In vitro and in vivo metabolic activation and hepatotoxicity of chlorzoxazone mediated by CYP3A
Arch Toxicol. 2024 Feb 18. doi: 10.1007/s00204-023-03674-2. Online ahead of print.ABSTRACTChlorzoxazone (CZX), a benzoxazolone derivative, has been approved for the treatment of musculoskeletal disorders to relieve localized muscle spasm. However, its idiosyncratic toxicity reported in patients brought attention, particularly for hepatotoxicity. The present study for the first time aimed at the relationship between CZX-induced hepatotoxicity and identification of oxirane intermediate resulting from metabolic activation of CZX. Two N-acetylcysteine (NAC) conjugates (namely M1 and M2) and two glutathione (GSH) conjugates (na...
Source: Archives of Toxicology - February 18, 2024 Category: Toxicology Authors: Chen Sun Mingyu Zhang Chunjing Guan Weiwei Li Ying Peng Jiang Zheng Source Type: research
The necroptosis-mediated imbalance of mitochondrial dynamics is involved in DEHP-induced toxicity to immature testes via the PGAM5-DRP1 interaction
Environ Pollut. 2024 Feb 15:123585. doi: 10.1016/j.envpol.2024.123585. Online ahead of print.ABSTRACTDi-(2-ethylhexyl) phthalate (DEHP) is a widely used plasticizer that has been shown to impair male reproduction, but the potential mechanism underlying testicular injury caused by DEHP remains unclear. In vivo, rats were gavaged consecutively from postnatal day (PND) 21 to PND 31 with 0, 250, or 500 mg/kg DEHP for 10 days, and impaired mitochondria and increased necroptosis were observed in immature testes. In vitro, the GC-1 and GC-2 cell lines were exposed to monoethylhexyl phthalate (MEHP) at 100, 200 and 400 μM for 24 ...
Source: Environmental Pollution - February 17, 2024 Category: Environmental Health Authors: Xiazhu Zhou Yifan Hong Jing Chen Yihang Yu Siyuan Wang Yuexin Wei Chunlan Long Lianju Shen Shengde Wu Guanghui Wei Source Type: research
Pharmacological management of gambling disorder: an update of the literature
Expert Rev Neurother. 2024 Feb 15. doi: 10.1080/14737175.2024.2316833. Online ahead of print.ABSTRACTINTRODUCTION: Gambling disorder (GD) is a mental health condition characterized by persistent and problematic betting behavior. GD generates distress and impairment, and treatment options include psychological and pharmacological interventions.AREAS COVERED: This narrative review explores existing pharmacological treatments for GD. The following classes of medications were considered: opioid-receptor antagonists (e.g. naltrexone and nalmefene), serotonin reuptake inhibitors (e.g. fluvoxamine, paroxetine, sertraline, escital...
Source: Expert Review of Neurotherapeutics - February 15, 2024 Category: Neurology Authors: Gemma Mestre-Bach Marc N Potenza Source Type: research
