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[Aspirin: Indications and use during pregnancy].
Authors: Belhomme N, Doudnikoff C, Polard E, Henriot B, Isly H, Jego P Abstract Aspirin (acetylsalicylic acid) has been used ever since the Antiquity for its painkilling and anti-inflammatory effects. Its antiplatelet properties have then extended its indications to the field of coronaropathy and vascular cerebral disease, and finally to vascular placental disease. Aspirin has been widely prescribed since the 1980's to prevent pre-eclampsia, intra-uterine growth retardation and fetal death of vascular origin. It has also been proposed to prevent unexplained recurrent miscarriages. Its use during pregnancy is consid...
Source: Revue de Medecine Interne - November 15, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Diagnostic issues of lymphogranuloma venereum: A case series of 5  patients].
CONCLUSION: LG should be evoked in any patient with inguinal adenomegaly, particularly in case of STI history or risk factors. Negativity of urinary PCR should lead to further investigations, essentially a lymph node cytopuncture to evidence C. trachomatis. PMID: 29128125 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 14, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Uveitis: Diagnostic work-up. Recommendations from an expert committee].
CONCLUSIONS: We propose a strategy for the etiologic diagnosis of uveitis. The recommendations should be updated regularly. The efficiency of more invasive investigations has yet to be evaluated. PMID: 29122311 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 12, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Cryopyrin-associated periodic syndromes].
Authors: Quartier P, Rodrigues F, Georgin-Lavialle S Abstract Cryopyrin-associated periodic syndromes (CAPS) are linked to one single gene mutations, however they are associated with 3 syndromes, which are, from the mildest to the most severe phenotype familial cold urticaria, Muckle-Wells syndrome and chronic, infantile, neurologic, cutaneous, articular (CINCA) syndrome also called neonatal-onset multisystem inflammatory disease (NOMID). Autosomic dominant inheritance is present in most cases but in CINCA/NOMID syndrome where neomutations are more common. Mutations in the gene encoding cryopyrin, NLRP3, are associ...
Source: Revue de Medecine Interne - November 8, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[End-of-life debate: Citizen's point of view about deep and continuous sedation].
CONCLUSION: Deep and continuous sedation is perceived as a euthanasic practice or raises fear of such a drift. Provision of extended and accurate information to the population and health professionals is essential to ensure that this new model of sedation is integrated into the care of the terminally ill patients and their families. PMID: 29102388 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Abnormal hair].
Authors: Coen M, Cramer B, Serratrice J PMID: 29054584 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - October 23, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Influence of epigenetic in Sj ögren's syndrome].
[Influence of epigenetic in Sjögren's syndrome]. Rev Med Interne. 2017 Oct 17;: Authors: Bordron A, Charras A, Le Dantec C, Renaudineau Y Abstract Sjögren's syndrome (SS) is a systemic autoimmune epithelitis with a major female incidence, and characterized by a dry syndrome, impaired quality of life, visceral involvement, and lymphoma for the most aggressive cases. During this process, epithelial cells acquire the capacity to produce cytokines, chemokines, and autoantigens which can in turn be presented to the immune system. Consequently, this epithelitis is accompanied by lymphocytic infiltr...
Source: Revue de Medecine Interne - October 23, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Movement disorders: An update].
Authors: Béreau M, Tranchant C Abstract Movement disorders (tremor, chorea, dystonia, tics, and myoclonus) are related to basal ganglia and/or interconnected brain areas dysfunction. Clinical examination is a key point in order to characterize the abnormal movement and identify associated signs that can guide etiological approach. Iatrogenic diseases will be systematically ruled out before conducting additional investigations (brain MRI, electrophysiological studies). Wilson disease, but also other treatable metabolic and/or genetic diseases, and auto-immune diseases will be systematically considered. Therap...
Source: Revue de Medecine Interne - October 22, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Ocular sarcoidosis: What the internist should know?]
Authors: Sève P, Kodjikian L, Jamilloux Y Abstract Sarcoidosis is one of the leading causes of inflammatory eye disease. Any part of the eye and its adnexal tissues can be involved. Uveitis and optic neuropathy are the main manifestations, which the internists face. This review reports the state of knowledge for these two ocular involvements and proposes an assessment-algorithm for sarcoidosis in patients with suspected sarcoid uveitis. Two groups of patients with sarcoid uveitis can be distinguished: one young and multiethnic group in which ophthalmological findings are various and another group of elderly ...
