Osteoarthritis in the Upper Extremity
Arthritis is defined broadly as pain and stiffness in a joint and can be the presenting symptom in broad range of pathologies. Autoimmune disease, infection, crystalline inflammation, and connective tissue disorders can also produce pain and inflammation of varying severities across the joints of the body.1 Osteoarthritis, or degenerative joint disease, is the most common of these etiologies, and is the form of arthritis commonly attributed to age and “wear and tear” throughout one's life.2 Osteoarthritis is a highly prevalent cause of morbidity worldwide, with an estimated 250 million individuals currently affected an...
Source: The American Journal of Medicine - February 3, 2023 Category: General Medicine Authors: Davis A. Hartnett, John D. Milner, Steven F. DeFroda Tags: Review Source Type: research

Research on Liver Damage Caused by the Treatment of Rheumatoid Arthritis with Novel Biological Agents or Targeted Agents
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - February 2, 2023 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research

Overview of Cochrane Systematic Reviews of rehabilitation interventions for persons with rheumatoid arthritis: a mapping synthesis
Eur J Phys Rehabil Med. 2023 Feb 2. doi: 10.23736/S1973-9087.22.07833-9. Online ahead of print.ABSTRACTThe aim of this paper was to provide an overview of Cochrane Systematic Reviews (CSRs), which synthesizes the quality and quantity of available evidence on the effectiveness of rehabilitation interventions in rheumatoid arthritis (RA). The World Health Organization (WHO) requested Cochrane Rehabilitation the CSRs search to develop the Package of Interventions in Rehabilitation (PIR). We searched the Cochrane Library using the terms "rheumatoid arthritis" and "rehabilitation." We screened the CSRs according to the search s...
Source: European Journal of Physical and Rehabilitation Medicine - February 2, 2023 Category: Rehabilitation Authors: Ay şe A Küçükdeveci Burak K Turan Chiara Arienti Stefano Negrini Source Type: research

Factors Associated With Glaucoma Surgery in Pediatric Non-Infectious Uveitis
CONCLUSION: The risk profile for undergoing glaucoma surgery as outlined in this study is a valuable help to recognize and treat secondary glaucoma in a timely manner.PMID:36731522 | DOI:10.1080/09273948.2023.2166849 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 2, 2023 Category: Allergy & Immunology Authors: Charlotte L L I van Meerwijk Wietse G Wieringa Joke H de Boer Nomdo M Jansonius Leonoor I Los Source Type: research

Alterations in Retinal Vascularity in Severe Psoriasis
CONCLUSION: Severe psoriasis causes a decrease in retinal blood flow and presence of psoriatic arthritis is related with decreased foveal VD.PMID:36731518 | DOI:10.1080/09273948.2023.2166536 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 2, 2023 Category: Allergy & Immunology Authors: Mine Esen Baris Funda Kuscu Akdeniz Idil Unal Suzan Guven Yilmaz Source Type: research

Prevalence and predictors of ambulatory care physicians' documentation of mobility limitations in older adults
CONCLUSIONS: Mobility limitations are under-documented and may be primarily captured when changes in function are overt.PMID:36731767 | DOI:10.1016/j.apmr.2022.11.018 (Source: Health Physics)
Source: Health Physics - February 2, 2023 Category: Physics Authors: Valerie Shuman Jennifer S Brach Jonathan F Bean Janet K Freburger Source Type: research

Overview of Cochrane Systematic Reviews of rehabilitation interventions for persons with rheumatoid arthritis: a mapping synthesis
Eur J Phys Rehabil Med. 2023 Feb 2. doi: 10.23736/S1973-9087.22.07833-9. Online ahead of print.ABSTRACTThe aim of this paper was to provide an overview of Cochrane Systematic Reviews (CSRs), which synthesizes the quality and quantity of available evidence on the effectiveness of rehabilitation interventions in rheumatoid arthritis (RA). The World Health Organization (WHO) requested Cochrane Rehabilitation the CSRs search to develop the Package of Interventions in Rehabilitation (PIR). We searched the Cochrane Library using the terms "rheumatoid arthritis" and "rehabilitation." We screened the CSRs according to the search s...
Source: Health Physics - February 2, 2023 Category: Physics Authors: Ay şe A Küçükdeveci Burak K Turan Chiara Arienti Stefano Negrini Source Type: research

Nanotransethosomes for enhanced transdermal delivery of  mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation
Drug Deliv. 2023 Dec;30(1):2173338. doi: 10.1080/10717544.2023.2173338.ABSTRACTThe present research study limns the preparation of MNF loaded transethosomes (MNF-TE) to improve MNF solubility, bioavailability and permeation through skin layers for transdermal delivery. MNF-TE was formulated using thin-film hydration method and optimization was done using Box-Behnken design (BBD). MNF-TEopt was characterized for Polydispersity index (PDI), vesicle size, entrapment efficiency, zeta potential and in vitro MNF release. For further evaluation, Pharmacokinetic study, Transmission electron microscopy (TEM), Skin permeation study ...
Source: Drug Delivery - February 2, 2023 Category: Drugs & Pharmacology Authors: Syeda Nashvia Adin Isha Gupta Md Abdur Rashid Yahya Alhamhoom Mohd Aqil Mohd Mujeeb Source Type: research

