Cinnarizine as alternative recommendation for migraine prophylaxis: a narrative review.
Authors: Togha M, Martami F, Abdollahi M, Mozafari M, Cheraghali H, Rafiee P, Shafaei M Abstract INTRODUCTION: Despite the available prophylactic and acute drugs for migraine management, this disabling disorder remains undertreated especially among pediatrics. In this review, the authors aim at assessing the preventive role cinnarizine plays in treating migraine based on previously published studies. AREAS COVERED: Randomized clinical trials, randomized controlled trials, non-randomized open-label trials and retrospective studies concerning cinnarizine in migraine prevention in children and adults were reviewed. Es...
Source: Expert Review of Neurotherapeutics - July 1, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Emerging cytoprotective peptide therapies for stroke.
Authors: Meloni BP, Blacker DJ, Mastaglia FL, Knuckey NW PMID: 32580598 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - June 26, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Understanding and managing metabolic dysfunction in Amyotrophic Lateral Sclerosis.
Authors: Blasco H, Lanznaster D, Veyrat-Durebex C, Hergesheimer R, Vourch P, Maillot F, Andres CR, Pradat PF, Corcia P Abstract Introduction Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron disease that leads to death after a median survival of 36 months. The development of an effective treatment has proven to be extremely difficult due to the inadequate understanding of the pathogenesis of ALS. Energy metabolism is thoroughly involved in the disease based on the discoveries of hypermetabolism, lipid/glucose metabolism, the tricarboxylic acid (TCA) cycle, and mitochondrial impairment. Area covered Many pert...
Source: Expert Review of Neurotherapeutics - June 26, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

What do we know about the variability in survival of patients with amyotrophic lateral sclerosis?
Authors: McCombe PA, Garton FC, Katz, Wray NR, Henderson RD Abstract INTRODUCTION: ALS is a fatal neurodegenerative disease. However, patients show variability in the length of survival after symptom onset. Understanding the mechanisms of long survival could lead to possible avenues for therapy. AREAS COVERED: This review surveys the reported length of survival in ALS, the clinical features that predict survival in individual patients, and possible factors, particularly genetic factors, that could cause short or long survival. The authors also speculate on possible mechanisms. EXPERT OPINION: A small number of k...
Source: Expert Review of Neurotherapeutics - June 23, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Metabolomics markers in Neurology: current knowledge and future perspectives for therapeutic targeting.
Authors: Bonomo R, Cavaletti G, Skene DJ Abstract INTRODUCTION: Metabolomics is an emerging approach providing new insights into the metabolic changes and underlying mechanisms involved in the pathogenesis of neurological disorders. AREAS COVERED: Here, the authors present an overview of the current knowledge of metabolic profiling (metabolomics) to provide critical insight on the role of biochemical markers and metabolic alterations in neurological diseases. EXPERT OPINION: Elucidation of characteristic metabolic alterations in neurological disorders is crucial for a better understanding of their pathogenesis, ...
Source: Expert Review of Neurotherapeutics - June 17, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Improving long-term survival in diffuse intrinsic pontine glioma.
Authors: Felker J, Broniscer A Abstract INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) is an almost universally fatal pediatric brain cancer. There has been no improvement in event-free survival (EFS) or overall survival (OS) despite immense effort through a multitude of clinical trials to find a cure. Recently, there has been a surge in the knowledge of DIPG biology, including the discovery of a recurrent H3F3A mutation in over 80% of these tumors. AREAS COVERED: The authors review the most recent approaches to diagnosis and treatment of DIPG including chemotherapy, biologics, surgical approaches, and immun...
Source: Expert Review of Neurotherapeutics - June 17, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

