N-acetylcysteine Treatment in Chronic Obstructive Pulmonary Disease (COPD) and Chronic Bronchitis/Pre-COPD: Distinct Meta-analyses
CONCLUSIONS: These findings provide novel data of NAC on the improvement in symptoms and QoL in addition to prevention of exacerbations in COPD and CB/pre-COPD. PROSPERO registry no. CRD42023468154.PMID:38555190 | DOI:10.1016/j.arbres.2024.03.010 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - March 30, 2024 Category: Respiratory Medicine Authors: Alberto Papi Franco Alfano Tommaso Bigoni Lorenzo Mancini Amal Mawass Federico Baraldi Cristina Aljama Marco Contoli Marc Miravitlles Source Type: research
N-acetylcysteine Treatment in Chronic Obstructive Pulmonary Disease (COPD) and Chronic Bronchitis/Pre-COPD: Distinct Meta-analyses
CONCLUSIONS: These findings provide novel data of NAC on the improvement in symptoms and QoL in addition to prevention of exacerbations in COPD and CB/pre-COPD. PROSPERO registry no. CRD42023468154.PMID:38555190 | DOI:10.1016/j.arbres.2024.03.010 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - March 30, 2024 Category: Respiratory Medicine Authors: Alberto Papi Franco Alfano Tommaso Bigoni Lorenzo Mancini Amal Mawass Federico Baraldi Cristina Aljama Marco Contoli Marc Miravitlles Source Type: research
N-acetylcysteine Treatment in Chronic Obstructive Pulmonary Disease (COPD) and Chronic Bronchitis/Pre-COPD: Distinct Meta-analyses
CONCLUSIONS: These findings provide novel data of NAC on the improvement in symptoms and QoL in addition to prevention of exacerbations in COPD and CB/pre-COPD. PROSPERO registry no. CRD42023468154.PMID:38555190 | DOI:10.1016/j.arbres.2024.03.010 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - March 30, 2024 Category: Respiratory Medicine Authors: Alberto Papi Franco Alfano Tommaso Bigoni Lorenzo Mancini Amal Mawass Federico Baraldi Cristina Aljama Marco Contoli Marc Miravitlles Source Type: research
Retracted: N-Acetylcysteine Improves Inflammatory Response in COPD Patients by Regulating Th17/Treg Balance through Hypoxia Inducible Factor-1 < em > α < /em > Pathway
Biomed Res Int. 2024 Mar 20;2024:9753627. doi: 10.1155/2024/9753627. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2021/6372128.].PMID:38550205 | PMC:PMC10977163 | DOI:10.1155/2024/9753627 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice
Arch Toxicol. 2024 Mar 29. doi: 10.1007/s00204-024-03725-2. Online ahead of print.ABSTRACTAcetaminophen (APAP)-induced hepatotoxicity is comprised of an injury and recovery phase. While pharmacological interventions, such as N-acetylcysteine (NAC) and 4-methylpyrazole (4-MP), prevent injury there are no therapeutics that promote recovery. JNJ-26366821 (TPOm) is a novel thrombopoietin mimetic peptide with no sequence homology to endogenous thrombopoietin (TPO). Endogenous thrombopoietin is produced by hepatocytes and the TPO receptor is present on liver sinusoidal endothelial cells in addition to megakaryocytes and platelet...
Source: Archives of Toxicology - March 29, 2024 Category: Toxicology Authors: Olamide B Adelusi Jephte Y Akakpo Gary Eichenbaum Ejaz Sadaff Anup Ramachandran Hartmut Jaeschke Source Type: research
Retracted: N-Acetylcysteine Improves Inflammatory Response in COPD Patients by Regulating Th17/Treg Balance through Hypoxia Inducible Factor-1 < em > α < /em > Pathway
Biomed Res Int. 2024 Mar 20;2024:9753627. doi: 10.1155/2024/9753627. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2021/6372128.].PMID:38550205 | PMC:PMC10977163 | DOI:10.1155/2024/9753627 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice
Arch Toxicol. 2024 Mar 29. doi: 10.1007/s00204-024-03725-2. Online ahead of print.ABSTRACTAcetaminophen (APAP)-induced hepatotoxicity is comprised of an injury and recovery phase. While pharmacological interventions, such as N-acetylcysteine (NAC) and 4-methylpyrazole (4-MP), prevent injury there are no therapeutics that promote recovery. JNJ-26366821 (TPOm) is a novel thrombopoietin mimetic peptide with no sequence homology to endogenous thrombopoietin (TPO). Endogenous thrombopoietin is produced by hepatocytes and the TPO receptor is present on liver sinusoidal endothelial cells in addition to megakaryocytes and platelet...
