Les colites microscopiques.
Authors: Rivière P, Zerbib F Abstract Microscopic colitis is frequently found as a cause of chronic watery diarrhea in women after menopause. The disease can be associated with a medication side effect in half of the patients (non-steroidal anti-inflammatory drugs or proton pump inhibitors for instance). Colonic biopsies are mandatory for the diagnosis of microscopic colitis and should be performed in several locations of the colon. Management of microscopic colitis is first based on avoiding iatrogenic factors and smoking together with symptomatic treatment of diarrhea (loperamide, cholestyramine). In case ...
Source: Revue de Medecine Interne - July 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[(the current place of non-invasive large-vessel imaging in the diagnosis and follow-up of giant cell arteritis)].
Authors: Liozon E Abstract Large vessel involvement in giant cell arteritis has long been described, although its right frequency and potential prognostic value have only been highlighted for two decades. Large vessel involvement not only is associated with a high incidence of late aortic aneurysms, but also might cause greater resistance to glucocorticoids and longer treatment duration, as well as worse late cardiovascular outcomes. These data were brought to our attention, thanks to substantial progress recently made in large vessel imaging. This relies on four single, often complementary, approaches of varying a...
Source: Revue de Medecine Interne - July 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Bioth érapies chez le sujet âgé.
Biothérapies chez le sujet âgé. Rev Med Interne. 2020 Jul 14;: Authors: Michaut A, Varin S Abstract The ageing of the population leads health professionals to question the tolerance and the effectiveness of the different biotherapies used in autoimmune diseases. Due to the exponential increase of biotherapies and their indications, several studies have been carried out to evaluate their impact on elderly patients suffering from autoimmune disease. However, these studies are still too few to take into account all the different specificities of elderly patients and their comorbidities...
Source: Revue de Medecine Interne - July 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Direct oral anticoagulants: In which indications? Which one to prescribe? For or against their use in frail patients and in atypical cases? Which monitoring and management haemorrhage complications?]
Authors: Hoffmann C, Leven C, Le Mao R, De Moreuil C, Lacut K Abstract Since their approval, the direct oral anticoagulants have been widely used in the management of venous thromboembolism, for stroke and systemic embolism prevention in non valvular atrial fibrillation, and in venous thromboembolism prophylaxis after surgical hip or knee replacement. Because they are easy to use, with oral fixed doses and no biological monitoring need, they are more and more prescribed. New indications are rising in cancer associated thrombosis in France beyond the 6 first months of treatment, and to prevent cardiovascular events ...
Source: Revue de Medecine Interne - July 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Evaluation of the use of a simulation software in the learning of cardiopulmonary auscultation in undergraduate medical students].
CONCLUSION: The supervised use of an online auscultation simulation software in addition to the traditional clinical training seems to improve the auscultation performances of undergraduated medical students. PMID: 32660857 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 16, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Coca ïne et lésions destructrices centro-faciales : à propos d'un cas.
CONCLUSION: CIMDL is a centrofacial destructive process due to intranasal cocaine use. It is frequently associated with the presence of p-ANCA with both anti-HNE and anti-PR3 specificity. PMID: 32660858 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 16, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Des gangues p éri-rénales.
Des gangues péri-rénales. Rev Med Interne. 2020 Jul 11;: Authors: Calvar E, Hankard A, Maigne G, Lobbedez T, Aouba A, Maillot F, Audemard-Verger A PMID: 32665094 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 16, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[An acute abdominal pain of unusual cause].
Authors: Belabbes S, En-Nafaa I, Ziadi T, Zainoun B, El Fenni J PMID: 32651012 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 13, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Functional immunoassays in the setting of infectious risk and immunosuppressive therapy of non-HIV immunocompromised patients].
Authors: Boccard M, Albert-Vega C, Mouton W, Durieu I, Brengel-Pesce K, Venet F, Trouillet-Assant S, Ader F Abstract The holistic approach of the human immune system is based on the study of its components collectively driving a functional response to an immunogenic stimulus. To appreciate a specific immune dysfunction, a condition is mimicked ex vivo and the immune response induced is assessed. The application field of such assays are broad and expanding, from the diagnosis of primary and secondary immunodeficiencies, immunotherapy for cancer to the management of patients at-risk for infections and vaccination. Th...
Source: Revue de Medecine Interne - July 7, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Une masse pelvienne.
Authors: Zamani O, Saouab R, Nouali H, El Fenni J, Edderai M PMID: 32624261 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 7, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Des paupi ères lourdes.
