Clinical characteristics and outcome of hospitalized patients with SARS-CoV-2 infection at Toulouse University hospital (France). Results from the Covid-clinic-Toul cohort.
CONCLUSION: This cohort provides epidemiological data on SARS-CoV-2 in hospitalized patients in a University hospital in the South of France. PMID: 33077266 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - October 21, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[In patients hospitalized for COVID-19, does dexamethasone reduce 28-days mortality compared to standard treatment?]
Authors: Lanthier L, Mayette M, Huard G, Plourde MÉ, Cauchon M PMID: 33077267 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - October 21, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Cerebral bleeding during a cryotherapy session: A case report].
CONCLUSION: We hypothesize that the whole-body cryotherapy was responsible for this stroke. PMID: 32994067 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - October 2, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Health crisis and reflexive crisis: The medical perspective in times of epidemic].
Authors: Galtier J, Rivière E PMID: 32928376 [PubMed - in process] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 17, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Infection associated cerebral vasculitis].
Authors: Lampros A, Caumes E, Psimaras D, Galanaud D, Clarençon F, Peyre M, Deltour S, Bielle F, Lhote R, Haroche J, Amoura Z, Cohen Aubart F Abstract Infections are a frequent cause of cerebral vasculitis, important to diagnose because a specific treatment may be required. Infection-associated vasculitis can be caused by angiotropic pathogens (varicella zoster virus, syphilis, aspergillus). They can be associated with subarachnoidal meningitis (tuberculosis, pyogenic meningitis, cysticercosis). They can appear contiguously to sinuses or orbital infection (aspergillosis, mucormycosis). Finally, they also may...
Source: Revue de Medecine Interne - September 2, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Atteinte osseuse axiale de la sarco ïdose.
CONCLUSION: These 4 cases, as well as recent literature, illustrate bone involvement of sarcoidosis on the axial skeleton. It is symptomatic in around 50% of cases but may be a source of significant disability. Differential diagnosis with neoplasm may require bone histological analysis. This condition appears to be responsive to usual treatments for sarcoidosis. PMID: 32868118 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 2, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Management of orbital inflammatory disorders in internal medicine: New findings resulting from a retrospective study of 31 consecutive patients].
CONCLUSION: After ruling out auto-immune orbital diseases, especially IgG4 ROD, IOIS should be discussed. Factors conditioning the corticosteroid response are yet to be determined. PMID: 32861532 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 1, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Cerebral infarction and tuberculosis: case report and literature review].
CONCLUSION: Cerebral infarctions in patients with tuberculous meningitis are events that cannot be underestimated in terms of frequency or severity. Their poor prognosis is partly the result of insufficiently defined management, which combines anti-tuberculosis treatment and early corticosteroid therapy. PMID: 32861533 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - September 1, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Emergency overcrowding and hospital organization: Causes and solutions].
Authors: Oberlin M, Andrès E, Behr M, Kepka S, Le Borgne P, Bilbault P Abstract Emergency Department (ED) overcrowding is a silent killer. Thus, several studies in different countries have described an increase in mortality, a decrease in the quality of care and prolonged hospital stays associated with ED overcrowding. Causes are multiple: input and in particular lack of access to lab test and imaging for general practitioners, throughput and unnecessary or time-consuming tasks, and output, in particular the availability of hospital beds for unscheduled patients. The main cause of overcrowding is waiting tim...
Source: Revue de Medecine Interne - September 1, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[French national emergency department's crisis: The outcome of a growing gap between health resources and needs?]
Authors: Behr M, Le Borgne P, Baicry F, Lavoignet CE, Berard L, Tuzin N, Oberlin M, Bilbault P Abstract Overcrowding in Emergency Departments is often considered as an outcome of insufficient access to hospital beds or primary care, therefore a potential lack of health resources. We sought to describe the quantitative evolution of health resources in the French health care system, in comparison with demographic and epidemiologic parameters that reflect health needs. Overall, in the last decade, parameters of capacity and human resources stagnated while activity and spending increased jointly, stimulated by ageing o...