What is the potential of neurostimulation in the treatment of motor symptoms in schizophrenia?
Authors: Lefebvre S, Pavlidou A, Walther S Abstract INTRODUCTION: Motor abnormalities in schizophrenia are frequent and linked to poor social functioning and low quality of life. To date, there are no effective treatments available to alleviate these motor impairments. Previous studies have linked altered connections within the cerebral motor circuits to motor abnormalities. AREAS COVERED: This perspective article will discuss the efficacy of noninvasive brain stimulation (NIBS) techniques as a potential therapeutic tool in improving motor impairments in schizophrenia. EXPERT OPINION: The cortical motor network ...
Source: Expert Review of Neurotherapeutics - June 17, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Withdrawal seizures: possible risk factors.
Authors: Matricardi S, Operto FF, Farello G, Coppola G, Verrotti A Abstract INTRODUCTION: Most of the patients usually achieve seizure freedom under treatment with antiseizure medications (ASMs). Drug withdrawal in seizure-free patients is still one of the most challenging issues in the management of epilepsy. The decision-making process of whether the treatment should be discontinued must be based on the evaluation of possible long-term side effects of chronic treatment and, on the other hand, the risk of seizure relapse. AREAS COVERED: This review aims to describe and discuss possible predictors and risk factors ...
Source: Expert Review of Neurotherapeutics - June 10, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Cannabis and Multiple Sclerosis.
Authors: Fragoso YD, Carra A, Macias MA Abstract INTRODUCTION: Patients with multiple sclerosis (MS) may suffer from spasticity and pain during their disease course. Baclofen, dantrolene, diazepam and gabapentin have been used as first-line options to treat these conditions, with modest results. Medical use of marijuana smoking has bypassed traditional clinical trials and has been legalized as a therapeutic option for MS-related spasticity and pain in some countries. Cannabis-derived drugs have been tested and approved for medical use. AREAS COVERED: With the development of nabiximols by the pharmaceutical industry...
Source: Expert Review of Neurotherapeutics - June 10, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Current Perspectives on Sex Differences in Tension Type Headache.
Authors: Fuensalida-Novo S, Jiménez-Antona C, Benito-González E, Cigarán-Méndez M, Parás-Bravo P, Fernández-de-Las-Peñas C Abstract INTRODUCTION: Clinical and experimental evidence supports the presence of several gender differences in the pain experience. AREAS COVERED: The current paper discusses biological, psychological, emotional, and social differences according to gender and their relevance to TTH. Gender differences have also been observed in men and women with tension-type headache and they should be considered by clinicians managing this condition. It appea...
Source: Expert Review of Neurotherapeutics - June 9, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Cortical excitability in epilepsy and the impact of antiepileptic drugs: Transcranial magnetic stimulation applications.
Authors: Hamed SA Abstract INTRODUCTION: Epileptic conditions are characterized by impaired cortical excitation/inhibition balance and interneuronal disinhibition. Transcranial magnetic stimulation (TMS) is a neurophysiological method which assesses brain excitation/inhibition. AREA COVERED: This review was written after detailed search in PubMed, EMBASE, ISI web of science, SciELO, Scopus and Cochrane Controlled Trials databases from 1990 to 2020. It summarizes TMS applications for diagnostic and therapeutic purposes in epilepsy. TMS studies help to distinguish different epilepsy conditions and explore the antiepi...
Source: Expert Review of Neurotherapeutics - June 9, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Incisionless MR-guided focused ultrasound: Technical considerations and current therapeutic approaches in psychiatric disorders.
Authors: Kinfe TM, Stadlbauer A, Winder K, Hurlemann R, Buchfelder M Abstract INTRODUCTION: MR-guided focused ultrasound operating at higher intensities have been reported to effectively and precisely ablate deeper brain structures like the basal ganglia or the thalamic nuclei for the treatment of refractory movement disorders, neuropathic pain and most recently neuropsychiatric disorders, while low-intensity focused ultrasound represents an approach promoting mechanical blood-brain-barrier opening and neuromodulation. This narrative review summarizes the technical development and the therapeutic potential of incision...
Source: Expert Review of Neurotherapeutics - June 9, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Post-traumatic hydrocephalus: the Cinderella of Neurotrauma.
Authors: De Bonis P, Anile C PMID: 32500770 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - June 6, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Perivascular tissue resident memory T cells as therapeutic target in multiple sclerosis.
Authors: Smolders J, Fransen NL, Hsiao CC, Hamann J, Huitinga I Abstract INTRODUCTION: Multiple sclerosis (MS) is characterized by inflammatory attacks of infiltrating leukocytes at onset but evolves into a smoldering, progressive disease within the central nervous system at its later stages. The authors discuss the contribution of white matter lesions to the pathology of advanced MS, thereby paying particular attention to the role of T cells. AREAS COVERED: Diagnostic biopsy and autopsy studies of white matter lesions in early MS show different pathological patterns of demyelination and leukocyte infiltration. Bra...
Source: Expert Review of Neurotherapeutics - June 2, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