Des paupières lourdes. Rev Med Interne. 2020 Jul 03;: Authors: Trefond L, Rieu V, Grobost V, Resseguier AS, Lemaire A, Le Guenno G, Ruivard M PMID: 32624262 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - July 7, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[An hereditary hemorrhagic telangiectasia of late revealed by a cerebral venous thrombosis: A case report].
CONCLUSION: This is the first case described of cerebral venous thrombosis treated with rivaroxaban revealing an HHT. PMID: 32565074 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 23, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Preventing Covid-19 after lockdown: For a rapid comeback to "life before"].
[Preventing Covid-19 after lockdown: For a rapid comeback to "life before"]. Rev Med Interne. 2020 Jun;41(6):358-359 Authors: Hanslik T, Flahault A PMID: 32540118 [PubMed - in process] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 18, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Clinico-radiological spectrum of cerebral small vessel diseases].
Authors: Ouin E, Jouvent E Abstract Cerebral small vessel diseases are frequent and can be seen through all ages. Although the most frequent forms related to age and hypertension or to cerebral amyloid angiopathy are mainly observed in subjects over 50 years of age, rarer forms may affect young people, sometimes even children. Some familial or inflammatory forms can be particularly misleading with some presentations very difficult to relate to a microvascular origin. Cerebral small vessel diseases thus raise both daily therapeutic issues and much rarer diagnostic questions, sometimes extremely complex. Our aim was ...
Source: Revue de Medecine Interne - June 18, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Update on beta blockers in 2020].
Authors: Bejan-Angoulvant T, Angoulvant D Abstract Beta-blockers (BB) are an heterogenous set of molecules actively blocking β adrenergic receptors. Their pharmacological properties depend on their various effects on the adrenergic signalling. Although they are no longer a first-choice treatment in hypertensive patients, they remain a cornerstone of pharmacological strategy in several cardiovascular diseases such as stable angina, heart failure, arrythmia and aortic related connective diseases. Beyond their usual non cardiovascular indications such as migraine, hepatic cirrhosis, glaucoma, infantile hemangioma...
Source: Revue de Medecine Interne - June 15, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[COVID-19: Pathogenesis of a multi-faceted disease].
Authors: Bonny V, Maillard A, Mousseaux C, Plaçais L, Richier Q Abstract SARS-CoV-2 infection, named COVID-19, can lead to a dysregulated immune response and abnormal coagulation responsible for a viral sepsis. In this review, we specify physiopathological mechanisms of each phase of COVID-19 - viral, immune and pro-thrombotic - notably because they involve different treatment. Finally, we specify the physiopathological mechanisms of organ injury. PMID: 32507520 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 10, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[In ambulatory patients with suspected pulmonary embolism, does a new diagnostic strategy using D-dimers adjusted to clinical probability make it possible to safely exclude this diagnosis without using chest imaging?]
Authors: Lanthier L, Le Templier G, Huard G, Plourde MÉ, Cauchon M PMID: 32499058 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 6, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Legitimate resistance without technophobia: Analysis of electronic medical records impacts on the medical profession].
The objective of this short narrative literature review is to highlight the different difficulties encountered by medical doctor in the daily use of EMR. We show that these are not simple transitional phenomena related to a "resistance to change", but rather the fact of a deeper and unfinished transformation. Beyond the "perception of misfit with work processes" or the threat of a loss of autonomy, we propose to analyze this so-called "resistance" in relation to the formalization of medical work induced by EMR. Our question concerns the compatibility of the multiple objectives of EMR, the pote...
Source: Revue de Medecine Interne - May 31, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Frequency and predictive factors of venous thrombosis in Beh çet's disease].
[Frequency and predictive factors of venous thrombosis in Behçet's disease]. Rev Med Interne. 2020 May 26;: Authors: Ha-Ou-Nou FZ, Essaadouni L Abstract OBJECTIVE: To investigate the clinical features of venous thrombosis in patients with Behçet's disease and to determine the patients at high risk for this complication. METHODS: We retrospectively studied patients with venous thrombosis (n = 157) who were followed up in the Internal Medicine department. These patients were divided into two groups according to the existence (n = 60, 38.2%) or not (n = 97, 61.8%) of Beh&cced...
Source: Revue de Medecine Interne - May 31, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A scalp lesion].
Authors: Hinschberger O, Bernier C, Damour AS, Oudeville P, Kieffer P PMID: 32456788 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 29, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Gynecological Lemierre's syndrome: A case report and literature review].
CONCLUSION: Gynecological Lemierre's syndrome is a rare and unrecognized condition, which could be lethal. Early recognition of the disorder enables initiation of appropriate antibiotic therapy for 4 to 6 weeks, and discussion of anticoagulant therapy which indications are not yet well defined. PMID: 32371121 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 7, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Fatal intracerebral hemorrhage in a patient with chronic neutrophilic leukemia: About one case and literature review].
