Next-Generation Anti-TNF α Agents: The Example of Ozoralizumab
AbstractBiologic therapy involving anti-tumor necrosis factor- α (anti-TNFα) agents has fundamentally changed the management of patients with immune-mediated inflammatory diseases, including rheumatoid arthritis, thus benefiting many patients. Nevertheless, the inability of some patients to achieve low disease activity or clinical remission remains a major co ncern. To address such concerns, next-generation anti-TNFα agents that differ from the immunoglobulin G-format anti-TNFα agents that have been used to date are being developed using antibody-engineering technology. Their unique design employing novel molecular cha...
Source: BioDrugs - April 8, 2024 Category: Drugs & Pharmacology Source Type: research
Characterizing the polygenic overlap and shared loci between rheumatoid arthritis and cardiovascular diseases
Despite substantial research revealing that patients with rheumatoid arthritis (RA) have excessive morbidity and mortality of cardiovascular disease (CVD), the mechanism underlying this association has not bee... (Source: BMC Medicine)
Source: BMC Medicine - April 8, 2024 Category: Internal Medicine Authors: Xiaohui Sun, Yu Qian, Weiqiu Cheng, Ding Ye, Bin Liu, Dan Zhou, Chengping Wen, Ole A. Andreassen and Yingying Mao Tags: Research article Source Type: research
Canakinumab treatment real world evidence in 3 monogenic periodic fever syndromes in 2009 –2022: an interim analysis using the French JIR cohort database
Our study aimed to provide real-world evidence on the treatment patterns, effectiveness and safety of canakinumab in France in Familial Mediterranean Fever (FMF), Mevalonate Kinase Deficiency (MKD), and Tumor ... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - April 8, 2024 Category: Rheumatology Authors: Isabelle Kon é-Paut, Sophie Georgin-Lavialle, Alexandre Belot, Magali Jover, Mathilde Pouriel, Laure Lacoin, Pascal Pillet and Véronique Hentgen Tags: Research Source Type: research
Sutures, Screws, Buttons, and Anchors: A Review of Current Bone Graft Fixation Devices for Glenoid Bone Loss in the Unstable Shoulder
AbstractPurpose of ReviewAnterior shoulder instability is associated with concomitant injury to several stabilizing structures of the shoulder, including glenoid bone loss. While instability is most common in young athletes and patients with predisposing conditions of hyperlaxity, recurrent shoulder instability can occur throughout various age ranges and may lead to longer term effects including pain and shoulder arthritis. Glenoid bone loss exceeding certain thresholds is generally treated by glenoid reconstruction via bone block augmentation to adequately stabilize the glenohumeral joint. These procedures increase the wi...
Source: Current Reviews in Musculoskeletal Medicine - April 8, 2024 Category: Orthopaedics Source Type: research
[18F]FDG PET/CT imaging of spinal infections
AbstractThe annual incidence of spinal infections has been rising significantly over the last years and is expected to increase even further. Spinal infections may include infection of the vertebral body and intervertebral disc (spondylodiscitis), paravertebral abscess, epidural abscess and septic arthritis of the facet joints. Positron emission tomography (PET) with [18F]FDG has high sensitivity for detecting spinal infections, may help in differentiating between spinal infection subtypes and is able to detect dissemination of infection outside the spine. [18F]FDG PET/CT is especially indicated if MRI is inconclusive, in ...
Source: Clinical and Translational Imaging - April 8, 2024 Category: Radiology Source Type: research
Provider assessment of the temporomandibular joint in Juvenile idiopathic arthritis: a retrospective analysis from the CARRA database
Temporomandibular joint (TMJ) involvement is an often underrecognized complication of juvenile idiopathic arthritis (JIA) that can cause decreased mandibular growth, altered facial morphology, and orofacial pa... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - April 8, 2024 Category: Rheumatology Authors: Anna Costello, Marinka Twilt and Melissa A. Lerman Tags: Research article Source Type: research
Hematological indices in psoriatic enthesopathy: relation to clinical and ultrasound evaluation
ConclusionMonitoring PsA disease activity can be improved by considering RDW and MPV as reliable indicators and using them to screen for psoriatic enthesopathy with MSUS indices.Key points•Clinically identifying enthesitis in patients with PsA can be challenging. Imaging MSUS indices hold promise for objective analysis, but there is no consensus on which indices to use in clinical trials and daily practice.•Patients with psoriatic enthesopathy have higher RDW and MPV levels, which are positively correlated with DAPSA28 score.•RDW and MPV can be considered in the turn of improved screening of psoriatic enthesopathy...
Source: Clinical Rheumatology - April 8, 2024 Category: Rheumatology Source Type: research
Next-Generation Anti-TNF α Agents: The Example of Ozoralizumab
AbstractBiologic therapy involving anti-tumor necrosis factor- α (anti-TNFα) agents has fundamentally changed the management of patients with immune-mediated inflammatory diseases, including rheumatoid arthritis, thus benefiting many patients. Nevertheless, the inability of some patients to achieve low disease activity or clinical remission remains a major co ncern. To address such concerns, next-generation anti-TNFα agents that differ from the immunoglobulin G-format anti-TNFα agents that have been used to date are being developed using antibody-engineering technology. Their unique design employing novel molecular cha...
