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[Relapsing polychondritis: What's new in 2017?]
Authors: Dion J, Leroux G, Mouthon L, Piette JC, Costedoat-Chalumeau N Abstract Relapsing polychondritis (RP) is a rare condition characterized by recurrent inflammation of cartilaginous tissue and systemic manifestations. Data on pathophysiology are scarce and suggest an autoimmune mechanism. Recently, the possibility of dividing patients with RP into three distinct clinical phenotypes has been suggested: the hematological form representing less than 10% of patients, essentially older men with associated myelodysplasia and poor prognosis, the respiratory form representing about 25% of patients with predominant tra...
Source: Revue de Medecine Interne - September 12, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Secondary thrombotic microangiopathies].
Authors: Coppo P, Centre de référence des microangiopathies thrombotiques (CNR-MAT) Abstract Thrombotic microangiopathies (TMA) are termed secondary when associated to a specific context favouring their occurrence. They encompass mainly TMA associated with pregnancy, allogeneic hematopoietic stem cell transplantation, cancer, drugs, or HIV infection. Secondary TMA represent a heterogeneous group of diseases which clinical presentation largely depends on the associated context. It is therefore mandatory to recognize these conditions since they have a significant impact in TMA management and prognosis. ...
Source: Revue de Medecine Interne - September 12, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Weight loss and fever].
Authors: Hocqueloux M, Enfrein A, Génin V, Caristan A, Néel A, Agard C PMID: 28882622 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 9, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acute management of ischemic stroke in 2017].
Authors: Blanc-Labarre C, Delpont B, Hervieu-Bègue M, Osseby GV, Ricolfi F, Thouant P, Giroud M, Béjot Y Abstract Acute management of ischemic stroke is a burning topic in 2017 since stroke represents the leading cause of acquired handicap in adults. Over the last past years, major improvement took place, especially with the demonstration of the efficacy of mechanical thrombectomy, thus needing to better organize care pathways, and optimize access to neurologists and interventional neuroradiology platforms. Intensive care stroke units remain the pivotal place of patients' management. A multidisciplina...
Source: Revue de Medecine Interne - September 6, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Eosinophilia heralding the diagnosis of eosinophilic fasciitis (Shulman's disease)].
CONCLUSION: In this case report, eosinophilia was preceding the clinical cutaneous signs that led to the diagnosis of eosinophilic fasciitis. It is likely to believe that myalgias, frequently found in the onset of eosinophilic fasciitis, may have been hidden by the history of infantile encephalopathy. The diagnosis of eosinophilic fasciitis must be kept in mind of physicians in the investigation of an eosinophilia, even though cutaneous signs are lacking. PMID: 28867532 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 6, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Primary intestinal lymphangiectasia (Waldmann's disease)].
Authors: Vignes S, Bellanger J Abstract Primary intestinal lymphangiectasia (PIL), Waldmann's disease, is a rare disorder of unknown etiology characterized by dilated intestinal lacteals leading to lymph leakage into the small-bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia, hypoalbuminemia and hypogammaglobulinemia. PIL is generally diagnosed before 3 years of age but may be diagnosed in older patients. The main symptom is bilateral lower limb edema. Edema may be moderate to severe including pleural effusion, pericarditis or ascites. Protein-losing enteropathy is confirmed by...
Source: Revue de Medecine Interne - September 6, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Vitamin K antagonist-induced necrotic leg ulcer, without protein C and S deficiencies].
CONCLUSION: We report an original case of necrotic leg ulcers induced by VKA without deficit of protein C or S, with a pyoderma like histology. Reported cases of ulcers induced by VKA are uncommon and the physiopathology is not well known. The involvement of VKA should be evoked in case of necrotic leg ulcer without specific etiology found. PMID: 28867534 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 6, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Statins in primary prevention of cardiovascular disease].
We report in this review the updated conclusions from clinical trials regarding the treatment with statins in primary prevention. PMID: 28866432 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 5, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A case of gonococcal arthritis: Diagnostic difficulties and usefulness of synovial fluid PCR].
CONCLUSION: In patients with high risk of N. gonorrhoeae infection, PCR for detection of gonorrhea in synovial fluid could potentially facilitate the diagnostic of gonococcal septic arthritis. PMID: 28844395 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 30, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Extensive cutaneous lesions].
Authors: Fenot M, Riegert M, Poiraud C, Gegu M, André V PMID: 28844396 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 30, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Vascular renal abnormalities].
Authors: Journeau L, Vincent M, Perret C, Connault J PMID: 28838606 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 27, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[From pathogenesis of giant cell arteritis to new therapeutic targets].