The evidence for multidisciplinary care in Parkinson's disease.
Authors: Lidstone SC, Bayley M, Lang AE Abstract INTRODUCTION: Parkinson's Disease (PD) is a chronic and slowly progressive neurodegenerative disease. Team-based care is required to address and manage the diverse array of motor and non-motor symptoms in PD and related conditions. As the evidence base for the efficacy of non-pharmacological treatment of PD is expanding, many different centers are implementing interdisciplinary models of care with allied health professionals trained in PD. AREAS COVERED: In this review, the authors outline these various models and review the evidence for multidisciplinary approaches ...
Source: Expert Review of Neurotherapeutics - June 2, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Medication overuse headache: an overview of clinical aspects, mechanisms, and treatments.
Authors: Krymchantowski AV, Jevoux CC, Krymchantowski AG, Vivas RS, Silva-Néto R Abstract INTRODUCTION: Medication-overuse headache (MOH) is a common debilitating neurological disorder, with a prevalence of 1% to 7% in general population. It affects more than 60 million people worldwide and provokes substantial burden. Despite that, most practitioners don't know MOH. This review aims at presenting MOH clinical features, pathophysiology insights, and recent knowledge and guidance regarding treatments. AREAS COVERED: A literature search in the major medical databases including the terms 'medication overuse hea...
Source: Expert Review of Neurotherapeutics - May 29, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

