Rio J) Source Type: research

Vitamin D deficiency in children and adolescents with obesity: a meta-analysis.
Abstract OBJECTIVE: To evaluate the prevalence of vitamin D deficiency in obese children and adolescents when compared to eutrophic controls. METHODS: Systematic review with meta-analysis covering studies with patients aged 0-18 years old diagnosed with obesity and vitamin D deficiency and control group of eutrophic patients. The studies were retrieved in the PubMed, Embase, and LILACS databases in December 2019. The search used the terms "obesity" in combination with "pediatric population" and "vitamin D". RESULTS: Through the search 3155 articles were retrieved; and after ...
Source: Jornal de Pediatria - October 3, 2020 Category: Pediatrics Authors: Fiamenghi VI, Mello ED Tags: J Pediatr (Rio J) Source Type: research

Performance of prognostic markers in pediatric sepsis.
CONCLUSIONS: PIM2, ferritin, lactate, and CRP alone showed good prognostic performance for mortality in pediatric patients older than 6 months with sepsis. When combined, they were able to predict death in three-fourths of the patients with sepsis. Total leukocyte count was not useful as a prognostic marker. PMID: 32991837 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 25, 2020 Category: Pediatrics Authors: Tonial CT, Costa CAD, Andrades GRH, Crestani F, Bruno F, Piva JP, Garcia PCR Tags: J Pediatr (Rio J) Source Type: research

Maternal weight before and during pregnancy in women with gestational diabetes: one step forward, one step back.
PMID: 32986998 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 24, 2020 Category: Pediatrics Authors: Mainland R, Retnakaran R Tags: J Pediatr (Rio J) Source Type: research

Allergic sensitization pattern of patients in Brazil.
CONCLUSION: Studies on the pattern of allergic sensitization to a specific population offer tools for the more effectual prevention, diagnosis, and treatment of allergic diseases. Sensitization to dust mites house was the most prevalent in the evaluated sample. High rates of sensitization to furry animals also stand out. Patients with food allergy, atopic dermatitis, or multimorbidity appear to be at greater risk for developing more severe allergic diseases. PMID: 32986999 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 24, 2020 Category: Pediatrics Authors: Aranda CS, Cocco RR, Pierotti FF, Sarinho E, Sano F, Porto A, Rosário N, Neto HJC, Goudouris E, Moraes LS, Wandalsen NF, Mallozi MC, Pastorino AC, Franco JM, Chavarria ML, Borres M, Solé D Tags: J Pediatr (Rio J) Source Type: research

The potential impact of the COVID-19 pandemic on child growth and development: a systematic review.
CONCLUSION: Information about the impact of epidemics on parents and children is relevant to policy makers to aid them in developing strategies to help families cope with epidemic/pandemic-driven adversity and ensure their children's healthy development. PMID: 32980318 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 22, 2020 Category: Pediatrics Authors: Araújo LA, Veloso CF, Souza MC, Azevedo JMC, Tarro G Tags: J Pediatr (Rio J) Source Type: research

Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations.
CONCLUSIONS: Differences in immune response of children and variations of tissue expression of angiotensin converting enzyme 2, the virus receptor, are likely to influence clinical, epidemiological, and pathophysiological patterns of the disease. PMID: 32980319 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 21, 2020 Category: Pediatrics Authors: Pousa PA, de Mendonça TSC, Oliveira EA, E Silva ACS Tags: J Pediatr (Rio J) Source Type: research

Association between asthma and sleep hours in Brazilian adolescents: ERICA.
ir FC Abstract OBJECTIVE: To investigate the association between asthma and sleep duration in participants of the Study of Cardiovascular Risks in Adolescents (ERICA). MATERIALS AND METHODS: Cross-sectional, national, school-based study, involving adolescents aged 12-17 years. In the period between 2013-14, data from 59,442 participants were analyzed. Bivariate analysis between current asthma and short sleep duration, defined as
Source: Jornal de Pediatria - September 17, 2020 Category: Pediatrics Authors: Estanislau NRDA, Jordão EAOC, Abreu GA, Bloch KV, Kuschnir MCC, Felix MMR, Kuschnir FC Tags: J Pediatr (Rio J) Source Type: research

Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view.
CONCLUSIONS: MIS-C associated with COVID-19 is serious, rare, and potentially fatal. The emergency department pediatrician must recognize and treat it early using immunomodulatory strategies to reduce systemic injury. Further studies are needed to identify the disease pathogenesis and establish the most appropriate treatment. PMID: 32946801 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 10, 2020 Category: Pediatrics Authors: Junior HS, Sakano TMS, Rodrigues RM, Eisencraft AP, Carvalho VEL, Schvartsman C, Reis AGADC Tags: J Pediatr (Rio J) Source Type: research

Evaluation of the prevalence and factors associated with acute kidney injury in a pediatric intensive care unit.
CONCLUSION: Older children, diagnosis of sepsis, demand for ventilatory support, and use of vasoactive amines were correlated with a higher risk of developing acute kidney injury. The mortality associated with acute kidney injury was elevated; it is crucial that all measures that ensure adequate renal perfusion are taken for patients with risk factors, to avoid the installation of the disease. PMID: 32919936 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 9, 2020 Category: Pediatrics Authors: Louzada CF, Ferreira AR Tags: J Pediatr (Rio J) Source Type: research

