Inhibitory Actions of Tropeines on the α3 Glycine Receptor Function

Conclusion The present work describes the sensitivity of homomeric α3GlyRs to tropeines. Our results provide additional insights on the molecular mechanisms associated with the modulation of GlyRs by tropeines. A better understanding of the structural basis involved in the tropeine-GlyR interactions may contribute to the design of novel tropeine-based derivatives for basic and/or clinical applications. Author Contributions VSM, CB, CL, AM, AS, and GM-C performed the research. JF, LG, PC, LA, GM-C, and GY designed the research and contributed with analytical tools. VSM, CB, CL, AM, GM-C, and GY analyzed the data. GM-C and GY wrote the manuscript. All authors read and approved the final version of the manuscript. Funding This work was supported by grant FONDECYT 1170252 (to GY), FONDECYT 1160851 (to GM-C), and FONDECYT 3170108 (to CB). CL and AM were supported by CONICYT doctoral fellowships 21171549 and 21181287, respectively. VSM and AS were supported by the University of Concepción postgraduate fellowships (Ph.D. Program in Biological Sciences and Master Program in Neurobiology, respectively). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments The authors thank L. Aguayo, I. Cid, and J. Gavilán for their outstanding technical assistance. Supplementary Material The Supplementary...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research