Isolation and Bioactivity Evaluation of Sesquiterpenes from an Alcyonarian of the Genus Lemnalia from the Saudi Arabian Red Sea
Chem Biodivers. 2024 Feb 27:e202400235. doi: 10.1002/cbdv.202400235. Online ahead of print.ABSTRACTOver the last decades, soft corals have been proven a rich source of biologically active compounds, featuring a wide range of chemical structures. Herein, we investigated the chemistry of an alcyonarian of the genus Lemnalia (Neptheidae), specimens of which were collected from the coral reefs near Al Lith, on the south-west coast of Saudi Arabia. A series of chromatographic separations led to the isolation of 31 sesquiterpenes, featuring mainly the nardosinane and neolemnane carbon skeletons, among which three (13, 14 and 28)...
Source: Chemistry and Biodiversity - February 27, 2024 Category: Biochemistry Authors: Efstathia Ioannou Aikaterini Koutsaviti Marie Kvasnicov á Gabriel Gonzalez Tereza Štenclová Susana Agusti Carlos M Duarte Lucie Rarov á Miroslav Strnad Vassilios Roussis Source Type: research
Molecules, Vol. 29, Pages 1032: The Copper Reduction Potential Determines the Reductive Cytotoxicity: Relevance to the Design of Metal & ndash;Organic Antitumor Drugs
Molecules, Vol. 29, Pages 1032: The Copper Reduction Potential Determines the Reductive Cytotoxicity: Relevance to the Design of Metal–Organic Antitumor Drugs
Molecules doi: 10.3390/molecules29051032
Authors:
Beloglazkina
Moiseeva
Tsymbal
Guk
Kuzmin
Krasnovskaya
Borisov
Barskaya
Tafeenko
Alpatova
Zaitsev
Finko
Ol’shevskaya
Shtil
Copper–organic compounds have gained momentum as potent antitumor drug candidates largely due to their ability to generate an oxidative burst upon the transition of Cu2+ to Cu1+ triggered by the exogenous-reducing agents. We ...
Source: Molecules - February 27, 2024 Category: Chemistry Authors: Beloglazkina Moiseeva Tsymbal Guk Kuzmin Krasnovskaya Borisov Barskaya Tafeenko Alpatova Zaitsev Finko Ol ’shevskaya Shtil Tags: Article Source Type: research
Glutathione Protects other Cellular Thiols against Oxidation by Cu < sup > II < /sup > -Dp44mT
Chemistry. 2024 Feb 26:e202304212. doi: 10.1002/chem.202304212. Online ahead of print.ABSTRACTCu-thiosemicarbazones have been intensively investigated for their application in cancer therapy or as antimicrobials. Copper(II)-di-2-pyridylketone-4,4-dimethyl-thiosemicarbazone (CuII -Dp44mT) showed anticancer activity in the submicromolar concentration range in cell culture. The interaction of CuII -Dp44mT with thiols leading to their depletion or inhibition was proposed to be involved in this activity. Indeed, CuII -Dp44mT can catalyze the oxidation of thiols although with slow kinetics. The present work aims to obtain insigh...
Source: Chemistry - February 26, 2024 Category: Chemistry Authors: Iman Doumi Lukas Lang Bertrand Vileno Marcel Deponte Peter Faller Source Type: research
Triphenyl phosphate induces cardiotoxicity through myocardial fibrosis mediated by apoptosis and mitophagy of cardiomyocyte in mice
Environ Pollut. 2024 Feb 24:123651. doi: 10.1016/j.envpol.2024.123651. Online ahead of print.ABSTRACTTriphenyl phosphate (TPHP) is an organophosphorus flame retardant, but its cardiac toxicity has not been adequately investigated. Therefore, in the current study, the effect of TPHP on the heart and the underlying mechanism involved was evaluated. C57BL/6 J mice were administered TPHP (0, 5, and 50 mg/kg/day) for 30 days. In addition, H9c2 cells were treated with three various concentrations (0, 50, and 150 μM) of TPHP, with and without the reactive oxygen species (ROS) scavenger N-acetyl-L-cysteine or the mitochondrial fu...
Source: Environmental Pollution - February 26, 2024 Category: Environmental Health Authors: Feibo Xu Yu He Aili Xu Lihua Ren Jinyu Xu Yali Shao Minxin Wang Wei Zhao Ying Zhang Peng Lu Lianshuang Zhang Source Type: research
3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway
In this study, we found that 3-MCPDE triggered necroptosis by RIPK1/RIPK3/MLKL pathway in HepG2 cells. Previous studies have shown that ROS is an important activator of RIPK1 and RIPK3. The data showed that 3-MCPDE induced excessive ROS production through mitochondrial damage. After treatment with ROS inhibitor N-acetylcysteine (NAC), 3-MCPDE-induced necroptosis was relieved. Further, we explored how 3-MCPDE destroys mitochondria. The data suggested that 3-MCPDE induced mitochondrial dysfunction through the CTSB/TFAM pathway. Overall, the results indicated that 3-MCPDE induced necroptosis through CTSB/TFAM/ROS pathway in H...
