Factors associated with discontinuation and resumption of implant maintenance therapy.
Authors: Arimizu C, Ayukawa Y, Kuwatsuru R, Haresaku S, Matsushita Y, Koyano K Abstract Discontinuation of implant maintenance is the main risk factor for implant failure. The purpose of this study was to identify factors associated with previous discontinuation and resumption of maintenance among implant patients. A questionnaire survey was sent to 171 patients receiving implant maintenance at a university hospital; 169 patients responded. To assess the effect of job status, 26 patients (15.4%) with a history of maintenance discontinuation were classified as employed and nonemployed. The main reasons for previousl...
Source: Journal of oral science - August 5, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Mechanical effects of residual bone mass, a maxillofacial prosthesis, and a reconstruction plate on the mandible after marginal resection.
In this study, analytic models were used to simulate marginal resection in the area of the second premolar to the second molar region, and the mechanical effects on the mandible of residual bone mass, a maxillofacial prosthesis, and a reconstruction plate were evaluated by three-dimensional finite element analysis. As residual bone mass decreased, maximum principal stress increased near the anterior ramus of the mandible, and maximum shear stress increased at the anterior buccal region of the resected area. In the mandible with a maxillofacial prosthesis, the maximum principal stress distribution at the anterior ramus was ...
Source: Journal of oral science - August 5, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Properties of heat-sensitive neurons in the premotor cortex of conscious monkeys.
Authors: Unno S, Shinoda M, Soma K, Kubo A, Sessle BJ, Matsui T, Ando M, Asaka J, Otsuki K, Yonemoto H, Onose H, Sakanashi K, Iwata K Abstract To investigate neuronal activity involved in responses to noxious stimuli in conscious monkeys, the animals were subjected to a task that required them to detect a small change in facial skin temperature or light (second temperature: T2, second light: V2) relative to an initial condition (T1 or V1), and to detect changes in V2 along with a heat task. Recordings were obtained from 57 neurons in the ventral premotor cortex (PMv) during the heat or light detection task. T1 neur...
Source: Journal of oral science - August 5, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Clinical outcomes of single crown restorations fabricated with resin-based CAD/CAM materials.
Authors: Komine F, Honda J, Kusaba K, Kubochi K, Takata H, Fujisawa M Abstract Computer-aided design/computer-aided manufacturing (CAD/CAM) restorative materials have been widely used owing to a number of advantages, including stable quality of the materials, lower costs, and time-saving factors. Resin-based CAD/CAM materials for definitive restorations are classified into two groups: dispersed nanoparticle-filled composite resin and polymer-infiltrated-ceramic-network materials. Resin-based CAD/CAM materials have been applied to single crown restorations as a monolithic structure for the posterior region. In addit...
Source: Journal of oral science - August 5, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Angiostatin-functionalized collagen scaffolds suppress angiogenesis but do not induce chondrogenesis by mesenchymal stromal cells in vivo.
The objective of this study was to investigate the effect of angiostatin on inhibition of angiogenesis and promotion of chondrogenesis by collagen scaffolds with or without MSC implanted subcutaneously in rats. One scaffold from the following groups was implanted in each animal: Collagen scaffolds only, scaffolds functionalized with angiostatin, scaffolds loaded with MSC and scaffolds functionalized with angiostatin and loaded with MSC. The various scaffolds were harvested after 2 and 8 weeks for histological analysis, Real-time quantitative polymerase chain reaction (RT-qPCR) and immunofluorescence quantification. Results...
Source: Journal of oral science - July 22, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

SSEA-3 and 4 are not essential for the induction or properties of mouse iPS cells.
This study investigated the biological and functional significance of globo-series glycolipids such as SSEA-3 and 4 in mouse iPS cells induced from tail-tip fibroblasts (TTFs) of α1,4Gal-T-knockout mice (lacking SSEA-3 and 4). These iPS cells were induced by retroviral transduction of four factors (Oct3/4, Sox2, Klf4, and c-Myc) into TTFs, and colonies were picked up. Morphologically, the colonies resembled ES cells and were positive for alkaline phosphatase and ES cell markers. Furthermore, in vitro-differentiated induction experiments after embryoid body formation revealed that some colonies derived from α1, ...
