Irbesartan ameliorates diabetic nephropathy by activating the Nrf2/Keap1 pathway and suppressing NLRP3 inflammasomes in vivo and in vitro
CONCLUSIONS: Our results suggested that IRB ameliorates diabetic nephropathy by activating the Nrf2/Keap1 pathway and suppressing the NLRP3 inflammasomes in vivo and in vitro. These findings provide new therapeutic strategies of diabetic nephropathy.PMID:38503013 | DOI:10.1016/j.intimp.2024.111844 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 19, 2024 Category: Allergy & Immunology Authors: Yuan Li Weihong Long Haifeng Zhang Meng Zhao Menghan Gao Weiying Guo Lu Yu Source Type: research
Irbesartan ameliorates diabetic nephropathy by activating the Nrf2/Keap1 pathway and suppressing NLRP3 inflammasomes in vivo and in vitro
CONCLUSIONS: Our results suggested that IRB ameliorates diabetic nephropathy by activating the Nrf2/Keap1 pathway and suppressing the NLRP3 inflammasomes in vivo and in vitro. These findings provide new therapeutic strategies of diabetic nephropathy.PMID:38503013 | DOI:10.1016/j.intimp.2024.111844 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 19, 2024 Category: Allergy & Immunology Authors: Yuan Li Weihong Long Haifeng Zhang Meng Zhao Menghan Gao Weiying Guo Lu Yu Source Type: research
Reactive oxygen species generation required for autophagy induction during butyrate- or propionate-induced release of damage-associated molecular patterns from dying gingival epithelial Ca9-22 cells
CONCLUSION: The findings suggest that ROS generation is necessary for autophagy, which is required for SCFA-induced cell death and accompanying DAMP release.PMID:38494703 | DOI:10.2334/josnusd.23-0421 (Source: Journal of oral science)
Source: Journal of oral science - March 18, 2024 Category: Dentistry Authors: Kiwa Miyake Yoshikazu Mikami Takayuki Asayama Taku Toriumi Keiji Shinozuka Morio Tonogi Yoshiyuki Yonehara Hiromasa Tsuda Source Type: research
< em > N < /em > -acetylcysteine increases dopamine release and prevents the deleterious effects of 6-OHDA on the expression of VMAT2, α-synuclein, and tyrosine hydroxylase
CONCLUSIONS: Our findings contribute to the validation of compounds capable to restore dopamine homeostasis and shed light on the metabolic pathways that could be targeted to normalize dopamine turnover. Furthermore, our results highlight the effectiveness of the antioxidant NAC in the prevention of dopaminergic neurodegeneration in the present model.ABBREVIATIONS: DAT, dopamine transporter; 6-OHDA, 6-hydroxydopamine; NAC, N-acetylcysteine; PARP, poly (ADP-ribose) polymerase; RA; retinoic acid; ROS, reactive oxygen species; TH, tyrosine hydroxylase; TPA, 12-O-tetradecanoyl-phorbol-13-acetate; VMAT2, vesicle monoamine trans...
Source: Neurological Research - March 18, 2024 Category: Neurology Authors: Roine El-Habta Sara Af Bjerk én Ana Virel Source Type: research
Reactive oxygen species generation required for autophagy induction during butyrate- or propionate-induced release of damage-associated molecular patterns from dying gingival epithelial Ca9-22 cells
CONCLUSION: The findings suggest that ROS generation is necessary for autophagy, which is required for SCFA-induced cell death and accompanying DAMP release.PMID:38494703 | DOI:10.2334/josnusd.23-0421 (Source: Journal of oral science)
Source: Journal of oral science - March 18, 2024 Category: Dentistry Authors: Kiwa Miyake Yoshikazu Mikami Takayuki Asayama Taku Toriumi Keiji Shinozuka Morio Tonogi Yoshiyuki Yonehara Hiromasa Tsuda Source Type: research
< em > N < /em > -acetylcysteine increases dopamine release and prevents the deleterious effects of 6-OHDA on the expression of VMAT2, α-synuclein, and tyrosine hydroxylase
CONCLUSIONS: Our findings contribute to the validation of compounds capable to restore dopamine homeostasis and shed light on the metabolic pathways that could be targeted to normalize dopamine turnover. Furthermore, our results highlight the effectiveness of the antioxidant NAC in the prevention of dopaminergic neurodegeneration in the present model.ABBREVIATIONS: DAT, dopamine transporter; 6-OHDA, 6-hydroxydopamine; NAC, N-acetylcysteine; PARP, poly (ADP-ribose) polymerase; RA; retinoic acid; ROS, reactive oxygen species; TH, tyrosine hydroxylase; TPA, 12-O-tetradecanoyl-phorbol-13-acetate; VMAT2, vesicle monoamine trans...
Source: Neurological Research - March 18, 2024 Category: Neurology Authors: Roine El-Habta Sara Af Bjerk én Ana Virel Source Type: research
Reactive oxygen species generation required for autophagy induction during butyrate- or propionate-induced release of damage-associated molecular patterns from dying gingival epithelial Ca9-22 cells
CONCLUSION: The findings suggest that ROS generation is necessary for autophagy, which is required for SCFA-induced cell death and accompanying DAMP release.PMID:38494703 | DOI:10.2334/josnusd.23-0421 (Source: Journal of oral science)
Source: Journal of oral science - March 18, 2024 Category: Dentistry Authors: Kiwa Miyake Yoshikazu Mikami Takayuki Asayama Taku Toriumi Keiji Shinozuka Morio Tonogi Yoshiyuki Yonehara Hiromasa Tsuda Source Type: research
