L ’hémolyse drépanocytaire : une victime malfaisante: Sickle cell hemolysis: a harmful sufferer
Rev Med Interne. 2023 Nov;44(4S1):4S1. doi: 10.1016/S0248-8663(23)01301-2.NO ABSTRACTPMID:38049240 | DOI:10.1016/S0248-8663(23)01301-2 (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - December 4, 2023 Category: Internal Medicine Authors: F Galact éros Source Type: research
Les an émies aiguës et la stratégie transfusionnelle chez les drépanocytaires adultes: Acute anemias transfusion strategy in adult sickle cell patients
Rev Med Interne. 2023 Nov;44(4S1):4S12-4S17. doi: 10.1016/S0248-8663(23)01304-8.ABSTRACTWorsening of anemia is very common in sickle cell disease. It is important to investigate specific complications related to sickle cell disease but also other causes of anemia in general. Transfusions or exchange transfusions are major therapeutic options and are frequently used for acute complications of sickle cell disease but also for primary and secondary prevention of some of the chronic complications. The transfusion strategy has been modified since the awareness of post-transfusion hemolysis by taking into account the transfusion...
Source: Revue de Medecine Interne - December 4, 2023 Category: Internal Medicine Authors: A Habibi F Pirenne Source Type: research
Le globule rouge dr épanocytaire : données fonctionnelles: The sickle red blood cell: functional data
Rev Med Interne. 2023 Nov;44(4S1):4S18-4S23. doi: 10.1016/S0248-8663(23)01305-X.ABSTRACTSickle cell anemia is a genetic disorder that affects hemoglobin leading to the production of an abnormal hemoglobin, called HbS. HbS has the property to polymerize under deoxygenated conditions, causing a mechanical distortion of red blood cells; a phenomenon called sickling. These sickle red blood cells are more fragile and rigid, leading to chronic hemolytic anemia and painful vaso-occlusive crises, as well as chronic vascular complications that can affect many organs. The abnormal functional properties of these sickle red blood cell...
Source: Revue de Medecine Interne - December 4, 2023 Category: Internal Medicine Authors: P Connes E Nader Source Type: research
Le globule rouge dr épanocytaire. Données génétiques et structurelles: The sickle cell. Genetic and structural data
Rev Med Interne. 2023 Nov;44(4S1):4S2-4S6. doi: 10.1016/S0248-8663(23)01302-4.ABSTRACTSickle cell disease is syndromic, associating a hemolytic anemia, a vaso-obstructive vascular disease, and an infectious risk linked to the precocity of the splenic function loss. The willingly hyperacute and potentially fatal character of the two last elements of the pathophysiologic syndrome, has, quite rightly, focused the therapeutic researches on them. Great success in those two domains have allowed a very important gain in life expectancy. However, chronic progressive organ dysfunction began to appear in older than 25 years-old pati...
Source: Revue de Medecine Interne - December 4, 2023 Category: Internal Medicine Authors: F Galact éros Source Type: research
Exploration de l ’hémolyse associée à la drépanocytose et perspectives thérapeutiques spécifiques: Sickle cell disease hemolysis investigations and targeted therapeutics prospects
Rev Med Interne. 2023 Nov;44(4S1):4S7-4S11. doi: 10.1016/S0248-8663(23)01303-6.ABSTRACTSickle Cell Anemia is a disease with a strong vascular tropism. Beyond anemia, the pathophysiological mechanisms responsible for hemolysis, directly affect both acute and chronic vascular damages, thus resulting in a systemic disease. Understanding the different types of hemolysis underline the need for novel specific biomarkers. Targeted therapeutic approaches for these pathophysiological pathways are necessary to improve Sickle Cell patients' prognosis. Finally, given its complexity, Sickle Cell Disease is often used as a "proof of con...
