In vitro study of synergy of ampicillin with ceftriaxone against Listeria monocytogenes.
CONCLUSIONS: The association of ceftriaxone with ampicillin increases the in vitro activity of ampicillin, and therefore could be a valuable option in the treatment of invasive infection by L. monocytogenes. PMID: 31515975 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 12, 2019 Category: Drugs & Pharmacology Authors: Lepe JA, Rodríguez-Villodres A, Martín-Gutiérrez G, Luque R, Aznar J Tags: Rev Esp Quimioter Source Type: research

[Male deep infections by Gardnerella vaginalis. A literature review and a case report].
Gutiérrez-Fernández J Abstract PMID: 31515976 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 12, 2019 Category: Drugs & Pharmacology Authors: Ruiz-Gómez ML, Martín-Way DA, Pérez-Ramírez MD, Gutiérrez-Fernández J Tags: Rev Esp Quimioter Source Type: research

Usefulness of FilmArray Meningitis/Encephalitis panel in the management of an uncommon case of Herpes Simplex Virus type 2 meningitis.
cute;guez-Lucas C Abstract PMID: 31515977 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 12, 2019 Category: Drugs & Pharmacology Authors: Suárez-Fernández S, Iturzaeta A, Rodríguez-Lucas C Tags: Rev Esp Quimioter Source Type: research

Male genitourinary infections by Corynebacterium glucuronolyticum. A review and clinical experience.
rrez-Fernández J PMID: 31515978 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 12, 2019 Category: Drugs & Pharmacology Authors: Ruiz-Pino M, Foronda-García-Hidalgo C, Alarcón-Blanco P, Gutiérrez-Fernández J Tags: Rev Esp Quimioter Source Type: research

Update in Infectious Diseases 2019.
anz M, González Del Castillo J, Arribi A Abstract The IX Course of Antimicrobials and Infectious Diseases update included a review of the main issues in clinical microbiology, epidemiology and clinical aspects for a current approach of infectious pathology. The present introduction summarizes about the most important meetings related to infectious diseases during 2018 (ECCMID, IAS, ASM and ID Week). In addition, the course provides a practical information to focus on nosocomial infection models, with immunosuppressed patients or complex multidrug-resistant pathogens. The closing lecture of this year reviewe...
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Candel FJ, Rico CM, Díaz de la Torre I, Laguna B, Martínez-Jordán J, Medrano S, Escobar-Porcel MC, López-Delgado A, López-González L, Viñuela-Prieto JM, Matesanz M, González Del Castillo J, Arribi A Tags: Rev Esp Quimioter Source Type: research

Highlights at the ASM Microbe 2018, Atlanta (USA).
Abstract PMID: 31475802 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Cercenado E Tags: Rev Esp Quimioter Source Type: research

Highlights at the 28th Congress of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), 2018.
uz JM Abstract PMID: 31475803 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Nabal S, Mormeneo S, García-Lechuz JM Tags: Rev Esp Quimioter Source Type: research

Some impressions of the content of the San Francisco ID-Week, in the area of bacterial infection.
Abstract PMID: 31475804 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Bouza E Tags: Rev Esp Quimioter Source Type: research

Highlights from 22nd International AIDS Conference.
na MJ, Estrada Pérez V Abstract PMID: 31475805 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Núñez-Orantos MJ, Cabello Clotet N, Vergas García J, Téllez Molina MJ, Estrada Pérez V Tags: Rev Esp Quimioter Source Type: research

Current status of ESKAPE microorganisms in Spain: Epidemiology and resistance phenotypes.
, Cantón R Abstract Resistance rates in ESKAPE microorganisms included in the EARS-net surveillance database from Spain have increased in most of the cases. In 2017, multi-drug resistant isolates rose to 5.5% in Escherichia coli and 13.0% in Klebsiella pneumoniae. Carbapenemase producing Enterobacterales (CPE) have also increased in Spain over the last years with a current spread of throughout the country. EuSCAPE project revealed dominance of OXA-48 carbapenemase with lower prevalence of KPC, VIM or NDM enzymes. Increase of faecal carriers and presence of carbapenemases in the so-called high-risk clones ha...
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Sánchez-López J, Cantón R Tags: Rev Esp Quimioter Source Type: research

Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa.
o A Abstract Pseudomonas aeruginosa is characterized by an important intrinsic resistance to antibiotics and it possess an extraordinary ability to develop resistance to nearly all available antimicrobials through selection of mutations. We review some of the pharmacodynamic principles of antibiotics predicting efficacy, clinical experience with monotherapy and combination therapy, and principles for antibiotic treatment for empirical and directed treatment of P. aeruginosa invasive infections. PMID: 31475807 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Cardozo C, Rico V, Agüero D, Soriano A Tags: Rev Esp Quimioter Source Type: research

The pharmacodynamic bases of the prescription of antimicrobials.
Abstract In the past, the dose of an antibiotic was chosen, always from among those that were well tolerated, by considering those with the ability to exceed the MIC of bacteria in plasma. This approach, which has still not widely changed, is contrast-ed with the pharmacokinetic and pharmacodynamic (PK/PD) relationships, which indicate that the efficacy of antibiotics is directly related to parameters that relate the sequence of con-centrations over time with a parameter of the MIC effect in vitro. Until now, three types of PK/PD relationships have been established for antibiotics: the inhibitory coefficient (Cmax...
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Azanza Perea JR Tags: Rev Esp Quimioter Source Type: research

Practical approach to the management of catheter-related bloodstream infection.
ero J Abstract Catheter-related bloodstream infections (CRBSI) is a common cause of nosocomial infection associated resulting in substantial morbidity, mortality, increased length of hospital stays and health-care costs. New clinical practice guidelines for the management of adults with CRBSI have been published in 2018 by the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC). This review focuses on updated recommendations for the diagnosis and management of CRBSI in adults. Prevention of CRBSI is e...
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Cantón-Bulnes ML, Garnacho-Montero J Tags: Rev Esp Quimioter Source Type: research

Stewardship in sepsis.
Abstract Sepsis is the major cause of mortality from any infectious disease worldwide. The goals of antimicrobial stewardship are to achieve optimum clinical outcomes and to ensure cost effectiveness and minimum unintended consequences, including toxic effects, selection of pathogenic organisms, and resistance. The combination of inadequate diagnostic criteria for sepsis with the extraordinary time pressure to provide broad-spectrum antimicrobial therapy is troubling from a stewardship perspective. Use of empirical therapy according to guidelines, de-escalation of therapy, switch from intravenous to oral therapy, ...
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Del Pozo JL Tags: Rev Esp Quimioter Source Type: research

Doctor, my patient has CDI and should continue to receive antibiotics. The (unresolved) risk of recurrent CDI.
Abstract Recurrence rate ranges from 12% to 40% of all cases of Clostridium difficile infection (CDI) and proposes an exceptional clinical challenge. Conventionally, treatment options of CDI have been limited to regimes of established antibiotics (eg, pulsed/tapered vancomycin) or "improvised" alternative antibiotics (eg. teicoplanin, tigecycline, nitazoxanide or rifaximin) occasionally even in combination, but faecal microbiota transplantation is emerging as a useful and quite safe alternative. In recent years, promising new strategies have emerged for effective prevention of recurrent CDI (rCDI) includ...
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Castro I, Tasias M, Calabuig E, Salavert M Tags: Rev Esp Quimioter Source Type: research

Update on the management of febrile neutropenia in hematologic patients.
Abstract Febrile neutropenia is a common complication in patients with hematologic malignancies receiving chemotherapy, and is associated with high morbidity and mortality. Infections caused by multidrug-resistant bacteria represent a therapeutic challenge in this high-risk patient population, since inadequate initial empirical antibiotic treatment can seriously compromise prognosis. Besides, reducing antimicrobial exposure is a cornerstone in the fight against resistance. PMID: 31475812 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Escrihuela-Vidal F, Laporte J, Albasanz-Puig A, Gudiol C Tags: Rev Esp Quimioter Source Type: research

