Use of apixaban in adults with congenital heart disease and atrial arrhythmias: The PROTECT-AR study
Adults with congenital heart disease (ACHD) and atrial arrhythmias (AA) face an increased risk of thromboembolic events. Limited data exist on the use of non-vitamin K oral anticoagulants for thromboprophylaxis in ACHD. We aimed to assess the effectiveness and safety of apixaban in ACHD patients with AA. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 30, 2024 Category: Cardiology Authors: Anastasios Kartas, Andreas S. Papazoglou, Dimitrios V. Moysidis, Stefanos Despotopoulos, Amalia Baroutidou, Diamantis Kosmidis, Athanasios Koutsakis, Sotiria Liori, Sotiria Apostolopoulou, Alexandra Frogoudaki, Afrodite Tzifa, Apostolos Galatas, Georgios Source Type: research
Randomized controlled trials of switching to a new medication vs continuing a chronic medication may underestimate the risk of adverse events in those continuing because of asymmetric depletion of susceptibles
For older adults with atrial fibrillation (AF), direct oral anticoagulants (DOACs) reduce a person's risk of stroke and bleeding, compared with vitamin k antagonists (VKAs) [1 –3]. However, a recently published randomized controlled trial (RCT) of frail older adults who were on a VKA and randomized to continue a VKA or switch to a DOAC was stopped early for futility due to greater risk of bleeding in adults switched to a DOAC [4]. Some have interpreted this to mean that VKAs are safer than DOACs in frail older adults [5]. (Source: Journal of Clinical Epidemiology)
Source: Journal of Clinical Epidemiology - March 27, 2024 Category: Epidemiology Authors: Michael Colacci, Afsaneh Raissi, Prachi Ray, Michelle Sholzberg, Kenneth J. Rothman, Michael Fralick Tags: Letter to the Editor Source Type: research
Combining SSRIs With Oral Anticoagulants Found to Increase Risk of Major Bleeding
People who take serotonin reuptake inhibitors (SSRIs) and oral anticoagulants have an increased risk of multiple types of major bleeding compared with people who take only oral anticoagulants, astudy inJAMA Network Open has found. The study findings also showed that bleeding risk differs depending on the type of anticoagulant.Christel Renoux, M.D., Ph.D., of Jewish General Hospital in Montreal and colleagues examined data from 331,305 patients in the United Kingdom aged 60 years or older who had atrial fibrillation and began taking oral anticoagulants between January 2, 1998, and March 29, 2021. The researchers included an...
Source: Psychiatr News - March 26, 2024 Category: Psychiatry Tags: adverse event anticoagulant bleeding blood thinner JAMA Network Open risk factor selective serotonin reuptake inhibitor SSRI warfarin Source Type: research
Plasma Cell-Free Adenomatous Polyposis Coli Gene Promoter Methylation as a Prognostic Biomarker for Hepatocellular Carcinoma
CONCLUSIONS: Hypermethylation of APC promoter appears to be a potential biomarker that could predict patient survival and disease progression outcome in patients with intermediate stage HCC after local ablation treatment.PMID:38527449 | DOI:10.1159/000538455 (Source: Oncology)
Source: Oncology - March 25, 2024 Category: Cancer & Oncology Authors: Chih-Yang Hsiao Chang-Yi Lu Hung-Ju Su Kai-Wen Huang Source Type: research
Matrix Gla protein and the long-term incidence and progression of coronary artery and aortic calcification in the Multi-Ethnic Study of Atherosclerosis
CONCLUSIONS: We found a positive association of the inactive form of matrix Gla protein, dp-ucMGP, and long-term incidence/progression of CAC, ATAC, and DTAC. Future studies should investigate dp-ucMGP as a calcification regulator and MGP as a possible therapeutic target to slow progression of calcification in the vasculature.PMID:38527383 | DOI:10.1016/j.atherosclerosis.2024.117505 (Source: Atherosclerosis)
Source: Atherosclerosis - March 25, 2024 Category: Cardiology Authors: Ashley A Berlot Xueyan Fu M Kyla Shea Russell Tracy Matthew Budoff Ryung S Kim Mahim Naveed Sarah L Booth Jorge R Kizer Anna E Bortnick Source Type: research
Plasma Cell-Free Adenomatous Polyposis Coli Gene Promoter Methylation as a Prognostic Biomarker for Hepatocellular Carcinoma
CONCLUSIONS: Hypermethylation of APC promoter appears to be a potential biomarker that could predict patient survival and disease progression outcome in patients with intermediate stage HCC after local ablation treatment.PMID:38527449 | DOI:10.1159/000538455 (Source: Oncology)
Source: Oncology - March 25, 2024 Category: Cancer & Oncology Authors: Chih-Yang Hsiao Chang-Yi Lu Hung-Ju Su Kai-Wen Huang Source Type: research
Plasma Cell-Free Adenomatous Polyposis Coli Gene Promoter Methylation as a Prognostic Biomarker for Hepatocellular Carcinoma
CONCLUSIONS: Hypermethylation of APC promoter appears to be a potential biomarker that could predict patient survival and disease progression outcome in patients with intermediate stage HCC after local ablation treatment.PMID:38527449 | DOI:10.1159/000538455 (Source: Oncology)
Source: Oncology - March 25, 2024 Category: Cancer & Oncology Authors: Chih-Yang Hsiao Chang-Yi Lu Hung-Ju Su Kai-Wen Huang Source Type: research
Challenges and lessons learned from a long-term postauthorisation safety study programme of rivaroxaban in Europe
Objectives
To describe opportunities and challenges experienced from the four pharmacoepidemiological database studies included in the rivaroxaban post authorisation safety study (PASS) programme and propose ways to maximise the value of population-based observational research when addressing regulatory requirements.