Source: Revue de Medecine Interne - December 4, 2023 Category: Internal Medicine Authors: P Bartolucci Source Type: research
L ’hémolyse drépanocytaire : une victime malfaisante: Sickle cell hemolysis: a harmful sufferer
Rev Med Interne. 2023 Nov;44(4S1):4S1. doi: 10.1016/S0248-8663(23)01301-2.NO ABSTRACTPMID:38049240 | DOI:10.1016/S0248-8663(23)01301-2 (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - December 4, 2023 Category: Internal Medicine Authors: F Galact éros Source Type: research
Les an émies aiguës et la stratégie transfusionnelle chez les drépanocytaires adultes: Acute anemias transfusion strategy in adult sickle cell patients
Rev Med Interne. 2023 Nov;44(4S1):4S12-4S17. doi: 10.1016/S0248-8663(23)01304-8.ABSTRACTWorsening of anemia is very common in sickle cell disease. It is important to investigate specific complications related to sickle cell disease but also other causes of anemia in general. Transfusions or exchange transfusions are major therapeutic options and are frequently used for acute complications of sickle cell disease but also for primary and secondary prevention of some of the chronic complications. The transfusion strategy has been modified since the awareness of post-transfusion hemolysis by taking into account the transfusion...
Source: Revue de Medecine Interne - December 4, 2023 Category: Internal Medicine Authors: A Habibi F Pirenne Source Type: research
Le globule rouge dr épanocytaire : données fonctionnelles: The sickle red blood cell: functional data
Rev Med Interne. 2023 Nov;44(4S1):4S18-4S23. doi: 10.1016/S0248-8663(23)01305-X.ABSTRACTSickle cell anemia is a genetic disorder that affects hemoglobin leading to the production of an abnormal hemoglobin, called HbS. HbS has the property to polymerize under deoxygenated conditions, causing a mechanical distortion of red blood cells; a phenomenon called sickling. These sickle red blood cells are more fragile and rigid, leading to chronic hemolytic anemia and painful vaso-occlusive crises, as well as chronic vascular complications that can affect many organs. The abnormal functional properties of these sickle red blood cell...
Source: Revue de Medecine Interne - December 4, 2023 Category: Internal Medicine Authors: P Connes E Nader Source Type: research
Le globule rouge dr épanocytaire. Données génétiques et structurelles: The sickle cell. Genetic and structural data
Rev Med Interne. 2023 Nov;44(4S1):4S2-4S6. doi: 10.1016/S0248-8663(23)01302-4.ABSTRACTSickle cell disease is syndromic, associating a hemolytic anemia, a vaso-obstructive vascular disease, and an infectious risk linked to the precocity of the splenic function loss. The willingly hyperacute and potentially fatal character of the two last elements of the pathophysiologic syndrome, has, quite rightly, focused the therapeutic researches on them. Great success in those two domains have allowed a very important gain in life expectancy. However, chronic progressive organ dysfunction began to appear in older than 25 years-old pati...
Source: Revue de Medecine Interne - December 4, 2023 Category: Internal Medicine Authors: F Galact éros Source Type: research
Exploration de l ’hémolyse associée à la drépanocytose et perspectives thérapeutiques spécifiques: Sickle cell disease hemolysis investigations and targeted therapeutics prospects
Rev Med Interne. 2023 Nov;44(4S1):4S7-4S11. doi: 10.1016/S0248-8663(23)01303-6.ABSTRACTSickle Cell Anemia is a disease with a strong vascular tropism. Beyond anemia, the pathophysiological mechanisms responsible for hemolysis, directly affect both acute and chronic vascular damages, thus resulting in a systemic disease. Understanding the different types of hemolysis underline the need for novel specific biomarkers. Targeted therapeutic approaches for these pathophysiological pathways are necessary to improve Sickle Cell patients' prognosis. Finally, given its complexity, Sickle Cell Disease is often used as a "proof of con...
Source: Revue de Medecine Interne - December 4, 2023 Category: Internal Medicine Authors: P Bartolucci Source Type: research
Estates general on internal medicine: For better knowledge and recognition of our specialty
Rev Med Interne. 2023 Dec;44(12):629-631. doi: 10.1016/j.revmed.2023.11.008.NO ABSTRACTPMID:38000831 | DOI:10.1016/j.revmed.2023.11.008 (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 24, 2023 Category: Internal Medicine Authors: P S ève L Mouthon Source Type: research