Prophylaxis of mould infections.
e;a-Vidal C Abstract Invasive fungal infection continues to be an important cause of morbidity and mortality in haematological patients. Antifungal prophylaxis in these patients has remarkably increased survival since its introduction. In recent years, new antifungals have been on the rise, being more effective and having less toxicity than previous ones. Nonetheless, the number of patients at risk of fungal infection has also been increasing due to the continuous appearance of new immunosuppressive treatments. As a result of such, we face a changing situation that requires constant updating. PMID: 31475813 [...
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Moreno-García E, Chumbita M, Puerta-Alcalde P, Cardozo C, García-Vidal C Tags: Rev Esp Quimioter Source Type: research

Assessment of latent infections in patients receiving biological therapies.
uiz M Abstract The use of biological (or targeted) therapies constitutes a major advance in the management of autoinflammatory and malignant diseases. However, due to the selective effect of these agents on the host's immune response, reactivation of certain pathogens that cause latent infection is to be expected. The most relevant concern is the risk of reactivation of latent tuberculosis infection (LTBI) and progression to active tuberculosis among patients treated with agents targeting tumor necrosis factor (TNF)-α. Systematic screening for LTBI at base-line with appropriate initiation of antituberculous ...
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Fernández-Ruiz M Tags: Rev Esp Quimioter Source Type: research

Infection in the process of organ donation.
This article aims to provide a general and up-to-date overview of this issue. PMID: 31475815 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - September 1, 2019 Category: Drugs & Pharmacology Authors: Len Abad O Tags: Rev Esp Quimioter Source Type: research

Introduction.
nsa J Abstract PMID: 31364334 [PubMed - in process] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - August 2, 2019 Category: Drugs & Pharmacology Authors: Llinares P, Barberán J, Mensa J Tags: Rev Esp Quimioter Source Type: research

Mechanisms of action and antimicrobial activity of ceftobiprole.
ón R Abstract Ceftobiprole, a novel last generation parenteral cephalosporin, has an extended spectrum of activity, notably against methicillin-resistant Staphylococcus aureus (MRSA), ampicillin-susceptible enterococci, penicillin-resistant pneumococci, Enterobacterales and susceptible Pseudomonas aeruginosa. It exerts an inhibitory action on essential peptidoglycan transpeptidases, interfering with cell wall synthesis. The inhibitory action of ceftobiprole through binding to abnormal PBPs like PBP2a in methicillin-resistant staphylococci and PBP2b and PBP2x in the case of β-lactam-resistant pneumococc...
Source: Revista Espanola de Quimioterapia - August 2, 2019 Category: Drugs & Pharmacology Authors: Morosini MI, Díez-Aguilar M, Cantón R Tags: Rev Esp Quimioter Source Type: research

Ceftobiprole: pharmacokinetics and PK/PD profile.
z de Rada B Abstract Ceftobiprole shows many similar pharmacokinetic properties to other cephalosporins, except for not being orally bioactive, and that it is administered by IV infusion as the prodrug ceftobiprole medocaril, which is subsequently hydrolyzed in the blood into the active molecule. Distribution focus in extracellular fluid and active antibiotic concentration has been proven in different corporal tissues using dosing regimen of 500 mg intravenous infusion over 2 h every 8 h. Ceftobiprole is eliminated exclusively into the urine, thus the reason why dose adjustment is required for patients with modera...
Source: Revista Espanola de Quimioterapia - August 2, 2019 Category: Drugs & Pharmacology Authors: Azanza Perea JR, Sádaba Díaz de Rada B Tags: Rev Esp Quimioter Source Type: research

Ceftobiprole for the treatment of pneumonia.
C, Torres A Abstract Ceftobiprole is a fifth-generation cephalosporin with potent antimicrobial activity against Gram positive and Gram-negative bacteria. It has been approved in major European countries for the treatment of community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP), excluding ventilator-associated pneumonia (VAP). Ceftobiprole is currently in a phase 3 clinical program for registration in the U.S. In 2015, it was designated as an infectious disease product qualified for the treatment of lung and skin infections by the FDA. The efficacy of ceftobiprole in pneumonia has been demonstra...
Source: Revista Espanola de Quimioterapia - August 2, 2019 Category: Drugs & Pharmacology Authors: Cillóniz C, Dominedò C, Garcia-Vidal C, Torres A Tags: Rev Esp Quimioter Source Type: research