Source: Journal of oral science - July 22, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Risk factors of head and neck cancer mortality compared with those of all-cause and all-cancer mortalities.
This study aimed to clarify the risk factors of head and neck cancer (HNC) mortality, relative to those of all-cause and all-cancer mortalities, using the Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) data set. Data from 238 HNC deaths, 14,769 all-cancer deaths, and 38,086 all-cause deaths were extracted during a median follow-up period of 9.5 years. Baseline characteristics were assessed via chi-square tests, t tests, and multivariable logistic regression. HNC mortality was found to be positively associated with male sex, past and current smoking habits, moderate-to-heavy alcohol consumptio...
Source: Journal of oral science - July 8, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Wettability and pre-osteoblastic behavior evaluations of a dense bovine hydroxyapatite ceramics.
In conclusion, this dense Ca10 (PO4)6(OH)2 ceramic can be considered as a potential biocompatible material. PMID: 32581175 [PubMed - in process] (Source: Journal of oral science)
Source: Journal of oral science - June 26, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Investigating the effect of antiseptic solution on the release of interleukin-6 and transforming growth factor beta 1 from human gingival fibroblasts using wound healing assays.
Authors: Berner T, Nakahara K, Kobayashi E, Tanaka A, Taniguchi Y, Iizuka T, Sawada K Abstract This in vitro study evaluated the effect of different antiseptics and different concentrations thereof in a model of wound healing using human gingival fibroblasts. The fibroblasts were rinsed with four different antiseptic solutions: sodium hypochlorite (HYP), hydrogen peroxide (H2O2), chlorhexidine digluconate (CHX), and benzalkonium chloride (BC). The effect on the release of interleukin-6 (IL-6) and transforming growth factor beta 1 (TGF-β1) was investigated using enzyme-linked immunosorbent assays (ELISAs). In a...
Source: Journal of oral science - June 26, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Inhibitory effect of omega-3 fatty acids on alveolar bone resorption and osteoclast differentiation.
In this study, a Porphyromonas gingivalis (P.g.)-infected mouse periodontitis model was used to investigate the effect of omega-3 fatty acid intake on differentiation and maturation of cultured osteoclast. Four-week-old C57BL/6JJcl mice were divided into four groups according to the diets they were fed from the beginning of the experiment (i.e., food containing omega-3 or omega-6 fatty acids) and whether they were orally administered P.g. Thirty-three days after beginning the experiment, bone marrow cells were sampled from the femoral bone of mice from each group and differentiated into osteoclasts; the effects of the inge...
Source: Journal of oral science - June 26, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Effect of lidocaine with adrenaline and landiolol on hemodynamics in spontaneously hypertensive rats.
This study assessed whether combined administration of landiolol with adrenaline and lidocaine would induce local anesthesia without causing hemodynamic changes. Normal saline (NS), lidocaine with adrenaline (LA), and lidocaine with adrenaline and landiolol (LLA) were injected into Wistar Kyoto (WKY/Izm) or spontaneously hypertensive (SHR/Izm) rats, followed by measurement of the pulse rate (PR), and the systolic, diastolic and mean blood pressures (SBP, DBP and MBP). In the LLA group, the increase in PR was significantly suppressed in both SHR/Izm and WKY/Izm rats relative to those in the LA group. Although SBP was signif...
Source: Journal of oral science - June 26, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Finite element analysis of stress caused by palatal orthodontic anchor screws.
This study used finite element (FE) analysis to investigate the stability of miniscrews (screws) placed at the median palate. FE models with variable suture maturity and screw-suture distances were used to examine the relationship with screw stability. Four groups were classified by extent of maturation of the midpalatal suture (0%, 60%, 75%, and 100%). The placement position was set at the center of the suture (0.0 mm), or 0.5, 1.0, and 1.5 mm to the side of the suture, and von Mises stress values in bone and screw displacement were compared among models. The stress value for the unsutured model, in which the screw was pl...
Source: Journal of oral science - June 26, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Effect of titanium or zirconia implant abutments on epithelial attachments after ultrasonic cleaning.
