Protein phosphatase 4 mediates palmitic acid-induced endothelial dysfunction by decreasing eNOS phosphorylation at serine 633 in HUVECs
This study demonstrated that palmitic acid (PA) induced ED by activating the NADPH oxidase (NOX)/ROS signaling pathway to activate protein phosphatase 4 (PP4) and protein phosphatase 2A (PP2A), thereby reducing endothelial nitric oxide synthase (eNOS) phosphorylation at Ser633 and Ser1177, respectively. Okadaic acid (OA) and fostriecin (FST), which are inhibitors of PP2A, inhibited the PA-induced decreases in eNOS phosphorylation at Ser633 and Ser1177. The antioxidants N-acetylcysteine (NAC) and apocynin (APO) or knockdown of gp91phox or p67phox (NOX subunits) restored PA-mediated downregulation of PP4R2 protein expression...
Source: Experimental Cell Research - March 21, 2024 Category: Cytology Authors: Zhengwei Liang Gang Sun Junshi Zhang Qian Zhang Xiaoyu Li Si Qin Sha Lv Jing Ding Qifang Zhang Yong Xia Deqin Lu Source Type: research
Protein phosphatase 4 mediates palmitic acid-induced endothelial dysfunction by decreasing eNOS phosphorylation at serine 633 in HUVECs
This study demonstrated that palmitic acid (PA) induced ED by activating the NADPH oxidase (NOX)/ROS signaling pathway to activate protein phosphatase 4 (PP4) and protein phosphatase 2A (PP2A), thereby reducing endothelial nitric oxide synthase (eNOS) phosphorylation at Ser633 and Ser1177, respectively. Okadaic acid (OA) and fostriecin (FST), which are inhibitors of PP2A, inhibited the PA-induced decreases in eNOS phosphorylation at Ser633 and Ser1177. The antioxidants N-acetylcysteine (NAC) and apocynin (APO) or knockdown of gp91phox or p67phox (NOX subunits) restored PA-mediated downregulation of PP4R2 protein expression...
Source: Experimental Cell Research - March 21, 2024 Category: Cytology Authors: Zhengwei Liang Gang Sun Junshi Zhang Qian Zhang Xiaoyu Li Si Qin Sha Lv Jing Ding Qifang Zhang Yong Xia Deqin Lu Source Type: research
Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer
CONCLUSIONS: In summary, MBZ inhibited NSCLC cell viability and migration by inducing cell apoptosis via the ROS-JAK2-STAT3 signaling pathway. These data provide a theoretical basis for the use of MBZ in treating NSCLC.PMID:38505087 | PMC:PMC10944755 | DOI:10.21037/jtd-23-1978 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Zhipan Liang Qiuyun Chen Liuying Pan Xiaowei She Tengfei Chen Source Type: research
Oxidized DJ-1 activates the p-IKK/NF- κB/Beclin1 pathway by binding PTEN to induce autophagy and exacerbate myocardial ischemia-reperfusion injury
In conclusion, ox-DJ-1 could activate detrimental autophagy through the PTEN/p-IKK/NF-κB/Beclin1 pathway and exacerbate myocardial I/R injury.PMID:38508437 | DOI:10.1016/j.ejphar.2024.176496 (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Authors: Huiru Liu Xueying Wang Kang He Zihan Chen Xiaoqi Li Jianmin Ren Xiaoyan Zhao Song Liu Tingting Zhou Heping Chen Source Type: research
Mebendazole induces apoptosis and inhibits migration via the reactive oxygen species-mediated STAT3 signaling downregulation in non-small cell lung cancer
CONCLUSIONS: In summary, MBZ inhibited NSCLC cell viability and migration by inducing cell apoptosis via the ROS-JAK2-STAT3 signaling pathway. These data provide a theoretical basis for the use of MBZ in treating NSCLC.PMID:38505087 | PMC:PMC10944755 | DOI:10.21037/jtd-23-1978 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Zhipan Liang Qiuyun Chen Liuying Pan Xiaowei She Tengfei Chen Source Type: research
