[Authors' response].
Authors: Rolland B, Authier N, Brousse G, Bouhassira D, Perrot S, Dematteis M PMID: 29526326 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Induced drug uveitis and drug side effects in ophthalmology].
Authors: Trad S, Bonnet C, Monnet D Abstract Ocular drug side effects are very varied and can affect all the structures of the eye. The purpose of this review is to help clinicians: (i) to evoke this drug-induced toxicity yearly in the course of an unexplained ocular injury, before its damage become irreversible, (ii) to be able to recognize induced paradoxical ocular inflammation, mimicking an inflammatory pathology flare-up, especially in patient under anti-TNF regimen and (iii) to propose a more in-depth knowledge on recently described ocular toxicities from targeted cancer therapy, mainly the tyrosine kinase in...
Source: Revue de Medecine Interne - March 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Gastroparesis may be the cause of unexplained dyspepsia in patients with primary Sj ögren syndrome].
CONCLUSION: In primary Sjögren syndrome, gastroparesis should be suspected in case of unexplained dyspepsia, and a scintigraphy performed to prove the diagnosis. A neurologic involvement could explain gastroparesis, but prospective studies are needed for a better understanding of this disorder. PMID: 29526328 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Familial Mediterranean fever].
Authors: Georgin-Lavialle S, Hentgen V, Stankovic Stojanovic K, Bachmeyer C, Rodrigues F, Savey L, Abbara S, Conan PL, Fraisse T, Delplanque M, Rouet A, Sbeih N, Koné-Paut I, Grateau G Abstract Familial Mediterranean Fever (FMF) is the most frequent monogenic auto-inflammatory disease. FMF is an autosomal recessive disease, which affects populations from Mediterranean origin and is associated with MEFV gene mutations encoding for the protein pyrin. Pyrin activation enhances the secretion of interleukin 1 by myelo-monocytic cells. Main features of the disease are acute attacks of serositis mainly located on t...
Source: Revue de Medecine Interne - March 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Tumor necrosis receptor associated periodic syndrome (TRAPS): State of the art].
Authors: Georgin-Lavialle S, Kone-Paut I, Delaleu J, Sarrabay G, Grateau G, Touitou I, Hentgen V Abstract Tumour necrosis receptor associated periodic syndrome (TRAPS) is a rare cosmopolitan dominant autosomal disease that belongs to the group of recurrent autoinflammatory syndromes. TRAPS is characterized by recurrent bouts of fever lasting more than 7 days, with arthralgia, myalgia, abdominal pain, erythematous rash and sometimes ocular symptoms. During flares, raised inflammatory markers are constant. The age of onset may occur during childhood but also during adulthood. TRAPS is caused by mutations in the TNF r...
Source: Revue de Medecine Interne - March 12, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Statin treatment must be personalized].
Authors: Bruckert E, Gallo A PMID: 29510859 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 9, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Propensity score: Interests, use and limitations. A practical guide for clinicians].
Authors: Moulis G, Lapeyre-Mestre M Abstract Propensity scores have been proposed in the early 1980s, and are increasingly used in epidemiology since the 2000s. They are is used to minimize the selection bias in observational studies, leading to a comparability between the exposure groups close to that observed in randomized trials. However, they have important limitations. Besides, new statistical techniques to improve the propensity score performances are more and more complex, while the build and the use of propensity score require a strict methodology to avoid bias, imprecision and non-reproducibility. This ove...
Source: Revue de Medecine Interne - March 9, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Benign metastasizing leiomyoma: An unusual cause of aggressive femoral bone tumor].
CONCLUSION: BML is a potential cause of aggressive, although histologically benign, bone tumor in women with a history of uterine surgery. PMID: 29502928 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 7, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[An unusual cause of abdominal pain].
Authors: Ugé S, Le Borgne P, Brunhuber C, Bilbault P, Kauffmann P PMID: 29502929 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 7, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Immunosuppressive therapy and fertility preservation: Indications and methods].
Authors: Choux C, Cavalieri M, Barberet J, Samson M, Bonnotte B, Fauque P, Sagot P Abstract Fertility preservation is routinely performed in cancerology but less systematically used in the field of immune diseases, even though the use of gonadotoxic treatments in young patients may be required and even though the disease itself can alter fertility. This review aimed to clarify the indications and methods of fertility preservation in this context. Cyclophosphamide is the only immunosuppressive drug requiring fertility preservation in women. In men, fertility preservation should be proposed before treatment with cycl...
