Vitamin K Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Usefulness of Vitamin K-Dependent Proteins in the Diagnosis of Colorectal Carcinoma
Int J Mol Sci. 2024 May 3;25(9):4997. doi: 10.3390/ijms25094997.ABSTRACTColorectal cancer (CRC) is one of the most common neoplasms in developed countries, with increasing incidence and mortality, even in young people. A variety of serum markers have been associated with CRC (CEA, CA 19-9), but neither should be used as a screening tool for the diagnosis or evolution staging of CRC. The sensitivity and specificity of these markers are not as good as is required, so new ones need to be found. Matrix Gla protein and PIVKA II are involved in carcinogenesis, but few studies have evaluated their usefulness in predicting the pre...
Source: Cancer Control - May 11, 2024 Category: Cancer & Oncology Authors: Mirela-Georgiana Pern é Adela-Viviana Sitar-T ăut Olga Hilda Or ășan Vasile Negrean C ălin Vasile Vlad Teodora-Gabriela Alexescu Mircea Vasile Milaciu Lorena Cium ărnean R ăzvan Dan Togănel Gabriel Emil Petre Ioan Șimon Alexandra Cr ăciun Source Type: research

Menaquinone-4 Alleviates Neurological Deficits Associated with Intracerebral Hemorrhage by Preserving Corticospinal Tract in Mice
Neurochem Res. 2024 May 10. doi: 10.1007/s11064-024-04150-8. Online ahead of print.ABSTRACTMenaquinone-4 (MK-4) is an isoform of vitamin K2 that has been shown to exert various biological actions besides its functions in blood coagulation and bone metabolism. Here we examined the effect of MK-4 on a mouse model of intracerebral hemorrhage (ICH). Daily oral administration of 200 mg/kg MK-4 starting from 3 h after induction of ICH by intrastriatal collagenase injection significantly ameliorated neurological deficits. Unexpectedly, MK-4 produced no significant effects on various histopathological parameters, including the dec...
Source: Neurochemical Research - May 10, 2024 Category: Neuroscience Authors: Keisuke Ushida Keita Kinoshita Yusei Ichihara Yuma Hirata Yuki Kurauchi Takahiro Seki Hiroshi Katsuki Source Type: research

Description of an anaerobic actinobacterium, Kribbibacterium absianum gen. nov., sp. nov., a new member of the novel family Kribbibacteriaceae fam. nov., and reclassification of the genera Granulimonas and Leptogranulimonas 
Int J Syst Evol Microbiol. 2024 May;74(5). doi: 10.1099/ijsem.0.006382.ABSTRACTTwo rod-shaped, obligate anaerobic, Gram-stain-positive bacteria isolated from the pig faeces were designated YH-ols2216 and YH-ols2217T. Analysis of 16S rRNA gene sequences revealed that these isolates were most related to the members of the family Atopobiaceae, within the order Coriobacteriales, and Granulimonas faecalis KCTC 25474T with 92.0 and 92.5% similarities, respectively. The 16S rRNA gene sequence similarity within isolates was 99.9 %; and those between isolates YH-ols2216 and YH-ols2217T, and Atopobium minutum DSM 20586T, the type sp...
Source: International Journal of Systematic and Evolutionary Microbiology - May 10, 2024 Category: Microbiology Authors: Lu Bai Jayoung Paek Yeseul Shin Hongik Kim Si Hyun Kim Jeong Hwan Shin Joong-Ki Kook Young-Hyo Chang Source Type: research

Minimally Modified Human Blood Coagulation Factor X to Bypass Direct Factor Xa Inhibitors
CONCLUSIONS: These human factor X variants have the potential to serve as a rescue reversal strategy to overcome the effect of direct factor Xa inhibitors in case of life-threatening bleeding events or emergency surgical interventions.PMID:38729577 | DOI:10.1016/j.jtha.2024.04.022 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - May 10, 2024 Category: Hematology Authors: Mark Schreuder Georges Jourdi Dejvid Veizaj David A Poole Ka Lei Cheung G éraldine Poenou Dani ël Verhoef Stella Thomassen Laura F H Janssen Alain Stepanian Tilman M Hackeng Pascale Gaussem Pieter H Reitsma Daan P Geerke Virginie Siguret Mettine H A Bos Source Type: research

Effects of radical scavengers for reactive oxygen species on vitamin K-induced phototoxicity under UVA irradiation
Toxicol In Vitro. 2024 May 7:105839. doi: 10.1016/j.tiv.2024.105839. Online ahead of print.ABSTRACTVitamin K possesses efficacy as a topical dermatological agent. However, vitamin K is phototoxic and susceptible to photodegradation. Herein, we investigated the mechanisms underlying the phototoxicity of phylloquinone (PK, vitamin K1) and menaquinone-4 (MK-4, vitamin K2) under ultraviolet A (UVA) irradiation using various reactive oxygen species (ROS) scavengers. This resulted in the production of superoxide anion radicals via type I and singlet oxygen via type II photodynamic reactions, which were quenched by the ROS scaven...
Source: Toxicology in Vitro - May 9, 2024 Category: Toxicology Authors: Shotaro Goto Shuichi Setoguchi Kazuhisa Matsunaga Jiro Takata Source Type: research