The dichotomous role of the gut microbiome in exacerbating and ameliorating neurodegenerative disorders.
Authors: Raval U, Harary J, Zeng E, Pasinetti GM Abstract INTRODUCTION: Age related neurodegenerative disorders affect millions of people around the world. The role of the gut microbiome (GM) in neurodegenerative disorders has been elucidated over the past few years. Dysbiosis of the gut microbiome ultimately results in neurodegeneration. However, the gut microbiome can be modulated to promote neuro-resilience. AREAS COVERED: This review is focused on demonstrating the role of the gut microbiome in host physiology in Parkinson's disease (PD) and other neurodegenerative disorders. We will discuss how the microbiome ...
Source: Expert Review of Neurotherapeutics - May 29, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Targeting CGRP for migraine treatment: mechanisms, antibodies, small molecules, perspectives.
Authors: De Matteis E, Guglielmetti M, Ornello R, Spuntarelli V, Martelletti P, Sacco S Abstract INTRODUCTION: Calcitonin Gene-Related Peptide (CGRP) has gradually emerged as a suitable therapeutic target to treat migraine. Considering the social and economic burden of migraine, it is fundamental to optimize the disease management with efficacious and safe treatments. In this scenario, drugs targeting GCRP, monoclonal antibodies (MoAbs) and gepants, represent new therapeutic strategies. AREAS COVERED: In the present work, the authors aim at appraising the main insights and implications of those treatments targeting...
Source: Expert Review of Neurotherapeutics - May 22, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Gene therapy for Parkinson's disease: contemporary practice and emerging concepts.
Authors: Merola A, Van Laar A, Lonser R, Bankiewicz K Abstract Introduction: Gene therapy is a rapidly evolving technology that has predominantly utilized viral vectors to effectively deliver genetic material inside neurons to modulate the expression of one or more particular genes. Several gene therapy clinical trials have been conducted in Parkinson's disease (PD) by exploring strategies to either restore dopamine synthesis, enhance the production of trophic factors, enhance lysosomal function, or modify the interaction between different functional nodes of the basal ganglia.Areas covered: In this review, the author...
Source: Expert Review of Neurotherapeutics - May 21, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Dyspnea in Parkinson's disease: an approach to diagnosis and management.
Authors: Vijayan S, Singh B, Ghosh S, Stell R, Mastaglia FL Abstract Introduction: Dyspnea is a complex and debilitating non-motor symptom experienced by a significant proportion of PD patients which results in limitations to physical ability and a reduction in quality of life.Areas covered: The authors highlight the underlying pathophysiological mechanisms that can contribute to dyspnea in PD patients, and provide the clinician with a practical working algorithm for the management of such patients. The authors further highlight important clinical red flags that should be heeded in dyspneic PD patients and discuss the...
Source: Expert Review of Neurotherapeutics - May 19, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Establishing apomorphine treatment in Thailand: Understanding the challenges and opportunities of Parkinson's disease management in developing countries.
Authors: Bhidayasiri R, Phokaewvarangkul O, Sakdisornchai K, Boonpang K, Chaudhuri KR, Parsons J, Lolekha P, Chairangsaris P, Srivanichpoom P, Benedierks S, Panyakaew P, Boonmongkol T, Thongchuam Y, Kantachadvanich N, Phumphid S, Evans AH, Viriyavejakul A, Pisarnpong A, van Laar T, Jagota P Abstract Introduction: The increasing global burden of Parkinson's disease (PD) poses a particular challenge for developing countries, such as Thailand, when delivering care to a geographically diverse populace with limited resources, often compounded by a lack of expertise in the use of certain PD medications, such as device-aided...
Source: Expert Review of Neurotherapeutics - May 19, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Developments in treating the nonmotor symptoms of stroke.
Authors: Hillis AE Abstract Introduction: Stroke is among the most common causes of disability worldwide. Nonmotor symptoms of stroke are common and disabling. Many are treatable, and intervention improves the quality of life for stroke survivors.Areas covered: Here the author summarizes evidence-based treatment of depression and other mood disorders, aphasia, hemispatial neglect, impairments of emotional communication and empathy, deficits in memory and other cognitive functions, sleep disorders, pain, fatigue, (1)and seizures resulting from stroke. The author focuses on treatments supported by randomized controlled ...
Source: Expert Review of Neurotherapeutics - May 5, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Moving beyond Anti-Aquaporin-4 Antibodies: Emerging Biomarkers in the Spectrum of Neuromyelitis Optica.
Authors: Rocca MA, Cacciaguerra L, Filippi M Abstract Introduction. With the advent of targeted drugs, a correct identification of patients with neuromyelitis optica spectrum disorders (NMOSD) is fundamental. Moreover, to assess treatment efficacy, sensitive biomarkers for monitoring disease activity are needed.Areas covered. In this review, the authors provide an up-to-date guide to NMOSD biomarkers, starting from the pathogenetic mechanisms and moving to clinical findings, focusing on their diagnostic meaning, their possible application for disease monitoring and their correlation with clinical features.Expert opini...
Source: Expert Review of Neurotherapeutics - May 3, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Current state-of-art of the application of serum neurofilaments in multiple sclerosis diagnosis and monitoring.
Authors: Preziosa P, Rocca MA, Filippi M Abstract Introduction: Neurodegenerative processes occur from the beginning of multiple sclerosis, contribute to irreversible clinical disability and are only partially addressed by current disease-modifying therapies. Reliable quantification of neuro-axonal damage may contribute to improve the assessment of disease activity and progression, the definition of patients' prognosis and treatment monitoring. Neurofilaments are neuron-specific cytoskeletal components that are released after neuro-axonal damage. Among them, neurofilament light chains represent a promising biomarker o...
Source: Expert Review of Neurotherapeutics - April 26, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Treatment of infantile spasms: why do we know so little?
Authors: Specchio N, Pietrafusa N, Ferretti A, de Palma L, Santarone M, Pepi C, Trivisano M, Vigevano F, Curatolo P Abstract Introduction: Infantile spasms (IS) is an epileptic syndrome with typical onset within the first 2 years of life. This condition might be caused by several etiologies. IS is associated with pathological neuronal networks; however, definite hypotheses on neurobiological processes are awaited.Areas covered: Changes in NMDA and GABAB receptors and increase of Ca2+ conductance are some of the possible pathophysiological mechanisms. Animals models can help, but most have only some features of IS. Out...
Source: Expert Review of Neurotherapeutics - April 23, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

