Vitamin K Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Non-vitamin K oral anticoagulants versus warfarin for the treatment of left ventricular thrombus
CONCLUSION: Non-vitamin K oral anticoagulants may be an efficacious and safe alternative to warfarin for LVT management. Future studies should explore the safety and efficacy of anticoagulation discontinuation by 1 year as an overall strategy.PMID:38327164 | DOI:10.12809/hkmj2210034 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - February 8, 2024 Category: General Medicine Authors: K K H Kam J S K Chan A P W Lee Source Type: research

Non-vitamin K oral anticoagulants versus warfarin for the treatment of left ventricular thrombus
CONCLUSION: Non-vitamin K oral anticoagulants may be an efficacious and safe alternative to warfarin for LVT management. Future studies should explore the safety and efficacy of anticoagulation discontinuation by 1 year as an overall strategy.PMID:38327164 | DOI:10.12809/hkmj2210034 (Source: Hong Kong Med J)
Source: Hong Kong Med J - February 8, 2024 Category: General Medicine Authors: K K H Kam J S K Chan A P W Lee Source Type: research

 Myceligenerans pegani sp. nov., an endophytic actinomycete isolated from Peganum harmala L. in Xinjiang, PR China
Int J Syst Evol Microbiol. 2024 Feb;74(2). doi: 10.1099/ijsem.0.006179.ABSTRACTAn endophytic actinomycete designated TRM65318T, was isolated from the root of Peganum harmala L. Its taxonomic status was determined using a polyphasic approach. Comparative 16S rRNA gene sequence analysis indicated that strain TRM65318T is phylogenetically most closely related to Myceligenerans salitolerans XHU 5031T (98.15 %) and Myceligenerans xiligouense DSM 15700T (97.78 %). The peptidoglycan belonged to type A4α. The polar lipids were phosphatidylinositol, phosphatidylglycerol, diphosphatidylglycerol, two unknown lipids and three glycoli...
Source: International Journal of Systematic and Evolutionary Microbiology - February 5, 2024 Category: Microbiology Authors: Xin Li YuXiang Yao Zhanfeng Xia XiaoXia Luo LiLi Zhang Source Type: research

 Streptomyces herbicida sp. nov., a novel actinomycete with antibacterial and herbicidal activity isolated from soil
Int J Syst Evol Microbiol. 2024 Feb;74(2). doi: 10.1099/ijsem.0.006263.ABSTRACTA novel actinobacterial strain (NEAU-HV9T) showing antibacterial activity against Ralstonia solanacearum and herbicidal activity against Amaranthus retroflexus L. was isolated from soil sampled in Bama yao Autonomous County, Hechi City, Guangxi Zhuang Autonomous Region. The strain is aerobic and Gram-positive. Phylogenetic analysis based on 16S rRNA gene sequence indicated that strain NEAU-HV9T belonged to the genus Streptomyces and showed high 16S rRNA sequence similarity to Streptomyces panaciradicis 1MR-8T (98.90 %), Streptomyces sasae JR-39T...
Source: International Journal of Systematic and Evolutionary Microbiology - February 5, 2024 Category: Microbiology Authors: Yanfang Luo Ling Ling Kun Zhang Zhengke Song Lida Zhang Jiaxin Li Jie Chen Wensheng Xiang Xiangjing Wang Junwei Zhao Source Type: research

Exploring 2-methyl-substituted vitamin K 3 derivatives with potent inhibitory activity against the 3CL protease of SARS-CoV-2
Bioorg Med Chem Lett. 2024 Feb 2;100:129642. doi: 10.1016/j.bmcl.2024.129642. Online ahead of print.ABSTRACTSince the outbreak of the pandemic, various anti-SARS-CoV-2 drugs have been developed. In particular, 3CL protease (3C-like protease, 3CLpro) is an attractive drug target because it is an essential enzyme for viral multiplication and is present only in viruses, not in humans. To date, 3CLpro inhibitors against SARS-CoV-2 such as nirmatrelvir and ensitrelvir have been launched as oral drugs in Japan, but there is still no potent drug against SARS-CoV-2, due to issues of in vivo absorption and stability. Recently, vita...
Source: Bioorganic and Medicinal Chemistry Letters - February 4, 2024 Category: Chemistry Authors: Ryohto Koharazawa Mayu Hayakawa Kazuki Takeda Kotone Miyazaki Chisato Tode Yoshihisa Hirota Yoshitomo Suhara Source Type: research

