Up to 5 Million Children Have Lost Parents During the Pandemic. Here ’s How They’ve Coped

Adin James is only 8 years old, but he has some very strict rules about how the world should work in the age of the pandemic. For starters, there’s the business of avoiding unmasked people. “They don’t have their masks on,” he’ll say when he sees an uncovered face on the street or in a store. “That’s not right. They’re making other people sick.” Then there’s the matter of doctors—who might have been trusted once but not anymore. “They lied to me. They told me my dad was gonna be better,” he tells his mother, Ebony James, 50, a principal at a middle school in Fresno, a suburb of Houston. [time-brightcove not-tgx=”true”] And then there’s the rule about spraying the room before bed. Ever since Adin’s father Terrence died on Feb. 19, Adin, the youngest of three children, has been sleeping in Ebony’s room. But that was where his father slept—which means that was the room where COVID-19 once lived. “Is it safe?” Adin will ask. “Is it safe?” And Ebony will promise him that it is, but he won’t believe it until she sprays the room with Lysol. And even then he’s not convinced that his world is not a place of mortal menace. “It’s almost like he closes the book,” says Ebony. “His face closes. His body language closes. The only thing I can do is just keep getting him counseling because I don’t know what else to...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

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T cell polyfunctionality is a hallmark of protective immunity against pathogens and cancer, yet the molecular mechanism governing it remains mostly elusive. We found that canonical Wnt agonists inhibited human memory CD8+ T cell differentiation while simultaneously promoting the generation of highly polyfunctional cells. Downstream effects of Wnt activation persisted after removal of the drug, and T cells remained polyfunctional following subsequent cell division, indicating the effect is epigenetically regulated. Wnt activation induced a gene expression pattern that is enriched with stem cell–specific gene signature...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
In this study, we report that osteoclast precursors (OPs) can function as a premetastatic niche component that facilitates breast cancer (BCa) bone metastasis at early stages. At the molecular level, unbiased GPCR ligand/agonist screening in BCa cells suggested that R-spondin 2 (RSPO2) and RANKL, through interaction with their receptor LGR4, promoted osteoclastic premetastatic niche formation and enhanced BCa bone metastasis. This was achieved by RSPO2/RANKL-LGR4 signal modulating the WNT inhibitor DKK1 through Gαq and β-catenin signaling. DKK1 directly facilitated OP recruitment through suppression of its recep...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
As cancers progress, they produce a local environment that acts to redirect, paralyze, exhaust, or otherwise evade immune detection and destruction. The tumor microenvironment (TME) has long been characterized as a metabolic desert, depleted of essential nutrients such as glucose, oxygen, and amino acids, that starves infiltrating immune cells and renders them dysfunctional. While not incorrect, this perspective is only half the picture. The TME is not a metabolic vacuum, only consuming essential nutrients and never producing by-products. Rather, the by-products of depleted nutrients, “toxic” metabolites in the...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Memory B cells (MBCs) can provide a recall response able to supplement waning antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses. We studied a cohort of elderly care home residents and younger staff (median age of 87 years and 56 years, respectively), who had survived COVID-19 outbreaks with only mild or asymptomatic infection. The cohort was selected because of its high proportion of individuals who had lost neutralizing antibodies (nAbs), thus allowing us to specifically investigate the reserve immunity from SARS-CoV-2–specific MBCs in this setting. Class-switched spike and...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
BACKGROUND The temporal clustering of a cancer diagnosis with dermatomyositis (DM) onset is strikingly associated with autoantibodies against transcriptional intermediary factor 1-γ (TIF1-γ). Nevertheless, many patients with anti–TIF1-γ antibodies never develop cancer. We investigated whether additional autoantibodies are found in anti–TIF1-γ–positive patients without cancer.METHODS Using a proteomic approach, we defined 10 previously undescribed autoantibody specificities in 5 index anti–TIF1-γ–positive DM patients without cancer. These were subsequently examined...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Dermatomyositis is an idiopathic inflammatory myopathy with a highly heterogeneous disease course. Although there is a known increase in cancer risk surrounding the time of dermatomyositis diagnosis, the mechanisms driving this increased risk are not well understood. Further, there are no current standardized cancer screening guidelines for dermatomyositis patients. In this issue of the JCI, Fiorentino, Mecoli, et al. discovered additional autoantibodies in patients with dermatomyositis and anti–TIF1-γ autoantibodies, a known risk factor for malignancy. They observed a decreased cancer risk with an increasing n...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Dalton Trans., 2022, Accepted Manuscript DOI: 10.1039/D1DT03700E, PaperXiaoyong Wang, Hongmei Zhang, Yanqing Wang, Ying Wang, Qianqian Han, Honghao Yan, Tao Yang, Zijian Guo Ku70 protein and topoisomerase II α (Topo IIα) are promising targets of anticancer drugs, which play critical roles in DNA repair and replication processes. Three platinum(II) complexes, [PtCl(NH3)2(9-(pyridin-2-ylmethyl)-9H-carbazole)]NO3 (OPPC), [PtCl(NH3)2(9-(pyridin-3-ylmethyl)-9H-carbazole)]NO3 (MPPC),... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2022, Advance Article DOI: 10.1039/D1CC06520C, CommunicationShi-Hao Zhou, Ru-Yan Zhang, Hai-Wei Zhang, Yan-Ling Liu, Yu Wen, Jian Wang, Yu-Ting Li, Zi-Wei You, Xu-Guang Yin, Hong Qiu, Rui Gong, Guang-Fu Yang, Jun Guo An RBD-based subunit vaccine with a built-in TLR1/2 agonist induced potent immune responses against SARS-CoV-2 and variants of concern. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2022, Advance Article DOI: 10.1039/D1AN01949J, PaperJieru Xu, Jiahui Xiang, Jialing Chen, Tao Wan, Hongli Deng, Dairong Li The multivalent structure-switching AS1411 aptamer probe based on the displacement strand duplex strategy (designated as “Multi-AS1411 ADSD”) was developed for the first time, and is a novel detection strategy for cancer cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Contributors : Amel Taibi ; Diana Wu ; Zhen Lin ; Lilian Thompson ; Elena ComelliSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculusBreast cancer is one of the most leading causes of cancer mortality in the world. A growing body of evidence demonstrates the association between flaxseed (FS) consumption and the reduction of breast cancer risk. Flaxseed (FS) is an oilseed rich in n-3 polyunsaturated fatty acids (PUFA), α-linolenic acid (ALA), in dietary phytoestrogen lignan, secoisolariciresinol diglucoside (SDG), and in fiber. Early-life exposure to FS or to its isolated components was associated wi...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Mus musculus Source Type: research
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