Source: Revue de Medecine Interne - October 19, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Severity of illness index in autoimmune diseases: Have there any usefulness in medical practice?]
CONCLUSION: The discrepancy between the ratio of practitioners who believe that scores have a place in daily practice and their actual use shows that the current scores do not meet the needs. The implementation of easily usable activity scores in inflammatory diseases remains a challenge for the internists. PMID: 29032100 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - October 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Lymphomas: A therapeutic update].
The objective of this review is to trace history of the latest advances, and to highlight the validated strategies representing the new standards of treatment of lymphomas in 2017. PMID: 28958786 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - October 1, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Focal myositis: An unknown disease].
Authors: Gallay L, Streichenberger N, Benveniste O, Allenbach Y Abstract Focal myositis are inflammatory muscle diseases of unknown origin. At the opposite from the other idiopathic inflammatory myopathies, they are restricted to a single muscle or to a muscle group. They are not associated with extramuscular manifestations, and they have a good prognosis without any treatment. They are characterized by a localized swelling affecting mostly lower limbs. The pseudo-tumor can be painful, but is not associated with a muscle weakness. Creatine kinase level is normal. Muscle MRI shows an inflammation restricted to a mus...
Source: Revue de Medecine Interne - September 29, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hemolytic and uremic syndrome and related thrombotic microangiopathies: Treatment and prognosis].
Authors: Rafat C, Coppo P, Fakhouri F, Frémeaux-Bacchi V, Loirat C, Zuber J, Rondeau E Abstract Major achievements in the understanding of thrombotic microangiopathies (TMA) have not only resulted in a reclassification of TMA but most of all they have culminated in the design of new treatments and have enabled clinicians to better delineate their prognosis. Recent multicenter studies have improved our understanding of the prognosis of atypical hemolytic and uremic syndromes (aHUS). More specifically, they have highlighted the role of genetic testing on predicting the recurrence of aHUS, the risk of chronic k...
Source: Revue de Medecine Interne - September 29, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hands and feet lesions].
Authors: Suzon B, Arnaud E, Galy C, Broner J PMID: 28942058 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 26, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Screening and clinical implications of silent atrial fibrillation].
Authors: Guenancia C, Garnier F, Mouhat B, Béjot Y, Maillot N, Fichot M, Fauchier L, Cottin Y Abstract Each year, 5 million new cases of atrial fibrillation (AF) are diagnosed, and the data for the last 20 years show that its incidence has continued to grow. The aging of the population is considered a major explanation for this pandemic phenomenon. The complications associated with atrial arrhythmia are numerous and frequent, with in the first place thromboembolic events. In addition to symptomatic atrial fibrillation, AF may be diagnosed by chance during a systematic ECG, an external Holter or a continuous ...
Source: Revue de Medecine Interne - September 26, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Cutaneous lesions].
Authors: Mohamed M, Korbi M, Hadhri R, Belhadjali H, Zili J PMID: 28942938 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 26, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Relapsing polychondritis: What's new in 2017?]
Authors: Dion J, Leroux G, Mouthon L, Piette JC, Costedoat-Chalumeau N Abstract Relapsing polychondritis (RP) is a rare condition characterized by recurrent inflammation of cartilaginous tissue and systemic manifestations. Data on pathophysiology are scarce and suggest an autoimmune mechanism. Recently, the possibility of dividing patients with RP into three distinct clinical phenotypes has been suggested: the hematological form representing less than 10% of patients, essentially older men with associated myelodysplasia and poor prognosis, the respiratory form representing about 25% of patients with predominant tra...
Source: Revue de Medecine Interne - September 12, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Secondary thrombotic microangiopathies].
Authors: Coppo P, Centre de référence des microangiopathies thrombotiques (CNR-MAT) Abstract Thrombotic microangiopathies (TMA) are termed secondary when associated to a specific context favouring their occurrence. They encompass mainly TMA associated with pregnancy, allogeneic hematopoietic stem cell transplantation, cancer, drugs, or HIV infection. Secondary TMA represent a heterogeneous group of diseases which clinical presentation largely depends on the associated context. It is therefore mandatory to recognize these conditions since they have a significant impact in TMA management and prognosis. ...