In conclusion, zirconia is harder than titanium and a better choice for use in the epithelial tissue attachment. Zirconia is more suitable as a material for implant abutments than titanium. PMID: 32581180 [PubMed - in process] (Source: Journal of oral science)
Source: Journal of oral science - June 26, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Taurocholic acid lowers the inflammatory response of gingival fibroblasts, epithelial cells, and macrophages.
Authors: Talebian R, Hashem O, Gruber R Abstract Taurocholic acid (TCA), a conjugation of cholic acid with taurine, is one of the main bile acids that is elevated in liver disease. Considering the epidemiologic linkage of periodontal disease to liver disease, the question arises about the possible effect of elevated TCA levels on periodontal cells. To answer this question, gingival fibroblasts and human oral squamous cell carcinoma cell line (HSC-2) were pretreated with interleukine1β (IL1β) and tumor necrosis factorα (TNFα) in the presence and absence of TCA. Also, mouse macrophages (RAW 264....
Source: Journal of oral science - June 26, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

The social insurance systems in foreign countries and pricing of medical devices.
Authors: Ide K, Hattori M Abstract In this aging Japanese society, the demand for ensuring a healthy life and improving the quality of life is on the rise. The government declared "Health Japan 21" and dental health has been identified as one of the most important issues. At the same time, national medical care expenditure is increasing year by year. As such, efficiency in dentistry is required, and the quality, efficacy, and safety of medical devices have been standardized. As one of the steps toward introducing new medical devices and technology, this report contains a collection of data, research, and ...
Source: Journal of oral science - June 26, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Saliva-based PCR tests for SARS-CoV-2 detection.
Authors: Takeuchi Y, Furuchi M, Kamimoto A, Honda K, Matsumura H, Kobayashi R Abstract The outbreak of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. Nasopharyngeal swabs are widely used in polymerase chain reaction (PCR) test to detect SARS-CoV-2. However, the collection of nasopharyngeal swabs has a series of drawbacks concerning exposure of healthcare staff, difficulty in collection, and discomfort of patients. Therefore, an alternative noninvasive sample for diagnostic of emerging viral diseases is required. The usefulness o...
Source: Journal of oral science - June 26, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Clinical and histological evaluations of alveolar ridge augmentation using a novel bi-layered porous polyethylene barrier membrane.
This study aimed to perform a preliminarily evaluation of the safety and performance of a new nonabsorbable bi-layered porous polyethylene (PPE) membrane, in combination with a freeze-dried cortical bone allograft in posterior mandibular ridge augmentation. Fifteen adults who had combined posterior mandibular defects were included for ridge augmentation via GBR using PPE membrane and allograft before implant placement. The keratinized mucosa width (KW), ridge width (RW), ridge height (RH), distance from measurement matrix to bone (DMB), and horizontal alveolar width at 14.0 mm apical to the occlusal plane (HAW) were clinic...
Source: Journal of oral science - June 12, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Use of experimental phantoms to determine the accuracy and reliability of mandibular cortical width measurements by panoramic radiography and cone-beam computed tomography.
Authors: Hayashi Y, Ito M, Imanishi Y, Watanabe K, Matsumoto K, Arai Y, Honda K Abstract The present study used an aluminum phantom to calculate accurate vertical magnification values around the mental foramen on panoramic radiography (PR) and compared corrected PR (Cor-PR) thickness measurements of the aluminum phantom and mandibular cortical width (MCW) of the human head with cone-beam computed tomography (CBCT) measurements at two fields of view (FOVs). The calculated vertical magnification value for PR around the mental foramen was 1.37. Measurements of the aluminum phantom significantly differed between Cor-PR...
Source: Journal of oral science - June 12, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Biological responses to pediatric stainless steel crowns.
Authors: Zafar S, Siddiqi A Abstract A systematic review was conducted to identify the biological responses, allergic reaction, hypersensitivity, toxicity, and ion release profile associated with pediatric stainless steel crowns (SSCs) in the existing literature. A systematic search was undertaken according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. The inclusion criteria consisted of patients younger than 20 years of age with SSC placement on primary or permanent teeth and in vivo and in vitro exposure to SSCs. Outcomes measures included adverse oral/mucosal effects; remo...
Source: Journal of oral science - June 12, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Sensitivity of conventional radiographs and cone-beam computed tomography in detecting the remaining root-canal filling material.