Authors: Samson M, Bonnotte B Abstract Giant cell arteritis (GCA) is the most common vasculitis in adults. GCA is a granulomatous large-vessel vasculitis involving the aorta and its major branches in people>50 years. Glucocorticoids (GC) remain the cornerstone of GCA treatment. Prednisone is usually started at 0.7 or 1mg/kg/day depending on the occurrence of ischemic complications. Then, GC are progressively tapered and stopped after a mean duration of 18 months. GC are very efficient but relapses often occur during their tapering. Moreover, GC-related side effects are very common during this long term...
Source: Revue de Medecine Interne - August 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Vasculitis of the hepatic artery: A case of a single-organ vasculitis].
We report the case of a patient who developed a vasculitis of the right and left hepatic arteries. CASE REPORT: A 63-year-old woman presented with unexplained abdominal pain. A computed tomography of the abdomen was suggestive of vasculitis of the hepatic arteries, showing a sequence of stenosis and aneurysmal dilatations of the hepatic arteries. There were no other arterial involvement, in particular of the abdomen and the brain. No other systemic disease or infection was found. The outcome was favorable, with corticosteroids alone. DISCUSSION: The exclusive involvement of the hepatic artery is an exceptional form...
Source: Revue de Medecine Interne - August 10, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Weakness of the left hand and pallor in a 21-year-old woman].
Authors: de Luna G, Arlet JB, Passeron A, Ranque B, Michon A, Pouchot J, Lozac'h P, Lapoirie J, Bourdin V PMID: 28780283 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Chronic asthenia and abdominal pain in a 26-year-old woman].
Authors: Abbara S, Georgin-Lavialle S, Bachmeyer C, Hermine O, Launay JM, de Lastours V PMID: 28755907 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 2, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hypersensitivity reactions to beta-lactam antibiotics].
Authors: Amsler E, Soria A Abstract Allergy to beta-lactam antibiotics is a common condition and about 10% of patients report being allergic to penicillin. However, this diagnosis is largely overestimated. Two types of allergy should be distinguished and include immediate hypersensitivity that can lead to anaphylactic shock and delayed hypersensitivity, ranging from the most common maculopapular exanthema to severe bullous toxidermia or life-threatening DRESS. Allergy challenge with oriented skin tests according to the clinical features, supplemented with oral challenge in the absence of contraindication, will conf...
Source: Revue de Medecine Interne - July 31, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A left peri-renal infiltration].
Authors: Masson E, Scemama UA, Lignères MA, Benyamine A, Rossi P, Chaumoitre K, Granel B PMID: 28734579 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 24, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Cutaneous lesions in a 69-year-old woman].
Authors: Masri R, Damade R, Al Gain M, Bouaziz JD, Wyndham-Thomas C PMID: 28734580 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 24, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[An unusual case of renal failure in a 22-year-old woman].
Authors: Gramont B, Guichard I, Basset T, Boucher A, Charmion S, Savall A, Munoz-Pons H, Schein F, Masson I, Cathébras P, Coute L PMID: 28728706 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 23, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Disseminated nocardiosis caused by Nocardia nova with brain abscesses and osteomyelitis in an immunocompetent patient].
CONCLUSION: This observation is original because it involves a immunocompetent patient with an association of two exceptional locations for N. nova: brain abscesses and femoral osteomyelitis. Screening for cerebral involvement should be systematic, even in the lack of neurological signs. An adapted and prolonged antibiotherapy must be conducted. PMID: 28716481 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Respiratory distress of unusual cause].
Authors: de Charry C, Bylicki O, Mavrovi E, Le Moigne F, de Charry F PMID: 28716482 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Diffuse arthromyalgia in a 59-year-old man].
Authors: Benyamine A, Brun M, Jarrot PA, Mazodier K, Jean R, Sevy A, Chagnaud C, Hanssens K, Granel B, Kaplanski G, Asli B PMID: 28711158 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hemolytic and uremic syndrome and related thrombotic microangiopathies: Epidemiology, pathophysiology and clinics].
Authors: Rafat C, Coppo P, Fakhouri F, Frémeaux-Bacchi V, Loirat C, Zuber J, Rondeau E Abstract Thrombotic microangiopathies (TMA) represent an eclectic group of conditions, which share hemolytic anemia and thrombocytopenia as a common defining basis. Remarkable breakthroughs in the physiopathological setting have allowed for a thorough recomposition of the disparate syndromes, which form the constellation of TMA. In this view, clinicians now discriminate thrombocytopenic thrombotic purpura (TTP) defined by a severe deficiency in ADAMTS13, which is rarely associated with a severe renal involvement and the he...
Source: Revue de Medecine Interne - July 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Systemic sclerosis and occupational difficulties: Results of a prospective study].
