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[An unexpected cause of knee pain].
Authors: Kauffmann P, Ries AS, Geronimus C, Bilbault P, Le Borgne P PMID: 29779864 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 22, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[What is the treatment duration after a venous thromboembolic event?]
Authors: Couturaud F, Mahé I PMID: 29754698 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 15, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Lymphedema in patients treated with sirolimus: 15 cases].
CONCLUSION: Sirolimus is associated with upper and/or lower limb lymphedema, without predominance of sex, and without disappearance after sirolimus discontinuation. Pathophysiological mechanisms remain unclear. Lymphedema management is based on low-stretch bandages and compression. PMID: 29752013 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Movement disorders in a 32-year-old woman].
Authors: Diot E, Brugirard S, Hascar T, Vallet P, Vallet AE, Badet F, Bouaziz A, Adelaide L, Régent A PMID: 29728281 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 10, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A sepsis of unusual cause].
Authors: Hodique F, Cambon Z, Chaix F, Condat B, Oehler E PMID: 29729948 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 10, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Intra-cardiac manifestation during adult-onset Still's disease's, a tricuspid vegetation as a rare expression of systemic disease].
CONCLUSION: Non-infectious endocarditis, with a vegetation made of cruoric and fibrinous material, is a rare complication of Adult-onset Still's disease. PMID: 29731191 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 10, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Tranexamic acid as first-line emergency treatment for episodes of bradykinin-mediated angioedema induced by ACE inhibitors].
CONCLUSION: Tranexamic acid is an easily accessible and affordable therapy that may provide effective treatment for ACE inhibitor-induced episodes of angioedema. It may help while waiting for a more specific treatment (icatibant and C1INH concentrate) that is at times unavailable in emergency departments. PMID: 29735174 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 10, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Writing to publish, a barrier to French medical research?]
Authors: Duracinsky M, Péretz F, Chassany O PMID: 29735175 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 10, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Use of a medical discharge sheet for medication reconciliation in an internal medicine department: Assessment of general practitioners' opinion].
CONCLUSION: Practitioners' opinion is in favor of the use of a DMS. Certain specific points need to be improved, such as better information of practitioners and patients, and transmission of the DMS via a secure email system. PMID: 29716754 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 4, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Pathway to diagnosis and real-life experience of patients believing they are affected by "chronic Lyme disease"].
CONCLUSION: Improving the diagnosis and therapeutic management of patients believing themselves to be affected by chronic Lyme disease appears highly necessary both to limit their search for diagnosis and their experience of pain. It could be based on existing guidelines concerning medically unexplained symptoms to which the chronic Lyme disease issue appears quite similar on several points. PMID: 29706237 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 3, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A fatal septic shock due to Capnocytophaga canimorsus and review of literature].
CONCLUSION: Among patients with a septic shock of unknown etiology, fatal evolution due to C. canimorsus should be avoided by systematic use of early antibiotherapy with amoxicilline and clavulanic acid, especially in patients who live near a pet, even if they are immunocompetent. PMID: 29706238 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 3, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Important weight loss in a 63 year-old man].
Authors: Ruch Y, Weingertner N, Hansmann Y, Douiri N, Lefebvre N, Martin A, Chenard MP, D'Urso A, Argemi X, Ranque B PMID: 29709298 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 3, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Biosimilars in Internal Medicine: Needed in-depth knowledge to best prescribe].
Authors: Chapelon-Abric C PMID: 29709299 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 3, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hepatic abnormalities].
Authors: En-Nafaa I, Hommadi A, Semlali S, El Fenni J, Amil T, Radouane B PMID: 29703610 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 1, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Amoebosis: May sexual transmission be an underestimated way of contamination?]
CONCLUSION: The diagnosis of amoebiasis should be suspected in case of dysentery or liver abscess even if there is no history of travel in endemic areas or of sexual intercourse between men. PMID: 29703611 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 1, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Day hospital in internal medicine: A chance for ambulatory care].
CONCLUSION: In the ambulatory shift advocated by the authorities, this experience shows that internal medicine should engage in the recognition of day-hospital as a place for diagnosis and synthesis reviews connected with the city while leaving the general practitioners coordinator of their patient care. This activity of synthesis in day-hospital is useful for the patients and efficient for our healthcare system. PMID: 29673918 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 21, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Pseudo pheochromocytoma induced by professional stress: A case report].
CONCLUSION: This observation involves professional stress in pseudo pheochromocytoma. PMID: 29673919 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 21, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Sinusoidal obstruction syndrome after BeAM conditioning regiment for autologous stem cell transplantation: Imputability of bendamustine? Report of two cases and literature review].