Ceftobripole: Experience in staphylococcal bacteremia.
Abstract Ceftobiprole is a new cephalosporin with an extended spectrum activity against the majority of microorganisms isolated in bacteremia including methicillin-susceptible (MSSA) and -resistant S. aureus (MRSA). This antibiotic has demonstrated a potent activity against MRSA in animal models of endocarditis in monotherapy but particularly in combination with daptomycin, suggesting that this combination could be a future option to improve the outcome of staphylococcal endovascular infections. In addition, the extended-spectrum ceftobiprole activity, including coagulase-negative staphylococci, Enterococcus faeca...
Source: Revista Espanola de Quimioterapia - August 2, 2019 Category: Drugs & Pharmacology Authors: Soriano A, Morata L Tags: Rev Esp Quimioter Source Type: research

Possible clinical indications of ceftobiprole.
e;n J Abstract Ceftobiprole is a fifth-generation cephalosporin approved for the treatment of adult community-acquired pneumonia and non-ventilator associated hospital-acquired pneumonia. However, its microbiological and pharmacokinetic profile is very attractive as armamentarium for empirical monotherapy treatment in other infections too. Among these, the following scenarios could be considered complicated skin and soft tissue infections, moderate-severe diabetic foot infections without bone involvement, vascular-catheter-associated-bloodstream infections, and fever without apparent focus in the hospitalized pati...
Source: Revista Espanola de Quimioterapia - August 2, 2019 Category: Drugs & Pharmacology Authors: Barberán J Tags: Rev Esp Quimioter Source Type: research

Safety and tolerability of ceftobiprole.
Abstract Ceftobiprole is a fifth generation cephalosporin with a series of characteristics differentiating it from other beta-lactams, including its antibacterial activity, mainly against methicillin-resistant Staphylococcus aureus, resistant Streptococcus pneumoniae and also Gram-negative microorganisms such as Pseudomonas aeruginosa. This antibiotic has been subjected to various clinical trials and the results of these have led to its approval in Spain for the treatment of nosocomial pneumonia, excluding that associated with mechanical ventilation, and community-acquired pneumonia. The results of various ceftobi...
Source: Revista Espanola de Quimioterapia - August 2, 2019 Category: Drugs & Pharmacology Authors: Grau S Tags: Rev Esp Quimioter Source Type: research

The situation of vaccines for the prevention of infections in adults: An opinion paper on the situation in Spain.
tiz de Lejarazu R, Urbiztondo L, Palomo E Abstract The childhood immunization schedule is well known and generally well implemented in developed countries. For various reasons, the same is not true of vaccines aimed at preventing infections in adults, in which vaccination coverage is incomplete and generally very deficient. In order to assess the situation of adult vaccination in Spain, the Fundación de Ciencias de la Salud has brought together a series of experts in different fields, including doctors, nurses, representatives of patient associations, health managers and economists, health authorities and j...
Source: Revista Espanola de Quimioterapia - July 26, 2019 Category: Drugs & Pharmacology Authors: Bouza E, Ancochea-Bermúdez J, Campins M, Eirós-Bouza JM, Fargas J, García Rojas A, Gracia D, Gutiérrez Sánchez A, Limia A, López JA, Magro MC, Mirada G, Muñoz P, Olier E, Ortiz de Lejarazu R, Urbiztondo L, Palomo E Tags: Rev Esp Quimioter Source Type: research

Is it possible to extrapolate the rates of resistance of Escherichia coli from asymptomatic bacteriuria in pregnant women to those of E. coli in uncomplicated community-acquired UTI?
CONCLUSIONS: We propose a simple model that could provide better guidance for selection of empirical antimicrobial therapy for non-pregnant women with UAC than do generic hospital antibiogram data based on reliably extrapolating the susceptibility data of strains isolated from pregnant women with AB as representation of women with community-acquired UAC. PMID: 31328907 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 22, 2019 Category: Drugs & Pharmacology Authors: Asenjo A, Grados MC, Oteo-Iglesias J, Alós JI Tags: Rev Esp Quimioter Source Type: research