Source: Revue de Medecine Interne - March 5, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Intermittent thoracic pain].
Authors: Louarn A, Ksiyer S, Ilardo C, Garnier LF, Evain S, Marsaudon E PMID: 29501511 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 5, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Clinical overview of auto-inflammatory diseases].
Authors: Georgin-Lavialle S, Rodrigues F, Hentgen V, Fayand A, Quartier P, Bader-Meunier B, Bachmeyer C, Savey L, Louvrier C, Sarrabay G, Melki I, Belot A, Koné-Paut I, Grateau G Abstract Monogenic auto-inflammatory diseases are characterized by genetic abnormalities coding for proteins involved in innate immunity. They were initially described in mirror with auto-immune diseases because of the absence of circulating autoantibodies. Their main feature is the presence of peripheral blood inflammation in crisis without infection. The best-known auto-inflammatory diseases are mediated by interleukines that cons...
Source: Revue de Medecine Interne - March 5, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Rosai-Dorfman disease: Diagnosis and therapeutic challenges].
Authors: Cohen Aubart F, Haroche J, Emile JF, Charlotte F, Barete S, Schleinitz N, Donadieu J, Amoura Z Abstract Rosai-Dorfman disease (RDD) was first described by the French pathologist Paul Destombes in 1965. It frequently affects children or young adults and is characterized by the presence of large histiocytes with emperipolesis. More than 50 years after this first description, the pathogenesis of this rare disease is still poorly understood. The revised classification of histiocytoses published in 2016 identified various forms of RDD, from familial RDD to IgG4-associated RDD. Almost 90% of the patients with RD...
Source: Revue de Medecine Interne - March 5, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Scleritis and systemic diseases: What should know the internist?]
Authors: Bielefeld P, Saadoun D, Héron E, Abad S, Devilliers H, Deschasse C, Trad S, Sène D, Kaplanski G, Sève P Abstract Scleritis is an inflammatory disease of the sclera; outer tunic of the eye on which the oculomotor muscles are inserted. It can be associated with a systemic disease up to one time out of 3. These associated diseases are mainly rheumatoid arthritis, vasculitis, including granulomatosis with polyangiitis in the first line and spondyloarthropathies. Before mentioning such an etiology, it is necessary to eliminate an infectious cause, mainly herpetic, which is regularly underes...
Source: Revue de Medecine Interne - March 4, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Antimalarial drug retinopathy].
We report the case of a 32-year-old male with a systemic lupus erythematosus treated with hydroxychloroquine 400mg per day and then chloroquine 300mg per day during 8 and 9years respectively. Eighteen months after his latest visual examination, the patient experienced bilateral vision loss. Fundus examination revealed a bull's eye maculopathy. Additional tests including multifocal electroretinogram showed severe bilateral functional impairment in the parafoveal area leading to diagnosis of severe toxic retinopathy induced by antimalarial drugs. DISCUSSION: In 2016, the American Academy of Ophthalmology revised the prev...
Source: Revue de Medecine Interne - March 4, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Management of vertigo and dizziness].
Authors: Bouccara D, Rubin F, Bonfils P, Lisan Q Abstract Balance disorders presenting with symptoms of dizziness and vertigo are due to various diseases. Clinical approach gives the opportunity to identify emergency situations and most common causes, among them the first one being the benign paroxysmal positional vertigo. Oculomotor assessment is pertinent as major clinical orientation, particularly between peripheral and central diseases. These clinical findings support the respective indication of modern imaging and/or vestibular tests, focused on the direction of presupposed diagnosis. On elderly the risk of fa...
Source: Revue de Medecine Interne - March 4, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[NLRC4  associated autoinflammatory diseases: A systematic review of the current literature].
[NLRC4 associated autoinflammatory diseases: A systematic review of the current literature]. Rev Med Interne. 2018 Feb 26;: Authors: Rodrigues F, Hentgen V, Bachmeyer C, Kone-Paut I, Belot A, Grateau G, Sarrabay G, Georgin-Lavialle S Abstract The auto-inflammatory diseases linked to NLRC4 mutations are recently described entities. Transmission is autosomal dominant in 80 % of cases; cases of somatic mutation have already been reported. The disease may display two very different clinical phenotypes: the phenotype 1 (30 %), severe, is dominated by a multisystemic inflammation starting...