CONCLUSION: Our observations highlight the difficulty to diagnose this complication with often non-specific clinical presentation and possible delayed occurrence after to transplantation, but also the therapeutic challenges, defibrotide being the only agent currently efficient. Physiopathology and potential responsibility of bendamustine in the sinusoidal obstruction syndrome occurrence will be discussed. PMID: 29673920 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 21, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Diagnostic workup in front of an atypical non hemolytic anemia].
Authors: Colin JY, Vignon G, Mottaz P, Labrousse J, Carrere F, Augereau PF, Aucher P, Lellouche F Abstract The most potential causes of "non hemolytic" anemias are iron, folate or vitamin B12 deficiencies, severe renal impairment, endocrine diseases, inflammation and medullary disorders. In a non-exceptionnal way no cause is found, sometimes because of a wrong interpretation of analysis results and sometimes because of a little known etiology. The goal of this review is to point out analytical difficulties and to remember some rarer etiologies. PMID: 29661593 [PubMed - as supplied by publisher] (Sourc...
Source: Revue de Medecine Interne - April 18, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acquired hemophilia A associated with chronic myelomonocytic leukemia successfully treated by rituximab and azacitidine].
CONCLUSION: We report a case of acquired hemophilia A complicating a chronic myelomonocytic leukemia. Management with steroids, rituximab and azacitidine was successful. Useful of rituximab during acquired hemophilia is proposed. PMID: 29653879 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 17, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Surgical treatment of an auto-immune hemolytic anemia].
CONCLUSION: Ovarian teratoma is a rare cause of secondary AIHA, with only few cases reported. Its treatment differs from primary AIHA as steroids may be ineffective. Indeed, complete response can only be achieved with surgical excision of the tumor. PMID: 29650300 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Pulmonary intravascular talcosis: A case report].
CONCLUSION: In the presence of pulmonary miliary in an intravenous drug addict, intravascular talcosis should be suspected. PMID: 29650301 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Impact of an evaluation of the professional practices on the relevance of proton pump inhibitors prescriptions pertinence at the hospital].
The objective of this work was to optimize the relevance of the prescriptions of the IPP in two services of internal medicine and geriatrics through an evaluation of the professional practices. All PPI prescriptions introduced in outpatient visits or during hospitalization were analyzed. PATIENTS AND METHODS: Data collection was prospective, over two periods of 2 months and included 163 (first phase), then 139 patients (second phase). An assessment grid of PPI prescriptions was completed by physicians regarding the active substance, the dose, the duration and the indication of the prescription. The relevance of the pre...
Source: Revue de Medecine Interne - April 11, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[The plague: An overview and hot topics].
Authors: Galy A, Loubet P, Peiffer-Smadja N, Yazdanpanah Y Abstract Plague is a bacterial zoonosis caused by Yersinia pestis, usually found in fleas and small rodents that constitute the reservoir of the disease. It is transmitted to humans by flea bite, contact with rodents or inhalation of infected droplets. There are three clinical forms: bubonic plague, pulmonary plague and septicemic plague. The usual presentation is a flu-like syndrome possibly accompanied by an inflammatory lymphadenopathy which appears after 1 to 7days of incubation. Bubonic plague has a case fatality rate of about 50% while other forms of ...
Source: Revue de Medecine Interne - April 11, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[New nosological and therapeutic perspectives in syndromic vascular malformations with a vein-lymphatic component].
Authors: Henneton P, Mestre S, Nou M, Quere I Abstract Vascular malformations are poorly recognized constitutional anomalies which arises during early childhood. Several classifications tried to draw a distinction across the different entities. Recent advances in molecular biology have contributed to the update of their nosology. Syndromic vascular malformations are an example: while Klippel-Trenaunay syndrome, Proteus or CLOVES syndrome share many common features, understanding of pathological mechanism and specially the role of the PIK3/AKT/mTOR pathway enables us to rethink their classification. Then, some syndr...
Source: Revue de Medecine Interne - April 10, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[An update on the opioid crisis].
Authors: Martinez V PMID: 29625714 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 8, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Enforcement of a new data protection law in Europe: A threat and an opportunity for registries and cohorts in the field of rare diseases].
Authors: Aymé S PMID: 29625715 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 8, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Ocular manifestations in Beh çet's disease].
[Ocular manifestations in Behçet's disease]. Rev Med Interne. 2018 Apr 03;: Authors: Desbois AC, Terrada C, Cacoub P, Bodaghi B, Saadoun D Abstract Ocular disease in Behçet's disease is frequent and may be associated with a poor functional prognosis. Uveitis is the most common ocular manifestation in Behçet's disease and represents a diagnostic criterion of the disease. The ocular involvement is inaugural of the disease in 20% of the cases or may develop 2 to 3 years after the beginning of the extraocular signs. The risk of blindness at 5 years is in the order of 15 to 25%, mainly ...