Source: Revue de Medecine Interne - August 30, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Transthyretin cardiac amyloidosis].
Authors: Eicher JC, Audia S, Damy T Abstract Transthyretin (TTR) cardiac amyloidosis results from the dissociation of the tetrameric, liver-synthetized transport protein, either because of a mutation (hereditary CA), or spontaneously due to ageing (wild type CA). Monomers self-associate into amyloid fibrils within the myocardium, causing heart failure, arrhythmias and conduction defects. This overlooked disease must be recognized in case of unexplained increased thickness of the myocardium, particularly in subjects of African descent, in patients with heart failure and preserved ejection fraction, and in those with...
Source: Revue de Medecine Interne - August 23, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Pituitary apoplexy following coronary bypass surgery: A case report and literature review].
CONCLUSION: Pituitary apoplexy is a rare and life-threatening complication that may occur after cardiac surgery (coronary artery bypass, cardiac valve surgery), often precipitated by the use of cardiopulmonary bypass. It can occur after other surgical procedures (orthopedic, digestive, thoracic). The diagnosis must be considered during the early postoperative period in the presence of unusual and severe headache associated with visual disturbances. PMID: 32800377 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Une masse m édiastinale multikystique.
Une masse médiastinale multikystique. Rev Med Interne. 2020 Aug 11;: Authors: El Aoufir O, Hassani S, Asfalou I, Nouali HEN PMID: 32798087 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 18, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[In patient with symptomatic peripheral arterial disease who had undergone lower-extremity revascularization, does rivaroxaban 2.5  mg twice daily plus aspirin reduce the composite risk of acute limb ischemia, major amputation for vascular causes, myocardial infarction, ischemic stroke or cardiovascular death compared to aspirin alone while being safe?]
[In patient with symptomatic peripheral arterial disease who had undergone lower-extremity revascularization, does rivaroxaban 2.5 mg twice daily plus aspirin reduce the composite risk of acute limb ischemia, major amputation for vascular causes, myocardial infarction, ischemic stroke or cardiovascular death compared to aspirin alone while being safe?] Rev Med Interne. 2020 Aug 11;: Authors: Lanthier L, Huard G, Plourde ME, Cauchon M PMID: 32798088 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 18, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[New insights into the epidemiology of immune thrombocytopenia in adult patients: Impact for clinical practice].
Authors: Moulis G, Comont T, Adoue D Abstract New insights into immune thrombocytopenia (ITP) epidemiology in adult patients highlight three main outcomes of morbidity and mortality: bleeding, infection and thrombosis. This review depicts current evidence about incidence and risk factors of bleeding, infection and thrombosis as well as predictors of chronicity, and shows how this assessment impacts the choice of ITP second-line treatment at the individual-level basis. PMID: 32798089 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 18, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Une masse abdominale.
Authors: Alamé K, Kauffmann P, Bitoun A, Lehr B, Le Borgne P PMID: 32792090 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 16, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Post-acute and rehabilitation care in young patients with multiple comorbidities: An observational study].
Authors: Hannane S, Sacre K, Alexandra JF, Dossier A, Goulenok T, Bernard C, Nolland M, van Gysel D, Papo T, Chauveheid MP Abstract INTRODUCTION: A unique structure devoted to post-acute and rehabilitation care for patients under 75 with multiple comorbidities has been created within the Department of Internal Medicine, Bichat Hospital, Paris. We aim to report on demographic factors, clinical characteristics and outcomes of patients hospitalized in this pilot structure. METHODS: All consecutive adult patients admitted between May 2017 and May 2018 were retrospectively reviewed. RESULTS: Analysis was perform...
Source: Revue de Medecine Interne - August 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acquired angioedema due to C1-inhibitor deficiency: CREAK recommendations for diagnosis and treatment].