Authors: Peres N, Morell-Dubois S, Hachulla E, Hatron PY, Duhamel A, Godard D, Tellart-Mamert AS, Lambert M, Launay D, Fantoni-Quinton S Abstract Between 9000 and 14000 people have systemic sclerosis (ScS) in France. The work is often affected. Our study aims to assess the frequency of professional difficulties (DP) of scleroderma patients, identify these DP, the symptoms involved and the solutions used. A heteroquestionnaire was offered to scleroderma patients the Lille University Hospital. Data were cross-checked with the clinical database of the National Observatory of scleroderma patients. We used 104 questionn...
Source: Revue de Medecine Interne - July 15, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Diffuse cutaneous abnormality].
Authors: Zenati N, Carpentier PH, Blaise S PMID: 28690089 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Pituitary hyperplasia due to primary hypothyroidism].
CONCLUSION: Pituitary hyperplasia due to primary hypothyroidism, although rare, should be recognized to avoid unnecessary surgery leading to irreversible complications. PMID: 28690090 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Paget's disease of bone: Diagnostic and therapeutic updates].
Authors: Alaya R, Alaya Z, Nang M, Bouajina E Abstract Paget's disease of bone is the second most common metabolic bone disease after osteoporosis. Its pathogenesis is not yet clearly understood. Geographic distribution and epidemiological variations suggest a role of genetic and environmental factors in its pathophysiology. The frequency of the Paget's disease of bone increases with age. Its discovery can be fortuitous. Prognosis mainly depends on the occurrence of complications involving bones and joints, neurological, cardiovascular or metabolic systems. Treatment of symptomatic forms currently relies on bisphos...
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Long-lasting thrombocytopenia induced by glycoprotein IIb/IIIa inhibitor].
CONCLUSION: Anti-GPIIbIIIa are associated with a risk of dramatic thrombocytopenia. The underlying mechanism is poorly understood. The management of these usually transient thrombocytopenias is based on platelet transfusion. As report here, in some cases persistent thrombocytopenia can respond to corticosteroids. PMID: 28690092 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[23rd  session of the "spring of internal medicine": How to train to solve unique cases?]
[23rd session of the "spring of internal medicine": How to train to solve unique cases?] Rev Med Interne. 2017 Jul 06;: Authors: Marchand AL PMID: 28690093 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Relevance assessment of requests for antineutrophil cytoplasmic antibodies detection: Retrospective study led in Bordeaux Hospital, France].
CONCLUSION: The majority of the requests for detection of ANCA was not relevant and could not lead to the diagnosis of AAV. Simple solutions enabled a partial but significant improvement of their relevance. PMID: 28690094 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Non-inferiority and equivalence trials: Key methodological issues].
This article presents the key points of the methodology of non-inferiority and equivalence trials in order to inform the readers of such trials about the issues and critical points. The general methodology (hypotheses, decision rules, number of subjects required, and strategy of analysis) is presented using examples and graphic illustrations. The issues and critical points are identified and discussed, in particular the choice of the comparator and of the margin of non-inferiority. PMID: 28693836 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Should doses of antibiotics be adjusted?]
Authors: de Lastours V Abstract While we are confronted with the major increase in antibiotic resistance, the preservation of existing antibiotics has become an absolute necessity both to achieve therapeutic success and to limit the risks of the emergence of resistance. The optimization of antibiotic use and dosages must have a threefold objective: guarantee antibacterial efficacy, limit toxicities and limit emergence of resistant strains. However, with the increase in the number of multipathological patients, particularly those with renal or hepatic impairment, the increase in the number of patients with extreme w...
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Once weekly L-thyroxine treatment in non-compliance: A case report].
CONCLUSION: The strategy of non-adherence treatment in hypothyroidism is well defined with oral testing of L-thyroxine, followed by oral or parenteral weekly administration of the drug. The L-thyroxine oral test is the gold standard for diagnosis after eliminating of the other conventional causes: drug interactions or digestive malabsorption. L-thyroxine treatment should be discussed on a case-by-case basis, either daily under surveillance or once weekly oral or parenteral high dose. PMID: 28688760 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 11, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Diagnosis and management of acquired immune haemolytic anaemia excluding neoplasia. Adequacy with the current guidelines published in 2009].
CONCLUSION: AIHA guidelines seem insufficiently applied in our center. PMID: 28687137 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 10, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

A multicentre, prospective, non-randomized, sequential, open-label trial to demonstrate the bioequivalence between intravenous immunoglobulin new generation (IGNG) and standard IV immunoglobulin (IVIG) in adult patients with primary immunodeficiency (PID).
CONCLUSION: ClairYg(®) is safe and effective in the treatment of adult PID. PMID: 28683953 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 8, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Weight loss, fever and arthralgia in a 43-year-old man treated for follicular lymphoma].