Source: Revue de Medecine Interne - April 8, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A bipallidal hyperintensity].
Authors: Bertolino J, Gutierrez B, Brun G, Meunier B, Borentain P, Kaphan E, Harle JR, Schleinitz N, Bernit E PMID: 29615271 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 5, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Therapeutic strategy for the treatment of non-infectious uveitis proposed by an expert panel].
Authors: Diwo E, Sève P, Trad S, Bielefeld P, Sène D, Abad S, Brézin A, Quartier P, Koné Paut I, Weber M, Chiquet C, Errera MH, Sellam J, Cacoub P, Kaplanski G, Kodjikian L, Bodaghi B, Saadoun D Abstract Conventional immunosuppressive drugs, anti-TNF alpha and other biotherapies used in clinical practice are capable of controlling non-infectious anterior uveitis, posterior uveitis and panuveitis. The present work has been led by a multidisciplinary panel of experts, internists, rheumatologists and ophthalmologists and is based on a review of the literature. In case of corticodependency o...
Source: Revue de Medecine Interne - April 4, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Bell's palsy].
Authors: Prud'hon S, Kubis N Abstract Idiopathic peripheral facial palsy, also named Bell's palsy, is the most common cause of peripheral facial palsy in adults. Although it is considered as a benign condition, its social and psychological impact can be dramatic, especially in the case of incomplete recovery. The main pathophysiological hypothesis is the reactivation of HSV 1 virus in the geniculate ganglia, leading to nerve edema and its compression through the petrosal bone. Patients experience an acute (less than 24 hours) motor deficit involving ipsilateral muscles of the upper and lower face and reaching ...
Source: Revue de Medecine Interne - April 4, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Iron deficiency: Recent pathophysiological approach and treatment consequences].
Authors: Cacoub P PMID: 29610005 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 4, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Type 3  Gaucher disease, also an adult disease?]
CONCLUSION: This mutation results in calcified heart valves, corneal opacities, alteration of oculomotricity and hydrocephalus. The mild manifestation at onset and the late neurological involvement in the medical history make the diagnosis more difficult. This particular clinical phenotype deserves to be known in adult medicine departments. PMID: 29610006 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 4, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Uveitis: From diagnosis to treatment].
Authors: Saadoun D, Trad S, Bielfeld P, Sene D, Abad S, Kaplanski G, Terrada C, Kodjikian L, Bodaghi B, Seve P PMID: 29602609 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 1, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Ocular tuberculosis  : A case series].
CONCLUSION: Ocular tuberculosis is a rare disease but still remains a diagnostic problem. It should be considered in case of any chronic ocular symptoms, especially in endemic countries. Early management can improve the visual prognosis. PMID: 29580651 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 29, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[The Script Concordance Test: A multimodal teaching tool].
Authors: Karila L, François H, Monnet X, Noel N, Roupret M, Gajdos V, Lambotte O, Benhamou D, Benyamina A Abstract In recent years, there has been a major interest in assessing learners during their medical education. The core of medical competence is the clinical reasoning that should be acquired by all medical actors. Its assessment includes the ability to integrate and apply different types of knowledge, weigh critical evidence and think about the process used to have a diagnosis. French faculties of medicine will have to include it in the training and evaluation of students during 2017. It should therefo...
Source: Revue de Medecine Interne - March 28, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Recurrent abdominal pain in an 88-year-old woman].
Authors: Cosserat J, Du Breuil F, Validire P, Lenoir S, Wolf S, Gayraud M, Vinit J PMID: 29576196 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 28, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[The nocebo effect: Various aspects and consequences in clinical practice].
Authors: Mouly S, Bergmann JF, Molimard M PMID: 29576197 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 28, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Influenzae and pneumococcal vaccination rate in an internal medicine ward].
CONCLUSION: These results underline the very low prevalence of pneumococcal vaccination rate in at-risk hospitalized patients, as compared with influenza, despite recent recommendations. PMID: 29571580 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 25, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Simulation-based learning development: More haste, less speed].
Authors: Galland J PMID: 29571581 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 25, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Cancer-screening for older patients].
Authors: Boureau AS, de Decker L Abstract Cancer-screening programmes are public health action for a target population. It guarantees an equal access to screening throughout the country with a high level of quality for every person of the target population. Given the heterogeneity of older subjects and the variability of the expected benefits of cancer-screening programmes, this collective public health action may not have a collective benefit for the population. However, for older person with a life expectancy of five years or more, it would be possible to propose an individualized cancer-screening decision. This ...