Effects of radical scavengers for reactive oxygen species on vitamin K-induced phototoxicity under UVA irradiation
Toxicol In Vitro. 2024 May 7;98:105839. doi: 10.1016/j.tiv.2024.105839. Online ahead of print.ABSTRACTVitamin K possesses efficacy as a topical dermatological agent. However, vitamin K is phototoxic and susceptible to photodegradation. Herein, we investigated the mechanisms underlying the phototoxicity of phylloquinone (PK, vitamin K1) and menaquinone-4 (MK-4, vitamin K2) under ultraviolet A (UVA) irradiation using various reactive oxygen species (ROS) scavengers. This resulted in the production of superoxide anion radicals via type I and singlet oxygen via type II photodynamic reactions, which were quenched by the ROS sca...
Source: Toxicology in Vitro - May 9, 2024 Category: Toxicology Authors: Shotaro Goto Shuichi Setoguchi Kazuhisa Matsunaga Jiro Takata Source Type: research

Critical Appraisal on the Role of Warfarin in the Current Era
J Assoc Physicians India. 2023 Oct;71(10):31-36. doi: 10.59556/japi.71.0378.ABSTRACTWarfarin has been the most extensively used oral anticoagulant (OAC) in medical settings for over 60 years. Its uses, potential adverse effects, and methods for reversing its effects have been firmly established, rendering it a routine medication in medical settings where most professionals feel at ease employing it. Compared to other vitamin K antagonists (VKAs), such as acenocoumarol, warfarin offers benefits like diminished prothrombin time (PT) assays leading to enhanced oral anticoagulation. Observations over the past few years have se...
Source: Journal of the Association of Physicians of India - May 8, 2024 Category: General Medicine Authors: Tiny Nair Source Type: research

 Streptomyces pyxinae sp. nov. and Streptomyces pyxinicus sp. nov. isolated from lichen Pyxine cocoes (Sw.) Nyl
Int J Syst Evol Microbiol. 2024 May;74(5). doi: 10.1099/ijsem.0.006364.ABSTRACTTwo novel actinobacteria, designated as LP05-1T and LP11T, were isolated from the lichen Pyxine cocoes (Sw.) Nyl. collected in Bangkok, Thailand. Genotypic and phenotypic analyses revealed that both strains represented members of the genus Streptomyces. The 16S rRNA gene of LP05-1T showed the highest similarity to the genome of Streptomyces gelaticus (98.41 %), while the 16S rRNA gene of LP11T was most similar to that of Streptomyces cinerochromogenes (98.93 %). The major menaquinones in LP05-1T were MK-9(H8), MK-9(H6), MK-9(H4) and MK-9(H2), an...
Source: International Journal of Systematic and Evolutionary Microbiology - May 7, 2024 Category: Microbiology Authors: Achiraya Somphong Wetchasart Polyiam Chanwit Suriyachadkun Paranee Sripreechasak Enjuro Harunari Yasuhiro Igarashi Somboon Tanasupawat Wongsakorn Phongsopitanun Source Type: research

Sa1577 THE ROLE OF INTRAVENOUS VITAMIN K IN THE CORRECTION OF CIRRHOSIS-ASSOCIATED COAGULOPATHY.
(Source: Gastroenterology)
Source: Gastroenterology - May 6, 2024 Category: Gastroenterology Authors: Hila Shaim, Kian Abdul-Baki, Jordan C. Malone, Anni Chowdhury, Edward Butt, Moe Ameri, Daniel Shofner, Marissa Lee, Milee Patel, Pooja Bhakta, Michael Antony, Peter McCaffrey, Sean Yates Tags: AASLD Abstracts Source Type: research

In older patients with AF and frailty, switching from VKA to NOAC therapy increased a composite of major or CRNM bleeding at 12 mo
Ann Intern Med. 2024 May 7. doi: 10.7326/J24-0024. Online ahead of print.ABSTRACTJoosten LP, van Doorn S, van de Ven PM, et al. Safety of switching from a vitamin K antagonist to a non-vitamin K antagonist oral anticoagulant in frail older patients with atrial fibrillation: results of the FRAIL-AF randomized controlled trial. Circulation. 2024;149:279-289. 37634130.PMID:38710082 | DOI:10.7326/J24-0024 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - May 6, 2024 Category: Internal Medicine Authors: Andrew Dunn Source Type: research