This study aimed to compare the sensitivity of radiographs and flat-panel volume-computed tomography (fpVCT) in detecting the remaining root-canal filling material. Thirty-two root canals in extracted human mandibular molars were prepared and obturated with gutta-percha and sealer. The filling material was removed, and the teeth were split longitudinally. Radiographs and fpVCT scans were obtained and digitized. Virtual images were developed using reconstruction software and then superimposed, and the remaining filling material was outlined. Direct observation of the split root halves using flatbed scans served as a control...
Source: Journal of oral science - June 6, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Orexins modulate membrane excitability in rat trigeminal motoneurons.
In this study, the direct effects of Oxs on the membrane properties of trigeminal motoneurons (TMNs) were examined, which critically participate in the genesis of rhythmical oral motor activities underlying suckling and mastication. Sprague-Dawley rats (3-6 day-old) were used to obtain whole-cell patch-clamp recordings from TMNs. Bath application of Ox-A depolarized the membrane potential and induced inward current, wherein Na+ and Ca2+ were charge carriers. Transient receptor potential channel activation potentially contributed to current and voltage responses by way of Ox-A. Ox-A increased the peak amplitude and duration...
Source: Journal of oral science - June 6, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Polymerization shrinkage kinetics and degree of conversion of resin composites.
This study compared shrinkage strain, polymerization shrinkage kinetics, and degree of conversion (DC) of a set of resin composites and investigated their influencing factors. Ten commercial resin composites were assessed, and 5 specimens (n = 5) were developed for material and subjected to light curing using light emitting diode light at 650 mW/cm2 for 40 s. The laser triangulation method was adopted to assess the shrinkage strain, and Fourier transform infrared spectroscopy was used to measure DC. The shrinkage strain was monitored for 5 min in real time and its data were subjected to differential calculations to get the...
Source: Journal of oral science - June 6, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Anti-heat shock protein 70 levels in gingival crevicular fluid of Japanese patients with chronic periodontitis.
Authors: Takai H, Furuse N, Ogata Y Abstract Periodontitis is an inflammatory disease involving complex tripartite cross-interactions among bacterial, host and environment factors. Heat shock proteins (Hsps) are a protein family produced in response to stress conditions. Hsps protect cells under adverse circumstances such as infection, inflammation and disease. One of the causes of periodontal disease is thought to be an imbalance in the expression of Hsps and anti-Hsp antibodies. Hsps are classified according to their molecular weight, and one of the major ones is Hsp70. In the present study, enzyme-linked immunos...
Source: Journal of oral science - June 6, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Endothelial nitric oxide synthase polymorphisms/haplotypes are strong modulators of oral cancer risk in Serbian population.
Authors: Carkic J, Nikolic N, Nisevic J, Lazarevic M, Kuzmanovic-Pficer J, Jelovac D, Milasin J Abstract Oral carcinoma is the sixth most common malignancy worldwide, with survival rates of approximately 50%. The major type of oral cancer, present in 90% of the cases, is oral squamous cell carcinoma (OSCC). The genetic background predisposing an individual to OSCC is complex and largely unknown. Studies have suggested that endothelial nitric oxide synthase (eNOS) gene polymorphisms modulate the cancer risk, prompting us to assess the impact of three functional eNOS gene polymorphisms on OSCC risk. The present study...
Source: Journal of oral science - June 6, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

A new enzyme-linked immunosorbent assay system against the N-terminal propiece of interleukin-1 α.
A new enzyme-linked immunosorbent assay system against the N-terminal propiece of interleukin-1α. J Oral Sci. 2020 Jun 04;: Authors: Sata E, Takada L, Kaetsu R, Fukasawa M, Ohtsu M, Motoyoshi M, Asano M Abstract Interleukin-1α (IL-1α) is produced inside cells in its precursor form (pIL-1α). Enzymatic cleavage yields mature (mIL-1α) and the propiece of IL-1α (ppIL-1α), which are thought to be localized in the nucleus, because of the presence of nuclear localizing signals. Studies of ppIL-1α function have been hampered by the lack of a ppIL-1α-specifi...