CONCLUSION: This bleeding phenotype has been reported several times in patients with CNL. However, the pathophysiological mechanisms that cause bleeding are not yet fully understood. PMID: 32362366 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 6, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Weight loss and cervical mass in a 50  year-old man].
[Weight loss and cervical mass in a 50 year-old man]. Rev Med Interne. 2020 Apr 30;: Authors: Sotier M, Stern JB, Brian E, Wyplosz B, Validire P, Lenoir S, Gayraud M, Cosserat J, Deroux A PMID: 32362367 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 6, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Des v ésicules cutanées.
Des vésicules cutanées. Rev Med Interne. 2020 Apr 28;: Authors: Martiano M, Chantalat L, Simon M, Fourgeaud C, Vignes S PMID: 32359817 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 4, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Introduction to debriefing for internists: how to transform real or simulated clinical situations into learning moments].
Authors: Galland J, Jaffrelot M, Sanges S, Fournier JP, Jouquan J, Chiniara G, Rivière É Abstract Debriefing is a phase of synthesis and reflection that immediately follows a real-life or simulated situation. It is an essential educational step that forces the learners to reflect upon the thought processes that underlie their actions. Debriefing encourages a personal and collective reflection in order to remodel erroneous mental schemas and rectify actions done in context. Debriefing cannot be improvised; it requires a sound structure and regular practice in order to be truly effective. The debriefer ...
Source: Revue de Medecine Interne - May 4, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A tularemia mimicking lymphoma].
CONCLUSION: The association of fever, night sweats, altered general state and mediastinal adenopathies should be considered as a diagnosis of tularemia. Ganglionic biopsy, combined with molecular biology techniques and serology, can confirm the diagnosis. PMID: 32359978 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 4, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Lower-limb peripheral arterial disease in 2019].
Authors: Le Hello C, Fouillet L, Boulon C, Rivière S, El Jaouhari A, Seffert B, Morel A, Boissier C Abstract Peripheral arterial disease is a result of atheroma. This disease is frequent in subjects with vascular risk factors. This disease is also frequent in low income countries. The detection and the diagnosis of peripheral arterial disease is obtained by calculating the ankle brachial index. Patients with peripheral arterial disease are not always symptomatic thus explaining how this disease is under diagnosed. The symptoms can be absent, and especially in case of diabetes or in women. In case of peripher...
Source: Revue de Medecine Interne - May 4, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Illnesses unrelated to systemic sclerosis (IUSS) diagnosed throughout the patient's follow-up in a referral center: A cohort of 200 patients].
CONCLUSION: This study focused on IUSS in SSc patients and highlights the need for a polyvalent clinical approach all along the follow up of SSc patients. PMID: 32354573 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 3, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Thoracic air bubbles of unusual cause].
Authors: Rousset S, Heylen M, Bonnet-Bellon M, Vedel B, Quesnel B, Billet S, Combres B, Henry C PMID: 32354574 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 3, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

La m édecine interne dans la pandémie à SARS-CoV-2.
La médecine interne dans la pandémie à SARS-CoV-2. Rev Med Interne. 2020 Apr 17;: Authors: Jamilloux Y, Lega JC PMID: 32334859 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 27, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

La recherche clinique à partir d’entrepôts de données. L’expérience de l’Assistance Publique – Hôpitaux de Paris (AP–HP) à l’épreuve de la pandémie de Covid-19.
La recherche clinique à partir d’entrepôts de données. L’expérience de l’Assistance Publique – Hôpitaux de Paris (AP–HP) à l’épreuve de la pandémie de Covid-19. Rev Med Interne. 2020 Apr 17;: Authors: Daniel C PMID: 32334860 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 27, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A rare cause of impaired general condition: Muscular and cardiac toxicity of antimalarials].
CONCLUSION: Cardiac and muscular toxicity related to antimalarials are rare and sometimes fatal; thus, they must be systematically assessed in a patient with several years of exposure. A muscle biopsy could be sufficient to allow for the diagnosis. PMID: 32334861 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 27, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[COVID-19: Clinical, biological and radiological characteristics in adults, infants and pregnant women. An up-to-date review at the heart of the pandemic].
Authors: Plaçais L, Richier Q Abstract The spread of the new coronavirus SARS-CoV-2, discovered in China in January 2020, led to a pandemic as early as March 2020, forcing every health care system in the affected countries to adapt quickly. In order to better address this major health crisis, which has given rise to numerous scientific publications, we have synthesized the main original clinical studies to facilitate the day-to-day management of patients with COVID-19. We detail the early signs and progression of the disease as well as the different clinical forms, including extra-pulmonary, as known at the ...
