Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells
CONCLUSION: Taken together, we provided the potential mechanism for treating ATC cells with honokiol, which significantly suppresses tumor proliferation and inhibits tumor metastasis in vitro through reactive oxygen species (ROS) induction.PMID:38659261 | DOI:10.2174/0118715303295608240408082523 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 25, 2024 Category: Drugs & Pharmacology Authors: Kai-Sheng Liao Ying-Ray Lee Wen-Ying Chao Yen-Ju Huang Hui-Chen Chung Shu-Hsin Chen Yi-Zhen Li Pei-Wen Zhao Hong-Yi Chang Source Type: research
Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells
CONCLUSION: Taken together, we provided the potential mechanism for treating ATC cells with honokiol, which significantly suppresses tumor proliferation and inhibits tumor metastasis in vitro through reactive oxygen species (ROS) induction.PMID:38659261 | DOI:10.2174/0118715303295608240408082523 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 25, 2024 Category: Endocrinology Authors: Kai-Sheng Liao Ying-Ray Lee Wen-Ying Chao Yen-Ju Huang Hui-Chen Chung Shu-Hsin Chen Yi-Zhen Li Pei-Wen Zhao Hong-Yi Chang Source Type: research
Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells
CONCLUSION: Taken together, we provided the potential mechanism for treating ATC cells with honokiol, which significantly suppresses tumor proliferation and inhibits tumor metastasis in vitro through reactive oxygen species (ROS) induction.PMID:38659261 | DOI:10.2174/0118715303295608240408082523 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 25, 2024 Category: Drugs & Pharmacology Authors: Kai-Sheng Liao Ying-Ray Lee Wen-Ying Chao Yen-Ju Huang Hui-Chen Chung Shu-Hsin Chen Yi-Zhen Li Pei-Wen Zhao Hong-Yi Chang Source Type: research
PM < sub > 2.5 < /sub > exposure upregulates pro-inflammatory protein expression in human microglial cells via oxidant stress and TLR4/NF- κB pathway
In this study, a human microglial cell line (HMC3) was used as the in vitro model to examine the inflammatory effect (hall marker of microglia activation) of PM2.5 and regulatory pathways. The expression of inflammatory mediators including interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) as well as the brain derived neurotrophic factor (BDNF) were determined by ELISA and/or real-time PCR, respectively. Flow cytometry was used to measure the production of intracellular reactive oxygen species (ROS). Western blot was used to measure protein levels of Toll-like receptor 4 (TLR4), NF-κB inhibitor α (IκBα) and COX-2. It wa...
Source: Ecotoxicology and Environmental Safety - April 24, 2024 Category: Environmental Health Authors: Ling Zhang Fei Xu Yishu Yang Lin Yang Qiong Wu Han Sun Zhen An Juan Li Hui Wu Jie Song Weidong Wu Source Type: research
PM < sub > 2.5 < /sub > exposure upregulates pro-inflammatory protein expression in human microglial cells via oxidant stress and TLR4/NF- κB pathway
In this study, a human microglial cell line (HMC3) was used as the in vitro model to examine the inflammatory effect (hall marker of microglia activation) of PM2.5 and regulatory pathways. The expression of inflammatory mediators including interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) as well as the brain derived neurotrophic factor (BDNF) were determined by ELISA and/or real-time PCR, respectively. Flow cytometry was used to measure the production of intracellular reactive oxygen species (ROS). Western blot was used to measure protein levels of Toll-like receptor 4 (TLR4), NF-κB inhibitor α (IκBα) and COX-2. It wa...
Source: Ecotoxicology and Environmental Safety - April 24, 2024 Category: Environmental Health Authors: Ling Zhang Fei Xu Yishu Yang Lin Yang Qiong Wu Han Sun Zhen An Juan Li Hui Wu Jie Song Weidong Wu Source Type: research
Bortezomib suppresses acute myelogenous leukaemia stem-like KG-1a cells via NF- κB inhibition and the induction of oxidative stress
J Cell Mol Med. 2024 Apr;28(8):e18333. doi: 10.1111/jcmm.18333.ABSTRACTAcute myelogenous leukaemia (AML) originates and is maintained by leukaemic stem cells (LSCs) that are inherently resistant to antiproliferative therapies, indicating that a critical strategy for overcoming chemoresistance in AML therapy is to eradicate LSCs. In this work, we investigated the anti-AML activity of bortezomib (BTZ), emphasizing its anti-LSC potential, using KG-1a cells, an AML cell line with stem-like properties. BTZ presented potent cytotoxicity to both solid and haematological malignancy cells and reduced the stem-like features of KG-1a...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Rafaela G A Costa Maiara de S Oliveira Ana Carolina B da C Rodrigues Suellen L R Silva Ingrid R S B Dias Milena B P Soares Ludmila de Faro Valverde Clarissa Araujo Gurgel Rocha Rosane Borges Dias Daniel P Bezerra Source Type: research
Bortezomib suppresses acute myelogenous leukaemia stem-like KG-1a cells via NF- κB inhibition and the induction of oxidative stress
J Cell Mol Med. 2024 Apr;28(8):e18333. doi: 10.1111/jcmm.18333.ABSTRACTAcute myelogenous leukaemia (AML) originates and is maintained by leukaemic stem cells (LSCs) that are inherently resistant to antiproliferative therapies, indicating that a critical strategy for overcoming chemoresistance in AML therapy is to eradicate LSCs. In this work, we investigated the anti-AML activity of bortezomib (BTZ), emphasizing its anti-LSC potential, using KG-1a cells, an AML cell line with stem-like properties. BTZ presented potent cytotoxicity to both solid and haematological malignancy cells and reduced the stem-like features of KG-1a...
