Cold atmospheric plasma attenuates skin cancer via ROS induced apoptosis
CONCLUSIONS: These evidences suggest the protective effect of CAP in CSCC, and CAP has the potential clinical application of CSCC.PMID:38622261 | DOI:10.1007/s11033-024-09486-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Changqing Liu Jingjing Zha Tao Sun Ling Kong Xinru Zhang Dong Wang Guohua Ni Source Type: research
Cold atmospheric plasma attenuates skin cancer via ROS induced apoptosis
CONCLUSIONS: These evidences suggest the protective effect of CAP in CSCC, and CAP has the potential clinical application of CSCC.PMID:38622261 | DOI:10.1007/s11033-024-09486-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Changqing Liu Jingjing Zha Tao Sun Ling Kong Xinru Zhang Dong Wang Guohua Ni Source Type: research
Cold atmospheric plasma attenuates skin cancer via ROS induced apoptosis
CONCLUSIONS: These evidences suggest the protective effect of CAP in CSCC, and CAP has the potential clinical application of CSCC.PMID:38622261 | DOI:10.1007/s11033-024-09486-6 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 15, 2024 Category: Molecular Biology Authors: Changqing Liu Jingjing Zha Tao Sun Ling Kong Xinru Zhang Dong Wang Guohua Ni Source Type: research
Eight weeks of treatment with mineralocorticoid receptor blockade does not alter vascular function in individuals with and without type 2 diabetes
In conclusion, we found no effect of MR blockade endothelial function in individuals with and without type 2 diabetes. As the individuals with type 2 diabetes did not have vascular dysfunction, these results might not apply to individuals with vascular dysfunction. (Source: Physiological Reports)
Source: Physiological Reports - April 13, 2024 Category: Physiology Authors: Stine H. Finsen,
Mie R. Hansen,
Pernille B. L. Hansen,
Stefan P. Mortensen Tags: ORIGINAL ARTICLE Source Type: research
Molecules, Vol. 29, Pages 1773: Exploring the Antiproliferative and Modulatory Effects of 1-Methoxyisobrassinin on Ovarian Cancer Cells: Insights into Cell Cycle Regulation, Apoptosis, Autophagy, and Its Interactions with NAC
This study explores the potential therapeutic efficacy of 1-methoxyisobrassinin (MB-591), a derivative of indole phytoalexins found in Cruciferae family plants, on both cisplatin-sensitive (A2780) and cisplatin-resistant ovarian cancer cells (A2780 cis). The findings reveal that MB-591 exhibits an antiproliferative effect on both cell lines, with significantly increased potency against cisplatin-sensitive cells. The substance induces alterations in the distribution of the cell cycle, particularly in the S and G2/M phases, accompanied by changes in key regulatory proteins. Moreover, MB-591 triggers apoptosis in both cell li...
Source: Molecules - April 13, 2024 Category: Chemistry Authors: Martina Zigov á Vikt ória Miškufová Marianna Budovsk á Radka Michalkov á J án Mojžiš Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1495: XPC Protects against Carcinogen-Induced Histologic Progression to Lung Squamous Cell Carcinoma by Reduced Basal Epithelial Cell Proliferation
l Nasrallah
Lung squamous cell carcinoma (LUSC) is the second leading cause of lung cancer. Although characterized by high DNA mutational burdens and genomic complexity, the role of DNA repair in LUSC development is poorly understood. We sought to better understand the role of the DNA repair protein Xeroderma Pigmentosum Group C (XPC) in LUSC development. XPC knock-out (KO), heterozygous, and wild-type (WT) mice were exposed topically to N-nitroso-tris-chloroethylurea (NTCU), and lungs were evaluated for histology and pre-malignant progression in a blinded fashion at various time-points from 8–24 weeks. H...