Source: Revue de Medecine Interne - April 27, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Is screening for lung cancer in high-risk subjects using low-dose CT scan effective in reducing mortality?]
Authors: Lanthier L, Bouchard N, Huard G, Plourde ME, Cauchon M PMID: 32312589 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 23, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Gout].
Authors: Scuiller A, Pascart T, Bernard A, Oehler E Abstract Gout is a chronic disease due to the deposition of monosodium urate microcrystals in joints and tissues. Its incidence and prevalence are increasing worldwide in close relation with the epidemic of obesity and metabolic syndrome. Gout is related to chronic hyperuricemia that should be treated to ensure the reduction or even the disappearance of acute attacks ("gout flares") and to reduce the size and number of tophi. If arthritis of the first metatarsophalangeal joint is the most typical form, other joints may be affected, including the spine. D...
Source: Revue de Medecine Interne - March 25, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Severe MDA5 dermatomyositis associated with cancer and controlled by JAK inhibitor].
We report the case of a 60-year-old woman referred to our hospital for an anti-melanoma differentiation-associated 5 gene antibody-positive dermatomyositis (MDA5 DM) with rapidly progressive interstitial pneumonia, typical cutaneous features and muscular impairment. Treatment with high-dose methylprednisolone, cyclophosphamide and gamma globulin was performed, but the patient remained corticodependant. Blood detection of positive interferon signature justified the administration of an anti-JAK1/2, leading to the clinical remission and the regression of the interferon signature. After 12 months of follow up, a small cell ca...
Source: Revue de Medecine Interne - March 21, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Basal ganglia calcification].
Authors: Auffray-Calvier E, Lintia-Gaultier A, Bourcier R, Aguilar Garcia J Abstract Calcifications of the basal ganglia are frequently seen on the cerebral CT scans and particularly in the globus pallidus. Their frequency increases physiologically with age after 50 years old. However, pathological processes can also be associated with calcium deposits in the gray nuclei, posterior fossa or white matter. Unilateral calcification is often related to an acquired origin whereas bilateral ones are mostly linked to an acquired or genetic origin that will be sought after eliminating a perturbation of phosphocalcic m...
Source: Revue de Medecine Interne - March 15, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[White matter hyper-intensities in ageing: Pathophysiology, associated cognitive disorders and prevention].
Authors: Garnier-Crussard A, Desestret V, Cotton F, Chételat G, Krolak-Salmon P Abstract White matter hyper-intensities (WMH), also known as leukoaraïosis are very common neuroradiological manifestations in the elderly. The main risk factors for WMH are age and high blood pressure. The vascular origin of these lesions is classically accepted and WMH are considered as one feature of the small vessel disease. WMH may be associated with clinical symptoms, depending notably on their importance according to age. They are associated with increased mortality, strokes and changes in cognition with a higher risk...
Source: Revue de Medecine Interne - March 5, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Do have patients with "Hashimoto disease" to be operated on? A critical reading of The Norvegian Trial Surgery Study, a prospective randomized investigation published in Annals of Internal Medicine (2019)].
[Do have patients with "Hashimoto disease" to be operated on? A critical reading of The Norvegian Trial Surgery Study, a prospective randomized investigation published in Annals of Internal Medicine (2019)]. Rev Med Interne. 2020 Feb 26;: Authors: Wémeau JL PMID: 32113635 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 4, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Use of targeting therapy in Erdheim-Chester disease: A case report with neurologic involvement].
CONCLUSION: Our case report shows the persistent diagnostic difficulty of the ECD and the particular gravity of neurologic involvement. PMID: 32113636 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 4, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Infectious myositis].
Authors: Molina B, Pogossian A, De Moreuil C, Rouvière B, Le Berre R Abstract Infectious myositis is a rare condition that can be caused by bacteria, viruses, parasites or fungi. Muscle pain or weakness are symptoms shared by all type of myositis. Diagnosis is made on clinical presentation: fever and poor general state is found in bacterial myositis, diffuse muscle pain with flu-like symptoms in viral causes, eosinophilia and a tropical travel history can be related to parasitic etiology, and immunocompromising condition suggests fungal infection. Rhabdomyolysis, leukocytosis and elevated C-reactive protein ...
Source: Revue de Medecine Interne - March 4, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Seronegative antiphospholipid syndrome: Myth or reality?]