Source: Food and Chemical Toxicology - February 26, 2024 Category: Food Science Authors: Shuang Guan Xiao Qu Jianfeng Wang Duoduo Zhang Jing Lu Source Type: research
Triphenyl phosphate induces cardiotoxicity through myocardial fibrosis mediated by apoptosis and mitophagy of cardiomyocyte in mice
Environ Pollut. 2024 Feb 24:123651. doi: 10.1016/j.envpol.2024.123651. Online ahead of print.ABSTRACTTriphenyl phosphate (TPHP) is an organophosphorus flame retardant, but its cardiac toxicity has not been adequately investigated. Therefore, in the current study, the effect of TPHP on the heart and the underlying mechanism involved was evaluated. C57BL/6 J mice were administered TPHP (0, 5, and 50 mg/kg/day) for 30 days. In addition, H9c2 cells were treated with three various concentrations (0, 50, and 150 μM) of TPHP, with and without the reactive oxygen species (ROS) scavenger N-acetyl-L-cysteine or the mitochondrial fu...
Source: Environmental Pollution - February 26, 2024 Category: Environmental Health Authors: Feibo Xu Yu He Aili Xu Lihua Ren Jinyu Xu Yali Shao Minxin Wang Wei Zhao Ying Zhang Peng Lu Lianshuang Zhang Source Type: research
3-Monochloropropane-1,2-diol esters induce HepG2 cells necroptosis via CTSB/TFAM/ROS pathway
In this study, we found that 3-MCPDE triggered necroptosis by RIPK1/RIPK3/MLKL pathway in HepG2 cells. Previous studies have shown that ROS is an important activator of RIPK1 and RIPK3. The data showed that 3-MCPDE induced excessive ROS production through mitochondrial damage. After treatment with ROS inhibitor N-acetylcysteine (NAC), 3-MCPDE-induced necroptosis was relieved. Further, we explored how 3-MCPDE destroys mitochondria. The data suggested that 3-MCPDE induced mitochondrial dysfunction through the CTSB/TFAM pathway. Overall, the results indicated that 3-MCPDE induced necroptosis through CTSB/TFAM/ROS pathway in H...
Source: Food and Chemical Toxicology - February 26, 2024 Category: Food Science Authors: Shuang Guan Xiao Qu Jianfeng Wang Duoduo Zhang Jing Lu Source Type: research
Triphenyl phosphate induces cardiotoxicity through myocardial fibrosis mediated by apoptosis and mitophagy of cardiomyocyte in mice
Environ Pollut. 2024 Feb 24:123651. doi: 10.1016/j.envpol.2024.123651. Online ahead of print.ABSTRACTTriphenyl phosphate (TPHP) is an organophosphorus flame retardant, but its cardiac toxicity has not been adequately investigated. Therefore, in the current study, the effect of TPHP on the heart and the underlying mechanism involved was evaluated. C57BL/6 J mice were administered TPHP (0, 5, and 50 mg/kg/day) for 30 days. In addition, H9c2 cells were treated with three various concentrations (0, 50, and 150 μM) of TPHP, with and without the reactive oxygen species (ROS) scavenger N-acetyl-L-cysteine or the mitochondrial fu...
Source: Environmental Pollution - February 26, 2024 Category: Environmental Health Authors: Feibo Xu Yu He Aili Xu Lihua Ren Jinyu Xu Yali Shao Minxin Wang Wei Zhao Ying Zhang Peng Lu Lianshuang Zhang Source Type: research
Network pharmacology analysis and experimental verification of the antitumor effect and molecular mechanism of isocryptomerin on HepG2 cells
This study investigated the antitumor effect and underlying molecular mechanism of ISO on hepatocellular carcinoma (HCC) HepG2 cells. The cell viability assay revealed that ISO has a considerable killing effect on HCC cell lines. The apoptosis assay showed that ISO induced mitochondria-dependent apoptosis through the Bad/cyto-c/cleaved (cle)-caspase-3/cleaved (cle)-PARP pathway. The network pharmacological analysis found 13 key target genes, and epidermal growth factor receptor (EGFR), AKT, mitogen-activated protein kinase (MAPK), and reactive oxygen species (ROS) signaling pathways were strongly associated with ISO agains...