[Septic shock secondary to Elizabethkingia meningoseptica: A case report].
ernand FJ, Boix Boix AS Abstract PMID: 31327187 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 19, 2019 Category: Drugs & Pharmacology Authors: Brandariz Núñez D, Rodríguez Pedreira P, Hernández Corredoira V, Puig Forcada J, Gurri Hernand FJ, Boix Boix AS Tags: Rev Esp Quimioter Source Type: research

Infectious endocarditis caused by Candida glabrata: evidence of in vivo development of echinocandin resistance.
;oz P Abstract PMID: 31327188 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 19, 2019 Category: Drugs & Pharmacology Authors: Agnelli C, Guinea J, Valerio M, Escribano P, Bouza E, Muñoz P Tags: Rev Esp Quimioter Source Type: research

[Peritonsillar abscess due to Actinomyces marseillensis].
Domingo García D Abstract PMID: 31313895 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 16, 2019 Category: Drugs & Pharmacology Authors: Gómez de Frutos S, Rodríguez Anzules MS, Fraile Torres AM, Cardeñoso Domingo L, Domingo García D Tags: Rev Esp Quimioter Source Type: research

[Hospital admission and mortality causes of HIV patients in a third level hospital].
CONCLUSIONS: Our results emphasize the need of intensifying the HIV early diagnosis as well as Pneumocystis jirovecii primary prophylaxis. Insist on ART adherence from infectology follow-up appointment and pharmacy care consultations, educate clinics on ART treatment prescription during hospital admission as well as requesting viral and CD4 lymphocytes loads to every HIV admitted patients. PMID: 31310085 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 15, 2019 Category: Drugs & Pharmacology Authors: Asensi-Diez R, Fernández-Cuerva C, Alcaraz Sánchez JJ, Muñoz-Castillo I Tags: Rev Esp Quimioter Source Type: research

[Bacteremia by Actynomices oris].
ntilde;as Gutiérrez CJ Abstract PMID: 31310086 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 15, 2019 Category: Drugs & Pharmacology Authors: Martín Guerra JM, Martín Asenjo M, Iglesias Pérez C, Dueñas Gutiérrez CJ Tags: Rev Esp Quimioter Source Type: research

Acute zoonotic total knee prosthetic joint infection due to Pasteurella multocida treated successfully with debridement, irrigation and antibiotics without prosthesis removal.
érez A, Morán Rodríguez MA Abstract PMID: 31310087 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 15, 2019 Category: Drugs & Pharmacology Authors: Ortega Lafont MP, Buzón Martín L, Álvarez Paredes L, Mora Fernández M, Rodríguez Pérez A, Morán Rodríguez MA Tags: Rev Esp Quimioter Source Type: research

[Dolutegravir in acute HIV-1 infection: first reported case].
Abstract PMID: 31298515 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 11, 2019 Category: Drugs & Pharmacology Authors: Garibaldi F, Pozzati M, Rodriguez C, Cecchini D Tags: Rev Esp Quimioter Source Type: research

Comparison of two methods skipping cell lysis and protein extraction for identification of bacteria from blood cultures by matrix-assisted laser desorption/ionization time-of-flight mass-spectrometry.
CONCLUSIONS: The pre-enrichment method outperformed the DI method for identification of virtually all bacterial species included in the panels. PMID: 31293114 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 10, 2019 Category: Drugs & Pharmacology Authors: Torres I, Giménez E, Huntley D, Martínez M, Colomina J, Navarro D Tags: Rev Esp Quimioter Source Type: research

[Evaluation of a rapid assay for detection of PBP2a Staphylococcus aureus].
CONCLUSIONS: ICPBP2a Culture Colony Test (AlereTM) is fast, efficient and economical technique for detection of penicillin binding protein 2a (PBP2a) from isolates. This assay is a useful tool for the management of hospital outbreaks. PMID: 31293115 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 10, 2019 Category: Drugs & Pharmacology Authors: Sáinz-Rodríguez R, de Toro-Peinado I, Valverde-Troya M, Bermúdez Ruíz MP, Palop-Borrás B Tags: Rev Esp Quimioter Source Type: research