Source: Journal of oral science - June 6, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

A new framework to identify dental emergencies in the COVID-19 era.
Authors: Spicciarelli V, Marruganti C, Viviano M, Baldini N, Franciosi G, Tortoriello M, Ferrari M, Grandini S Abstract In order to reduce the spread of COVID-19 (Coronavirus Disease 2019), it is crucial to take extraordinary prevention and safety measures in dental offices, and to defer all elective and non-urgent procedures. Dental emergencies are defined through oral symptoms but, the systemic and psychological conditions of each patient should be considered. The present short communication proposes a multilevel evaluation (oral, systemic and psychological) and risk assessment score for the management of dental ...
Source: Journal of oral science - June 6, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Monomer release from bulk-fill composite resins in different curing protocols.
Authors: Gul P, Alp HH, Özcan M Abstract The purpose of this study was to determine the depth of cure and the type and amount of monomers released from bulk-fill composites in different curing protocols. Five different composite resins Filtek Bulk-Fill Posterior, Filtek Bulk-Fill Flowable, SureFil SDR, X-tra Fil, and X-tra base, were used. A light-emitting diode (LED) device was used in 3 different modes (standard, high power, and extra power mode), and a halogen light device was also used as a control. Surface hardness was measured and the depth of cure was calculated. Monomer analysis was performed using hig...
Source: Journal of oral science - June 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Cytotoxic effects of alkaline tetrasodium EDTA irrigating solutions.
Authors: Solana C, Ferrer-Luque CM, Wang X, Baca P, Ruiz-Linares M, Cabrera T Abstract The aim of this study is to determine the cytotoxic effects of tetrasodium ethylenediaminetetraacetic acid (EDTANa4) when used alone or when combined with sodium hypochlorite (NaOCl), with and without the addition of cetrimide (CTR). Human pulmonary fibroblast cell line was exposed to the following irrigating solutions: group 1, 2.5% NaOCl; group 2, 10% EDTANa4; group 3, 20% EDTANa4; group 4, 2.5% NaOCl/5% EDTANa4; group 5, 2.5% NaOCl/10% EDTANa4; group 6, 2.5% NaOCl/5% EDTANa4/0.2% CTR; group 7, 2.5% NaOCl/10% EDTANa4/0.2% CTR; ...
Source: Journal of oral science - June 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Differences in the corono-apical location of sinus tracts and buccal cortical bone defects between vertically root-fractured and non-root-fractured teeth based on periradicular microsurgery.
Authors: Kasahara Y, Iino Y, Ebihara A, Okiji T Abstract This retrospective study aimed to investigate whether the corono-apical location of sinus tracts differs according to the presence/location of vertical root fracture (VRF) in microsurgically treated root-filled teeth. The cases included were (1) anterior and premolar teeth without a preoperative diagnosis of VRF, (2) those with a periodontal probing depth of ≤3 mm, and (3) those for which preoperative cone-beam computed tomography (CBCT) scans and intraoperative video records were available. VRF was diagnosed intraoperatively. The locations of buccal corti...
Source: Journal of oral science - June 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Detection of hepatocyte growth factor in oral rinses using water for possible periodontal diagnosis.
Authors: Suzuki S, Aoki A, Katagiri S, Maekawa S, Ejiri K, Kong S, Nagata M, Yamaguchi Y, Ohshima M, Izumi Y Abstract The aim of this study is to analyze the relationship between Hepatocyte Growth Factor (HGF) levels in oral rinses using water and clinical parameters of periodontitis; and furthermore, to evaluate the potential of a prototype HGF immunochromatographic paper test strip (HGF-TS) for screening of periodontitis, in comparison with a commercially-available occult blood (hemoglobin) test strip (Hb-TS). Clinical periodontal parameters were recorded, and oral rinses were collected, from 125 subjects. Then, ...
Source: Journal of oral science - May 20, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Synthesis and characterization of a methacrylate monomer with a thiohydantoin structure.
