Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | PMC:PMC10911935 | DOI:10.3346/jkms.2024.39.e72 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 5, 2024 Category: General Medicine Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | PMC:PMC10911935 | DOI:10.3346/jkms.2024.39.e72 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 5, 2024 Category: Biomedical Science Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | PMC:PMC10911935 | DOI:10.3346/jkms.2024.39.e72 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 5, 2024 Category: General Medicine Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | PMC:PMC10911935 | DOI:10.3346/jkms.2024.39.e72 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 5, 2024 Category: Biomedical Science Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | PMC:PMC10911935 | DOI:10.3346/jkms.2024.39.e72 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 5, 2024 Category: General Medicine Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Identification of a murder caused by brodifacoum poisoning based on clinical examinations and LC-MS/MS results
AbstractBrodifacoum exerts its antagonistic effect against the metabolism of vitamin K, an essential component in the synthesis of blood coagulation factors. This effect ultimately hinders the blood ’s capacity to clot effectively, rendering it a commonly employed rodenticide. Instances of lethal poisonings are exceedingly rare owing to expeditious medical intervention and treatment. Within this report, we present a case of brodifacoum-induced homicide, wherein the patient exhibited distinct clinical examinations and symptoms. Moreover, the patient’s blood sample exhibited a noteworthy brodifacoum concentration of 0.68...
Source: International Journal of Legal Medicine - March 5, 2024 Category: Medical Law Source Type: research
Matrix gla protein and the long-term incidence and progression of coronary artery and aortic calcification in the multi-ethnic study of atherosclerosis
Matrix Gla protein (MGP) is an inhibitor of calcification that requires carboxylation by vitamin K for activity. The inactive form of MGP, dephosphorylated-uncarboxylated matrix Gla protein (dp-ucMGP), has been associated with increased calcification. However, it is not known whether there is a longitudinal relationship between dephosphorylated-uncarboxylated matrix Gla protein levels and coronary and aortic calcification in large population cohorts. (Source: Atherosclerosis)
Source: Atherosclerosis - March 5, 2024 Category: Cardiology Authors: Ashley A. Berlot, Xueyan Fu, M Kyla Shea, Russell Tracy, Matthew Budoff, Ryung S. Kim, Mahim Naveed, Sarah L. Booth, Jorge R. Kizer, Anna E. Bortnick Source Type: research
Comparative effectiveness of factor Xa non-vitamin K antagonist oral anticoagulants versus phenprocoumon in patients with non-valvular atrial fibrillation
Non-vitamin K antagonist oral anticoagulants (NOACs) have largely supplanted vitamin K antagonists (VKAs) for oral anticoagulation in non-valvular atrial fibrillation (NVAF). However, data on the real-world effectiveness of NOACs vs. phenprocoumon, a VKA widely used in Germany, are limited. The RELOADED study aimed to compare effectiveness of factor Xa NOACs and phenprocoumon in NVAF in clinical practice. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 2, 2024 Category: Cardiology Authors: Reinhold Kreutz, Sebastian Kloss, Dirk Enders, Khaled Abdelgawwad, Dennis H äckl, Niklas Schmedt, Hendrik Bonnemeier Source Type: research
Vitamin K-dependent carboxylation in β-cells and diabetes
Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00035-3. doi: 10.1016/j.tem.2024.02.006. Online ahead of print.ABSTRACTVitamin K is an essential micronutrient and a cofactor for the enzyme γ-glutamyl carboxylase, which adds a carboxyl group to specific glutamic acid residues in proteins transiting through the secretory pathway. Higher vitamin K intake has been linked to a reduced incidence of type 2 diabetes (T2D) in humans. Preclinical work suggests that this effect depends on the γ-carboxylation of specific proteins in β-cells, including endoplasmic reticulum Gla protein (ERGP), implicated in the control of intrace...
Source: Trends in Endocrinology and Metabolism: TEM - March 1, 2024 Category: Endocrinology Authors: Julie Lacombe Mathieu Ferron Source Type: research
Vitamin K-dependent carboxylation in β-cells and diabetes
Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00035-3. doi: 10.1016/j.tem.2024.02.006. Online ahead of print.ABSTRACTVitamin K is an essential micronutrient and a cofactor for the enzyme γ-glutamyl carboxylase, which adds a carboxyl group to specific glutamic acid residues in proteins transiting through the secretory pathway. Higher vitamin K intake has been linked to a reduced incidence of type 2 diabetes (T2D) in humans. Preclinical work suggests that this effect depends on the γ-carboxylation of specific proteins in β-cells, including endoplasmic reticulum Gla protein (ERGP), implicated in the control of intrace...
Source: Trends in Endocrinology and Metabolism: TEM - March 1, 2024 Category: Endocrinology Authors: Julie Lacombe Mathieu Ferron Source Type: research
Efficacy and safety of rivaroxaban versus apixaban for venous thromboembolism: A systematic review and meta-analysis of observational studies
ConclusionsApixaban is associated with a significantly lower risk of major bleeding compared to rivaroxaban for treatment of VTE. Given the limitations of the existing evidence, further interventional studies comparing the two drugs are needed. (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - March 1, 2024 Category: Hematology Source Type: research
How the Hemostasis Laboratory can Help Clinicians to Manage Patients on Oral Anticoagulants
This article aims to overview how the hemostasis laboratory can help clinicians to manage patients on oral anticoagulants. Special interest is devoted to the international normalized ratio, used to manage patients on VKAs and to the measurement of DOAC concentrations, for which the role of the laboratory is still not very well defined and most interferences of DOACs with some of the most common hemostatic parameters are not widely appreciated. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - February 29, 2024 Category: Hematology Authors: Armando Tripodi Source Type: research
Early-stage hepatocellular carcinoma screening in patients with chronic hepatitis B in China: a cost-effectiveness analysis
Conclusion: GAAD+US was the most cost-effective strategy for early HCC diagnosis among CHB patients which could be considered as the liver cancer screening scheme for the high-risk population in China.PMID:38415341 | DOI:10.57264/cer-2023-0146 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - February 28, 2024 Category: General Medicine Authors: Yuemin Nan Osvaldo Ulises Garay Xianzhong Lu Yue Zhang Li Xie Zhongyi Niu Wen Chen Source Type: research
Venous thromboembolism - was is new in the revised AWMF guideline?
Dtsch Med Wochenschr. 2024 Mar;149(6):274-282. doi: 10.1055/a-2128-0005. Epub 2024 Feb 27.ABSTRACTFor the diagnosis of a lower-extremity deep vein thrombosis (LEDVT), venous duplex ultrasound is the method of first choice. If a qualified ultrasonography is not timely available, D-dimer testing, and limited ultrasound protocols (point-of-care ultrasound, POCUS) can contribute to therapeutic decision-making when clinical probability is low. A DOAC-based treatment regimen is preferable to a vitamin K antagonist for both acute therapy and secondary prophylaxis of venous thromboembolism (VTE). Treatment with DOACs is unproblema...
Source: Hamostaseologie - February 27, 2024 Category: Hematology Authors: Birgit Linnemann Katja Sibylle M ühlberg Robert Klamroth Source Type: research
