Gross Motor Skills Training Leads to Increased Brain-Derived Neurotrophic Factor Levels in Healthy Older Adults: A Pilot Study

Conclusion This study supports the notion that exercise programs with a focus on gross motor skills development could result in elevated BDNF concentrations in healthy older adults. Furthermore, improvements in cognitive performances could be observed without significant concomitant increases in BDNF levels. Ethics Statement This study was approved and carried out in accordance with the recommendations of the ethics guidelines of the Comité d’éthique de la recherche vieillissement-neuroimagerie du CIUSSS du Centre-Sud-de-l’île-de-Montréal with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. Author Contributions NB, LBo, and LBh conceived and designed the experiments. NB, FSt-O, and TV performed the tests. C-AG, NB, FSt-O, and NA analyzed the data. C-AG, NB, and LBh wrote the manuscript. All authors revised and contributed to the manuscript for important intellectual content. Funding This study was supported by a grant from the Canadian Institutes of Health Research. NA holds a New Investigator Salary Award from the Canadian Institutes of Health Research. NB was supported by a doctoral scholarship offered by the Quebec Network for Research on Aging. LBh was supported by the Canadian Research Chair program. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationshi...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

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Abbott Laboratories is bringing two of its pediatric devices in the cardiology space to Europe. The Abbott Park, IL-based company has received CE mark for both the Masters HP 15mm rotatable mechanical heart valve and the Amplatzer Piccolo Occluder. The Masters valve is the world's smallest mechanical heart valve and allows doctors to treat babies and toddlers in need of a mitral or aortic heart valve replacement. Until Abbott's device, surgeons could only use a range of larger-sized valves to replace a pediatric heart valve that could not be repaired, which could result in improper fit and complications. The Masters pediat...
Source: MDDI - Category: Medical Devices Authors: Tags: Cardiovascular Source Type: news
CONCLUSION: There is considerable variation in PLLA reconstitution and use. Further well-designed studies are needed to establish the safest, most effective ways to use this product. J Drugs Dermatol. 2019;18(9):880-886. PMID: 31524343 [PubMed - in process]
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Publication date: Available online 17 September 2019Source: Microbial PathogenesisAuthor(s): Azar Najafi, Mohammad Reza Chaechi Nosrati, Ezatollah Ghasemi, Zahra Navi, Ali Yousefi, Hamidreza Majidiani, Hori Ghaneialvar, Kourosh Sayehmiri, Ma De la Luz Galvan-Ramirez, Mahdi FakharAbstractWe performed a systematic review and meta-analysis to reveal the association between Trichomonas vaginalis (TV) infection and the risk of prostate cancer (PCa) development. Systematic searching (PubMed/Medline, Scopus, Embase, Web of Science, Cinhal, Wiley, Cochrane, Psychoinfo, ProQuest and Google Scholar) was done, up to March 2018 for ca...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Conclusions: End-of-life decision-making is significantly different for ICU patients with limited English proficiency. Participants identified several barriers and facilitators to high-quality end-of-life decision-making for ICU patients and families with limited English proficiency. Awareness of these factors can facilitate interventions to improve high-quality, compassionate, and culturally sensitive decision-making for patients and families with limited English proficiency.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
Objectives: Electroencephalogram features predict neurologic recovery following cardiac arrest. Recent work has shown that prognostic implications of some key electroencephalogram features change over time. We explore whether time dependence exists for an expanded selection of quantitative electroencephalogram features and whether accounting for this time dependence enables better prognostic predictions. Design: Retrospective. Setting: ICUs at four academic medical centers in the United States. Patients: Comatose patients with acute hypoxic-ischemic encephalopathy. Interventions: None. Measurements and Main ...
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Neurologic Critical Care Source Type: research
Conclusions: Although patients requiring rapid response team activation have high inpatient mortality, most rapid response team activations involve relatively few interventions, which may limit these teams’ ability to improve patient outcomes.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Feature Articles Source Type: research
Objectives: We aimed to describe changes over time in admissions and outcomes, including length of stay, discharge destinations, and mortality of cirrhotic patients admitted to the ICU for variceal bleeding, and to compare it to the outcomes of those with other causes of ICU admissions. Design: Retrospective analysis of data captured prospectively in the Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation Adult Patient Database. Settings: One hundred eighty-three ICUs in Australia and New Zealand. Patients: Consecutive admissions to these ICUs for upper gastrointestinal b...
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
Rosenbaum J Abstract PURPOSE OF THE STUDY Lumbar spinal stenosis (LSS) is a serious and fairly frequent disorder with prevalence increasing with age which often results in a disability. The surgical procedures are often very risky due to the greater age of patients with severe stenosis and their comorbidities. The study aimed to assess the functional outcomes and complications in patients who underwent surgical treatment for LSS at one year postoperatively and to identify the differences in the functional outcomes, if any, in dependence on the number of operated segments. MATERIAL AND METHODS It was a prospective ...
Source: Acta Orthopaedica - Category: Orthopaedics Authors: Tags: Acta Chir Orthop Traumatol Cech Source Type: research
The National Institute of Mental Health (NIMH) convened a two-day meeting with researchers and suicide prevention advocates to identify and prioritize research needs in the application of predictive modeling in suicide prevention among healthcare providers. Meeting participants aimed to discuss best practices for developing, implementing, and evaluating these predictive tools in clinical and research settings.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
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