Reactive oxygen species generation required for autophagy induction during butyrate- or propionate-induced release of damage-associated molecular patterns from dying gingival epithelial Ca9-22 cells
CONCLUSION: The findings suggest that ROS generation is necessary for autophagy, which is required for SCFA-induced cell death and accompanying DAMP release.PMID:38494703 | DOI:10.2334/josnusd.23-0421 (Source: Journal of oral science)
Source: Journal of oral science - March 18, 2024 Category: Dentistry Authors: Kiwa Miyake Yoshikazu Mikami Takayuki Asayama Taku Toriumi Keiji Shinozuka Morio Tonogi Yoshiyuki Yonehara Hiromasa Tsuda Source Type: research
Combined use of multiparametric high-content-screening and in vitro circadian reporter assays in neurotoxicity evaluation
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03686-6. Online ahead of print.ABSTRACTAccumulating evidence indicates that chronic circadian rhythm disruption is associated with the development of neurodegenerative diseases induced by exposure to neurotoxic chemicals. Herein, we examined the relationship between cellular circadian rhythm disruption and cytotoxicity in neural cells. Moreover, we evaluated the potential application of an in vitro cellular circadian rhythm assay in determining circadian rhythm disruption as a sensitive and early marker of neurotoxicant-induced adverse effects. To explore these objectives,...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Youngil Park Hwan-Goo Kang Seok-Jin Kang Hyun-Ok Ku Helmut Zarbl Ming-Zhu Fang Jae-Hak Park Source Type: research
Current Understanding of Compulsive Sexual Behavior Disorder and Co-occurring Conditions: What Clinicians Should Know about Pharmacological Options
AbstractCompulsive sexual behavior disorder (CSBD) has recently been recognized as a psychiatric disorder. Pharmacological treatments for CSBD have received little study and thus have limited empirical support. The main objective of the present work is to review existing literature on the efficacy of different drugs on the symptomatology of CSBD, including the subtype of problematic pornography use (PPU). The main pharmacological approaches to treating CSBD have included opioid antagonists (naltrexone and nalmefene), selective serotonin reuptake inhibitors (paroxetine, citalopram, fluoxetine, and sertraline), mood stabiliz...
Source: CNS Drugs - March 14, 2024 Category: Neurology Source Type: research
Intra-tumoural bromelain and N-acetylcysteine for recurrent and unresectable pseudomyxoma peritonei: phase I/II trial
Br J Surg. 2024 Mar 2;111(3):znae045. doi: 10.1093/bjs/znae045.NO ABSTRACTPMID:38477594 | DOI:10.1093/bjs/znae045 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - March 13, 2024 Category: Surgery Authors: Lidia Rodr íguez-Ortiz Mari C V ázquez-Borrego Florina I Bura Melissa Granados-Rodr íguez Francisca Valenzuela-Molina Blanca Rufi án-Andújar Ana Mart ínez-López Rosa Ortega-Salas Juan Jos é Espejo-Herrero Antonio Romero-Ruiz Álvaro Arjona-Sánche Source Type: research
Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation
In conclusion, our findings suggest that NaF induces renal damage through ROS-mediated activation of LMP and the GSDME/HMGB1 axis, leading to pyroptosis and inflammation. Rutin, a natural antioxidative and anti-inflammatory dietary supplement, offers a novel approach to prevent and treat fluoride-induced nephrotoxicity.PMID:38479315 | DOI:10.1016/j.ecoenv.2024.116195 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Yue Ma Panpan Xu Hengrui Xing Yue Zhang Tingting Li Xueman Ding Li Liu Qiang Niu Source Type: research
Intra-tumoural bromelain and N-acetylcysteine for recurrent and unresectable pseudomyxoma peritonei: phase I/II trial
Br J Surg. 2024 Mar 2;111(3):znae045. doi: 10.1093/bjs/znae045.NO ABSTRACTPMID:38477594 | DOI:10.1093/bjs/znae045 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - March 13, 2024 Category: Surgery Authors: Lidia Rodr íguez-Ortiz Mari C V ázquez-Borrego Florina I Bura Melissa Granados-Rodr íguez Francisca Valenzuela-Molina Blanca Rufi án-Andújar Ana Mart ínez-López Rosa Ortega-Salas Juan Jos é Espejo-Herrero Antonio Romero-Ruiz Álvaro Arjona-Sánche Source Type: research
Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation
In conclusion, our findings suggest that NaF induces renal damage through ROS-mediated activation of LMP and the GSDME/HMGB1 axis, leading to pyroptosis and inflammation. Rutin, a natural antioxidative and anti-inflammatory dietary supplement, offers a novel approach to prevent and treat fluoride-induced nephrotoxicity.PMID:38479315 | DOI:10.1016/j.ecoenv.2024.116195 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Yue Ma Panpan Xu Hengrui Xing Yue Zhang Tingting Li Xueman Ding Li Liu Qiang Niu Source Type: research
Intra-tumoural bromelain and N-acetylcysteine for recurrent and unresectable pseudomyxoma peritonei: phase I/II trial
Br J Surg. 2024 Mar 2;111(3):znae045. doi: 10.1093/bjs/znae045.NO ABSTRACTPMID:38477594 | DOI:10.1093/bjs/znae045 (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - March 13, 2024 Category: Surgery Authors: Lidia Rodr íguez-Ortiz Mari C V ázquez-Borrego Florina I Bura Melissa Granados-Rodr íguez Francisca Valenzuela-Molina Blanca Rufi án-Andújar Ana Mart ínez-López Rosa Ortega-Salas Juan Jos é Espejo-Herrero Antonio Romero-Ruiz Álvaro Arjona-Sánche Source Type: research
Rutin mitigates fluoride-induced nephrotoxicity by inhibiting ROS-mediated lysosomal membrane permeabilization and the GSDME-HMGB1 axis involved in pyroptosis and inflammation
In conclusion, our findings suggest that NaF induces renal damage through ROS-mediated activation of LMP and the GSDME/HMGB1 axis, leading to pyroptosis and inflammation. Rutin, a natural antioxidative and anti-inflammatory dietary supplement, offers a novel approach to prevent and treat fluoride-induced nephrotoxicity.PMID:38479315 | DOI:10.1016/j.ecoenv.2024.116195 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Yue Ma Panpan Xu Hengrui Xing Yue Zhang Tingting Li Xueman Ding Li Liu Qiang Niu Source Type: research
Severe dengue infection unmasking drug ‐induced liver injury: Successful management with N‐acetylcysteine
Key Clinical MessageClinicians in tuberculosis and dengue endemic regions should have heightened vigilance for drug-induced liver injury (DILI) overlapping with active infections, enabling prompt recognition and life-saving conservative management.AbstractSevere dengue and drug-induced liver injury (DILI) are significant independent risk factors for acute liver failure. The co-occurrence of these conditions significantly complicates clinical management. Here, we describe the case of a 21-year-old Nepali female who developed acute liver failure during antitubercular therapy (ATT). The patient, presenting with fever and naus...
Source: Clinical Case Reports - March 11, 2024 Category: General Medicine Authors: Naveen Gautam,
Nishan Shrestha,
Sanjeev Bhandari,
Sabin Thapaliya Tags: CASE REPORT Source Type: research
Pubertal exposure to Microcystin-LR arrests spermatogonia proliferation by inducing DSB and inhibiting SIRT6 dependent DNA repair in vivo and in vitro
This study reports the effect of pubertal exposure to MC-LR on spermatogenesis and complex mechanism how MC-LR induces spermatogonia cell proliferation inhibition.PMID:38460408 | DOI:10.1016/j.ecoenv.2024.116191 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - March 9, 2024 Category: Environmental Health Authors: Yu-Lin Liu Jia-Yu Liu Xin-Xin Zhu Jian-Hua Wei Shuang-Ling Mi Su-Ya Liu Xiu-Liang Li Wei-Wei Zhang Ling-Li Zhao Hua Wang De-Xiang Xu Lan Gao Source Type: research
Protective effects of N-acetylcysteine and S-adenosyl-Lmethionine against nephrotoxicity and immunotoxicity induced by ochratoxin A in rats
CONCLUSION: NAC and SAMe have a protective role against nephrotoxicity and immunotoxicity induced by continuous administration of OTA. NAC was more effective in reducing OTA nephrotoxicity, whereas SAMe was more potent than NAC in reducing OTA immunotoxicity.PMID:38455596 | PMC:PMC10915916 (Source: Cancer Control)
Source: Cancer Control - March 8, 2024 Category: Cancer & Oncology Authors: Nuha A Alkhattabi Fares K Khalifa Huda A Al Doghaither Ayat B Al-Ghafari Nesrin Ibrahim Tarbiah Aliaa Sabban Source Type: research