Authors: Gobert D, Bouillet L, Armengol G, Coppo P, Defendi F, Du-Thanh A, Hardy G, Javaud N, Jeandel PY, Launay D, Panayotopoulos V, Pelletier F, Boccon-Gibod I, Fain O Abstract Acquired angioedema with C1-inhibitor deficiency is a rare and peculiar entity belonging to the spectrum of bradykinin angioedemas. It usually occurs in subjects over 60 years old, and is mostly associated with a B-cell lymphoid hemopathy or a monoclonal gammopathy. The diagnosis relies on at least one angioedema episode, lasting more than 24 h, and on the decrease of functional C1-inhibitor. Low C1q is observed in 90% of patient...
Source: Revue de Medecine Interne - August 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Des douleurs des genoux.
Authors: Deprez V, Grados F, Aboudiab M, Bonnaire B, Fardellone P, Goëb V PMID: 32768265 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Sickle cell trait complications: A case series of 6 patients].
CONCLUSION: SCT may cause acute ischemic complications in a context of prolonged hypoxia or dehydration. The most commonly reported are the splenic infarct and the renal papillary necrosis. A study of hemoglobin should be considered in these clinical situations in patients with compatible ethnic origin. PMID: 32768266 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Auto-immunit é et médecine personnalisée.
Auto-immunité et médecine personnalisée. Rev Med Interne. 2020 Aug 04;: Authors: Guffroy A, Martin T, Gies V PMID: 32768267 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Is SARS-CoV-2 also attacking the French language?]
Authors: Andrès E, Pessaux P PMID: 32768268 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Syndrome de Cogan.
Authors: Mekinian A, Pouchot J, Zenone T, Fain O Abstract "Typical" Cogan's syndrome is defined as a non-syphilitic interstitial keratitis associated with audio-vestibular resembling Ménière's disease with a 2-year maximum delay between these 2 organ impairment. Cogan syndrome is classified as "atypical" in the absence of interstitial keratitis and the presence of other inflammatory eye manifestations, an audio-vestibular impairment different from typical Menière-like disease, or a delay longer than 2 years between eye and audio-vestibular manifestations. Constitutional si...
Source: Revue de Medecine Interne - August 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Corticosteroid-induced diabetes: Novelties in pathophysiology and management].
Authors: Bastin M, Andreelli F Abstract Diabetes frequently occurs during corticosteroid treatment, sometimes necessitating urgent therapeutic management, with insulin for example. Corticosteroids induce insulin resistance in the liver, adipocytes and skeletal muscle, and have direct deleterious effects on insulin secretion. The development of insulin resistance during corticosteroid treatment, and the insufficient adaptation of insulin secretion, are key elements in the pathophysiology of corticosteroid-induced diabetes. The capacity of pancreatic β-cells to increase insulin secretion in response to insulin r...
Source: Revue de Medecine Interne - August 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Immune thrombocytopenia: From pathogenesis to treatment].
Authors: Audia S, Mahevas M, Bonnotte B Abstract Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an immune peripheral destruction of platelets and an inappropriate platelet production. The pathogenesis of ITP is now better understood: it involves a humoral immune response which dependents on the stimulation of B cells by specific T cells called T follicular helper cells, leading to their differentiation into plasma cells that produce antiplatelet antibodies thus promoting the phagocytosis of platelets mainly by splenic macrophages. The deciphering of ITP pathogenesis has led to a better understand...
Source: Revue de Medecine Interne - August 5, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[IgG4-related disease: Diagnostic criteria evolution toward the 2019 ACR/EULAR classification criteria].
The objective of this review is to discuss the evolution from organ specific and general diagnostic criteria toward the 2019 ACR/EULAR classification criteria, as well as respective benefits and limits of these criteria. The use of the 2019 ACR/EULAR classification criteria will help to better define homogeneous group of IgG4-RD patients in future clinical, epidemiological and basic science research studies on the disease. PMID: 32732082 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 2, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Une sarco ïdose atypique.