MRI biomarkers of disease progression and conversion to secondary-progressive multiple sclerosis.
Authors: Tavazzi E, Zivadinov R, Dwyer MG, Jakimovski D, Singhal T, Weinstock-Guttman B, Bergsland N Abstract Introduction: Conventional imaging measures remain a key clinical tool for the diagnosis multiple sclerosis (MS) and monitoring of patients. However, most measures used in the clinic show unsatisfactory performance in predicting disease progression and conversion to secondary progressive MS.Areas covered: Sophisticated imaging techniques have facilitated the identification of imaging biomarkers associated with disease progression, such as global and regional brain volume measures, and with conversion to second...
Source: Expert Review of Neurotherapeutics - April 21, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Targeting IL-6 receptor in the treatment of neuromyelitis optica spectrum: a review of emerging treatment options.
Authors: Rosso M, Saxena S, Chitnis T Abstract Introduction: Recent research has shown that IL-6 receptor (IL-6R) inhibitors like tocilizumab and satralizumab are effective in reducing the relapse rate in patients with NMOSD.Areas covered: This review article explores current concepts in NMOSD management and focuses on IL-6R as a therapeutic target. The authors delve into the biological and immunological role of IL-6 in the pathogenesis of NMOSD. Further, the authors summarize the most recent findings on the use of anti-IL-6R monoclonal antibodies, tocilizumab and satralizumab, in the treatment of NMOSD.Expert opinion...
Source: Expert Review of Neurotherapeutics - April 21, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

How close is ketamine to routine use in refractory status epilepticus?
Authors: Yan Y, Peng X, Jing W, Wang X PMID: 32306782 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - April 21, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

The therapeutic potential of galectin-1 and galectin-3 in the treatment of neurodegenerative diseases.
Authors: Ramírez Hernández E, Sánchez-Maldonado C, Mayoral Chávez MA, Hernández-Zimbrón LF, Patricio Martínez A, Zenteno E, Limón Pérez de León ID Abstract Introduction: Neuroinflammation has been proposed as a common factor and one of the main inducers of neuronal degeneration. Galectins are a group of β-galactoside-binding lectins, that play an important role in the immune response, adhesion, proliferation, differentiation, migration and cell growth. Up to 15 members of the galectin's family have been identified; however, the expression of ga...
Source: Expert Review of Neurotherapeutics - April 19, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Identifying and responding to fatigue and apathy in Parkinson's disease: a review of current practice.
Authors: Lazcano Ocampo C, Wan YM, van Wamelen DJ, Batzu L, Boura I, Titova N, Leta V, Qamar M, Martinez-Martin P, Ray Chaudhuri K Abstract Introduction: Fatigue and apathy are two key non-motor symptoms in Parkinson's disease (PD), with documented negative impact on Quality of life (QoL) and a frequent burden for caregivers.Areas covered: In this invited review, researchers from the Parkinson Foundation Centre of Excellence in non-motor research at King's College Hospital and King's College London comment on the latest pathophysiology, clinical phenomenology, the most frequently used scales for fatigue and apathy in ...
Source: Expert Review of Neurotherapeutics - April 17, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Memory Deficits in Patients with Major Depression: Yes, they are trying hard enough!
Conclusions: These findings support studies indicating no motivational deficits in patients with depression during standardized neuropsychological testing. Reduced motivation is not a plausible explanation for depressive patients' cognitive deficits assessed with neuropsychological tests. PMID: 32293197 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - April 17, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

The correlation between feeding intolerance and poor prognosis of patients with severe neurological conditions: a case-control study.
This study aims to investigate the current status of feeding intolerance (FI) among patients with severe neurological conditions and to further determine the correlation between FI and their poor prognosis. METHODS: This study performed a retrospective analysis of the medical data of 58 patients from January 2017 and December 2017. Patients were divided into two groups according to modified Rankin Scale (mRS) scores. Logistic regression was used to analyze the relevant factors for the poor prognosis of these patients. RESULTS: General data analysis showed that age and diagnosis(stroke) were significantly different be...
Source: Expert Review of Neurotherapeutics - April 11, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Prevention of sudden unexpected death in epilepsy: current status and future perspectives.
This article reviews epidemiology, pathophysiology, risk factors, assessment of individual SUDEP risk and available measures for SUDEP prevention. Literature search was done using Medline and Pubmed in October 2019.Expert opinion:Significant advances in the understanding of SUDEP were made in the last decade which allow testing of novel strategies to prevent SUDEP. Promising current strategies target neuronal mechanisms of brain stem dysfunction, cardiac susceptibility for fatal arrhythmias, and reliable detection of tonic-clonic seizures using mobile health technologies. PMID: 32270723 [PubMed - as supplied by publishe...
Source: Expert Review of Neurotherapeutics - April 11, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