Design
PASS programme of rivaroxaban carried out as part of the regulatory postapproval commitment to the European Medicines Agency.
Setting
Clinical practice in Germany, the Netherlands, Sweden and the UK (electronic health records)—undertaken by pharmacoepidemiology research teams using country-speci...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Brobert, G., Ruigomez, A., Schink, T., Voss, A., Herings, R., Smits, E., Swart, K. M. A., Friberg, L., Balabanova, Y., Tarenz, C., Suzart-Woischnik, K., Soriano-Gabarro, M., Vora, P., Homering, M., Dyszynski, T., Nagel, G., Amaya, P., Garcia Rodriguez, L. Tags: Open access Cardiovascular medicine Source Type: research
< em > Planococcus notacanthi < /em > sp. nov., isolated from the skin of a deep-sea snub-nosed spiny eel
Int J Syst Evol Microbiol. 2024 Mar;74(3). doi: 10.1099/ijsem.0.006298.ABSTRACTA novel bacterial strain, APC 4016T, was previously isolated from the skin of a snub-nosed spiny eel, Notacanthus chemnitzii, from a depth of 1000 m in the northern Atlantic Ocean. Cells were aerobic, cocci, motile, Gram-positive to Gram-variable staining, and gave rise to orange-pigmented colonies. Growth occurred at 4-40 °C (optimum, 25-28 °C), pH 5.5-12 (optimum, pH 7-7.5), and 0-12 % (w/v) NaCl (optimum, 1 %). 16S rRNA gene phylogenetic analysis confirmed that strain APC 4016T belonged to the genus Planococcus and was most closely related ...
Source: International Journal of Systematic and Evolutionary Microbiology - March 21, 2024 Category: Microbiology Authors: Shona Uniacke-Lowe Catherine Stanton Colin Hill Paul Ross Source Type: research
< em > Planococcus notacanthi < /em > sp. nov., isolated from the skin of a deep-sea snub-nosed spiny eel
Int J Syst Evol Microbiol. 2024 Mar;74(3). doi: 10.1099/ijsem.0.006298.ABSTRACTA novel bacterial strain, APC 4016T, was previously isolated from the skin of a snub-nosed spiny eel, Notacanthus chemnitzii, from a depth of 1000 m in the northern Atlantic Ocean. Cells were aerobic, cocci, motile, Gram-positive to Gram-variable staining, and gave rise to orange-pigmented colonies. Growth occurred at 4-40 °C (optimum, 25-28 °C), pH 5.5-12 (optimum, pH 7-7.5), and 0-12 % (w/v) NaCl (optimum, 1 %). 16S rRNA gene phylogenetic analysis confirmed that strain APC 4016T belonged to the genus Planococcus and was most closely related ...
Source: International Journal of Systematic and Evolutionary Microbiology - March 21, 2024 Category: Microbiology Authors: Shona Uniacke-Lowe Catherine Stanton Colin Hill Paul Ross Source Type: research
< em > Planococcus notacanthi < /em > sp. nov., isolated from the skin of a deep-sea snub-nosed spiny eel
Int J Syst Evol Microbiol. 2024 Mar;74(3). doi: 10.1099/ijsem.0.006298.ABSTRACTA novel bacterial strain, APC 4016T, was previously isolated from the skin of a snub-nosed spiny eel, Notacanthus chemnitzii, from a depth of 1000 m in the northern Atlantic Ocean. Cells were aerobic, cocci, motile, Gram-positive to Gram-variable staining, and gave rise to orange-pigmented colonies. Growth occurred at 4-40 °C (optimum, 25-28 °C), pH 5.5-12 (optimum, pH 7-7.5), and 0-12 % (w/v) NaCl (optimum, 1 %). 16S rRNA gene phylogenetic analysis confirmed that strain APC 4016T belonged to the genus Planococcus and was most closely related ...
Source: International Journal of Systematic and Evolutionary Microbiology - March 21, 2024 Category: Microbiology Authors: Shona Uniacke-Lowe Catherine Stanton Colin Hill Paul Ross Source Type: research
GAS6/TAM Axis as Therapeutic Target in Liver Diseases
In conclusion, the TAM system is becoming an interesting pharmacological target in liver pathology and a focus of future biomedical research in this field. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Seminars in Liver Disease)
Source: Seminars in Liver Disease - March 21, 2024 Category: Gastroenterology Authors: Tutusaus, Anna Morales, Albert Garc ía de Frutos, Pablo Mar í, Montserrat Tags: Review Article Source Type: research
Direct oral anticoagulants compared with warfarin in patients with left ventricular thrombus: a cohort study from China
CONCLUSIONS: This study showed no significant difference in thrombus resolution between DOAC and warfarin. DOAC might be an alternative to warfarin for the treatment of LV thrombus. However, further large prospective studies are required to explore the efficacy and safety of DOAC in patients with LV thrombus.PMID:38505052 | PMC:PMC10944738 | DOI:10.21037/jtd-23-1582 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Yang Zhou Xiaoxuan Zhang Yang Lin Wenxing Peng Source Type: research
