Oxidized DJ-1 activates the p-IKK/NF- κB/Beclin1 pathway by binding PTEN to induce autophagy and exacerbate myocardial ischemia-reperfusion injury

In conclusion, ox-DJ-1 could activate detrimental autophagy through the PTEN/p-IKK/NF-κB/Beclin1 pathway and exacerbate myocardial I/R injury.PMID:38508437 | DOI:10.1016/j.ejphar.2024.176496

Source: European Journal of Pharmacology - March 20, 2024 Category: Drugs & Pharmacology Authors: Huiru Liu Xueying Wang Kang He Zihan Chen Xiaoqi Li Jianmin Ren Xiaoyan Zhao Song Liu Tingting Zhou Heping Chen Source Type: research