How would defining Parkinson's as a prion disease impact the search of a cure?
Authors: Scialò C, Legname G PMID: 32253950 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - April 8, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

A reappraisal of the value of video-EEG recording in the emergency department.
Authors: Raucci U, Pro S, Di Capua M, Di Nardo G, Villa MP, Striano P, Parisi P Abstract Introduction: Some neurologic conditions that can quickly and with low costs be recognized, classified and treated thanks to the availability of an EEG recording in an emergency setting. However, although considered a cheap, not invasive, highly accurate diagnostic investigation, still today, an EEG recording in emergency, in real time during the event paroxysmal ictal phase, is not yet been become a routine.Areas covered: This review will cover the role and utility of EEG recording in the emergency setting, both in emergency depa...
Source: Expert Review of Neurotherapeutics - April 8, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Feeding intolerance associated poor prognosis of patients with severe neurological conditions.
Authors: Peng C, Lei J PMID: 32240598 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - April 3, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Deep brain stimulation for treatment-resistant depression: a safe and effective option.
Authors: La Torre D, Della Torre A, Chirchiglia D, Volpentesta G, Guzzi G, Lavano A Abstract Introduction: Major depression (MDD) is the leading cause of years lost to disability worldwide. Pharmacotherapy and psychotherapy are effective treatments in most depressive episodes: but, about the 30% of MDD patients remain symptomatic, and relapse is a common event. Recently, deep brain stimulation (DBS) has emerged as a valid therapeutic option in treatment-resistant depression (TRD) patients.Areas covered: In this paper, the authors summarize the findings of studies focused on these pathophysiologic phenomena and specifi...
Source: Expert Review of Neurotherapeutics - April 1, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Smoking and disability progression in multiple sclerosis.
Authors: Hedström AK PMID: 32208034 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - March 26, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Neuropsychological performance across symptom dimensions of obsessive-compulsive disorder: a comment on the state and critical review of the literature.
Authors: Cameron DH, Rowa K, McKinnon MC, Rector NA, McCabe RE Abstract AbstractIntroduction: Obsessive-compulsive disorder (OCD) is a heterogeneous disorder, with multiple symptom presentations. Delineating the neuropsychological characteristics associated with previously identified symptom clusters may therefore be useful in assisting to better define symptom subtypes of OCD.Areas Covered: This review summarizes the existing literature on the assessment of neuropsychological performance in symptom-based dimensions of OCD. Results of 23 studies are described and the methodological issues and challenges present in thi...
Source: Expert Review of Neurotherapeutics - March 24, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

A systematic review of morbidities suggestive of the multiple sclerosis prodrome.
Authors: Yusuf FLA, Ng BC, Wijnands JMA, Kingwell E, Marrie RA, Tremlett H Abstract Introduction: The identification of a prodromal phase in multiple sclerosis (MS) could have major implications for earlier recognition and management of MS. The authors conducted a systematic review assessing studies of morbidities before, or at, MS onset or diagnosis.Areas covered: Two independent reviewers searched Medline, Embase, Psycinfo and CINAHL from inception to February 8th, 2019. To be eligible, studies had to be published in English and report the relative occurrence of at least one morbidity or symptom before, or at, MS on...
Source: Expert Review of Neurotherapeutics - March 24, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Compassion Focused Therapy: a systematic review of its effectiveness and acceptability in clinical populations.
Authors: Craig C, Hiskey S, Spector A Abstract IntroductionCompassion focused therapy (CFT) is an increasingly popular therapeutic modality. Its holistic and integrative approach to universal human suffering means that it is well-placed as a transdiagnostic therapy. Research into its effectiveness and acceptability has increased over the previous 10 years as the therapy has evolved, and to help consider its status as an evidence-based therapy research concerning its treatment outcomes needs evaluating.Areas coveredThis paper reviews research investigating the effectiveness of CFT in clinical populations.Expert opinion...
Source: Expert Review of Neurotherapeutics - March 21, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