Source: Archives of Toxicology - March 29, 2024 Category: Toxicology Authors: Olamide B Adelusi Jephte Y Akakpo Gary Eichenbaum Ejaz Sadaff Anup Ramachandran Hartmut Jaeschke Source Type: research
Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
In conclusion, our study revealed that over-activated Notch1 signaling induces prostatic enlargement by increasing androgen receptor sensitivity, disrupting cellular mitochondrial metabolism, increasing ROS, and a higher number of progenitor cells, all of which can be effectively rescued by NAC treatment.PMID:38538986 | DOI:10.1007/s00018-024-05143-0 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - March 28, 2024 Category: Cytology Authors: Jin-Wen Kang Jia-Peng He Ying-Nan Liu Yu Zhang Shan-Shan Song Qi-Xin Xu Shu-Wen Wei Lei Lu Xiang-Qi Meng Lin Xu Bin Guo Ren-Wei Su Source Type: research
Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
In conclusion, our study revealed that over-activated Notch1 signaling induces prostatic enlargement by increasing androgen receptor sensitivity, disrupting cellular mitochondrial metabolism, increasing ROS, and a higher number of progenitor cells, all of which can be effectively rescued by NAC treatment.PMID:38538986 | DOI:10.1007/s00018-024-05143-0 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - March 28, 2024 Category: Cytology Authors: Jin-Wen Kang Jia-Peng He Ying-Nan Liu Yu Zhang Shan-Shan Song Qi-Xin Xu Shu-Wen Wei Lei Lu Xiang-Qi Meng Lin Xu Bin Guo Ren-Wei Su Source Type: research
Clinical Efficacy Observation of Acetylcysteine Combined with Tiotropium Bromide Inhalation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - March 27, 2024 Category: Nanotechnology Authors: Yuan, Lei Tags: research-article Source Type: research
n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats
Toxicol Res. 2024 Mar 7;40(2):285-295. doi: 10.1007/s43188-024-00226-3. eCollection 2024 Apr.ABSTRACTDiazinon (DZN) is a member of organophosphorus insecticides that has cytotoxic effects on different organs. n-Acetyl cysteine (NAC) is a widely used antioxidant in clinical, in vivo and in vitro studies. We evaluated the protective role of NAC against DZN-induced toxicity in kidney tissue of Wistar rats. 30 male Wistar rats were divided into 5 groups of control, single dose of DZN, continuous dose of DZN, single doses of DZN + NAC and continuous doses of DZN + NAC. Kidney function test (blood urea nitrogen, creatinine and u...
Source: Cell Research - March 25, 2024 Category: Cytology Authors: Gaiqin Dong Qingfeng Li Chun Yu Qing Wang Danhua Zuo Xiaozhong Li Source Type: research
In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
Toxicol In Vitro. 2024 Mar 22:105812. doi: 10.1016/j.tiv.2024.105812. Online ahead of print.ABSTRACTCarbendazim (CBZ) is a benzimidazole fungicide widely used worldwide in industrial, agricultural, and veterinary practices. Although, CBZ was found in all brain tissues causing serious neurotoxicity, its impact on brain immune cells remain scarcely understood. Our study investigated the in vitro effects of CBZ on activated microglial BV-2 cells. Lipopolysaccharide (LPS)-stimulated BV-2 cells were exposed to increasing concentrations of CBZ and cytokine release was measured by ELISA, and Cytometric Bead Array (CBA) assays. Mi...
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Narjesse E L Mabrouk Maha Mastouri G érard Lizard Mahjoub Aouni Hedi Harizi Source Type: research
In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
Toxicol In Vitro. 2024 Mar 24;97:105812. doi: 10.1016/j.tiv.2024.105812. Online ahead of print.ABSTRACTCarbendazim (CBZ) is a benzimidazole fungicide widely used worldwide in industrial, agricultural, and veterinary practices. Although, CBZ was found in all brain tissues causing serious neurotoxicity, its impact on brain immune cells remain scarcely understood. Our study investigated the in vitro effects of CBZ on activated microglial BV-2 cells. Lipopolysaccharide (LPS)-stimulated BV-2 cells were exposed to increasing concentrations of CBZ and cytokine release was measured by ELISA, and Cytometric Bead Array (CBA) assays....
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Narjesse E L Mabrouk Maha Mastouri G érard Lizard Mahjoub Aouni Hedi Harizi Source Type: research
In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
Toxicol In Vitro. 2024 Mar 24;97:105812. doi: 10.1016/j.tiv.2024.105812. Online ahead of print.ABSTRACTCarbendazim (CBZ) is a benzimidazole fungicide widely used worldwide in industrial, agricultural, and veterinary practices. Although, CBZ was found in all brain tissues causing serious neurotoxicity, its impact on brain immune cells remain scarcely understood. Our study investigated the in vitro effects of CBZ on activated microglial BV-2 cells. Lipopolysaccharide (LPS)-stimulated BV-2 cells were exposed to increasing concentrations of CBZ and cytokine release was measured by ELISA, and Cytometric Bead Array (CBA) assays....
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Narjesse E L Mabrouk Maha Mastouri G érard Lizard Mahjoub Aouni Hedi Harizi Source Type: research
In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
Toxicol In Vitro. 2024 Mar 24;97:105812. doi: 10.1016/j.tiv.2024.105812. Online ahead of print.ABSTRACTCarbendazim (CBZ) is a benzimidazole fungicide widely used worldwide in industrial, agricultural, and veterinary practices. Although, CBZ was found in all brain tissues causing serious neurotoxicity, its impact on brain immune cells remain scarcely understood. Our study investigated the in vitro effects of CBZ on activated microglial BV-2 cells. Lipopolysaccharide (LPS)-stimulated BV-2 cells were exposed to increasing concentrations of CBZ and cytokine release was measured by ELISA, and Cytometric Bead Array (CBA) assays....
Source: Toxicology in Vitro - March 24, 2024 Category: Toxicology Authors: Narjesse E L Mabrouk Maha Mastouri G érard Lizard Mahjoub Aouni Hedi Harizi Source Type: research