Source: Cancers - April 13, 2024 Category: Cancer & Oncology Authors: Catherine R. Sears Huaxin Zhou Emily Hulsey Bea A. Aidoo George E. Sandusky Nawar Al Nasrallah Tags: Article Source Type: research
Antioxidants accelerate tendon-to-bone healing after rotator cuff repair surgery
This study aimed to investigate the effects of reduction of oxidative stress induced by antioxidants such as N-acetylcysteine (NAC) and vitamin C (VC) on rotator cuff repair in a rotator cuff repair model in rats. Infraspinatus tendon was ruptured in 48 rats and repaired 1 week later. Rats were divided into 3 groups: NAC group, VC group, or control group, and were administered NAC, VC, or distilled water respectively. The specimens were collected at 3, 6, and 12 weeks after repair. Histological evaluation was performed using hematoxylin/eosin and toluidine blue staining, and oxidative stress was evaluated using dihydroethi...
Source: Journal of Shoulder and Elbow Surgery - April 11, 2024 Category: Orthopaedics Authors: Hirohisa Uehara, Yoshiaki Itoigawa, Daichi Morikawa, Akihisa Koga, Hironori Tsurukami, Muneaki Ishijima Source Type: research
Potential adverse outcome pathway of neurodevelopmental toxicity, inflammatory response, and oxidative stress induction mediated by three alkyl organophosphate flame retardants in zebrafish larvae
This study investigated the neurodevelopmental effects, inflammatory response, and oxidative stress induction of three alkyl organophosphate flame retardants using a zebrafish embryo/larvae model. After exposure of zebrafish embryos to TMP, TEP, and TBEP (0, 0.02, 0.2, 2, 20, and 200 μg L-1) for 96 h, survival, development, swimming behavior, changes in acetylcholinesterase (AChE) activity, dopamine, tumor necrosis factor-alpha (TNF-α), interleukin (IL), reactive oxygen species (ROS), and antioxidant enzyme activities were observed. Concentrations of TMP, TEP, and TBEP were also measured in the whole body of exposed larv...
Source: Chemosphere - April 7, 2024 Category: Chemistry Authors: Kijeong Yun Hyeri Jeon Younglim Kho Kyunghee Ji Source Type: research
Potential adverse outcome pathway of neurodevelopmental toxicity, inflammatory response, and oxidative stress induction mediated by three alkyl organophosphate flame retardants in zebrafish larvae
This study investigated the neurodevelopmental effects, inflammatory response, and oxidative stress induction of three alkyl organophosphate flame retardants using a zebrafish embryo/larvae model. After exposure of zebrafish embryos to TMP, TEP, and TBEP (0, 0.02, 0.2, 2, 20, and 200 μg L-1) for 96 h, survival, development, swimming behavior, changes in acetylcholinesterase (AChE) activity, dopamine, tumor necrosis factor-alpha (TNF-α), interleukin (IL), reactive oxygen species (ROS), and antioxidant enzyme activities were observed. Concentrations of TMP, TEP, and TBEP were also measured in the whole body of exposed larv...
Source: Chemosphere - April 7, 2024 Category: Chemistry Authors: Kijeong Yun Hyeri Jeon Younglim Kho Kyunghee Ji Source Type: research
Potential adverse outcome pathway of neurodevelopmental toxicity, inflammatory response, and oxidative stress induction mediated by three alkyl organophosphate flame retardants in zebrafish larvae
This study investigated the neurodevelopmental effects, inflammatory response, and oxidative stress induction of three alkyl organophosphate flame retardants using a zebrafish embryo/larvae model. After exposure of zebrafish embryos to TMP, TEP, and TBEP (0, 0.02, 0.2, 2, 20, and 200 μg L-1) for 96 h, survival, development, swimming behavior, changes in acetylcholinesterase (AChE) activity, dopamine, tumor necrosis factor-alpha (TNF-α), interleukin (IL), reactive oxygen species (ROS), and antioxidant enzyme activities were observed. Concentrations of TMP, TEP, and TBEP were also measured in the whole body of exposed larv...