Une sarcoïdose atypique. Rev Med Interne. 2020 Jul 28;: Authors: Fermon C, Gerfaud-Valentin M, Sève P PMID: 32736819 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 2, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

La fibrose r étropéritonéale idiopathique.
La fibrose rétropéritonéale idiopathique. Rev Med Interne. 2020 Jul 26;: Authors: Le Joncour A, Saadoun D, Cacoub P Abstract Retroperitoneal fibrosis (RPF) is a rare disease characterized by the presence of fibro-inflammatory tissue around the aorta entrapping the adjacent structures. RPF can be idiopathic or secondary to many disorders. The physiopathology is unknown but can be part of the spectrum of IgG4 related diseases. Imaging studies and inflammatory markers are essential for initial evaluation and follow-up. Biopsy is usually not recommended. The first line of treatment is ...
Source: Revue de Medecine Interne - August 1, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Venous thrombo-embolism during immune-mediated thrombotic thrombocytopenic purpura is prevalent in patients with a prolonged treatment with therapeutic plasma exchange].
Authors: Benhamou Y, Sauvètre G, Grangé S, Veyradier A, Coppo P Abstract INTRODUCTION: Thrombotic thrombocytopenic purpura (TTP) is a devastating disease characterized by disseminated microvascular thrombosis. Despite pro-thrombotic predisposing conditions, the prevalence of macrovascular venous thrombosis event (VTE) in immune-mediated TTP (iTTP) has rarely been assessed. METHODS: We reviewed data of all iTTP patients of the French reference Center for thrombotic microangiopathies registry prospectively enrolled through a 10-year period, between 2008 and 2018. Venous thrombosis included either th...
Source: Revue de Medecine Interne - August 1, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Raynaud phenomenon with arterial thromboses and IgG4-related disease].
CONCLUSION: A Raynaud phenomenon with distal arterial thrombosis is rarely observed in the IgG4-RD. PMID: 32727696 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - August 1, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Toward the use of direct oral anticoagulants as a first line therapy in cancer-associated venous thromboembolism].
Authors: Miranda S, Levesque H PMID: 32718707 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 30, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Microangiopathie c érébrale: du diagnostic à la prise en charge small vessel disease of the brain: Diagnosis and management.
Microangiopathie cérébrale: du diagnostic à la prise en charge small vessel disease of the brain: Diagnosis and management. Rev Med Interne. 2020 Jul 24;: Authors: Ayrignac X, Gaillard N, Carra-Dallière C, Labauge P Abstract Small vessel disease of the brain is commonly identified among ageing people. It causes almost 25% of strokes and is associated with cognitive impairment and dementia as well as gait difficulties. Its diagnosis is usually made on MRI in the presence of deep white matter and basal ganglia hyperintensities as well as deep lacunar infarcts (lacunes), microb...
Source: Revue de Medecine Interne - July 30, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Brain abscess and Osler-Weber-Rendu syndrome: Do not forget to look for pulmonary arteriovenous malformations].
CONCLUSION: In case of brain abscess without obvious promoting factor, don't forget to looking for a right-left shunt providing septic or aseptic emboli. Furthermore, diagnosis of Rendu-Osler-Weber syndrome should be considered presence of telangiectasias and/or epistaxis. PMID: 32723482 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 30, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Une couleur inhabituelle.
Authors: Campagne J, Kurt S, Moulinet T, Mohamed S, Deibener-Kaminsky J, Jaussaud R PMID: 32709435 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 29, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Haemothorax revealing thoracic endometriosis].
CONCLUSION: Thoracic endometriosis needs to be considered as a cause of haemothorax in women of childbearing age. PMID: 32709436 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 29, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A gastric mass].