Letter to the Editor: Assessment for Septic Arthritis in Immunocompetent and Immunocompromised Patients: A Single-Institution Study
J Am Acad Orthop Surg. 2022 Nov 3. doi: 10.5435/JAAOS-D-22-00239. Online ahead of print.NO ABSTRACTPMID:36730775 | DOI:10.5435/JAAOS-D-22-00239 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - February 2, 2023 Category: Orthopaedics Authors: Moses I Markowitz Dylan Luxenburg Michael G Rizzo Fernando E Vilella Source Type: research

Response to Letter to the Editor: A Comparison of Risk Factors for Septic Arthritis in Immunocompromised Patients: A Single Institution Study
J Am Acad Orthop Surg. 2022 Dec 9. doi: 10.5435/JAAOS-D-22-01044. Online ahead of print.NO ABSTRACTPMID:36729705 | DOI:10.5435/JAAOS-D-22-01044 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - February 2, 2023 Category: Orthopaedics Authors: Chelsea R Brown Richard Samade Karilyn T M Larkin Amy L Speeckaert Source Type: research

Tinker, tailor, soldier, cell: the role of C-type lectins in the defense and promotion of disease
Protein Cell. 2022 Jul 15;14(1):4-16. doi: 10.1093/procel/pwac012. eCollection 2023 Jan.ABSTRACTC-type lectins (CTLs) represent a large family of soluble and membrane-bound proteins which bind calcium dependently via carbohydrate recognition domains (CRDs) to glycan residues presented on the surface of a variety of pathogens. The deconvolution of a cell's glycan code by CTLs underpins several important physiological processes in mammals such as pathogen neutralization and opsonization, leukocyte trafficking, and the inflammatory response. However, as our knowledge of CTLs has developed it has become apparent that the role ...
Source: Protein and Cell - February 2, 2023 Category: Cytology Authors: James N Arnold Daniel A Mitchell Source Type: research

Cardiovascular Manifestations in Rheumatoid Arthritis
Cardiol Rev. 2022 Dec 20. doi: 10.1097/CRD.0000000000000486. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a systemic inflammatory disorder that characteristically affects the joints. RA has extra-articular manifestations that can impact multiple organ systems including the heart, lungs, eyes, skin, and brain. Cardiovascular involvement is a leading cause of mortality in RA. Cardiovascular manifestations of RA include accelerated atherosclerosis, heart failure, pericarditis, myocarditis, endocarditis, rheumatoid nodules, and amyloidosis. Inflammation is an important mediator of endothelial dysfunction and is a...
Source: Atherosclerosis - February 2, 2023 Category: Cardiology Authors: Nirali Sanghavi Jenne P Ingressia Sindhuja Korem Julia Ash Stephen Pan Amy Wasserman Source Type: research

Implementation of automated behavior metrics to evaluate voluntary wheel running effects on inflammatory-erosive arthritis and interstitial lung disease in TNF-Tg mice
Although treatment options and algorithms for rheumatoid arthritis (RA) have improved remarkably in recent decades, there continues to be no definitive cure or pharmacologic intervention with reliable long-ter... (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - February 2, 2023 Category: Rheumatology Authors: H. Mark Kenney, Ronald W. Wood, Gabriel Ramirez, Richard D. Bell, Kiana L. Chen, Lindsay Schnur, Homaira Rahimi, Benjamin D. Korman, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz and Calvin L. Cole Tags: Research Source Type: research

Levofloxacin induces differential effects in the transcriptome between the gut, peripheral and axial joints in the Spondyloarthritis DBA/1 mice: Improvement of intestinal dysbiosis and the overall inflammatory process
by Susana Aide é González-Chávez, Joan S. Salas-Leiva, Dayana E. Salas-Leiva, Salma Marcela López-Loeza, Jasanai Sausameda-García, Erasmo Orrantia-Borunda, Rubén Burgos-Vargas, Maria Fernanda Alvarado-Jáquez, Mayra Torres-Quintana, Rubén Cuevas-Martínez, Eduardo Chaparro-Barrera, Carlos Marín-Terrazas, G erardo Pável Espino-Solís, José Pablo Romero-López, Brian de Jesús Bernal-Alferes, César Pacheco-Tena To analyze the effect of levofloxacin-induced intestinal microbiota modifications on intestinal, joint, and systemic inflammation in the DBA/1 mice with spontaneous arthritis. The study included two groups...
Source: PLoS One - February 2, 2023 Category: Biomedical Science Authors: Susana Aide é González-Chávez Source Type: research

Study on the correlation between the severity of patellofemoral arthritis and the morphology of the distal femur
This study aims to evaluate the correlation between distal femoral torsion and the severity of patellofemoral arthritis, and t... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - February 2, 2023 Category: Orthopaedics Authors: Chongyi Fan, Yingzhen Niu, Maozheng Wei, Lingce Kong and Fei Wang Tags: Research Source Type: research