Adenovirus 36 infection and daycare starting age are associated with adiposity in children and adolescents.
CONCLUSION: This study concluded that excessive weight was positively associated with seropositivity for Adv36. Early enrollment in a full-time daycare was also an associated factor for obesity. Such data, confirmed in new studies, reinforces the role of Adv36 in the increase of childhood adiposity. PMID: 32910885 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 6, 2020 Category: Pediatrics Authors: Cancelier ACL, Dhurandhar N, Peddibhotla S, Atkinson RL, Silva HCG, Trevisol DJ, Schuelter-Trevisol F Tags: J Pediatr (Rio J) Source Type: research

Validation of the Adolescent Barriers Questionnaire for use in Brazilian adolescents with cancer.
CONCLUSION: After the process of translation, validation, and analysis of psychometric properties, the Brazilian Portuguese version of ABQ was considered to be culturally adapted, valid, and reliable for the Brazilian adolescent population with cancer aged 12-18 years. It can be a useful tool in clinical practice, offering the health professionals the opportunity to understand the barriers adolescents with cancer can encounter and offer support to overcome them. PMID: 32905784 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 5, 2020 Category: Pediatrics Authors: Campos DR, Paiva CE, Brandão APMS, Ameringer S, Paiva BSR Tags: J Pediatr (Rio J) Source Type: research

Laboratory diagnosis of COVID-19.
CONCLUSIONS: The identification of genetic material of the virus by RT-PCR is the gold standard test, but its sensitivity is not satisfactory. The diagnosis of COVID-19 should be based on clinical data, epidemiological history, tests for etiological diagnosis, and tests to support the diagnosis of the disease and/or its complications. New diagnostic methods with higher sensitivity and specificity, as well as faster results, are necessary. PMID: 32882235 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - August 30, 2020 Category: Pediatrics Authors: Goudouris ES Tags: J Pediatr (Rio J) Source Type: research

Temporal trend in early sepsis in a very low birth weight infants' cohort: an opportunity for a rational antimicrobial use.
This study aimed to evaluate annual trends of early neonatal sepsis and antimicrobial use in very low birth weight infants for 12 years, as well as to identify microbiological agents, antimicrobial sensitivity profiles, and association with early neonatal death. METHOD: This was a retrospective cohort study including 1254 very low birth weight infants admitted from 2006 to 2017. Four groups were evaluated: culture-confirmed sepsis; presumed neonatal sepsis; ruled out neonatal sepsis group; and infants not exposed to antibiotics. RESULTS: The medians of gestational age and birth weight were 29 weeks (27-31) and 10...
Source: Jornal de Pediatria - August 22, 2020 Category: Pediatrics Authors: Caldas JPS, Montera LC, Calil R, Marba STM Tags: J Pediatr (Rio J) Source Type: research

The value of oxygen index and base excess in predicting the outcome of neonatal acute respiratory distress syndrome.
CONCLUSION: The combination of oxygen index and base excess can be used as a predictor of outcomes in neonates receiving non-extra corporal membrane oxygenation treatment for acute respiratory distress syndrome. In neonates with acute respiratory distress syndrome, if oxygen index>30 and base excess
Source: Jornal de Pediatria - August 17, 2020 Category: Pediatrics Authors: Wu H, Hong X, Qu Y, Liu Z, Zhao Z, Liu C, Ji Q, Wang J, Xueli Q, Jianwei S, Cheng D, Feng ZC, Yuan S Tags: J Pediatr (Rio J) Source Type: research

IL-4-C-590T locus polymorphism and susceptibility to asthma in children: a meta-analysis.
CONCLUSIONS: The IL-4-C590T polymorphism was associated with asthma susceptibility, and T allele and TT genotype may increase the risk of asthma susceptibility in children, especially in the Asian population. PMID: 32781035 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - August 7, 2020 Category: Pediatrics Authors: Jin X, Zheng J Tags: J Pediatr (Rio J) Source Type: research

Translation, cross-cultural adaptation, and validation of the Leuven Knowledge Questionnaire for congenital heart disease instrument into Brazilian Portuguese.
CONCLUSIONS: The results suggest reliability among the evaluators, indicating the instrument's accuracy and the possibility of using it to assess the knowledge of parents and family caregivers about congenital heart disease. PMID: 32781036 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - August 7, 2020 Category: Pediatrics Authors: Cecchetto FH, Bonato GD, Barreto TSM, Riegel F, Pellanda LC Tags: J Pediatr (Rio J) Source Type: research

Point-of-care ultrasound by the pediatrician in the diagnosis and follow-up of community-acquired pneumonia.
CONCLUSIONS: Point-of-care ultrasonography represents an opportunity to improve the diagnosis and monitoring of CAP. However, as an operator-dependent technique, training is required for adequate image acquisition, correct interpretation, and integration with clinical data for correct decision-making. PMID: 32781037 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - August 7, 2020 Category: Pediatrics Authors: Toro MS, Martínez JLV, Falcão RV, Prata-Barbosa A, Cunha AJLAD Tags: J Pediatr (Rio J) Source Type: research