Source: Revue de Medecine Interne - March 21, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Simulation-based learning and internal medicine: Opportunities and current perspectives for a national harmonized program].
Authors: Galland J, Abbara S, Terrier B, Samson M, Tesnières A, Fournier JP, Braun M Abstract Simulation-based learning (SBL) is developing rapidly in France and the question of its use in the teaching of internal medicine (IM) is essential. While HAS encourages its integration into medical education, French Young Internists (AJI) set up a working group to reflect on the added-value of this tool in our specialty. Different sorts of SBL exist: human, synthetic and electronic. It enables student to acquire and evaluate technical skills (strengths, invasive procedures, etc.) and non-technical skills (relational...
Source: Revue de Medecine Interne - March 21, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Vitamine K antagonists overdose: Physician adherence to the French guidelines].
CONCLUSION: Adherence to HAS guidelines seems finally limited. It is necessary to put in place procedures to secure the behavior of physicians. PMID: 29550092 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 21, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Buschke's scleredema successfully treated with extracorporeal photopheresis].
We report a case of a 50-year-old woman who presented a chronic sclerodermiform syndrome for 2 years associated with type 1 diabetes. Physical examination revealed an extensive skin induration involving the shoulders, neck and back. Histologic examination confirmed the diagnosis of scleredema adultorum. The patient was treated with extracorporeal photopheresis (EPP) twice a month for two months. At follow-up, mobility was highly improved after two months. Beneficial effect of EPP was maintained on the long term while sessions were spaced. DISCUSSION: EPP is an unconventional treatment of Buschke's scleredema. We descri...
Source: Revue de Medecine Interne - March 19, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Misuse and dependence on prescription opioids: Prevention, identification and treatment. Rolland B. et al. Rev Med Interne 2017;38:539-546].
Authors: Gelot B, Wiet AS, Sarram S PMID: 29530409 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 15, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Authors' response].
Authors: Rolland B, Authier N, Brousse G, Bouhassira D, Perrot S, Dematteis M PMID: 29526326 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Induced drug uveitis and drug side effects in ophthalmology].
Authors: Trad S, Bonnet C, Monnet D Abstract Ocular drug side effects are very varied and can affect all the structures of the eye. The purpose of this review is to help clinicians: (i) to evoke this drug-induced toxicity yearly in the course of an unexplained ocular injury, before its damage become irreversible, (ii) to be able to recognize induced paradoxical ocular inflammation, mimicking an inflammatory pathology flare-up, especially in patient under anti-TNF regimen and (iii) to propose a more in-depth knowledge on recently described ocular toxicities from targeted cancer therapy, mainly the tyrosine kinase in...
Source: Revue de Medecine Interne - March 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Gastroparesis may be the cause of unexplained dyspepsia in patients with primary Sj ögren syndrome].
CONCLUSION: In primary Sjögren syndrome, gastroparesis should be suspected in case of unexplained dyspepsia, and a scintigraphy performed to prove the diagnosis. A neurologic involvement could explain gastroparesis, but prospective studies are needed for a better understanding of this disorder. PMID: 29526328 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Familial Mediterranean fever].
Authors: Georgin-Lavialle S, Hentgen V, Stankovic Stojanovic K, Bachmeyer C, Rodrigues F, Savey L, Abbara S, Conan PL, Fraisse T, Delplanque M, Rouet A, Sbeih N, Koné-Paut I, Grateau G Abstract Familial Mediterranean Fever (FMF) is the most frequent monogenic auto-inflammatory disease. FMF is an autosomal recessive disease, which affects populations from Mediterranean origin and is associated with MEFV gene mutations encoding for the protein pyrin. Pyrin activation enhances the secretion of interleukin 1 by myelo-monocytic cells. Main features of the disease are acute attacks of serositis mainly located on t...
Source: Revue de Medecine Interne - March 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Tumor necrosis receptor associated periodic syndrome (TRAPS): State of the art].
Authors: Georgin-Lavialle S, Kone-Paut I, Delaleu J, Sarrabay G, Grateau G, Touitou I, Hentgen V Abstract Tumour necrosis receptor associated periodic syndrome (TRAPS) is a rare cosmopolitan dominant autosomal disease that belongs to the group of recurrent autoinflammatory syndromes. TRAPS is characterized by recurrent bouts of fever lasting more than 7 days, with arthralgia, myalgia, abdominal pain, erythematous rash and sometimes ocular symptoms. During flares, raised inflammatory markers are constant. The age of onset may occur during childhood but also during adulthood. TRAPS is caused by mutations in the TNF r...
Source: Revue de Medecine Interne - March 12, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research