Authors: Vandeputte M, Couturier B, Vandergheynst F, Maerevoet M, Jullie ML, Kolivras A, Fontanges Q, Verset L, André J, Cogan E, Boysson H PMID: 28673687 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 5, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Two cases of myeloid sarcomas with review of literature].
CONCLUSION: The diagnosis of myeloid sarcoma must be considered when unusual tumors occur in patients with a chronic myeloid disease. In that case, therapeutic options are those of an acute myeloid leukemia. PMID: 28668372 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 4, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[The role of erythroferrone in iron metabolism: From experimental results to pathogenesis].
Authors: Vallet N, Club du Globule Rouge et du Fer Abstract In case of erythropoiesis, body iron needs to increase to enable the production of new red blood cells. In the 1950s, the observation of an increased digestive iron absorption in the case of phlebotomies had led to propose the existence of an "erythroid factor", which regulate the availability of iron for erythropoiesis in this situation. The factor regulating iron stores has been identified in 2000 to be hepcidin. Recently, in 2014, a new factor was discovered, which regulates iron metabolism, independently of iron stores and responds to the inc...
Source: Revue de Medecine Interne - July 3, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A new therapeutic era in sickle cell disease].
Authors: Arlet JB PMID: 28624233 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[An unusual cause of low back pain].
Authors: Kauffmann P, Le Borgne P, Kirsch S, Renfer C, Bilbault P PMID: 28624234 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Pulmonary hypertension screening in systemic sclerosis: The best strategy remains to be defined].
Authors: Launay D, Sobanski V PMID: 28623031 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Smoking cessation in pregnancy].
Authors: Underner M, Pourrat O, Perriot J, Peiffer G, Jaafari N PMID: 28623032 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Prevalence of macrovascular arterial involvement of the 4  limbs in systemic sclerosis: About a case series of 14 patients].
CONCLUSION: The distal macrovascular disease preferentially affecting the ulnar and posterior tibial arteries with a high frequency to the UL and two times less at LL. The pathophysiology is unclear but it could be a proper manifestation of SSc. It seems necessary that SSc patients have a strict balance of their CVRF and a screening of macrovascular arterial lesions. There is also the question of the place of an anti-atherosclerotic therapy in these patients. PMID: 28602440 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 14, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Recent dyspnea in an 86-year-old woman].
Authors: Ponsoye M, Hanslik T, Noël N PMID: 28579107 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Abnormal nails and chronic cough].
Authors: Vignes S, Simon L, Vidal F, Arrault M PMID: 28579108 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Fracture of unusual cause].
Authors: Caré W, Arnautou P, Segot A, de Charry F, Heyraud-Blanchet C, Livartowski J, Konopacki J, Malfuson JV PMID: 28579109 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A complex case of diabetes due to LMNA mutation].
CONCLUSION: Familial partial lipodystrophic syndromes may have varied phenotypes, mainly cardio-metabolic, which could mimic a particularly severe type 2 diabetes. The diagnostic work-up of this disease has to include a careful investigation of gait troubles and paroxysmal conduction that could lead to sudden death, as well as a genetic examination. In some cases, recombinant leptin can be proposed. PMID: 28545855 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 28, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Screening for pulmonary arterial hypertension in patients with systemic sclerosis: Comparison of DETECT algorithm to decisions of a multidisciplinary team, in a competence centre].
The objective of our study was to compare the indication of right heart catheterisation (RHC) as suggested by the DETECT algorithm with the decisions of a multidisciplinary team. METHODS: This prospective monocentric non-interventional study consecutively included systemic sclerosis patients when data required to apply DETECT algorithm were available. We evaluate the number of RHC as requested by this algorithm and confronted it with the indications of RHC suggested by a multidisciplinary group blinded for the result of DETECT algorithm. RESULTS: In total, 117 systemic sclerosis patients were included. When DETECT ...
Source: Revue de Medecine Interne - May 28, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Management of the bleeding risk associated with antiplatelet agents].
Authors: Martin AC, Houssany-Pissot S, Zlotnik D, Taylor G, Godier A Abstract Like all antithrombotic drugs, antiplatelet agents expose to a risk of bleeding complications. Clinical research has extensively focused on the efficacy of these drugs to reduce ischemic events. The bleeding risk associated with them was solely considered as an inevitable and acceptable complication. When two new potent P2Y12-receptor inhibitors, prasugrel and ticagrelor, were marketed, the risk of major bleeding increased. These new agents have modified the balance between the absolute risk reduction in ischemic events and the absolute r...
Source: Revue de Medecine Interne - May 22, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acute abdominal pain].
Authors: Marsaudon E, Berthy J, Gautreault A, Mamoune S, Boucekkine R PMID: 28477948 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 11, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research