Potential of postbiotics for the treatment of metabolic disorders
Drug Discov Today. 2024 Feb 19:103921. doi: 10.1016/j.drudis.2024.103921. Online ahead of print.ABSTRACTPostbiotics, the next generation of probiotics, are extracts that are free of living and nonviable bacteria and show strong modulatory effects on the gut flora. Examples include vitamin B12, vitamin K, folate, lipopolysaccharides, enzymes, and short-chain fatty acids (SCFAs), representing a subset of essential nutrients commonly found in the human diet. Postbiotics have been observed to demonstrate antiobesity and antidiabetic effects through a variety of mechanisms. These pathways primarily involve an elevation in energ...
Source: Drug Discovery Today - February 21, 2024 Category: Drugs & Pharmacology Authors: Neeraj Mishra Ashish Garg Sumel Ashique Shvetank Bhatt Source Type: research
Potential of postbiotics for the treatment of metabolic disorders
Drug Discov Today. 2024 Feb 19:103921. doi: 10.1016/j.drudis.2024.103921. Online ahead of print.ABSTRACTPostbiotics, the next generation of probiotics, are extracts that are free of living and nonviable bacteria and show strong modulatory effects on the gut flora. Examples include vitamin B12, vitamin K, folate, lipopolysaccharides, enzymes, and short-chain fatty acids (SCFAs), representing a subset of essential nutrients commonly found in the human diet. Postbiotics have been observed to demonstrate antiobesity and antidiabetic effects through a variety of mechanisms. These pathways primarily involve an elevation in energ...
Source: Drug Discovery Today - February 21, 2024 Category: Drugs & Pharmacology Authors: Neeraj Mishra Ashish Garg Sumel Ashique Shvetank Bhatt Source Type: research
Vitamin K: Infection, Inflammation, and Auto-Immunity
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - February 20, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Effect of China national centralized drug procurement policy on anticoagulation selection and hemorrhage events in patients with AF in Suining
Conclusion: The NCDP policy has markedly improved anticoagulation management in patients with AF. This policy has played a crucial role in enhancing medication adherence and significantly reducing the incidence of hemorrhagic events among these patients. Additionally, the NCDP policy has proven to be a key factor in guiding the selection and modification of anticoagulant therapies in the AF patient population. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Source Type: research
Plasma: indications, controversies, and opportunities
Postgrad Med. 2024 Feb 16. doi: 10.1080/00325481.2024.2320080. Online ahead of print.ABSTRACTPlasma is overused as a blood product worldwide; however, data supporting appropriate use of plasma is scant. Its most common utilization is for treatment of coagulopathy in actively bleeding patients; it is also used for coagulation optimization prior to procedures with specific coagulation profile targets. A baseline literature review in PUBMED and Google Scholar was done (1 January 2000 to 1 June 2023), utilizing the following search terms: plasma, fresh frozen plasma, lyophilized plasma, indications, massive transfusion protoco...
Source: Postgraduate Medicine - February 16, 2024 Category: Internal Medicine Authors: Michael A Benson Deborah Tolich Jeannie L Callum Moises Auron Source Type: research
Diagnostic accuracy of serum protein induced by vitamin K absence (PIVKA ‐II), serum a‐fetoprotein and their combination for hepatocellular carcinoma among Caucasian cirrhotic patients with diagnostic or non‐diagnostic serum a‐fetoprotein levels
ConclusionsEach biomarker separately showed acceptable accuracy for detecting HCC in cirrhotic patients and excellent for those in BCLC-C stage. The combination of the biomarkers presented excellent results in BCLC-B/C patients. The diagnostic accuracy of PIVKA-II and the combination of the two biomarkers in patients expressing low/non-diagnostic AFP levels was good in BCLC-B and excellent in BCLC-C patients. (Source: Cancer Medicine)
Source: Cancer Medicine - February 16, 2024 Category: Cancer & Oncology Authors: Antonia Syriha,
Spyridon Pantzios,
Dionysia Mandilara,
Petros Galanis,
Ioanna Stathopoulou,
Georgia Barla,
Ioannis Elefsiniotis Tags: RESEARCH ARTICLE Source Type: research
Development of propolis, hyaluronic acid, and vitamin K nano-emulsion for the treatment of second-degree burns in albino rats
Burns are the fourth most common type of injury worldwide. Many patients also suffer numerous infections and complications that impair the burn healing process, which makes the treatment of burns a challenge. ... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - February 16, 2024 Category: Complementary Medicine Authors: Marwan Elsamman, Ola M. El-borady, Mohanad M. Nasr, Zeinab Al-Amgad and Asmaa A. Metwally Tags: Research Source Type: research
Correction for 'Long-term comparative effectiveness of antihypertensive monotherapies in primary prevention of cardiovascular events: a population-based retrospective inception cohort study in the Netherlands
This article has been corrected since it was published online. We identified a small error in the syntax defining the outcome in our study. The outcome definition is defined as ‘at least two drug prescriptions of either a platelet aggregation inhibitor (B01AC), organic nitrate (C01DA) and/ or a vitamin K antagonist (B01AA) or other vasodilators used in acute cardiac disease therapies (C01DX), in a time window of 180 days whichever comes first, after the index date.’ In the current published version, we observed 5205 patients who had an outcome. However, due to an overseen error in the SQL syntax used to define ...
Source: BMJ Open - February 15, 2024 Category: General Medicine Tags: Open access Correction Source Type: research
Splanchnic Vein Thrombosis: The State-of-the-Art on Anticoagulant Treatment
Hamostaseologie. 2024 Feb 14. doi: 10.1055/a-2232-5480. Online ahead of print.ABSTRACTSplanchnic vein thrombosis (SVT) is a rare type of venous thromboembolism occurring within the splanchnic venous system. Portal vein thrombosis is the most common presentation, while Budd-Chiari syndrome is the least common. Liver cirrhosis and abdominal solid cancer are the main local risk factors for SVT, whereas myeloproliferative neoplasms are the predominant systemic risk factors. Signs and symptoms of SVT are nonspecific and include abdominal pain, gastrointestinal bleeding, and ascites. Asymptomatic SVT is not uncommon, and the maj...
Source: Hamostaseologie - February 14, 2024 Category: Hematology Authors: Scott Custo Emma Tabone Alexia Aquilina Alex Gatt Nicoletta Riva Source Type: research
Microbacterium aquilitoris sp. nov. and Microbacterium gwkjiense sp. nov., isolated from beach
Arch Microbiol. 2024 Feb 14;206(3):100. doi: 10.1007/s00203-023-03804-5.ABSTRACTThree Gram-reaction-positive bacterial strains, designated KSW-18T, KSW2-22, and KSW4-11T, were isolated from seawater, and two dried seaweed samples collected at Gwakji Beach in Jeju, Republic of Korea, respectively, and their taxonomic positions were examined by a polyphasic approach. The 16S rRNA gene phylogeny showed that strain KSW4-11T was tightly associated with Microbacterium oleivorans NBRC 103075T, while strains KSW-18T and KSW2-22 formed a distinctive subline at the base of a clade including the above two strains. The three isolates ...
Source: Archives of Microbiology - February 14, 2024 Category: Microbiology Authors: Soon Dong Lee Hong Lim Yang Ji-Sun Kim In Seop Kim Source Type: research
