Management of Deep Vein Thrombosis: An Update Based on the Revised AWMF S2k Guideline
Hamostaseologie. 2024 Apr;44(2):97-110. doi: 10.1055/a-2178-6574. Epub 2024 Apr 30.ABSTRACTDeep vein thrombosis (DVT) and pulmonary embolism (PE) are the most common manifestations of venous thromboembolism (VTE). Most DVTs affect the lower-extremity veins. Since the symptoms of DVT are non-specific, a prompt and standardised diagnostic work-up is essential to minimise the risk of PE in the acute phase and to prevent thrombosis progression, post-thrombotic syndrome and VTE recurrence in the long-term. Only recently, the AWMF S2k guidelines on Diagnostics and Therapy of Venous Thrombosis and Pulmonary Embolism have been rev...
Source: Hamostaseologie - April 30, 2024 Category: Hematology Authors: Birgit Linnemann Jan Beyer-Westendorf Christine Espinola-Klein Katja S M ühlberg Oliver J M üller Robert Klamroth Source Type: research
Management of Deep Vein Thrombosis: An Update Based on the Revised AWMF S2k Guideline
Hamostaseologie. 2024 Apr;44(2):97-110. doi: 10.1055/a-2178-6574. Epub 2024 Apr 30.ABSTRACTDeep vein thrombosis (DVT) and pulmonary embolism (PE) are the most common manifestations of venous thromboembolism (VTE). Most DVTs affect the lower-extremity veins. Since the symptoms of DVT are non-specific, a prompt and standardised diagnostic work-up is essential to minimise the risk of PE in the acute phase and to prevent thrombosis progression, post-thrombotic syndrome and VTE recurrence in the long-term. Only recently, the AWMF S2k guidelines on Diagnostics and Therapy of Venous Thrombosis and Pulmonary Embolism have been rev...
Source: Hamostaseologie - April 30, 2024 Category: Hematology Authors: Birgit Linnemann Jan Beyer-Westendorf Christine Espinola-Klein Katja S M ühlberg Oliver J M üller Robert Klamroth Source Type: research
Genetic polymorphisms and major bleeding risk during vitamin K antagonists treatment: The BLEEDS case ‐cohort
ConclusionsCYP4F2 polymorphism was associated with major bleeding, especially in combination withVKORC1 genetic variants. These variants could be considered to further personalize anticoagulant treatment. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 30, 2024 Category: Drugs & Pharmacology Authors: Eleonora Camilleri,
Mira Ghobreyal,
Mettine H. A. Bos,
Pieter H. Reitsma,
Felix J. M. Van Der Meer,
Jesse J. Swen,
Suzanne C. Cannegieter,
Nienke van Rein Tags: RESEARCH ARTICLE Source Type: research
Clinical care pathway and management of major bleeding associated with non-vitamin k antagonist oral anticoagulants: a modified delphi consensus from saudi arabia and uae
Conclusion: The present Delphi consensus provides evidence-based recommendations and protocols for the management of NOAC-associated bleeding in the region. Patients with major NOAC-induced bleeding should be referred to a well-equipped ED with standardized management protocols. A multidisciplinary approach is recommended for establishing the association between NOAC use and major bleeding. Treating physicians should have prompt access to specific reversal agents to optimize patient outcomes. Real-world evidence and national guidelines are needed to aid all stakeholders involved in NOAC-induced bleeding management. (Source...