Source: Revue de Medecine Interne - March 4, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Systemic sclerosis: Efficacy of intravenous immunoglobulins in severe cardiac involvement?]
CONCLUSION: Our case illustrates a severe heart involvement in systemic sclerosis which have been improved by intravenous immunoglobulins. PMID: 29415815 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 10, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Impact of the 2009 Afssaps guidelines on the management of venous thromboembolic disease in emergency department: Before/after study].
CONCLUSION: Our study shows that globally there is no impact of RGP. The reasons appear multiple with first, the mere dissemination and the absence of implementation of these guidelines. PMID: 29415816 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 10, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Emphysematous cystitis: Report of one case].
CONCLUSION: Clinicians should be aware of this diagnosis: early management is essential to reduce morbidity and mortality. PMID: 29395295 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 6, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Usefulness of eosinopenia for the diagnosis of sepsis in emergency department: Still debated].
Authors: Moussiegt A, Davido B PMID: 29395296 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 6, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hyper-IgE in internal medicine].
Authors: Devilliers H, Turcu A, Vernier N, Muller G, Bielefeld P, Bonniaud P, Besancenot JF Abstract Hyper-IgE may be found under many pathological conditions. The role of IgE is essentially associated with the occurrence of allergic manifestations, which may be accompanied by an increase of their serum levels. Elevation of total IgE has also been reported in association with certain rare genetic immune deficiencies called hyper-IgE syndromes. Other circumstances such as infectious diseases, tumors or autoimmune diseases may also be accompanied by an excessive synthesis of IgE. Considering the diversity of these si...
Source: Revue de Medecine Interne - February 6, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Authors' reply about « Impact diagnostique de l'éosinopénie aux urgences dans le sepsis : les données sont controversées », Moussiegt et al.]
[Authors' reply about « Impact diagnostique de l'éosinopénie aux urgences dans le sepsis : les données sont controversées », Moussiegt et al.] Rev Med Interne. 2018 Jan 31;: Authors: Lavoignet CE, Le Borgne P, Bilbault P PMID: 29397234 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 6, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[It is necessary to quit smoking: Only reducing smoking does not decrease the risk of cardiovascular morbidity and mortality].
Authors: Underner M, Thomas D PMID: 29397235 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 6, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Management of orbital inflammation in internal medicine. Proposal for a diagnostic work-up].
Authors: Abad S, Héran F, Terrada C, Bielefeld P, Sène D, Trad S, Saadoun D, Sève P Abstract Inflammatory orbitopathies relate to an inflammatory state originating within the orbit and its adnexes, except the inner ocular globe. Orbital inflammation (OI) may be either localized manifestation of a proven or like autoimmune disease, or local response from immune system against infectious, structural or tumoral antigens. We review the clinical manifestations of OI, which provide helpful clues to the diagnosis and describe the inflammatory, infectious and neoplastic conditions classically associate...
Source: Revue de Medecine Interne - February 6, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Usefulness of thiopurine methyltransferase polymorphism study and metabolites measurement for patients treated by azathioprine].
Authors: Guillotin V, Galli G, Viallard JF Abstract Azathioprine is widely used in internal medicine and frequently implicated in occurrence of adverse events. Among these adverse events the bone marrow suppression, a dose-related one, is the most serious because of is potential morbidity and mortality. Severe myelosuppression, associated with abnormal AZA metabolism, is linked to the thiopurine methyltransferase (TPMT) genetic polymorphism that results in a high variability of its activity with 89% of patients with a normal activity, 11% with an intermediate activity, and 0.3% with very low activity leading to a v...
Source: Revue de Medecine Interne - January 27, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A Listeria breast abscess in a man].
CONCLUSION: Listeriosis sometimes uncover an unknown immunosuppression, especially in the elderly. Breast is a non-sterile tissue containing a stable microbiome partly from digestive origin. It can thereby be contaminated by Listeria. The specific cutaneous infiltrate of chronic lymphocytic leukemia can create the conditions for a local infection. PMID: 29329700 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 14, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A blue finger].
Authors: Blaison F, Lifermann F, Baudry V PMID: 29310967 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 11, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Abdominal pain of vascular cause].
Authors: Nuzzo A, Ronot M, Maggiori L, Joly F, Corcos O PMID: 29307604 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 10, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Prospective study of the factors associated with the acceptance of generics substitution by patients and their liberal doctors].