Source: Revue de Medecine Interne - September 12, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Weight loss and fever].
Authors: Hocqueloux M, Enfrein A, Génin V, Caristan A, Néel A, Agard C PMID: 28882622 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 9, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acute management of ischemic stroke in 2017].
Authors: Blanc-Labarre C, Delpont B, Hervieu-Bègue M, Osseby GV, Ricolfi F, Thouant P, Giroud M, Béjot Y Abstract Acute management of ischemic stroke is a burning topic in 2017 since stroke represents the leading cause of acquired handicap in adults. Over the last past years, major improvement took place, especially with the demonstration of the efficacy of mechanical thrombectomy, thus needing to better organize care pathways, and optimize access to neurologists and interventional neuroradiology platforms. Intensive care stroke units remain the pivotal place of patients' management. A multidisciplina...
Source: Revue de Medecine Interne - September 6, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Eosinophilia heralding the diagnosis of eosinophilic fasciitis (Shulman's disease)].
CONCLUSION: In this case report, eosinophilia was preceding the clinical cutaneous signs that led to the diagnosis of eosinophilic fasciitis. It is likely to believe that myalgias, frequently found in the onset of eosinophilic fasciitis, may have been hidden by the history of infantile encephalopathy. The diagnosis of eosinophilic fasciitis must be kept in mind of physicians in the investigation of an eosinophilia, even though cutaneous signs are lacking. PMID: 28867532 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 6, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Primary intestinal lymphangiectasia (Waldmann's disease)].
Authors: Vignes S, Bellanger J Abstract Primary intestinal lymphangiectasia (PIL), Waldmann's disease, is a rare disorder of unknown etiology characterized by dilated intestinal lacteals leading to lymph leakage into the small-bowel lumen and responsible for protein-losing enteropathy leading to lymphopenia, hypoalbuminemia and hypogammaglobulinemia. PIL is generally diagnosed before 3 years of age but may be diagnosed in older patients. The main symptom is bilateral lower limb edema. Edema may be moderate to severe including pleural effusion, pericarditis or ascites. Protein-losing enteropathy is confirmed by...
Source: Revue de Medecine Interne - September 6, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Vitamin K antagonist-induced necrotic leg ulcer, without protein C and S deficiencies].
CONCLUSION: We report an original case of necrotic leg ulcers induced by VKA without deficit of protein C or S, with a pyoderma like histology. Reported cases of ulcers induced by VKA are uncommon and the physiopathology is not well known. The involvement of VKA should be evoked in case of necrotic leg ulcer without specific etiology found. PMID: 28867534 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 6, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Statins in primary prevention of cardiovascular disease].
We report in this review the updated conclusions from clinical trials regarding the treatment with statins in primary prevention. PMID: 28866432 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 5, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A case of gonococcal arthritis: Diagnostic difficulties and usefulness of synovial fluid PCR].
CONCLUSION: In patients with high risk of N. gonorrhoeae infection, PCR for detection of gonorrhea in synovial fluid could potentially facilitate the diagnostic of gonococcal septic arthritis. PMID: 28844395 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 30, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Extensive cutaneous lesions].
Authors: Fenot M, Riegert M, Poiraud C, Gegu M, André V PMID: 28844396 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 30, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Vascular renal abnormalities].
Authors: Journeau L, Vincent M, Perret C, Connault J PMID: 28838606 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 27, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[From pathogenesis of giant cell arteritis to new therapeutic targets].
Authors: Samson M, Bonnotte B Abstract Giant cell arteritis (GCA) is the most common vasculitis in adults. GCA is a granulomatous large-vessel vasculitis involving the aorta and its major branches in people>50 years. Glucocorticoids (GC) remain the cornerstone of GCA treatment. Prednisone is usually started at 0.7 or 1mg/kg/day depending on the occurrence of ischemic complications. Then, GC are progressively tapered and stopped after a mean duration of 18 months. GC are very efficient but relapses often occur during their tapering. Moreover, GC-related side effects are very common during this long term...
Source: Revue de Medecine Interne - August 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Vasculitis of the hepatic artery: A case of a single-organ vasculitis].
