Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection

Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection Pedro Curto1,2,3,4, Sean P. Riley4, Isaura Simões3,4*† and Juan J. Martinez4*† 1Ph.D. Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal2Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal3CNC-Center for Neuroscience and Cell Biology, Coimbra, Portugal4Vector Borne Disease Laboratories, Department of Pathobiological Sciences, LSU School of Veterinary Medicine, Baton Rouge, LA, United States Despite their high degree of genomic similarity, different spotted fever group (SFG) Rickettsia are often associated with very different clinical presentations. For example, Rickettsia conorii causes Mediterranean spotted fever, a life-threatening disease for humans, whereas Rickettsia montanensis is associated with limited or no pathogenicity to humans. However, the molecular basis responsible for the different pathogenicity attributes are still not understood. Although killing microbes is a critical function of macrophages, the ability to survive and/or proliferate within phagocytic cells seems to be a phenotypic feature of several intracellular pathogens. We have previously shown that R. conorii and R. montanensis exhibit different intracellular fates within macrophage-like cells. By evaluating early ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research

Related Links:

Publication date: Available online 13 November 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Pandiyan Nithya, Murugesan Balaji, Arumugam Mayakrishnan, Chinnalagu Dhilip Kumar, Selvaraj Rajesh, Azhagar Surya, Mahalingam SundrarajanAbstractThe noble metal such as Ag and Au doped CeO2 nanoparticles was successfully prepared by ionic liquid assisted hydrothermal method in the presence of Justicia adhatoda leaves extract and were used as an antibacterial and anticancer agent. The FT-IR and Raman spectrum exhibit the peaks at 460 and 464 cm−1 assigned to CeO stretching vibrations of NPs. The...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
ConclusionsBased on the obtained data, the PortaCount may be applicable for the determination of WPF.
Source: Safety and Health at Work - Category: Occupational Health Source Type: research
Publication date: September 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 5Author(s): Tiffany Wong, Simin GoralLupus nephritis (LN) is the cause of end-stage kidney disease (ESKD) for 1.9% of the ESKD population in the United States. Although the incidence rates of ESKD from LN stopped rising in recent years, racial disparities in waiting time, pre-emptive kidney transplant, and transplant outcomes still exist. Patients with LN who progress to ESKD tend to be female, of African ancestry, and young. Kidney transplantation is safe in this population and associated with a substantial survival benefit, prima...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Publication date: Available online 14 November 2019Source: The Lancet Global HealthAuthor(s): Karoun H Bagamian, John D Anderson, Farzana Muhib, Oliver Cumming, Lindsey A Laytner, Thomas F Wierzba, Richard RheingansSummaryBackgroundDiarrhoea, a global cause of child mortality and morbidity, is linked to adverse consequences including childhood stunting and death from other diseases. Few studies explore how diarrhoeal mortality varies subnationally, especially by cause, which is important for targeting investments. Even fewer examine indirect effects of diarrhoeal morbidity on child mortality. We estimated the subnational d...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 14 November 2019Source: The Lancet Global HealthAuthor(s): Karen H Keddy
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
This article considers explanations for the challenge in recruiting schools for surveys ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
On April 20, 1999, two active shooters attacked Columbine High School. This attack became a catalyst that changed the manner in which law enforcement prepared for similar attacks at schools and other locations. Departments across the United States develope...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
This study examined chronic illnesses, sensory and memory problems, and injury characteristics that were associated with ED visits and hospitalizat...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Motor vehicle crashes are a leading cause of unintentional injury deaths for children in the United States. Child safety seats are effective in reducing the rate and severity of injury for children. Families seen in an emergency department (ED) outside of ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
CONCLUSIONS: Complete data on noncountable TB cases help support estimates of programmatic burden. Ongoing training and a streamlined reporting system to NTSS can facilitate noncountable case reporting. PMID: 31722186 [PubMed - as supplied by publisher]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
More News: Biology | Brain | Cold Sores | Cytology | Databases & Libraries | Dysentery | Employment | Environmental Health | G6PD | Gastroenteritis | Genetics | Helicobacter Pylori | Herpes | HIV-Leishmania Co-infection | Legionnaires' Disease | Lymphoma | Men | Microbiology | Mitochondria | Mitochondrial Disease | Molecular Biology | Neurology | Neuroscience | Parasitology | Salmonella | Sodium | Statistics | Study | Tickborne Diseases | Tuberculosis | Urinary Tract Infections | USA Health | Veterinary Research