Authors: Zenaidi H, Ben Ismail I, Yahmadi A, Rebii S, Zoghlami A PMID: 32709437 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 29, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Adult immune thrombocytopenia and thrombopoietin receptor agonist: Ten years later].
Authors: Ebbo M, Rivière E, Godeau B Abstract Ten years after their licence in France, the use of the two thrombopoietin receptor agonists (TPO-RA), eltrombopag and romiplostim, has deeply modified the landscape of immune thrombocytopenia (ITP) treatment. In this review, we summarise data on efficacy and safety of these treatments during ITP, as well as their use in clinical practice. Their place in therapeutic strategy, the recent description of persistant remission after discontinuation of TPO-RA, and future new thrombopoietic agents are also discussed. Their use has progressively increased and early use a...
Source: Revue de Medecine Interne - July 29, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Tryptase: A practical guide for the physician].
Authors: Lobbes H, Reynaud Q, Mainbourg S, Lega JC, Durieu I, Durupt S Abstract Tryptase is the most abundant endopeptidase released by mast cells degranulation, involved in many pro and anti-inflammatory processes. Normal serum tryptase range is 0-11.4 μg/L. Tryptase is a useful diagnostic tool for anaphylaxis, systemic mastocytosis (SM) and mast cell activation syndrome (MCAS), where specific threshold values must be used. SM diagnosis criteria include evidence of dense mast cell infiltrate either in the bone marrow or the affected organ (such as skin), presence of KIT D816V mutation and elevated serum tr...
Source: Revue de Medecine Interne - July 29, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Development of sarcoma on a ectopic extramedullary hematopoiesis secondary to hereditary spherocytosis: Case report and literature review].
CONCLUSION: This case report illustrates the risk of neoplastic transformation of extramedullary hematopoiesis, and the need for a biopsy when confronted to atypical aspect. PMID: 32712043 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 29, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Challenges and potential solutions in first-line treatments for immune thrombocytopenia in adults].
Authors: Godeau B, Bonnotte B, Michel M Abstract The first line treatment of immune thrombocytopenic purpura (ITP) is well established and based on short course of corticosteroids associated with intravenous immunoglobulins (IVIg) for the most severe forms. Predniso(lo)ne is the corticosteroid agent usually given but dexamethasone appears as an alternative. Some guidelines recommend to use dexamethasone as first line when a rapid increase of platelet count is required. Dexamethasone could be used rather than IVIg except for moderate to severe but non life-threatening bleeding manifestations. Other therapeutic optio...
Source: Revue de Medecine Interne - July 29, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Nasopharyngeal carriage of SARS-CoV-2 among health personnel with symptoms suggestive of COVID-19 in a University Hospital in the Paris suburbs].
The objective of this work was to estimate the frequency of SARS-Cov-2 nasopharyngeal carriage in symptomatic healthcare workers suspected of having COVID-19 and to determine the factors associated with this carriage. METHODS: Of the 522 consultants, 308 worked in the Hospital and 214 outside. They had mild forms of COVID-19 and non-specific clinical signs with the exception of agueusia/anosmia, which was significantly more common in those with positive RT-PCR. The rate of RT-PCR positivity was 38% overall, without significant difference according to profession. It was higher among external consultants (47% versus 31%)...
Source: Revue de Medecine Interne - July 20, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Rituximab and immune thrombocytopenia in adults: The state of knowledge 20  years later.
Rituximab and immune thrombocytopenia in adults: The state of knowledge 20 years later. Rev Med Interne. 2020 Jul 14;: Authors: Deshayes S, Mahévas M, Godeau B Abstract Rituximab has been used for immune thrombocytopenia (ITP) for almost 20 years and is now considered a valid off-label second-line treatment. About 60% to 70% of patients with ITP show initial response to rituximab, but in half of these patients, the disease will eventually relapse. Therefore, in 30% of patients with persistent or chronic ITP, one course of rituximab at 375 mg/m2/week for 4 weeks or 2 fixed 100...
