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Comparison of factor X inhibitors versus vitamin K antagonists in atrial fibrillation patients on dialysis
Eur J Intern Med. 2024 May 18:S0953-6205(24)00214-0. doi: 10.1016/j.ejim.2024.05.010. Online ahead of print.NO ABSTRACTPMID:38763847 | DOI:10.1016/j.ejim.2024.05.010 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 19, 2024 Category: Internal Medicine Authors: Xi Chen Wengen Zhu Meiming Lin Source Type: research

Translation into French and republication of: "Management of venous thromboembolic disease in patients with malignant brain tumours"
This article addresses the management of venous thromboembolism in patients with malignant brain tumours, including both primary and secondary (metastatic) tumours. The available data on patients on venous thromboembolism recurrence and bleeding risks in patients with brain tumours is limited, since these patients have been excluded from most randomised, interventional, head-to-head, clinical trials comparing low molecular weight heparins to vitamin K antagonists or to direct oral factor Xa inhibitors. More information is available from retrospective observational studies, which however were generally small, and carried a ...
Source: Revue de Medecine Interne - May 19, 2024 Category: Internal Medicine Authors: I Mah é C Fr ère G Pernod O Sanchez A Id Baih INNOVTE CAT Working Group Source Type: research

Acute Q fever revealed by an anti-phospholipid syndrome: A case report
CONCLUSION: During acute C. burnetii infections, anti-phospholipid antibodies are highly prevalent but thrombotic complications are rare. The 2023 ACR/EULAR APS criteria restricts the diagnosis of APS, as in our case of acute severe infection. In front of an atypical pneumonia and/or thrombotic events, screening of C. burnetii and anti-phospholipid antibodies could be useful. Given its low level of evidence, prolongated treatment by doxycycline, hydroxychloroquine ± anticoagulant for C. burnetii's associated anti-phospholipid syndrome is discussed, but succeeded in our case.PMID:38762438 | DOI:10.1016/j.revmed.2024.05.006...
Source: Revue de Medecine Interne - May 18, 2024 Category: Internal Medicine Authors: K Balasoupramanien J-B Roseau N Cazes C Surcouf E Le Dault Source Type: research

< em > Phytohabitans maris < /em > sp. nov., isolated from marine sediment
Int J Syst Evol Microbiol. 2024 May;74(5). doi: 10.1099/ijsem.0.006393.ABSTRACTA novel actinobacterium, strain ZYX-F-186T, was isolated from marine sediment sampled on Yongxing Island, Hainan Province, PR China. Based on the results of 16S rRNA gene sequence analysis, strain ZYX-F-186T belongs to the genus Phytohabitans, with high similarity to Phytohabitans kaempferiae KK1-3T (98.3 %), Phytohabitans rumicis K11-0047T (98.1 %), Phytohabitans flavus K09-0627T (98.1 %), Phytohabitans houttuyneae K11-0057T (97.9 %), Phytohabitans suffuscus K07-0523T (97.7 %), and Phytohabitans aurantiacus RD004123T (97.7 %). Phylogenetic anal...
Source: International Journal of Systematic and Evolutionary Microbiology - May 16, 2024 Category: Microbiology Authors: Ke-Xin Yi Qing-Yi Xie Qing-Yun Ma Li Yang Hao-Fu Dai Yu-E Hao You-Xing Zhao Source Type: research

Ischemic Stroke Severity and Mortality After Left Atrial Appendage Closure vs Non-warfarin Oral Anticoagulants in Patients with Prior Stroke
In a multicenter observational study of stroke severity after various stroke prevention strategies, we recently demonstrated that ischemic stroke (IS) in patients with atrial fibrillation (AF) who had received left atrial appendage closure (LAAC) is less often disabling/fatal than IS in patients receiving non-vitamin K oral antagonists (NOAC). (1) However, AF patients with a previous IS are distinguished by a higher propensity for recurrent stroke and greater resulting neurological disability and mortality. (Source: Heart Rhythm)
Source: Heart Rhythm - May 16, 2024 Category: Cardiology Authors: Mohit K. Turagam, Iwanari Kawamura, Petr Neuzil, Devi Nair, Shephal Doshi, Miguel Valderrabano, Pavel Hala, Domenico Della Rocca, Douglas Gibson, Moritoshi Funasako, Grace Ha, Bridget Lee, Daniel Musikantow, David Yoo, Thomas Flautt, Srinivas Dukkipati, A Source Type: research

Is There an Alternative Oral Anticoagulation to Vitamin-K-Antagonists for Patients with Mechanical Aortic Valve Replacement? – A Literature Review
AbstractCurrent guidelines exclusively recommend vitamin-K-antagonists (VKA) as anticoagulation for patients after mechanical aortic valve replacement due to the increased postoperative risk of valve thrombosis and thrombo-embolism. Strict and regular assessments are mandatory during VKA therapy to ensure a potent anticoagulatory effect within the desired range. From the patients ’ perspective, VKA are associated with relevant interactions and side effects reducing the quality of life and contributing to a high number of patients not achieving the optimal therapeutic target. Direct oral anticoagulants (DOAC) have replace...
Source: Cardiology and Therapy - May 16, 2024 Category: Cardiology Source Type: research

Update on Perioperative Antithrombotic Management
AbstractPurpose of the ReviewIn this review, we discuss the recent studies and recommendations on the perioperative management of oral anticoagulant and antiplatelet drugs.Recent FindingsIn elective surgery, clear and simple recommendations exist for oral anticoagulants and antiplatelet drugs. The shorter stopping intervals with direct-acting oral anticoagulants have simplified the perioperative management compared with vitamin K antagonists. The specific use of laboratory testing is suggested for bleeding patients treated with antithrombotic drugs or for emergent surgery. The postoperative prevention of thromboembolism ha...
Source: Current Anesthesiology Reports - May 15, 2024 Category: Anesthesiology Source Type: research