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 30, 2024 Category: Hematology Authors: Abdulrahman Al Raizah, Fakhr Alayoubi, Galal Hassan Abdelnaby, Hazzaa Alzahrani, Majid Farraj Bakheet, Mohammed A Alskaini, Rasha Buhumaid, Sameer Al Awadhi, Sara Nooruddin Kazim, Thiagarajan Jaiganesh, Zohair Al Asiri Source Type: research
Appropriateness of prescribing profiles and intake adherence to non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: analysis of a retrospective longitudinal study using real-world data from Northern Portugal (AF-React Study)
Conclusions
Dabigatran had the lowest percentage of guideline-consistent doses. Patients younger than 75 years with GFR >60 mL/min had the highest percentage with an adequate GFR range, while other groups who require closer GFR monitoring had lower percentages within an adequate GFR range. Adherence to NOACs differed among different drugs, with greater adherence to treatment with edoxaban and less adherence to apixaban. (Source: BMJ Open)
Source: BMJ Open - April 30, 2024 Category: General Medicine Authors: Silva Pinto, S., Henriques, T. S., Teixeira, A. S. C., Monteiro, H., Martins, C. Tags: Open access, General practice / Family practice Source Type: research
Oral anticoagulants and cognitive impairment in patients with atrial fibrillation: A systematic review with meta-analysis and trial sequential analysis
This systematic review assesses the likelihood of developing dementia and cognitive impairment in patients with atrial fibrillation (AF) receiving non-vitamin K antagonist oral anticoagulants (NOACs) as opposed to vitamin K antagonists (VKAs). (Source: Thrombosis Research)
Source: Thrombosis Research - April 30, 2024 Category: Hematology Authors: Kun-Han Lee, Jiunn-Tyng Yeh, Meng-Lun Wu, Wan-Yu Yeh, Gregory Y.H. Lip, Chern-En Chiang, Chen-Huan Chen, Hao-Min Cheng Source Type: research
Exploring the Link between Anticoagulation, Cognitive Impairment and Dementia in Atrial Fibrillation: A Systematic Review
Conclusions: The use of oral anticoagulants has the potential to prevent cognitive impairment and dementia in patients with AF. Since most of the published research on this subject is observational in nature, more randomized controlled trials are needed to fully understand the effect of anticoagulants on cognitive function.PMID:38673694 | DOI:10.3390/jcm13082418 (Source: Cancer Control)
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Abhimanyu Agarwal Mohamed A Mostafa Muhammad Imtiaz Ahmad Elsayed Z Soliman Source Type: research
Vitamin K prophylaxis in neonates: comparing two different oral regimens
Journal of Perinatology, Published online: 27 April 2024; doi:10.1038/s41372-024-01981-9Vitamin K prophylaxis in neonates: comparing two different oral regimens (Source: Journal of Perinatology)
Source: Journal of Perinatology - April 27, 2024 Category: Perinatology & Neonatology Authors: Daijiro Takahashi Naoki Egami Masayuki Ochiai Taeko Hotta Shutaro Suga Masataka Ishimura Chiharu Kawaguchi Takeshi Uchiumi Toshiya Nishikubo Keiji Nogami Kei Goto Shouichi Ohga Source Type: research
The Vitamin K-Dependent Anticoagulant Factor, Protein S, Regulates Vascular Permeability
Curr Issues Mol Biol. 2024 Apr 9;46(4):3278-3293. doi: 10.3390/cimb46040205.ABSTRACTProtein S (PROS1) is a vitamin K-dependent anticoagulant factor, which also acts as an agonist for the TYRO3, AXL, and MERTK (TAM) tyrosine kinase receptors. PROS1 is produced by the endothelium which also expresses TAM receptors, but little is known about its effects on vascular function and permeability. Transwell permeability assays as well as Western blotting and immunostaining analysis were used to monitor the possible effects of PROS1 on both endothelial cell permeability and on the phosphorylation state of specific signaling proteins...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Aur élie Joussaume Chryso Kanthou Olivier E Pardo Lucie Karayan-Tapon Omar Benzakour Fatima Dkhissi Source Type: research
The Vitamin K-Dependent Anticoagulant Factor, Protein S, Regulates Vascular Permeability
Curr Issues Mol Biol. 2024 Apr 9;46(4):3278-3293. doi: 10.3390/cimb46040205.ABSTRACTProtein S (PROS1) is a vitamin K-dependent anticoagulant factor, which also acts as an agonist for the TYRO3, AXL, and MERTK (TAM) tyrosine kinase receptors. PROS1 is produced by the endothelium which also expresses TAM receptors, but little is known about its effects on vascular function and permeability. Transwell permeability assays as well as Western blotting and immunostaining analysis were used to monitor the possible effects of PROS1 on both endothelial cell permeability and on the phosphorylation state of specific signaling proteins...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Aur élie Joussaume Chryso Kanthou Olivier E Pardo Lucie Karayan-Tapon Omar Benzakour Fatima Dkhissi Source Type: research
