The Potential Role of T Helper Cell 22 and IL-22 in Immunopathogenesis of Multiple Sclerosis

Conclusion Recent evidence shows changes in frequency and function of Th22 and its cytokine IL-22 in patients with MS, which suggests a potential relationship between Th22 cells, IL-22 levels, and the development and disease course of MS and its response to treatment. How Th22 cells and IL-22 levels affect the disease course of MS requires further elucidation. Additional studies on the immunopathogenesis of MS, specifically the roles Th22 cells and IL-22 cytokines may play in disease progression, are warranted and may lead to the development of new therapeutic strategies for treating neuro-inflammatory diseases, such as MS. References 1. Weiner HL. Multiple sclerosis is an inflammatory T-cell–mediated autoimmune disease. Arch Neurol. 2004;61(10):1613–1615. 2. O’Brien K, Gran B, Rostami A. T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunotherapy. 2010;2(1):99–115. 3. R&D Systems website. Multiple sclerosis: immune cell access to the central nervous system. 2006. https://www.rndsystems.com/resources/articles/multiple-sclerosis-immune-cell-access-central-nervous-system. Accessed June 15, 2016. 4. Gandhi R, Laroni A, Weiner HL. Role of the innate immune system in the pathogenesis of multiple sclerosis. J Neuroimmunol. 2010;221(1):7–14. 5. Constantinescu CS, Farooqi N, O’Brien K, Gran B. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol. 201...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Demyelinating Disease Genetics Multiple Sclerosis Neurology Review interleukin-22 T helper 22 Source Type: research

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Discussion The hands are one of the most important parts of the body for interacting with the world. They are remarkably adapted having sensitive sensory receptors as well as feedback receptors for grasping, holding, and manipulating objects. Hands, especially with an opposable thumb, multiple joints within the hand, along with the wrist and elbow, allow the hand to move in multiple positions to manipulate the world. Hands also symbolize an emotional caring and sharing between individuals as hands are used to provide a true “human touch” in personal and social situations. Due to their important interactions in ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
European Journal of Human Genetics, Published online: 06 December 2021; doi:10.1038/s41431-021-01011-830 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
Source: European Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
STATINS are a commonly prescribed medication for people at risk of heart attacks or who have had heart attacks previously. Serious side effects are exceedingly rare.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
STOMACH cancer can often go undetected. Early symptoms of stomach cancer can be like symptoms of common stomach conditions.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
STATINS are one of the most commonly prescribed drugs in the UK by around 8 million adults. They became available in the late 1980s, and there have been several reported side effects.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Purpose of review Systemic treatment is the only therapeutic option for patients with progressive, metastatic medullary thyroid cancer (MTC). Since the discovery of the rearranged during transfection (RET) proto-oncogene (100% hereditary, 60–90% sporadic MTC), research has focused on finding effective systemic therapies to target this mutation. This review surveys recent findings. Recent findings Multikinase inhibitors are systemic agents targeting angiogenesis, inhibiting growth of tumor cells and cells in the tumor environment and healthy endothelium. In the phase III EXAM and ZETA trials, cabozantinib a...
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: ENDOCRINE TUMORS: Edited by Christiane Jungels Source Type: research
Purpose of review Activating mutations in the mitogen-activated protein kinase (MAPK) pathway play an important role in papillary (PTC) and anaplastic (ATC) thyroid cancer. The aim of this review is to discuss the impact of BRAF mutations on clinical features and treatment of patients with thyroid cancer. Recent findings Despite the unfavorable course associated with PTCs harboring BRAF V600E mutation, its prognostic role remains debated. BRAF V600E-driven tumors exhibit high Extracellular signal-regulated kinase phosphorylation, leading to unregulated cell proliferation and inhibition of the required genes for ...
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: ENDOCRINE TUMORS: Edited by Christiane Jungels Source Type: research
No abstract available
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: LUNG AND MEDIASTINUM: Edited by Robert Pirker and Caicun Zhou Source Type: research
Purpose of review Discussed the main approaches for lung control and point out differences among Central Europe and other countries. Recent findings Three main approaches exist: smoking ban, early computed tomography screening and access to novel therapies; major differences exist between Central Europe and some other countries. Summary A major effort will be needed from Central Europe countries in all three approaches; it will require strong involvement from the political authorities.
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: LUNG AND MEDIASTINUM: Edited by Robert Pirker and Caicun Zhou Source Type: research
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