Authors: Matsumura H, Kojima K, Mio S, Yamamoto T, Kodaira A, Koizumi H Abstract The purpose of the current study was to synthesize a methacrylate monomer with a thiohydantoin structure. In a flask, (2-thiohydantoin-4-yl) propionic acid, 10-hyroxydecyl methacrylate, 4-dimethylaminopyridine, and tetrahydrofuran (THF) were placed in a nitrogen atmosphere. A THF solution of N,N'-dicyclohexylcarbodiimide was added and stirred at room temperature. Ethyl acetate and n-hexane were then added to the reaction mixture. The reacted slurry was purified by chromatography with silica gel and hexane-ethyl acetate gradient elution...
Source: Journal of oral science - May 20, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Preface.
Authors: Kobayashi M PMID: 32224565 [PubMed - in process] (Source: Journal of oral science)
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Morphological foundations of pain processing in dental pulp.
Authors: Bae YC, Yoshida A Abstract Dental pulp is densely innervated by sensory afferents that are primarily involved in nociception. Elucidating the type and properties of these afferents and their distribution patterns within the dental pulp is crucial for understanding the mechanisms of acute dental pain and dental hypersensitivity. Recent studies on the release of the transmitter glutamate and the expression of glutamate receptors and vesicular glutamate transporters (VGLUT) in the pulpal axons and trigeminal ganglion (TG) have suggested the possibility of a distinct glutamate signaling mechanism underlying th...
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Extracellular signal-regulated kinases (ERK) 1 and 2 as a key molecule in pain research.
Authors: Kondo M, Shibuta I Abstract Pain can be divided into nociceptive, inflammatory, and neuropathic pain. It is important to understanding the molecular mechanism of pain signaling in the development of pain relief therapies. Twenty years ago, extracellular signal-regulated kinases (ERK) 1 and 2, which are members of the mitogen-activated protein kinase superfamily, were identified as molecules activated in neurons by the exposure of peripheral tissues to noxious stimuli. Further studies have revealed that peripheral nerve injury induces ERK activation in glial cells, sensory neurons, and second-order neurons,...
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Evaluation of the association between orofacial pain and dysphagia.
Authors: Tsujimura T, Inoue M Abstract Swallowing has a vital function in airway protection and is the next step after mastication. Swallowing impairment, which is known as dysphagia, is frequently accompanied by pain. Previous clinical studies have shown that orofacial pain affects swallowing function. Thus, it was hypothesized that orofacial noxious inputs may modulate swallowing function. Previous studies using anesthetized animals has proposed that the facial skin-nucleus tractus solitarii (NTS), masseter muscle-NTS, lingual muscle-NTS, and lingual muscle-paratrigeminal nucleus-NTS pathways may be involved in t...
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Multi-dimensional role of the parabrachial nucleus in regulating pain-related affective disturbances in trigeminal neuropathic pain.
Authors: Katagiri A, Kato T Abstract Neuropathic pain is characterized by sensory abnormalities, such as mechanical allodynia and heat hyperalgesia, associated with alteration in the peripheral and central nervous systems. After trigeminal nerve injury, phenotypic changes that involve the expression of calcitonin gene-related peptide occur in large- and medium-sized myelinated neurons; primary afferent neurons exhibit hyperexcitability because of neuron-glia interactions in the trigeminal ganglion. Increased nociceptive inputs from C- and Aδ-fiber and innocuous inputs from Aβ-fiber into the trigeminal sp...
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Time-dependent responses in brain activity to ongoing hot stimulation in burning mouth syndrome.
Authors: Kohashi R, Shinozaki T, Sekine N, Watanabe K, Takanezawa D, Nishihara C, Ozasa K, Ikeda M, Noma N, Okada-Ogawa A, Imamura Y Abstract Burning mouth syndrome (BMS) is classified into idiopathic orofacial pain conditions. Although central and peripheral neuropathic mechanisms are believed to be involved, the etiology remains to be fully elucidated. The present study examined temporal brain responses to an ongoing hot stimulus to investigate the pain modulating system in patients with BMS. The thermal stimulation sequence comprised baseline (32°C, 40 s) to warm (40°C, 32 s) to baseline (32°C, 40 s)...
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Cone-beam-computed-tomography of the symmetry of root canal anatomy in mandibular incisors.