Authors: Salle V Abstract The antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombosis and/or obstetrical manifestations and the persistent presence, at least 12 weeks apart, of antiphospholipid antibodies (aPL) such as lupus anticoagulant (LA) and/or anticardiolipin antibodies (ACL) and/or anti-β2 glycoprotein I antibodies (aβ2GPI). The finding of patients with clinical profile highly suggestive of APS but who are negative for conventional biological criteria has led to the concept of seronegative APS. In the last few years, new antigen targets and methodological appro...
Source: Revue de Medecine Interne - March 4, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Scientific misconduct: A major threat for medical research].
Authors: Barde F, Peiffer-Smadja N, de La Blanchardière A Abstract Scientific misconduct (fabrication, falsification, and plagiarism) and detrimental research practices (selective reporting of data, inappropriate citation practice, ghostwriting) are admitted respectively by 2 % and 33 % of researchers. The consequences of scientific misconduct and detrimental research practices are disastrous, both for the doctors, who are the most affected researchers in view of the number of retracted articles, and for the patients, victims of false information that may have health consequences. In order to fight...
Source: Revue de Medecine Interne - March 1, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Thyroiditis: What's new in 2019?]
Authors: Rouland A, Buffier P, Petit JM, Vergès B, Bouillet B Abstract Thyroiditis is a frequent and mostly benign disease that can sometimes disrupt the thyroid balance. Their diagnosis, as well as their aetiology, is a necessary step in the management of the patients. Painful thyroiditis includes acute thyroiditis of infectious origin and subacute thyroiditis. The first one can be treated by antibiotics or antifungals depending on the germ found. The second one will be treated with non-steroidal anti-inflammatory drugs or corticosteroids. In cases of Hashimoto's thyroiditis with overt hypothyroidism, repla...
Source: Revue de Medecine Interne - March 1, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Wells syndrome misdiagnosed as bacterial cellulitis].
We report a case of WS presenting as bacterial cellulitis. A 59 year-old woman was referred to our department with a 10-day history of a rapidly extending erysipelatoid rash of the left upper limb, non-responding to oral antibiotics. Upon physical examination, erythema with swelling and blisters were found on the left upper limb with urticarial-like lesions on the breast, the belly and on the inner thighs. The patient was admitted with presumed bacterial cellulitis and was treated with intravenous ampicillin. Blood count showed raised eosinophils (2050/ul) along with a biological inflammatory syndrome. Biopsies were perfor...
Source: Revue de Medecine Interne - February 26, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Cholesterol crystal embolism mimicking a DRESS].
CONCLUSION: This case is the first to report a DRESS like presentation of CCE. Clinical findings are secondary to HE and not to occlusion of cutaneous arteries. PMID: 32089328 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 26, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Update on cholesterol crystal embolism].
Authors: Denis Le Seve J, Gourraud Vercel C, Connault J, Artifoni M Abstract Cholesterol crystal embolism is a systemic pathology associated with diffuse atherosclerosis. Pathophysiology corresponds to tissue necro-inflammation secondary to arteriolar occlusion associated with microembolism from atherosclerotic plaques of large diameter arteries. The clinical presentation is heterogeneous and polymorphic. Multiple organs may be the targets, but preferential damage is skin, kidneys and digestive system. It is a serious pathology, underdiagnosed, with a poor prognosis. The risk factors for developing the disease rema...
Source: Revue de Medecine Interne - February 24, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Comments on Gratzer et al.: ``Des guidelines pour l'intelligence artificielle !''].
Authors: Galland J PMID: 32088098 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 24, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Botulism: A case report and literature review].
CONCLUSION: Although botulism is uncommon, better awareness of its manifestations and high clinical suspicion should shorten diagnostic delay that makes the use of specific antitoxin ineffective. An acute onset of a bilateral oculomotor palsy, a fixed pupillary dilation and descending weakness in the absence of fever is typical of botulism. Outcome is usually favorable with a slow but full neurological recovery. PMID: 32061395 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Characteristics of Systemic Sclerosis patients with positive anti-Th/To antibodies: About 6 patients and literature review.
Authors: Muller R, Benyamine A, Bertin D, Harlé JR, Kaplanski G, Mazodier K, Reynaud-Gaubert M, Granel B, Bardin N Abstract Among the antibodies described in Systemic Sclerosis (SSc), anti-Th/To antibodies (anti-Th/To) are rare and have been poorly studied. Thus, little is known about the profile of anti-Th/To positive patients. From our local Biobank (Marseille, France), we retrospectively selected data for 6 patients positive for anti-Th/To with an Immunodot assay. All of them suffered from SSc, sharing clinical and biological common features such as a limited cutaneous form of SSc, a decreased lung diffus...
Source: Revue de Medecine Interne - February 19, 2020 Category: Internal Medicine Tags: Rev Med Interne Source Type: research