N-Acetyl Cysteine Augments Adipose Tissue-Derived Stem Cell Efficacy on Inflammatory Markers and Regulatory T Cell System Balance in an Allergic Asthma Model
Conclusion: The results of the present study documented that the administration of ADSCs plus NAC has an inhibitory effect on the inflammation caused by allergic asthma in a rat model. The improvement of inflammatory indexes was significantly higher than that with prednisolone treatment.PMID:38376812 | DOI:10.1080/02770903.2024.2321296 (Source: Journal of Asthma)
Source: Journal of Asthma - February 20, 2024 Category: Respiratory Medicine Authors: Maryam Radan Farhad Abol Nejadian Vahid Bayati Ali Asghar Hemmati Khojasteh Hoseinynejad Seyyed Ali Mard Source Type: research
In vitro and in vivo metabolic activation and hepatotoxicity of chlorzoxazone mediated by CYP3A
Arch Toxicol. 2024 Feb 18. doi: 10.1007/s00204-023-03674-2. Online ahead of print.ABSTRACTChlorzoxazone (CZX), a benzoxazolone derivative, has been approved for the treatment of musculoskeletal disorders to relieve localized muscle spasm. However, its idiosyncratic toxicity reported in patients brought attention, particularly for hepatotoxicity. The present study for the first time aimed at the relationship between CZX-induced hepatotoxicity and identification of oxirane intermediate resulting from metabolic activation of CZX. Two N-acetylcysteine (NAC) conjugates (namely M1 and M2) and two glutathione (GSH) conjugates (na...
Source: Archives of Toxicology - February 18, 2024 Category: Toxicology Authors: Chen Sun Mingyu Zhang Chunjing Guan Weiwei Li Ying Peng Jiang Zheng Source Type: research
In vitro and in vivo metabolic activation and hepatotoxicity of chlorzoxazone mediated by CYP3A
Arch Toxicol. 2024 Feb 18. doi: 10.1007/s00204-023-03674-2. Online ahead of print.ABSTRACTChlorzoxazone (CZX), a benzoxazolone derivative, has been approved for the treatment of musculoskeletal disorders to relieve localized muscle spasm. However, its idiosyncratic toxicity reported in patients brought attention, particularly for hepatotoxicity. The present study for the first time aimed at the relationship between CZX-induced hepatotoxicity and identification of oxirane intermediate resulting from metabolic activation of CZX. Two N-acetylcysteine (NAC) conjugates (namely M1 and M2) and two glutathione (GSH) conjugates (na...
Source: Archives of Toxicology - February 18, 2024 Category: Toxicology Authors: Chen Sun Mingyu Zhang Chunjing Guan Weiwei Li Ying Peng Jiang Zheng Source Type: research