We report the case of a patient who developed a vasculitis of the right and left hepatic arteries. CASE REPORT: A 63-year-old woman presented with unexplained abdominal pain. A computed tomography of the abdomen was suggestive of vasculitis of the hepatic arteries, showing a sequence of stenosis and aneurysmal dilatations of the hepatic arteries. There were no other arterial involvement, in particular of the abdomen and the brain. No other systemic disease or infection was found. The outcome was favorable, with corticosteroids alone. DISCUSSION: The exclusive involvement of the hepatic artery is an exceptional form...
Source: Revue de Medecine Interne - August 10, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Weakness of the left hand and pallor in a 21-year-old woman].
Authors: de Luna G, Arlet JB, Passeron A, Ranque B, Michon A, Pouchot J, Lozac'h P, Lapoirie J, Bourdin V PMID: 28780283 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Chronic asthenia and abdominal pain in a 26-year-old woman].
Authors: Abbara S, Georgin-Lavialle S, Bachmeyer C, Hermine O, Launay JM, de Lastours V PMID: 28755907 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 2, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hypersensitivity reactions to beta-lactam antibiotics].
Authors: Amsler E, Soria A Abstract Allergy to beta-lactam antibiotics is a common condition and about 10% of patients report being allergic to penicillin. However, this diagnosis is largely overestimated. Two types of allergy should be distinguished and include immediate hypersensitivity that can lead to anaphylactic shock and delayed hypersensitivity, ranging from the most common maculopapular exanthema to severe bullous toxidermia or life-threatening DRESS. Allergy challenge with oriented skin tests according to the clinical features, supplemented with oral challenge in the absence of contraindication, will conf...
Source: Revue de Medecine Interne - July 31, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A left peri-renal infiltration].
Authors: Masson E, Scemama UA, Lignères MA, Benyamine A, Rossi P, Chaumoitre K, Granel B PMID: 28734579 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 24, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Cutaneous lesions in a 69-year-old woman].
Authors: Masri R, Damade R, Al Gain M, Bouaziz JD, Wyndham-Thomas C PMID: 28734580 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 24, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[An unusual case of renal failure in a 22-year-old woman].
Authors: Gramont B, Guichard I, Basset T, Boucher A, Charmion S, Savall A, Munoz-Pons H, Schein F, Masson I, Cathébras P, Coute L PMID: 28728706 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 23, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Disseminated nocardiosis caused by Nocardia nova with brain abscesses and osteomyelitis in an immunocompetent patient].
CONCLUSION: This observation is original because it involves a immunocompetent patient with an association of two exceptional locations for N. nova: brain abscesses and femoral osteomyelitis. Screening for cerebral involvement should be systematic, even in the lack of neurological signs. An adapted and prolonged antibiotherapy must be conducted. PMID: 28716481 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Respiratory distress of unusual cause].
Authors: de Charry C, Bylicki O, Mavrovi E, Le Moigne F, de Charry F PMID: 28716482 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Diffuse arthromyalgia in a 59-year-old man].
Authors: Benyamine A, Brun M, Jarrot PA, Mazodier K, Jean R, Sevy A, Chagnaud C, Hanssens K, Granel B, Kaplanski G, Asli B PMID: 28711158 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hemolytic and uremic syndrome and related thrombotic microangiopathies: Epidemiology, pathophysiology and clinics].
Authors: Rafat C, Coppo P, Fakhouri F, Frémeaux-Bacchi V, Loirat C, Zuber J, Rondeau E Abstract Thrombotic microangiopathies (TMA) represent an eclectic group of conditions, which share hemolytic anemia and thrombocytopenia as a common defining basis. Remarkable breakthroughs in the physiopathological setting have allowed for a thorough recomposition of the disparate syndromes, which form the constellation of TMA. In this view, clinicians now discriminate thrombocytopenic thrombotic purpura (TTP) defined by a severe deficiency in ADAMTS13, which is rarely associated with a severe renal involvement and the he...
Source: Revue de Medecine Interne - July 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Systemic sclerosis and occupational difficulties: Results of a prospective study].
