Antioxidants accelerate tendon-to-bone healing after rotator cuff repair surgery

This study aimed to investigate the effects of reduction of oxidative stress induced by antioxidants such as N-acetylcysteine (NAC) and vitamin C (VC) on rotator cuff repair in a rotator cuff repair model in rats. Infraspinatus tendon was ruptured in 48 rats and repaired 1 week later. Rats were divided into 3 groups: NAC group, VC group, or control group, and were administered NAC, VC, or distilled water respectively. The specimens were collected at 3, 6, and 12 weeks after repair. Histological evaluation was performed using hematoxylin/eosin and toluidine blue staining, and oxidative stress was evaluated using dihydroethidium (DHE) and protein carbonyls.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research