The Vitamin K-Dependent Anticoagulant Factor, Protein S, Regulates Vascular Permeability
Curr Issues Mol Biol. 2024 Apr 9;46(4):3278-3293. doi: 10.3390/cimb46040205.ABSTRACTProtein S (PROS1) is a vitamin K-dependent anticoagulant factor, which also acts as an agonist for the TYRO3, AXL, and MERTK (TAM) tyrosine kinase receptors. PROS1 is produced by the endothelium which also expresses TAM receptors, but little is known about its effects on vascular function and permeability. Transwell permeability assays as well as Western blotting and immunostaining analysis were used to monitor the possible effects of PROS1 on both endothelial cell permeability and on the phosphorylation state of specific signaling proteins...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Aur élie Joussaume Chryso Kanthou Olivier E Pardo Lucie Karayan-Tapon Omar Benzakour Fatima Dkhissi Source Type: research
The Vitamin K-Dependent Anticoagulant Factor, Protein S, Regulates Vascular Permeability
Curr Issues Mol Biol. 2024 Apr 9;46(4):3278-3293. doi: 10.3390/cimb46040205.ABSTRACTProtein S (PROS1) is a vitamin K-dependent anticoagulant factor, which also acts as an agonist for the TYRO3, AXL, and MERTK (TAM) tyrosine kinase receptors. PROS1 is produced by the endothelium which also expresses TAM receptors, but little is known about its effects on vascular function and permeability. Transwell permeability assays as well as Western blotting and immunostaining analysis were used to monitor the possible effects of PROS1 on both endothelial cell permeability and on the phosphorylation state of specific signaling proteins...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Aur élie Joussaume Chryso Kanthou Olivier E Pardo Lucie Karayan-Tapon Omar Benzakour Fatima Dkhissi Source Type: research
The Vitamin K-Dependent Anticoagulant Factor, Protein S, Regulates Vascular Permeability
Curr Issues Mol Biol. 2024 Apr 9;46(4):3278-3293. doi: 10.3390/cimb46040205.ABSTRACTProtein S (PROS1) is a vitamin K-dependent anticoagulant factor, which also acts as an agonist for the TYRO3, AXL, and MERTK (TAM) tyrosine kinase receptors. PROS1 is produced by the endothelium which also expresses TAM receptors, but little is known about its effects on vascular function and permeability. Transwell permeability assays as well as Western blotting and immunostaining analysis were used to monitor the possible effects of PROS1 on both endothelial cell permeability and on the phosphorylation state of specific signaling proteins...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Aur élie Joussaume Chryso Kanthou Olivier E Pardo Lucie Karayan-Tapon Omar Benzakour Fatima Dkhissi Source Type: research
The Vitamin K-Dependent Anticoagulant Factor, Protein S, Regulates Vascular Permeability
Curr Issues Mol Biol. 2024 Apr 9;46(4):3278-3293. doi: 10.3390/cimb46040205.ABSTRACTProtein S (PROS1) is a vitamin K-dependent anticoagulant factor, which also acts as an agonist for the TYRO3, AXL, and MERTK (TAM) tyrosine kinase receptors. PROS1 is produced by the endothelium which also expresses TAM receptors, but little is known about its effects on vascular function and permeability. Transwell permeability assays as well as Western blotting and immunostaining analysis were used to monitor the possible effects of PROS1 on both endothelial cell permeability and on the phosphorylation state of specific signaling proteins...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Aur élie Joussaume Chryso Kanthou Olivier E Pardo Lucie Karayan-Tapon Omar Benzakour Fatima Dkhissi Source Type: research
The Vitamin K-Dependent Anticoagulant Factor, Protein S, Regulates Vascular Permeability
Curr Issues Mol Biol. 2024 Apr 9;46(4):3278-3293. doi: 10.3390/cimb46040205.ABSTRACTProtein S (PROS1) is a vitamin K-dependent anticoagulant factor, which also acts as an agonist for the TYRO3, AXL, and MERTK (TAM) tyrosine kinase receptors. PROS1 is produced by the endothelium which also expresses TAM receptors, but little is known about its effects on vascular function and permeability. Transwell permeability assays as well as Western blotting and immunostaining analysis were used to monitor the possible effects of PROS1 on both endothelial cell permeability and on the phosphorylation state of specific signaling proteins...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Aur élie Joussaume Chryso Kanthou Olivier E Pardo Lucie Karayan-Tapon Omar Benzakour Fatima Dkhissi Source Type: research