Authors: Peres N, Morell-Dubois S, Hachulla E, Hatron PY, Duhamel A, Godard D, Tellart-Mamert AS, Lambert M, Launay D, Fantoni-Quinton S Abstract Between 9000 and 14000 people have systemic sclerosis (ScS) in France. The work is often affected. Our study aims to assess the frequency of professional difficulties (DP) of scleroderma patients, identify these DP, the symptoms involved and the solutions used. A heteroquestionnaire was offered to scleroderma patients the Lille University Hospital. Data were cross-checked with the clinical database of the National Observatory of scleroderma patients. We used 104 questionn...
Source: Revue de Medecine Interne - July 15, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Diffuse cutaneous abnormality].
Authors: Zenati N, Carpentier PH, Blaise S PMID: 28690089 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Pituitary hyperplasia due to primary hypothyroidism].
CONCLUSION: Pituitary hyperplasia due to primary hypothyroidism, although rare, should be recognized to avoid unnecessary surgery leading to irreversible complications. PMID: 28690090 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Paget's disease of bone: Diagnostic and therapeutic updates].
Authors: Alaya R, Alaya Z, Nang M, Bouajina E Abstract Paget's disease of bone is the second most common metabolic bone disease after osteoporosis. Its pathogenesis is not yet clearly understood. Geographic distribution and epidemiological variations suggest a role of genetic and environmental factors in its pathophysiology. The frequency of the Paget's disease of bone increases with age. Its discovery can be fortuitous. Prognosis mainly depends on the occurrence of complications involving bones and joints, neurological, cardiovascular or metabolic systems. Treatment of symptomatic forms currently relies on bisphos...
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Long-lasting thrombocytopenia induced by glycoprotein IIb/IIIa inhibitor].
CONCLUSION: Anti-GPIIbIIIa are associated with a risk of dramatic thrombocytopenia. The underlying mechanism is poorly understood. The management of these usually transient thrombocytopenias is based on platelet transfusion. As report here, in some cases persistent thrombocytopenia can respond to corticosteroids. PMID: 28690092 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[23rd  session of the "spring of internal medicine": How to train to solve unique cases?]
[23rd session of the "spring of internal medicine": How to train to solve unique cases?] Rev Med Interne. 2017 Jul 06;: Authors: Marchand AL PMID: 28690093 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Relevance assessment of requests for antineutrophil cytoplasmic antibodies detection: Retrospective study led in Bordeaux Hospital, France].
CONCLUSION: The majority of the requests for detection of ANCA was not relevant and could not lead to the diagnosis of AAV. Simple solutions enabled a partial but significant improvement of their relevance. PMID: 28690094 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Non-inferiority and equivalence trials: Key methodological issues].
This article presents the key points of the methodology of non-inferiority and equivalence trials in order to inform the readers of such trials about the issues and critical points. The general methodology (hypotheses, decision rules, number of subjects required, and strategy of analysis) is presented using examples and graphic illustrations. The issues and critical points are identified and discussed, in particular the choice of the comparator and of the margin of non-inferiority. PMID: 28693836 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Should doses of antibiotics be adjusted?]
Authors: de Lastours V Abstract While we are confronted with the major increase in antibiotic resistance, the preservation of existing antibiotics has become an absolute necessity both to achieve therapeutic success and to limit the risks of the emergence of resistance. The optimization of antibiotic use and dosages must have a threefold objective: guarantee antibacterial efficacy, limit toxicities and limit emergence of resistant strains. However, with the increase in the number of multipathological patients, particularly those with renal or hepatic impairment, the increase in the number of patients with extreme w...
Source: Revue de Medecine Interne - July 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Once weekly L-thyroxine treatment in non-compliance: A case report].
CONCLUSION: The strategy of non-adherence treatment in hypothyroidism is well defined with oral testing of L-thyroxine, followed by oral or parenteral weekly administration of the drug. The L-thyroxine oral test is the gold standard for diagnosis after eliminating of the other conventional causes: drug interactions or digestive malabsorption. L-thyroxine treatment should be discussed on a case-by-case basis, either daily under surveillance or once weekly oral or parenteral high dose. PMID: 28688760 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 11, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Diagnosis and management of acquired immune haemolytic anaemia excluding neoplasia. Adequacy with the current guidelines published in 2009].
CONCLUSION: AIHA guidelines seem insufficiently applied in our center. PMID: 28687137 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 10, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research