Trazodone Commonly Used Off-Label for Insomnia
(MedPage Today) -- NEW ORLEANS -- The antidepressant trazodone is no stranger to off-label use, especially for insomnia, a real-world study found. Among 1.4 million patients identified from U.S. medical and pharmacy claims data, over 100,000... (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - September 20, 2022 Category: Psychiatry Source Type: news

Why So Many Long COVID Patients Are Reporting Suicidal Thoughts
Last year, Diana Berrent—the founder of Survivor Corps, a Long COVID support group—asked the group’s members if they’d ever had thoughts of suicide since developing Long COVID. About 18% of people who responded said they had, a number much higher than the 4% of the general U.S. adult population that has experienced recent suicidal thoughts. A few weeks ago, Berrent posed the same question to current members of her group. This time, of the nearly 200 people who responded, 45% said they’d contemplated suicide. While her poll was small and informal, the results point to a serious problem. “...
Source: TIME: Health - June 13, 2022 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 healthscienceclimate Source Type: news

Safety and efficacy of melatonin, clonazepam, and trazodone in patients with Parkinson's disease and sleep disorders: a randomized, double-blind trial - Hadi F, Agah E, Tavanbakhsh S, Mirsepassi Z, Mousavi SV, Talachi N, Tafakhori A, Aghamollaii V.
Sleep disturbances are common non-motor symptoms of Parkinson's disease (PD). We aimed to compare the safety and efficacy of trazodone with melatonin and clonazepam in patients with PD and sleep complaints. Language: en... (Source: SafetyLit)
Source: SafetyLit - June 9, 2022 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Falls, healthcare resources and costs in older adults with insomnia treated with zolpidem, trazodone, or benzodiazepines - Amari DT, Juday T, Frech FH, Wang W, Wu Z, Atkins NJ, Wickwire EM.
BACKGROUND: Falls are the leading cause of injury-related death among older Americans. While some research has found that insomnia heightens falls, health care resource utilization (HCRU) and costs, the impact of insomnia treatments on fall risk, mortality... (Source: SafetyLit)
Source: SafetyLit - June 8, 2022 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Single-substance trazodone exposures reported to US poison centers from 2000 to 2019 - Husak N, Leonard JB, Seung H, Klein-Schwartz W.
BACKGROUND: Individual case reports describe trazodone overdose resulting in QTc prolongation and cardiac arrhythmias. The clinical effects and outcomes associated with trazodone exposures on a large-scale basis are less well known. OBJECTIVE: The ... (Source: SafetyLit)
Source: SafetyLit - May 2, 2022 Category: International Medicine & Public Health Tags: Poisoning Source Type: news

Fall risk, healthcare resource use, and costs among adult patients in the United States treated for insomnia with zolpidem, trazodone, or benzodiazepines: a retrospective cohort study - Amari DT, Juday TR, Frech FH, Wang W, Gor D, Atkins NJ, Wickwire EM.
The objective of this study is to compare the risk of falls, all-cause healthcare resource utilization (HCRU), and costs among patien... (Source: SafetyLit)
Source: SafetyLit - January 27, 2022 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

Prescribing of Psychotropic Meds Up in Nursing Homes During COVID - 19
Compared with Jan. to Feb. 2020, prescriptions for antipsychotics, antidepressants, trazodone up from March to Sept. 2020 (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - March 16, 2021 Category: Psychiatry Tags: Infections, Neurology, Nursing, Pharmacy, Psychiatry, Geriatrics, Journal, Source Type: news

Zolpidem versus trazodone initiation and the risk of fall-related fractures among individuals receiving maintenance hemodialysis - Assimon MM, Flythe JE.
BACKGROUND AND OBJECTIVES: Zolpidem, a nonbenzodiazepine hypnotic, and trazodone, a sedating antidepressant, are the most common medications used to treat insomnia in the United States. Both drugs have side effect profiles (e.g., drowsiness, dizziness, ... (Source: SafetyLit)
Source: SafetyLit - December 25, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Sildenafil, Trazodone Tablets Recalled After Being Packaged Together
AvKARE says it is not aware of any patients being harmed by the recalled products (Source: The Doctors Lounge - Psychiatry)
Source: The Doctors Lounge - Psychiatry - December 11, 2020 Category: Psychiatry Tags: Family Medicine, Internal Medicine, Pharmacy, Psychiatry, Urology, Institutional, Source Type: news

Sildenafil, Trazodone Tablets Recalled After Being Packaged Together
THURSDAY, Dec. 10, 2020 -- Sildenafil and trazodone tablets have been recalled by pharmaceutical distributor AvKARE because the drugs were " inadvertently packaged together " when they were bottled by a third-party vendor, according to the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 10, 2020 Category: Pharmaceuticals Source Type: news

Sildenafil and Trazodone Tablets Recalled After Being Packaged Together
Title: Sildenafil and Trazodone Tablets Recalled After Being Packaged TogetherCategory: Health NewsCreated: 12/10/2020 12:00:00 AMLast Editorial Review: 12/10/2020 12:00:00 AM (Source: MedicineNet Depression General)
Source: MedicineNet Depression General - December 10, 2020 Category: Psychiatry Source Type: news

AvKARE Issues Voluntary Nationwide Recall of Sildenafil 100mg Tablets and Trazodone 100mg Tablets Due to Product Mix-Up
AvKARE, Pulaski, TN is voluntarily recalling one lot of Sildenafil 100 mg tablets and one lot of Trazodone 100mg tablets to the consumer level. These products have been recalled due to a product mix-up of the listed two separate products inadvertently packaged together during bottling at a 3rd party (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - December 9, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Trazodone (Desyrel)
Title: Trazodone (Desyrel)Category: MedicationsCreated: 3/26/1998 12:00:00 AMLast Editorial Review: 2/12/2020 12:00:00 AM (Source: MedicineNet Depression General)
Source: MedicineNet Depression General - February 12, 2020 Category: Psychiatry Source Type: news

Signaling from mTOR to eIF2{alpha} mediates cell migration in response to the chemotherapeutic doxorubicin
After exposure to cytotoxic chemotherapeutics, tumor cells alter their translatome to promote cell survival programs through the regulation of eukaryotic initiation factor 4F (eIF4F) and ternary complex. Compounds that block mTOR signaling and eIF4F complex formation, such as rapamycin and its analogs, have been used in combination therapies to enhance cell killing, although their success has been limited. This is likely because the cross-talk between signaling pathways that coordinate eIF4F regulation with ternary complex formation after treatment with genotoxic therapeutics has not been fully explored. Here, we described...
Source: Signal Transduction Knowledge Environment - December 16, 2019 Category: Science Authors: Harvey, R. F., Pöyry, T. A. A., Stoneley, M., Willis, A. E. Tags: STKE Research Articles Source Type: news

Rhabdomyolysis risk with donepezil double that of other AD meds
Rhabdomyolysis more likely in those starting donepezil compared with rivastigmine or galantamine Related items fromOnMedica Suicide no more likely in men on 5 α-reductase inhibitors NICE calls for safer use of controlled drugs Falls risk just as high with trazodone as antipsychotics Over 75s not taking medication correctly, say GPs Debate goes on over valproate in pregnancy (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 15, 2019 Category: UK Health Source Type: news