Authors: Iskounen S, Simoneau G, Mouly S Abstract BACKGROUND: Many prescribers and patients remain reluctant to substitution to generics. METHODS: We conducted a prospective observational study, using semi-structured interviews adapted to identify factors independently associated with the acceptance of alternative to a generic drug by doctors and patients. RESULTS: Between December 2014 and August 2015, 108 patients and 73 private doctors from Île-de-France and Nord-Pas-de-Calais were enrolled. Only 48 % of patients thought that the effectiveness and safety of generic were identica...
Source: Revue de Medecine Interne - January 3, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A POEMS syndrome revealed by a blue toe syndrome].
CONCLUSION: This is to our knowledge the first case of thrombotic microangiopathy in POEMS syndrome without embolic cause or calciphylaxis. PMID: 29288001 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 1, 2018 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Blood management in geriatric hospitalized population].
The objective of our study was to show the impact of a decision support tool on transfusion practices, specifically in a hospitalized elderly population. METHOD: A clinical decision support, validated in the improvement of practices, was created, based on the latest transfusion recommendations of 2014. Our study was interventional, monocentric, within the departments of internal medicine and geriatrics of a university hospital from February to July 2016. The clinical decision support was available for any request of transfusion of packed red blood cells for 75 years old or older patient who was hospitalized in one of t...
Source: Revue de Medecine Interne - December 31, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Sarcoidosis post-anti-PD-1 therapy, mimicking relapse of metastatic melanoma in a patient undergoing complete remission.
We report a patient developing pulmonary and cutaneous sarcoidosis after pembrolizumab therapy while complete regression of stage IV melanoma was perceived. Coincident development of sarcoidosis and metastatic melanoma as illustrated by this case report poses a diagnostic challenge because, in contrast to other irAEs, both diseases share common features such as pulmonary lesions, hilar adenopathies and skin nodules. Considering sarcoidosis as a potential side-effect of pembrolizumab treatment is crucial to avoid misdiagnosis with malignant lesions, hence careful description and reporting of such cases is primordial for pat...
Source: Revue de Medecine Interne - December 28, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Multiple facets of ADA2 deficiency: Vasculitis, auto-inflammatory disease and immunodeficiency: A literature review of 135 cases from literature].
Authors: Fayand A, Sarrabay G, Belot A, Hentgen V, Kone-Paut I, Grateau G, Melki I, Georgin-Lavialle S Abstract Deficiency of adenosine deaminase 2 (DADA2) is a recently described auto-inflammatory disorder. It is an autosomal recessive inherited disease, caused by mutations in the ADA2 gene (formerly known as CECR1) encoding ADA2 enzyme. Besides its role in the purine metabolism, it has been postulated that ADA2 may act as a growth factor for endothelial cells and in the differenciation of monocytes. Thus, deficiency of ADA2 would lead to endothelial damage and a skewing of monocytes into M1 pro-inflammatory macro...
Source: Revue de Medecine Interne - December 25, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Splenic sarcoidosis diagnosed by US-guided biopsy: About a case].
CONCLUSION: Diagnosis of splenic nodular sarcoidosis can be challenging without any other localization. Splenic biopsy achieved diagnosis. This procedure is associated with a low risk of complications - in particular hemorragic ones. Diagnostic splenectomy should be an exceptional intervention. PMID: 29274795 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - December 25, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Compliance with treatment in Wilson's disease: On the interest of a multidisciplinary closer follow-up].
CONCLUSION: Wilsons's disease patients have important problems with compliance, without necessary being depressed. A close follow-up may help them become compliant, particularly those with neurological symptoms. PMID: 29274796 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - December 25, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Lemierre's syndrome: Diagnosis, exploration, treatment].
Authors: Mesrar H, Mesrar J, Maillier B, Kraoua S, Chapoutot L, Delclaux B Abstract Lemierre's syndrome is a rare and severe sepsis that can rapidly lead to a life-threatening condition in the absence of early management. This syndrome described at the beginning of the 20th century combines oropharyngeal infection complicated with septic thrombosis of the internal jugular vein and septic emboli predominantly pulmonary. Fusobacterium necrophorum, anaerobic germ, Gram negative bacillus is the main germ in this "necrobacillosis". The diagnosis is should be confirmed precociously with cervicothoracic CT-scan,...
Source: Revue de Medecine Interne - December 24, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A predictive bacterial infection score according to eosinophil level: An observational study].