Taipan snake venom time has high sensitivity for lupus anticoagulants in non-anticoagulated, triple positive antiphospholipid syndrome patients
CONCLUSIONS: TSVT/ET has high sensitivity for the clinically significant LA found in triple positive APS patients. TSVT/ET can establish multiple LA assay positivity in nonanticoagulated patients negative for one of dRVVT or APTT, and is the only assay pairing insensitive to VKAs, the recommended anticoagulation for APS.PMID:38303489 | DOI:10.1111/ijlh.14240 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - February 2, 2024 Category: Hematology Authors: Gary W Moore Sean Platton Nada Yartey Eleanor Foxton Danielle White Stephen G MacDonald Source Type: research

Outcomes after TAVI in patients with atrial fibrillation and a history of recent PCI: Results from the ENVISAGE-TAVI AF trial
ConclusionsPatients with AF undergoing TAVI with a recent PCI have a similar risk of ischemic events and mortality, but an increased risk of major bleeding compared with patients without a recent PCI.Graphical abstract (Source: Clinical Research in Cardiology)
Source: Clinical Research in Cardiology - January 31, 2024 Category: Cardiology Source Type: research

Direct oral anticoagulants versus vitamin K antagonists in patients with atrial fibrillation and stage 5 chronic kidney disease under dialysis: A systematic review and meta-analysis of randomized controlled trials
ConclusionThis meta-analysis suggests that in patients with AF on dialysis, the use of DOACs was associated with a significant reduction in stroke, and a numerical trend of less incidence of major bleeding compared with VKAs, but in this case with no statistical significance. Results may be limited by a small sample size or insufficient statistical power. (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - January 28, 2024 Category: Hematology Source Type: research

Prevalence of Guideline Discordant Aspirin use and Associated Adverse Events in Patients on Warfarin for Mechanical Valve Replacement
Antithrombotic therapy guidelines change over time due to evolving research and available treatments. For concomitant aspirin in patients on vitamin K antagonists for ischemic stroke prevention in mechanical heart valves, guidelines have shifted. In 2020, citing the fact that previous studies included many patients with older-generation valve prostheses and acknowledging the increased risk of major bleeding, the American College of Cardiology (ACC) and American Heart Association (AHA) reversed their previous recommendations to routinely add aspirin to VKA therapy. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - January 25, 2024 Category: General Medicine Authors: Brian Haymart, Xiaowen Kong, Mona Ali, Jordan K. Schaefer, James B. Froehlich, Noelle Ryan, Beverly Stallings, Geoffrey D. Barnes, Scott Kaatz Tags: Clinical Research Study Source Type: research

Non-vitamin-K-antagonist oral anticoagulants (NOACs) after acute myocardial infarction: a network meta-analysis
CONCLUSIONS: Compared with placebo, rivaroxaban reduces all-cause mortality and probably reduces cardiovascular mortality after AMI in people without an indication for anticoagulation. Dabigatran may reduce the rate of all-cause mortality and may have little or no effect on cardiovascular mortality. There is probably no meaningful difference in the rate of all-cause mortality and cardiovascular mortality between apixaban and placebo. Moreover, we found no meaningful benefit in efficacy outcomes for specific therapy doses of any investigated NOACs following AMI in people without an indication for anticoagulation. Evidence f...
Source: Cochrane Database of Systematic Reviews - January 24, 2024 Category: General Medicine Authors: Samer Al Said Klaus Kaier Wael Sumaya Dima Alsaid Daniel Duerschmied Robert F Storey C Michael Gibson Dirk Westermann Samer Alabed Source Type: research

Efficacy and Safety of Non-Vitamin-K Antagonist Oral Anticoagulants Versus Warfarin Across the Spectrum of Body Mass Index and Body Weight: An Individual Patient Data Meta-Analysis of Four Randomized Clinical Trials of 58 464 Patients With Atrial Fibrillation
CONCLUSIONS: The treatment effect of NOAC versus warfarin in atrial fibrillation is generally consistent for stroke/SEE across the spectrum of BMI and BW, whereas the reduction in major bleeding is attenuated at a higher BMI and BW. Death and the net clinical outcome are reduced with NOACs versus warfarin overall, although there remain uncertainties for these outcomes at a very high BMI and BW.PMID:38264923 | DOI:10.1161/CIRCULATIONAHA.123.066279 (Source: Circulation)
Source: Circulation - January 24, 2024 Category: Cardiology Authors: Siddharth M Patel Eugene Braunwald Jan Steffel Giuseppe Boriani Michael G Palazzolo Elliott M Antman Erin A Bohula Anthony P Carnicelli Stuart J Connolly John Eikelboom Baris Gencer Christopher B Granger David A Morrow Manesh R Patel Lars Wallentin Christ Source Type: research