Source: J Cell Mol Med - April 23, 2024 Category: Molecular Biology Authors: Rafaela G A Costa Maiara de S Oliveira Ana Carolina B da C Rodrigues Suellen L R Silva Ingrid R S B Dias Milena B P Soares Ludmila de Faro Valverde Clarissa Araujo Gurgel Rocha Rosane Borges Dias Daniel P Bezerra Source Type: research
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
N-acetylcysteine Protects Against Myocardial Ischemia-Reperfusion Injury Through Anti-ferroptosis in Type 1 Diabetic Mice
Cardiovasc Toxicol. 2024 Apr 22. doi: 10.1007/s12012-024-09852-7. Online ahead of print.ABSTRACTThe hearts of subjects with diabetes are vulnerable to ischemia-reperfusion injury (IRI). In contrast, experimentally rodent hearts have been shown to be more resistant to IRI at the very early stages of diabetes induction than the heart of the non-diabetic control mice, and the mechanism is largely unclear. Ferroptosis has recently been shown to play an important role in myocardial IRI including that in diabetes, while the specific mechanisms are still unclear. Non-diabetic control (NC) and streptozotocin-induced diabetic (DM) ...
Source: Cardiovascular Toxicology - April 22, 2024 Category: Cardiology Authors: Dongcheng Zhou Yuhui Yang Jiajia Chen Jiaqi Zhou Jianfeng He Danyong Liu Anyuan Zhang Bixian Yuan Yuxin Jiang Weiyi Xia Ronghui Han Zhengyuan Xia Source Type: research
The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan ’s National Health Insurance Research Database
ConclusionColchicine was associated with the lower aHR of the all cancer and colorectal cancer formation in patients with the IMIDs. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 22, 2024 Category: Research Source Type: research
Lycium barbarum polysaccharides attenuate nonylphenol and octylphenol-induced oxidative stress and neurotransmitter disorders in PC-12 cells
This study aims to explore the cytotoxicity of combined NP and OP exposure and evaluate the potential of Lycium barbarum polysaccharides (LBP) in mitigating the aforementioned toxicity. In present study, LBP (62.5, 125 and 250µg/mL) were applied to intervene rat adrenal pheochromocytoma (PC-12) cells treated with combined NP and OP (NP: OP = 4:1, w/w; 1, 2, 4 and 8µg/mL). The results showed that NP and OP induced oxidative stress, disrupted the 5-hydroxytryptamine (5-HT) and cholinergic systems in PC-12 cells. Additionally, they activated the p38 protein kinase (p38) and suppressed the expression of silent information re...
Source: Toxicology - April 20, 2024 Category: Toxicology Authors: Linjing Xu Huan Liu Yifeng Rang Lizi Zhou Xukai Wang Yinhuan Li Chunhong Liu Source Type: research
Evaluation of capillary miR-122 as a prognostic biomarker of paracetamol-induced liver toxicity
CONCLUSION: This work supports the potential use of capillary miR-122 as a prognostic biomarker of liver injury throughout clinical management of patients with paracetamol overdose. Capillary miR-122 can be measured in a blood drop collected by a finger prick, a minimally invasive diagnostic test for patient stratification.PMID:38642142 | DOI:10.1007/s11033-024-09327-6 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 20, 2024 Category: Molecular Biology Authors: Marco Cirronis Sarah Schneemann Janice Pettie Guido Mannaioni James W Dear Source Type: research
Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study
AbstractChemotherapy-induced alopecia (CIA) represents one of the most severe side effects of chemotherapy, which forces some patients to reject cancer treatment. The exact pathophysiological mechanisms of CIA are not clearly understood, which makes it difficult to discover efficient preventive or therapeutic procedures for this adverse effect. N-acetylcysteine (NAC) has a strong antioxidant activity as it stimulates glutathione synthesis and acts as an oxygen radical scavenger. The current study tried to investigate the efficacy of NAC in preserving biochemical parameters and hair follicle structure against cyclophosphami...
Source: Histochemistry and Cell Biology - April 20, 2024 Category: Biomedical Science Source Type: research
Celecoxib and sulindac sulfide elicit anticancer effects on PIK3CA-mutated head and neck cancer cells through endoplasmic reticulum stress, reactive oxygen species, and mitochondrial dysfunction
Biochem Pharmacol. 2024 Apr 18;224:116221. doi: 10.1016/j.bcp.2024.116221. Online ahead of print.ABSTRACTGain-of-function mutation in the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) is a significant factor in head and neck cancer (HNC). Patients with HNC harboring PIK3CA mutations receive therapeutic benefits from the use of non-steroidal anti-inflammatory drugs (NSAIDs). However, the molecular mechanisms underlying these effects remain unknown. Here, we examined the Detroit562 and FaDu cell lines as HNC models with and without a hyperactive PIK3CA mutation (H1047R), respecti...
Source: Biochemical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Authors: Nga Thi Thanh Nguyen Sang Yoon Lee Source Type: research