Source: Chemosphere - April 7, 2024 Category: Chemistry Authors: Kijeong Yun Hyeri Jeon Younglim Kho Kyunghee Ji Source Type: research
Potential adverse outcome pathway of neurodevelopmental toxicity, inflammatory response, and oxidative stress induction mediated by three alkyl organophosphate flame retardants in zebrafish larvae
This study investigated the neurodevelopmental effects, inflammatory response, and oxidative stress induction of three alkyl organophosphate flame retardants using a zebrafish embryo/larvae model. After exposure of zebrafish embryos to TMP, TEP, and TBEP (0, 0.02, 0.2, 2, 20, and 200 μg L-1) for 96 h, survival, development, swimming behavior, changes in acetylcholinesterase (AChE) activity, dopamine, tumor necrosis factor-alpha (TNF-α), interleukin (IL), reactive oxygen species (ROS), and antioxidant enzyme activities were observed. Concentrations of TMP, TEP, and TBEP were also measured in the whole body of exposed larv...
Source: Chemosphere - April 7, 2024 Category: Chemistry Authors: Kijeong Yun Hyeri Jeon Younglim Kho Kyunghee Ji Source Type: research
Maternal exposure to beta-Cypermethrin disrupts placental development by dysfunction of trophoblast cells from oxidative stress
The objective of this study was to investigate the effect of β-CYP exposure on placental development and the function of trophoblast, as well as the underlying mechanisms through CD-1 mouse model (1, 10, 20mg/kg.bw) and in vitro HTR-8/SVneo cell model (12.5, 25, 50, 100μM). We found slower weight gain and reduced uterine wet weight in pregnant mice with maternal exposure to β-CYP during pregnancy, as well as adverse pregnancy outcomes such as uterine bleeding and embryo resorption. The abnormal placental development in response to β-CYP was noticed, including imbalanced placental structure and disrupted labyrinthine va...
Source: Toxicology - April 6, 2024 Category: Toxicology Authors: Xiaoli Tang Yanqing Geng Rufei Gao Zhuxiu Chen Xinyi Mu Yan Zhang Xin Yin Yidan Ma Xuemei Chen Fangfang Li Junlin He Source Type: research
Doxorubicin induces phosphorylation of lamin A/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity
Free Radic Biol Med. 2024 Apr 4:S0891-5849(24)00383-6. doi: 10.1016/j.freeradbiomed.2024.04.212. Online ahead of print.ABSTRACTLamin A/C, essential inner nuclear membrane proteins, have been linked to progeria, a disease of accelerated aging, and many other diseases, which include cardiac disorder. Lamin A/C mutation and its phosphorylation are associated with altering nuclear shape and size. The role of lamin A/C in regulating normal cardiac function was reported earlier. In the present study, we hypothesized that Doxorubicin (Dox) may alter total lamin A/C expression and phosphorylation, thereby taking part in cardiac in...
Source: Free Radical Biology and Medicine - April 6, 2024 Category: Biology Authors: Vikas Tiwari Paras Gupta Navya Malladi Sanjay Salgar Sanjay K Banerjee Source Type: research
Doxorubicin induces phosphorylation of lamin A/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity
Free Radic Biol Med. 2024 Apr 4:S0891-5849(24)00383-6. doi: 10.1016/j.freeradbiomed.2024.04.212. Online ahead of print.ABSTRACTLamin A/C, essential inner nuclear membrane proteins, have been linked to progeria, a disease of accelerated aging, and many other diseases, which include cardiac disorder. Lamin A/C mutation and its phosphorylation are associated with altering nuclear shape and size. The role of lamin A/C in regulating normal cardiac function was reported earlier. In the present study, we hypothesized that Doxorubicin (Dox) may alter total lamin A/C expression and phosphorylation, thereby taking part in cardiac in...
Source: Free Radical Biology and Medicine - April 6, 2024 Category: Biology Authors: Vikas Tiwari Paras Gupta Navya Malladi Sanjay Salgar Sanjay K Banerjee Source Type: research