Risk factors to secondary nosocomial bacteremia to UTI in a tertiary hospital.
Abstract OBJECTIVE: Nosocomial bacteremia secondary to urinary tract infections (NBS-UTI) occur in 1-4% of episodes and the associated mortality can increase up to 33%. However, very little is known about the epidemiology of these infections. The determination of modifiable risk factors to develop this type of bacteremia could help to control the infection and reduce health costs. METHODS: Cases-control study of NBS-UTI diagnosed at the University Hospital of Canary Islands between 2010-2014. The clinical-epidemiological variables and the intrinsic and extrinsic potential risk factors were collected. Logistic...
Source: Revista Espanola de Quimioterapia - July 5, 2019 Category: Drugs & Pharmacology Authors: Sante L, Lecuona M, Jaime-Aguirre A, Arias A Tags: Rev Esp Quimioter Source Type: research

Prevalence of genital Mycoplasma and response to eradication treatment in patients undergoing assisted reproductive techniques.
CONCLUSIONS: We consider that genital mycoplasma routine screening could be useful in order to increase the quality of semen which could simplify the in vitro fertilisation procedures and raise the success rate of embryo implantation and pregnancy, especially when fast, sensitive and specific technics as real time PCR are used. PMID: 31271277 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - July 4, 2019 Category: Drugs & Pharmacology Authors: Veiga E, Treviño M, Romay AB, Navarro D, Trastoy R, Macía M Tags: Rev Esp Quimioter Source Type: research

Drug-resistant bacteria on hands of healthcare workers and in the patient area: an environmental survey in Southern Italy's hospital.
CONCLUSIONS: These findings are in line with the international literature, confirming that antimicrobial resistance is also steadily growing in Italy with rates varied for the different pathogens. PMID: 31257821 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - June 28, 2019 Category: Drugs & Pharmacology Authors: La Fauci V, Costa GB, Genovese C, Palamara MAR, Alessi V, Squeri R Tags: Rev Esp Quimioter Source Type: research

[Reactivation of the cryopyrin-associated periodic syndrome after vaccination in a patient who is a candidate for immunosuppression].
adera J, Martínez-Ortega C, Huerta-González I Abstract PMID: 31241279 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - June 24, 2019 Category: Drugs & Pharmacology Authors: Fernández-Prada M, Rugeles-Niño J, Suárez-Pérez L, Ruiz-Álvarez M, López-Díaz JB, Fernández-Madera J, Martínez-Ortega C, Huerta-González I Tags: Rev Esp Quimioter Source Type: research

Effectiveness of 12 week ledipasvir/sofosbuvir and predictors of treatment failure in patients with hepatitis C.
CONCLUSIONS: LDV/SOF combination has been very effective to treat GT1 and GT4 infected patients, however, has constituted a suboptimal therapeutic option for those patients infected with GT3, regardless of the rest of the variables analyzed. PMID: 31232572 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - June 21, 2019 Category: Drugs & Pharmacology Authors: Del Rio-Valencia JC, Asensi-Diez R, Tamayo-Bermejo R, Muñoz-Castillo I Tags: Rev Esp Quimioter Source Type: research

Guillain-Barr é syndrome and influenza vaccines: current evidence.
CONCLUSIONS: The present systematic review, conducted after the publication of our previous meta-analysis, seems to confirm its previous results. Therefore, GBS should be considered an infrequent adverse effect of influenza vaccination, which should not negatively influence its acceptance. Unfortunately, very few of the systematically surveyed studies meeting inclusion criteria. This fact sharply contrasts with the current consensus as to the need of continuously monitoring the safety of influenza vaccines. PMID: 31232571 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - June 20, 2019 Category: Drugs & Pharmacology Authors: Sanz Fadrique R, Martín Arias L, Molina-Guarneros JA, Jimeno Bulnes N, García Ortega P Tags: Rev Esp Quimioter Source Type: research

