The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke

Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as a manifestation of metabolic syndrome in the liver (5). Furthermore, NAFLD is known to be clearly associated with cardiovascular morbidity and mortality (6, 7), and liver fibrosis is especially considered the key determinant (7–11). Ischemic stroke is also suggested to be associated with NAFLD, especially liver fibrosis (7, 10, 12). In the previous study, we found that there was 41.5% of patients with NAFLD in ischemic stroke patients (10), similar with previous reports (23.0–42.7%) from other countries (12–14). However, there is a paucity of studies attempting to find the association between NAFLD and the stroke severity or functional outcome after ischemic stroke (12, 14, 15). Some previous studies, which defined NAFLD as the presence of elevated aminotransferase levels without apparent causes (12, 14, 15), failed to show a statistically...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Publication date: Available online 22 October 2019Source: Sensors and Actuators A: PhysicalAuthor(s): Dong Sun, Yu-juan Tang, Jiong Wang, Xin-jie WangAbstractIn this contribution, an H-shaped piezoelectric motor based safety and arming device that is driven by the hybrid of symmetrical first longitudinal mode and second bending mode is proposed, designed and experimental investigated. The proposed system operates based on the concept of self-moving and show potential infield of fuse system with different calibers. The actuating mechanism is that the four driving feet contact with the guides alternately and push the motor t...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
Publication date: Available online 23 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): V. Arroyo-Jousse, A. Jaramillo, E. Castaño-Moreno, M. Lépez, K. Carrasco-Negüe, P. CasanelloAbstractMaternal pregestational obesity is a well-known risk factor for offspring obesity, metabolic syndrome, cardiovascular disease and type 2 diabetes. The mechanisms by which maternal obesity can induce alterations in fetal and later neonatal metabolism are not fully elucidated due to its complexity and multifactorial causes. Two adipokines, leptin and adiponectin, are involved i...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Org. Biomol. Chem., 2019, Advance Article DOI: 10.1039/C9OB01858A, CommunicationJulie E. Laudenschlager, Logan A. Combee, Michael K. Hilinski Sc(OTf)3-promoted [5 + 1] cycloaddition of vinylcyclopropanes with PhINTs is reported, enabling the regioselective preparation of a range of 1,2,3,6-tetrahydropyridine scaffolds under mild conditions. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Publication date: Available online 22 October 2019Source: Saudi Journal of Biological SciencesAuthor(s): Mohammad I. Al-Obaida, Alaa K.M. Al-Nakhli, Ibrahim A. Arif, Asmaa Faden, Sahar Al-Otaibi, Bushra Al-Eid, Aishah Ekhzaimy, Haseeb A. KhanAbstractPeriodontal disease is a chronic infectious disease, which is characterized by the damaged dental hard tissue by lactic acid generated by microorganisms after the fermentation of carbohydrates rich diet. The risk of periodontal disease is known to be higher in diabetic patients. We compared the diversity of five commonly occurring dental bacteria including Porphyromonas gingiva...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 23 October 2019Source: Life SciencesAuthor(s): Qi Li, Xinglan An, Xiaxia Man, Meiran Chu, Tianchuang Zhao, Hao Yu, Ziyi LiAbstractAimsThe present study aimed to investigate the effects of cyclophosphamide (Cytoxan, CTX) on premature ovarian failure (POF) in mice and its regulatory mechanisms by transcriptome analysis.Main methodsFemale C57BL/6 mice were treated with a single intraperitoneal injection of 70 mg/kg CTX. Serum levels of estradiol (E2) and follicle stimulating hormone (FSH) were measured by enzyme-linked immunosorbent assay (ELISA), and follicular structure differences were ob...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 October 2019Source: Life SciencesAuthor(s): Chao He, Guiting Zhang, Hang Ouyang, Peng Zhang, Yudan Chen, Ren Wang, Hong ZhouAbstractAimsβ2-glycoprotein I/anti-β2-glycoprotein I antibody complex (β2/aβ2) could promote oxLDL-induced endothelial inflammation through Toll-like receptor 4 (TLR4), therefore accelerates atherosclerosis in patients with anti-phospholipid syndrome (APS). However, effects of β2/aβ2 and TLR4 on oxLDL-induced CD36 activation in macrophages remain to be elucidated and are currently under investigation.Materials and MethodsTHP-1 macroph...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 23 October 2019Source: Fungal BiologyAuthor(s): D.Q. Nguyen, Hua Li, T.T. Tran, K. Sivasithamparam, M.G.K. Jones, S.J. WylieAbstractOf the more than 400 indigenous orchid species in Western Australia, Cryptostylis ovata is the only species that retains its leaves all year round. It exists as a terrestrial herb and occasionally as an epiphyte in forested areas. Like all terrestrial orchids, C. ovata plants associate with mycorrhizal fungi, but their identities have not previously been investigated. Fungi were isolated from pelotons in rhizomes collected from three southern and two northern...
Source: Fungal Biology - Category: Biology Source Type: research
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Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
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Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Publication date: Available online 23 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Margarida Lorigo, Melissa Mariana, Manuel C. Lemos, Elisa CairraoAbstractTestosterone (T) is the predominant endogenous androgen in the bloodstream. At the vascular level, T presents genomic and non-genomic effects, and both effects may overlap. The genomic actions assume that androgens can freely cross the plasma membrane of target cells and bind to nuclear androgen receptors, inducing gene transcription and protein synthesis. The non-genomic effects have a more rapid onset and may be related to th...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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