Source: Cell Research - February 24, 2024 Category: Cytology Authors: Jing-Long Cao Shu-Mei Li Yan-Jun Tang Wen-Shuang Hou An-Qi Wang Tian-Zhu Li Cheng-Hao Jin Source Type: research
Emerging disinfection byproducts 3-bromine carbazole induces cardiac developmental toxicity via aryl hydrocarbon receptor activation in zebrafish larvae
This study provides new evidence for potential risks associated with ingesting 3-BCZ as well as revealing underlying mechanisms responsible for its cardiotoxic effects on zebrafish embryos.PMID:38395134 | DOI:10.1016/j.envpol.2024.123609 (Source: Environmental Pollution)
Source: Environmental Pollution - February 23, 2024 Category: Environmental Health Authors: Yingying Liu Xudong Jin Yanan Ye Zeqiong Xu Zhongkun Du Huachang Hong Haiying Yu Hongjun Lin Xianfeng Huang Hongjie Sun Source Type: research
Epigallocatechin-3-gallate Synergistically Enhanced Arecoline-Induced Cytotoxicity by Redirecting Cycle Arrest to Apoptosis
This study investigated whether epigallocatechin-3-gallate (EGCG), an antioxidant from green tea, could resolve this paradox. Prostate cancer cells (PC-3 cell line) were cultured and treated with arecoline combined with NAC (N-acetylcysteine) or EGCG; the combined effects on intracellular ROS levels and cell viability were examined using the MTT and DCFDA assays, respectively. In addition, apoptosis, cell cycle, and protein expression were investigated using flow cytometry and western blot analysis. Our results showed that EGCG, similar to NAC (N-acetylcysteine), reduced the intracellular ROS levels, which were elevated by...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Li-Jane Shih Po-Chi Hsu Chih-Pin Chuu Hao-Ai Shui Chien-Chih Yeh Yueh-Chung Chen Yung-Hsi Kao Source Type: research
Epigallocatechin-3-gallate Synergistically Enhanced Arecoline-Induced Cytotoxicity by Redirecting Cycle Arrest to Apoptosis
This study investigated whether epigallocatechin-3-gallate (EGCG), an antioxidant from green tea, could resolve this paradox. Prostate cancer cells (PC-3 cell line) were cultured and treated with arecoline combined with NAC (N-acetylcysteine) or EGCG; the combined effects on intracellular ROS levels and cell viability were examined using the MTT and DCFDA assays, respectively. In addition, apoptosis, cell cycle, and protein expression were investigated using flow cytometry and western blot analysis. Our results showed that EGCG, similar to NAC (N-acetylcysteine), reduced the intracellular ROS levels, which were elevated by...
Source: Mol Biol Cell - February 23, 2024 Category: Molecular Biology Authors: Li-Jane Shih Po-Chi Hsu Chih-Pin Chuu Hao-Ai Shui Chien-Chih Yeh Yueh-Chung Chen Yung-Hsi Kao Source Type: research
Emerging disinfection byproducts 3-bromine carbazole induces cardiac developmental toxicity via aryl hydrocarbon receptor activation in zebrafish larvae
This study provides new evidence for potential risks associated with ingesting 3-BCZ as well as revealing underlying mechanisms responsible for its cardiotoxic effects on zebrafish embryos.PMID:38395134 | DOI:10.1016/j.envpol.2024.123609 (Source: Environmental Pollution)
Source: Environmental Pollution - February 23, 2024 Category: Environmental Health Authors: Yingying Liu Xudong Jin Yanan Ye Zeqiong Xu Zhongkun Du Huachang Hong Haiying Yu Hongjun Lin Xianfeng Huang Hongjie Sun Source Type: research
Epigallocatechin-3-gallate Synergistically Enhanced Arecoline-Induced Cytotoxicity by Redirecting Cycle Arrest to Apoptosis
This study investigated whether epigallocatechin-3-gallate (EGCG), an antioxidant from green tea, could resolve this paradox. Prostate cancer cells (PC-3 cell line) were cultured and treated with arecoline combined with NAC (N-acetylcysteine) or EGCG; the combined effects on intracellular ROS levels and cell viability were examined using the MTT and DCFDA assays, respectively. In addition, apoptosis, cell cycle, and protein expression were investigated using flow cytometry and western blot analysis. Our results showed that EGCG, similar to NAC (N-acetylcysteine), reduced the intracellular ROS levels, which were elevated by...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Li-Jane Shih Po-Chi Hsu Chih-Pin Chuu Hao-Ai Shui Chien-Chih Yeh Yueh-Chung Chen Yung-Hsi Kao Source Type: research
Epigallocatechin-3-gallate Synergistically Enhanced Arecoline-Induced Cytotoxicity by Redirecting Cycle Arrest to Apoptosis
This study investigated whether epigallocatechin-3-gallate (EGCG), an antioxidant from green tea, could resolve this paradox. Prostate cancer cells (PC-3 cell line) were cultured and treated with arecoline combined with NAC (N-acetylcysteine) or EGCG; the combined effects on intracellular ROS levels and cell viability were examined using the MTT and DCFDA assays, respectively. In addition, apoptosis, cell cycle, and protein expression were investigated using flow cytometry and western blot analysis. Our results showed that EGCG, similar to NAC (N-acetylcysteine), reduced the intracellular ROS levels, which were elevated by...
Source: Current Issues in Molecular Biology - February 23, 2024 Category: Molecular Biology Authors: Li-Jane Shih Po-Chi Hsu Chih-Pin Chuu Hao-Ai Shui Chien-Chih Yeh Yueh-Chung Chen Yung-Hsi Kao Source Type: research