Source: Revue de Medecine Interne - July 20, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Non-motor symptoms of Parkinson's disease from pathophysiology to early diagnosis].
Authors: Aubignat M, Tir M, Krystkowiak P Abstract Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease. The pathophysiology of Parkinson's disease is complex and imperfectly known. Primum movens is abnormal intra-neuronal accumulation of the protein α-synuclein, leading to metabolic disturbances and neurodegeneration. This abnormal accumulation of α-synuclein is also found in dementia with Lewy bodies and multiple system atrophy, which together with Parkinson's disease form the group of α-synucleinopathies. Well known by its motor signs (bradykinesia, ...
Source: Revue de Medecine Interne - July 20, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Aceruloplasminemia, a rare condition not to be overlooked].
Authors: Lobbes H, Reynaud Q, Mainbourg S, Lega JC, Durieu I, Durupt S Abstract Aceruloplasminemia is a rare iron-overload disease that should be better known by physicians. It is an autosomal recessive disorder due to mutations in ceruloplasmin gene causing systemic iron overload, including cerebral and liver parenchyma. The impairment of ferroxidase ceruloplasmin activity leads to intracellular iron retention leading aceruloplasminemia symptoms. Neurologic manifestations include cognitive impairment, ataxia, extrapyramidal syndrome, abnormal movements, and psychiatric-like syndromes. Physicians should search for ...
Source: Revue de Medecine Interne - July 20, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Delays in the management of ocular complications of giant cell arteritis: A retrospective monocentric study of 33 patients].
CONCLUSION: There is a significant delay in the appropriate management of ophthalmological complications of ACG and deviations from current recommendations. Numerous actions must therefore be taken to improve the visual prognosis of patients with ACG, both preventively (i.e. early diagnosis and treatment of ACG before the possible occurrence of visual complications), and curatively (rapid recognition and immediate treatment of ocular complications). These elements support the relevance of specific fast-track pathways for GCA. PMID: 32682624 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 20, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[An abscessed granulomatous prostatitis].
CONCLUSION: The diagnosis of granulomatosis with polyangiitis should be considered in the presence of a non-infectious granulomatous prostatitis with systemic involvement. PMID: 32674890 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Une cause rare de douleur sciatique.
Authors: Sninate S, Allioui S, En-Nafaa I, Darbi A, El Fenni J, Radouane B PMID: 32674891 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Lymphomes T p ériphériques : diagnostic et prise en charge.
Lymphomes T périphériques : diagnostic et prise en charge. Rev Med Interne. 2020 Jul 14;: Authors: Galtier J, Parrens M, Milpied N Abstract Peripheral T cell lymphomas are rare malignancies with aggressive course, with several different subtype described in the 2016 WHO classification. Their distribution across the world is heterogenous, with marked difference between Western and Asian country. Their clinical presentation often comprise extra-nodal involvement, B symptoms and immune system disorder which can lead to wrong diagnosis orientation. Make a right diagnosis need a experienc...
Source: Revue de Medecine Interne - July 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[How to formalise the supervision of learning of clinical reasoning].
Authors: Cogan E, Maisonneuve H, Leeman M, Goffard JC, Michelet E, Audétat MC Abstract Since clinical reasoning is central to most decisions made in the clinic, it is essential to teach it with the greatest relevance. Knowing that around 10% of learners encounter major difficulties in clinical reasoning during their course, training supervisors in effective pedagogical interventions is crucial. Here we summarize the methods allowing supervisors to identify errors of clinical reasoning in medical students and interns and we explain remediation techniques adapted to the types of error identified. Access to sho...
Source: Revue de Medecine Interne - July 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Puffy hand syndrome: A little-known diagnosis].
CONCLUSION: Puffy hand syndrome seen in intravenous drug addicts is poorly understood. It is a chronic complication despite the cessation of drug use. This syndrome has to become more widely known because its management is mandatory, although symptomatic. PMID: 32674894 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research