This study aimed to evaluate the prevalence of internal symmetry (the number and morphology of root canals) in the mandibular incisors using cone beam computed tomography (CBCT). A total of 302 CBCT scans involving 1,208 mandibular incisors were evaluated using the Vertucci's classification regarding the number and configuration of root canals. The central mandibular incisors exhibited two root canals in 22.6% of patients and lateral incisors in 24.3% of patients. Most teeth (76.4%) had a type I configuration (a single root canal, 1-1), 21.7% had type II (2-1), 1.1% had type V (1-2), and 0.8% had type IV (2-2). Teeth with ...
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Rat mandibular condyle and fossa grew separately then unified as a single joint at 20 days old, which was the weaning age.
In conclusion, the mandibular condyle with cartilage and disc grows on the posterior side of the mandibular fossa until P20, which was the weaning age. Then, the condyle fit into the mandibular fossa and completed the functional unit. PMID: 32224572 [PubMed - indexed for MEDLINE] (Source: Journal of oral science)
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Wound healing after applying a gelatin-based hydrogel sheet to resected rat submandibular gland.
Authors: Miyake Y, Shimizu O, Shiratsuchi H, Tamagawa T, Tonogi M Abstract The present study was done to develop a useful experimental model for analysis of the effects of physiologically active substances on atrophy and regeneration of salivary gland acinar cells. Resection wounds (diameter, 3 mm) were made in the submandibular glands of 8-week-old Wistar rats (n = 24) for histochemical examination on Days 3, 5, 7, 10, 14, and 21 after implantation of a gelatin-based hydrogel sheet. The results showed that the sheet had nearly disappeared by Day 10. Regions around the resection wounds were classified as normal, at...
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Analysis of salivary factors related to the oral health status in children.
This study aimed to perform a quantitative assessment of the saliva components as a first stage of the research to screen oral homeostasis. Here, saliva secretions collected from children were evaluated, and their constituents were analyzed to investigate the potential correlations between the buffering capacity and a range of salivary factors. Subjects aged 3-16 years in the primary, mixed, or permanent dentition stage, were selected for this study. The following salivary factors were analyzed: flow rate, total protein, total sugar quantifications, and constituent analyses using RT-PCR and western blotting. The associatio...
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

A survey on medications received by elderly persons with dysphagia living at home or in a nursing home.
Authors: Matsumura E, Nohara K, Tanaka N, Fujii N, Sakai T Abstract Polypharmacy in elderly persons living at home or in a nursing home is an issue. In the field of dentistry, strategies to reduce polypharmacy must be promoted; however, there is insufficient basic data on medications received by elderly persons with dysphagia living at home or in a nursing home. The subjects were 106 elderly persons with dysphagia living at home or in a nursing home. Based on their medical records, the presence of disease and number/type of drugs being administered were investigated. Stroke, dementia, and hypertension were common. ...
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Sinus floor elevation using tricalcium phosphate plate.
This report presents a case where sinus floor elevation was performed using tricalcium phosphate (TCP) plates supported by implant bodies, and only the blood clot was present around the implant bodies. Cone-beam computed tomography images, taken one year after the lateral approach, revealed the presence of a TCP-like radio-opacity, which almost disappeared after two years. About seven years after the surgery, the patient's superstructure and occlusion were stable. Furthermore, the grafted TCP was completely absorbed, and the implant body appeared to be in good condition, with no signs of bone resorption around the implant....
Source: Journal of oral science - April 2, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Thermal-induced hydrophilicity enhancement of titanium dental implant surfaces.
Authors: Toffoli A, Parisi L, Tatti R, Lorenzi A, Verucchi R, Manfredi E, Lumetti S, Macaluso GM Abstract Titanium surface characteristics, including microtopography, chemical composition, and wettability, are essential features to achieve osseointegration of dental implants, but the choice of a particular surface topography is still a debated topic among clinicians. An increased level of implant surface hydrophilicity has been demonstrated to ameliorate osseointegration and shorten healing times. The aim of this work is to develop and test a suitable thermal-based method to enhance titanium surface wettability wit...
Source: Journal of oral science - March 14, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Inhibitory effect of a mouth rinse formulated with chlorhexidine gluconate, ethanol, and green tea extract against major oral bacterial species.
