Two older drugs could be 'repurposed' to fight dementia

Conclusion This early stage experimental research has demonstrated a beneficial neurological effect of trazodone and dibenzoylmethane on mice with diseases mimicking neurodegenerative diseases. It is important to acknowledge that this is animal research and therefore the drugs might not have the same effect when they are trialled on humans. That being said, trazodone is already an approved drug for depression and sleep problems and has therefore already passed safety tests. If the mechanisms of neurodegeneration in humans and mice are similar, it is possible trazodone could be used in the future in treating Alzheimer's and other neurodegenerative diseases. These early tests are promising. However, these drugs need to be proven effective and safe in people with neurodegenerative diseases before becoming available. Even if these are proven safe and effective, it is often a lengthy process from the start of human clinical trials to drugs being marketed and available to healthcare providers. This is especially true for long-term conditions where progression may be slow. Therefore, it could well be several years before these drugs are available for the treatment of neurodegenerative diseases. Links To The Headlines Depression and cancer drugs offer hope for dementia sufferers – study. Sky News, April 20 2017 Experts excited by brain 'wonder-drug'. BBC News, April 20 2017 Could cancer drugs help slow down dementia? ITV News, April 20 2017 Depression drug that could slow...
Source: NHS News Feed - Category: Consumer Health News Tags: Older people Neurology Medication Source Type: news

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The abnormal growth of cells in the brain is known as brain tumor. A brain tumor is a kind of disease that can hit children, adults, and older adults. In this work, a proposed method for brain tumor detection and classification using MATLAB and based on magnetic resonance imaging plays an essential role in the brain-tumor disease diagnostic application that is based on manual and automatic detection. Moreover, various kinds of tumors exist so it is complicated to detect, and thus it is hard to make decisions. Correct segmentation and image enhancement give an accurate classification of brain tumor types. A probabilistic ne...
Source: Journal of Clinical Engineering - Category: Medical Devices Tags: FEATURE ARTICLES Source Type: research
Arcangelo Barbonetti, Alessio Martorella, Elisa Minaldi, Settimio D'Andrea, Dorian Bardhi, Chiara Castellini, Felice Francavilla, Sandro Francavilla
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Fallah J, Olszewski AJ Abstract OBJECTIVES: To examine the use of splenectomy, chemotherapy, and subsequent overall survival (OS) in contemporary patients with splenic lymphomas. METHODS: We analyzed records of 6450 patients with various splenic lymphomas recorded in the National Cancer Data Base (2004-2013). Survival was compared using Mantel-Byer test to account for guarantee-time bias, stratified by age, sex, comorbidities, and lymphoma stage. RESULTS: Splenectomy rate was overall 58%, and varied from 49% in splenic marginal zone (SMZL) to 77% in follicular lymphoma (FL). It significantly decrea...
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
Authors: Komen N, Dewint P, Van den Broeck S, Pauli S, de Schepper H Abstract The field of rectal cancer treatment is a dynamic and changing field, due to better understanding of the pathology and new medical treatment options, but perhaps mostly due to innovations in the surgical approach. Surgery is the cornerstone for rectal cancer treatment. Currently, Total Mesorectal Excision is the gold standard. After evolution towards laparoscopic TME, improving technology has led to the development of platforms that allow transanal TME and robotic TME. In addition, local excision can be performed safer and more accurately...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Chun-Chieh Huang, Yu-Li Su, Hao-Lun Luo, Yen-Ta Chen, Terence T. Sio, Hsuan-Chih Hsu, Chia-Hsuan Lai
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion The efficacy of fertility preservation procedures in females with TS is still unknown. Future studies with focus on efficacy, safety and long-term follow-up are desperately needed. PMID: 30888127 [PubMed - in process]
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Authors: Kushchayeva Y, Lightbourne M, Lodish M, Stratakis CA Abstract Many hereditary and sporadic tumor and other syndromes are associated with endocrine functional and or structural abnormalities. The last few decades have yielded advancements in the field with improvements in diagnostic testing, screening guidelines and novel treatment options. In general, endocrine functional abnormalities and neoplasms share an early age of onset. There remains room for improvement as limited literature exists regarding clinical course, prognosis, and screening for earlier cancer detection. This should allow for more timely i...
Source: Pediatric Endocrinology Reviews - Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research
Source: Journal of Biomedical Nanotechnology - Category: Nanotechnology Authors: Tags: Articles Source Type: research
Source: Journal of Biomedical Nanotechnology - Category: Nanotechnology Authors: Tags: Articles Source Type: research
Source: Journal of Biomedical Nanotechnology - Category: Nanotechnology Authors: Tags: Articles Source Type: research
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