CONCLUSION: The CIBLE score appears to be a relevant and inexpensive tool to establish a probability for bacterial infection. PMID: 29223347 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - December 12, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Efficacy and tolerance of tocilizumab for corticosteroid sparing in giant cell arteritis and aortitis: Experience of Nimes University Hospital about eleven patients].
CONCLUSION: Tocilizumab could be efficient and well-tolerated in steroid-dependent giant cell arteritis and aortitis. The modalities of its use remain to be precised. PMID: 29221884 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - December 11, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Does tocilizumab mean the end of glucocorticoids in giant cell arteritis?]
Authors: Samson M, Bonnotte B PMID: 29217104 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - December 9, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Sedimentary cutaneous lesions].
Authors: Oehler E, Fialek M PMID: 29195771 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - December 5, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Heart failure of unusual cause].
Authors: Nèji H, Baccouche I, Attia M, Affes M, Kammoun I, Hantous-Zannad S, Ben Miled-M'rad K PMID: 29153345 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 22, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Validit é et reproductibilité de deux grilles d’observation des compétences cliniques des internes en DES de médecine interne.
CONCLUSION: If the absolute value of the scores should not be taken into account in the evaluation process given its high variability, it could be of interest for the follow-up of the progression in the competencies. These forms could support the residents' debriefing based on the general trends given by the scores. PMID: 29157753 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 22, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Should statin therapy be discontinued in the elderly?]
Authors: Bonnet F PMID: 29157754 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 22, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acetaminophen induced 5-oxoproline acidosis: An uncommon case of high anion gap metabolic acidosis].
We describe a case of 5-oxoproline (pyroglutamate) acidosis due to chronic acetaminophen ingestion at therapeutic dose in a 79-year-old inpatient. The pathophysiology of this condition is detailed, with abnormalities in the gamma-glutamyl cycle due to acetaminophen ingestion and severe chronic morbidities, resulting in glutathione and cysteine deficiency and then accumulation of 5-oxoproline. In HAGMA, when usual causes have been excluded, 5-oxoproline acidosis should be suspected in patients with chronic morbidities and acetaminophen ingestion. This diagnosis should be kept in mind because it generally resolves quickly wi...
Source: Revue de Medecine Interne - November 22, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Chronic histiocytic intervillositis: Diagnosis and management].
Authors: Mekinian A, Costedoat-Chalumeau N, Carbillon L, Coulomb-L'Hermine A, Le Guern V, Masseau A, Lazaro E, Cohen J, Bornes M, Kayem G, Fain O Abstract Chronic intervillositis is a rare condition, which is associated with severe obstetrical outcome and high recurrence rate. Obstetrical adverse events are intrauterine growth restriction, recurrent early miscarriages, intrauterine deaths and prematurity by placental insufficiency. The determination of the extension and the intensity of the chronic intervillositis are not currently standardized. High rates of recurrence have been described, but actually there is no...
Source: Revue de Medecine Interne - November 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Confusion and weight loss].
Authors: Cacciatore C, Mekinian A, Arrivé L, Adedjouma A, Fain O PMID: 29146014 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Aspirin: Indications and use during pregnancy].
Authors: Belhomme N, Doudnikoff C, Polard E, Henriot B, Isly H, Jego P Abstract Aspirin (acetylsalicylic acid) has been used ever since the Antiquity for its painkilling and anti-inflammatory effects. Its antiplatelet properties have then extended its indications to the field of coronaropathy and vascular cerebral disease, and finally to vascular placental disease. Aspirin has been widely prescribed since the 1980's to prevent pre-eclampsia, intra-uterine growth retardation and fetal death of vascular origin. It has also been proposed to prevent unexplained recurrent miscarriages. Its use during pregnancy is consid...
Source: Revue de Medecine Interne - November 15, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Diagnostic issues of lymphogranuloma venereum: A case series of 5  patients].
CONCLUSION: LG should be evoked in any patient with inguinal adenomegaly, particularly in case of STI history or risk factors. Negativity of urinary PCR should lead to further investigations, essentially a lymph node cytopuncture to evidence C. trachomatis. PMID: 29128125 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 14, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Uveitis: Diagnostic work-up. Recommendations from an expert committee].
CONCLUSIONS: We propose a strategy for the etiologic diagnosis of uveitis. The recommendations should be updated regularly. The efficiency of more invasive investigations has yet to be evaluated. PMID: 29122311 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 12, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research