Nocardia farcinica isolated meningitis in a patient with Beh çet's disease: case report and literature review.
Nocardia farcinica isolated meningitis in a patient with Behçet's disease: case report and literature review. Rev Esp Quimioter. 2019 Jun 05;: Authors: Shirani K, Mohajeri F Abstract PMID: 31179675 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - June 5, 2019 Category: Drugs & Pharmacology Authors: Shirani K, Mohajeri F Tags: Rev Esp Quimioter Source Type: research

[From a pathogen's genome to an effective vaccine: the four-component meningococcal serogroup B vaccine].
a MG, Vázquez JA Abstract Invasive meningococcal disease (IMD), caused by the bacterium Neisseria meningitidis, entails significant mortality and morbidity. Disease incidence is highest in infants
Source: Revista Espanola de Quimioterapia - May 30, 2019 Category: Drugs & Pharmacology Authors: Abad R, Martinón-Torres F, Santolaya ME, Banzhoff A, González-Inchausti C, Graña MG, Vázquez JA Tags: Rev Esp Quimioter Source Type: research

[Conjunctivitis by Capnocytophaga ochracea in a two weeks newborn].
cute;n Sánchez L Abstract PMID: 31132007 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - May 6, 2019 Category: Drugs & Pharmacology Authors: Bolaños Rivero M, Aroca Ferri M, Ruíz Derlinchan B, Martín Sánchez L Tags: Rev Esp Quimioter Source Type: research

[About two cases of human ocular thelaziosis].
Iglesias M Abstract PMID: 31132008 [PubMed - as supplied by publisher] (Source: Revista Espanola de Quimioterapia)
Source: Revista Espanola de Quimioterapia - May 6, 2019 Category: Drugs & Pharmacology Authors: Guitián Deltell J, Rodriguez Calderón S, Paz Vidal MI, de La Fuente Iglesias M Tags: Rev Esp Quimioter Source Type: research

New perspectives for reassessing fosfomycin: applicability in current clinical practice.
e;n J Abstract Fosfomycin is a bactericidal antibiotic that interferes with cell wall synthesis. The drug therefore has a broad spectrum of activity against a wide range of Gram-positive and Gram-negative bacteria. Both the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) have started review processes of the accumulated information on the use of fosfomycin and on information from new clinical trials. The intent is to establish usage terms in Europe and to authorize the sale of fosfomycin in the US. This monograph reviews the most current aspects of the compound. From the microbiologica...
Source: Revista Espanola de Quimioterapia - May 1, 2019 Category: Drugs & Pharmacology Authors: Candel FJ, Matesanz David M, Barberán J Tags: Rev Esp Quimioter Source Type: research

New microbiological aspects of fosfomycin.
ón R Abstract The discovery of fosfomycin more than 40 years ago was an important milestone in antibiotic therapy. The antibiotic's usefulness, alone or in combination, for treating infections caused by multidrug-resistant microorganisms is clearer than ever. Both the European Medicines Agency and the US Food and Drug Administration have open processes for reviewing the accumulated information on the use of fosfomycin and the information from new clinical trials on this compound. The agencies' objectives are to establish common usage criteria for Europe and authorize the sale of fosfomycin in the US, respec...
Source: Revista Espanola de Quimioterapia - May 1, 2019 Category: Drugs & Pharmacology Authors: Díez-Aguilar M, Cantón R Tags: Rev Esp Quimioter Source Type: research

Deciphering pharmacokinetics and pharmacodynamics of fosfomycin.
ut-Blasco A Abstract Fosfomycin, a low molecular weight and hydrophilic drug with negligible protein binding, is eliminated almost exclusively by glomerular filtration, whose clearance is subject to patient renal function. The volume of distribution approximates to the extracellular body water (about 0.3 L/Kg) in healthy volunteers, but it is increased in critically ill patients with bacterial infections. Fosfomycin presents a high ability to distribute into many tissues, including inflamed tissues and abscess fluids. Based on PK/PD analysis and Monte Carlo simulations, we have evaluated different fosfomycin dosin...
Source: Revista Espanola de Quimioterapia - May 1, 2019 Category: Drugs & Pharmacology Authors: Rodríguez-Gascón A, Canut-Blasco A Tags: Rev Esp Quimioter Source Type: research