Authors: Nomura R, Inaba H, Matayoshi S, Yoshida S, Matsumi Y, Matsumoto-Nakano M, Nakano K Abstract Mouth rinses are a useful supplementary tool for the prevention of oral infectious diseases. Although the antimicrobial effects of mouth rinses have been investigated, there are few studies focusing on the comparison of the effects among various oral bacterial species. In the present study, the inhibitory effect of a commercial mouth rinse, "ConCoolF," and each of its major components, chlorhexidine gluconate, ethanol, and green tea extract, on multiple species of oral bacteria were investigated. Inhibitio...
Source: Journal of oral science - March 14, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Automatic drawing of customized removable partial denture diagrams based on textual design for the clinical decision support system.
Authors: Chen Q, Lin S, Wu J, Lyu P, Zhou Y Abstract Qualified diagrams of removable partial denture (RPD) designs created by dentists provide technicians with clear and dynamic information. Generating RPD design in the clinical decision support system (CDSS) can be achieved by producing the RPD design in a textual format and then transferring the design onto diagrams. The drawing of RPD diagrams automatically and efficiently for the given textual designs is still under investigation. A new workflow consisting of three major steps is developed to produce and visualize two-dimensional RPD design diagrams. Annotation...
Source: Journal of oral science - March 14, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Effect of two different alcohol-free chlorhexidine formulations in mouthrinses on the immediate postoperative period for oral mucosal biopsies.
Authors: Arduino PG, Gambino A, Cabras M, Sciannameo V, Nimot Y, Karimi D, Ricceri F, Broccoletti R Abstract Oral biopsy is a common surgical practice. To date, few authors have described the healing of mucosal wounds following oral biopsy. The aim of the present single-center, prospective, randomized, controlled study is to evaluate the differences between two chlorhexidine (CHX) mouthrinses and a treatment-free approach in the immediate postoperative period following oral mucosal biopsy. 354 patients were included in this study and were randomly allocated to three groups: A) CHX 0.12% mouthrinse (twice daily, 10 ...
Source: Journal of oral science - March 14, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Temporospatial distribution of osteogenic and osteoclastic cells during development of the tarsometatarsal skeleton in the chick embryo (Gallus gallus).
Authors: Usami S, Yamazaki Y, Yuguchi M, Namba Y, Kanazawa H, Isokawa K Abstract The morphogenesis of long bones is a multistep process that generates a variety of genetically defined forms. The tarsometatarsal (TMT) long bone morphology in birds develops through lateral fusion of three initially independent periosteal bone cylinders (BCs). Previous studies have clarified the histological details and chronology of the changes occurring during development. The present study investigated the temporospatial distribution of osteogenic and osteoclastic cells in the embryonic chicken using histochemistry for alkaline pho...
Source: Journal of oral science - March 14, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

A perspective from experimental studies of burning mouth syndrome.
Authors: Imamura Y, Okada-Ogawa A, Noma N, Shinozaki T, Watanabe K, Kohashi R, Shinoda M, Wada A, Abe O, Iwata K Abstract Burning mouth syndrome (BMS) is one of the most frequently seen idiopathic pain conditions in a dental setting. Peri- and postmenopausal women are most frequently affected, and patients who experience BMS complain of persistent burning pain mainly at the tip and the bilateral border of the tongue. Recent studies have assessed whether BMS is a neuropathic pain condition, based on morphologic changes in biopsied tongue specimens, and whether there are abnormal pain responses in patients with this ...
Source: Journal of oral science - March 14, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research

Underexpression of SRSF3 and its target gene RBMX predicts good prognosis in patients with head and neck cancer.
Authors: Guo J, Wang X, Jia J, Jia R Abstract Head and neck cancer collectively is one of the most common cancer types in the world. Oral squamous cell carcinoma (OSCC) is the most common subtype of head and neck cancer. SRSF3 is a proto-oncogene and is overexpressed in patients with OSCC. However, the relationship between SRSF3 expression and the clinical outcomes of patients with head and neck cancer remains unclear. By using the cBioPortal for Cancer Genomics, a public online tool originally developed at Memorial Sloan Kettering Cancer Center (New York, NY, USA), it was revealed that patients with head and neck ...
Source: Journal of oral science - March 7, 2020 Category: Dentistry Tags: J Oral Sci Source Type: research