What is the potential of statins in the treatment of depression?
Authors: De Uribe Viloria N, Berk M PMID: 32191534 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - March 20, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Broad spectrum micronutrient formulas for the treatment of symptoms of depression, stress and/or anxiety: a systematic review.
Authors: Blampied M, Bell C, Gilbert C, Rucklidge JJ Abstract INTRODUCTION: Vitamin and mineral nutritional supplements are becoming increasingly popular as alternative treatments for anxiety and depression, as issues such as side effects from medication, failure to respond to psychotherapy and workforce limitations pose barriers for successful treatment.Areas covered: This review covered double-blind, randomized controlled trials (DBRCTs) testing formulas including at least four vitamins and/or minerals used for the treatment of symptoms of anxiety, stress or depression in adults not currently taking medication for p...
Source: Expert Review of Neurotherapeutics - March 18, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Managing bipolar disorder during pregnancy and the postpartum period: a critical review of current practice.
Authors: Sharma V, Sharma P, Sharma S Abstract IntroductionDespite increased interest in the pharmacotherapy of bipolar disorder during pregnancy and the postpartum period, management of the disorder during these critical periods in a woman's life remains challenging.Areas coveredThe authors review the effect of pregnancy and the postpartum period on the course of bipolar disorder, describe adverse pregnancy and birth outcomes, and discuss the pharmacotherapy of bipolar disorder during and after pregnancy.Expert opinionWhen treating women with bipolar disorder of childbearing age, clinicians should consider the possib...
Source: Expert Review of Neurotherapeutics - March 17, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Correction.
Authors: PMID: 32164468 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - March 14, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Emerging treatments for progressive myoclonus epilepsies.
Authors: Riva A, Guglielmo A, Balagura G, Marchese F, Amadori E, Iacomino M, Minassian BA, Zara F, Striano P Abstract Introduction: Progressive myoclonus epilepsies (PMEs) are a group of neurodegenerative diseases, invariably leading to severe disability or fatal outcome in a few years or decades. Nowadays, PMEs treatment remains challenging with a significant burden of disability for patients. Pharmacotherapy is primarily used to treat seizures, which impact patients' quality of life. However, new approaches have emerged in the last few years, which try to curb the neurological deterioration of PMEs through a better ...
Source: Expert Review of Neurotherapeutics - March 11, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

An Interview with Shawn Singh: Chief Executive Officer and Director of VistaGen Therapeutics.
Authors: Singh S PMID: 32141345 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - March 7, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

What role should spinal cord MRI take in the future of multiple sclerosis surveillance?
Authors: Rocca MA, Preziosa P, Filippi M Abstract Introduction. In multiple sclerosis (MS), inflammatory, demyelinating and neurodegenerative phenomena affect the spinal cord, with detrimental effects on patients' clinical disability. Although spinal cord imaging may be challenging, improvements in MRI technologies have contributed to better evaluate spinal cord involvement in MS.Areas covered. This review summarizes the current state-of-art of the application of conventional and advanced MRI techniques to evaluate spinal cord damage in MS. Typical features of spinal cord lesions, their role in the diagnostic work-up ...
Source: Expert Review of Neurotherapeutics - March 6, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Non-invasive brain stimulation combined with exercise in chronic pain: a systematic review and meta-analysis.
Conclusions: This meta-analysis suggests a significant moderate to large effects of the NIBS and exercise combination in chronic pain. The authors discuss the potential theoretical framework for this synergistic effect. PMID: 32130037 [PubMed - as supplied by publisher] (Source: Expert Review of Neurotherapeutics)
Source: Expert Review of Neurotherapeutics - March 5, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Deep Brain Stimulation in Essential Tremor: Targets, Technology, and a Comprehensive Review of Clinical Outcomes.
Authors: Wong JK, Hess CW, Almeida L, Middlebrooks EH, Christou EA, Patrick EE, Shukla AW, Foote KD, Okun MS Abstract Introduction: Essential tremor (ET) is a common movement disorder with an estimated prevalence of 0.9% worldwide. Deep brain stimulation (DBS) is an established therapy for medication refractory and debilitating tremor. With the arrival of next generation technology, the implementation and delivery of DBS has been rapidly evolving. This review will highlight the current applications and constraints for DBS in ET.Areas covered: The mechanism of action, targets for neuromodulation, next generation guidan...
Source: Expert Review of Neurotherapeutics - March 3, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research