Source: BioDrugs - April 8, 2024 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 29, Pages 1671: An Evaluation of the Impact of 60Co Irradiation on Volatile Organic Compounds of Olibanum Using Gas Chromatography Ion Mobility Spectrometry
This study provides a theoretical basis for the irradiation processing and quality control of resinous medicinal materials such as olibanum and it also provides a good reference for irradiation technology development and its application to functional foods, thus making it both significant from a research perspective and useful from an application perspective. (Source: Molecules)
Source: Molecules - April 8, 2024 Category: Chemistry Authors: Qiao Luo Shanshuo Liu Ye He Jiayao Liu Xinyu Zhang Liqiu Zheng Dan Huang Tags: Article Source Type: research
Maackia amurensis seed lectin (MASL) and soluble human podoplanin (shPDPN) sequence analysis and effects on human oral squamous cell carcinoma (OSCC) cell migration and viability
Biochem Biophys Res Commun. 2024 Apr 3;710:149881. doi: 10.1016/j.bbrc.2024.149881. Online ahead of print.ABSTRACTMaackia amurensis lectins serve as research and botanical agents that bind to sialic residues on proteins. For example, M. amurensis seed lectin (MASL) targets the sialic acid modified podoplanin (PDPN) receptor to suppress arthritic chondrocyte inflammation, and inhibit tumor cell growth and motility. However, M. amurensis lectin nomenclature and composition are not clearly defined. Here, we sought to definitively characterize MASL and its effects on tumor cell behavior. We utilized SDS-PAGE and LC-MS/MS to fi...
Source: Biochemical and Biophysical Research communications - April 7, 2024 Category: Biochemistry Authors: Ariel C Yin Cayla J Holdcraft Eamonn J Brace Tyler J Hellmig Sayan Basu Saumil Parikh Katarzyna Jachimowska Evelyne Kalyoussef Dylan Roden Soly Baredes Eugenio M Capitle David I Suster Alan J Shienbaum Caifeng Zhao Haiyan Zheng Kevin Balcaen Simon Devos J Source Type: research
Non-Pharmacological Interventions for Treating Psoriatic Arthritis
CONCLUSIONS: The polyhedral clinical expression of PsA underlines the need for a multidisciplinary approach combining the synergistic effects of pharmacological and non-pharmacological treatments. The latter range from preventive measures, like dietary modifications, weight loss, and cigarette smoking cessation, to personalized training protocols according to disease activity and phenotype, comorbidities, and individual tolerability. In these patients, we strongly encourage the regular practice of motor activity at progressively increasing intensity with combined supervised aerobic, strength, endurance, and stretching exer...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Rossella Talotta Maria Rita Aiello Roberto Restuccia Ludovico Magaudda Source Type: research
Association Between Arthritis and the Risk of Depressive Symptoms in Middle-Aged and Older Adults: A Nationwide Population-Based Study
CONCLUSIONS: This study establishes a significant association between arthritis and the development of depressive symptoms in middle-aged and older adults. Arthritis emerges as a potential risk factor, emphasizing the need for targeted interventions to enhance mental well-being in this population.PMID:38581332 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Da-Long Hou Yang Yang Source Type: research
Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome - A sham-controlled, randomized, clinical trial
CONCLUSION: The IA intervention was associated with a promising effect on the decrease in RA disease activity and delayed overall disease progression.PMID:38582376 | DOI:10.1016/j.ctim.2024.103037 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - April 6, 2024 Category: Complementary Medicine Authors: Huifang Luo Ping Du Wenyan Qin Yiyi Hu Zhen Xian Changsong Lin Peiwu Li Yang Song Xiangwei Yang Source Type: research
Intradermal acupuncture in the treatment of rheumatoid arthritis with liver and kidney deficiency syndrome - A sham-controlled, randomized, clinical trial
CONCLUSION: The IA intervention was associated with a promising effect on the decrease in RA disease activity and delayed overall disease progression.PMID:38582376 | DOI:10.1016/j.ctim.2024.103037 (Source: Complementary Therapies in Medicine)
Source: Complementary Therapies in Medicine - April 6, 2024 Category: Complementary Medicine Authors: Huifang Luo Ping Du Wenyan Qin Yiyi Hu Zhen Xian Changsong Lin Peiwu Li Yang Song Xiangwei Yang Source Type: research
Non-Pharmacological Interventions for Treating Psoriatic Arthritis
CONCLUSIONS: The polyhedral clinical expression of PsA underlines the need for a multidisciplinary approach combining the synergistic effects of pharmacological and non-pharmacological treatments. The latter range from preventive measures, like dietary modifications, weight loss, and cigarette smoking cessation, to personalized training protocols according to disease activity and phenotype, comorbidities, and individual tolerability. In these patients, we strongly encourage the regular practice of motor activity at progressively increasing intensity with combined supervised aerobic, strength, endurance, and stretching exer...
Source: Alternative Therapies in Health and Medicine - April 6, 2024 Category: Complementary Medicine Authors: Rossella Talotta Maria Rita Aiello Roberto Restuccia Ludovico Magaudda Source Type: research
