[Functional somatic syndromes: A comprehensive cognitive model].
Authors: Pitron V, Ranque B, Vulser H, Rotge JY, Limosin F, Lemogne C Abstract Functional somatic syndromes are frequent in general and specialized medicine practices. Several treatments can be useful. However, the treatment program is often hampered by patients' reluctance to acknowledge the diagnosis because of erroneous lay representations. Recent advances in cognitive science offer a new understanding of the pathophysiology of functional somatic disorders, making this diagnosis more acceptable for patients and caregivers. Simply explained with practical examples, the Bayesian model in particular provides some i...
Source: Revue de Medecine Interne - June 6, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Unusual occupational poisoning].
Authors: Dufayet L, Galletto Pregliasco A, Meng P, Gilleron P, Vodovar D PMID: 31153650 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 4, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Mesenteric lymph node cavitation in celiac disease: Report of four cases and literature review].
CONCLUSION: The severity of this complication deserves to be known and should lead to its research in celiac patients, especially in cases diagnosed in adulthood or in case of refractory disease. PMID: 31155369 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - June 4, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A large thigh of unusual cause].
Authors: Benoughidane B, Vignes S PMID: 31122821 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 29, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Clonal haematopoiesis: A concise review].
Authors: Danlos FX, Papo M, Micol JB Abstract Clonal hematopoiesis of undetermined significance or CHIP describes the identification, in individuals without hematologic disease, of one or more somatic mutations in hematopoietic cells. These mutations, detected by high-throughput genes sequencing (Next-Generation Sequencing or NGS), affect genes first identified in acute myeloid leukemia or myelodysplastic syndrome, such as DNMT3A, TET2 and ASXL1. CHIP is associated with an increased risk of malignant hemopathy, both myeloid and lymphoid, evaluated from 0.5 to 1% per year. CHIP is also associated with an increased r...
Source: Revue de Medecine Interne - May 29, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Confusion in a 45-year-old woman].
Authors: Morbieu C, Rollin G, Saada N, Botterel F, Limal N, Lepeule R, Michel M, Sobanski V PMID: 31128857 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 29, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Finger lesions].
Authors: Khibri H, Soughi M, Boujraf S, Rabhi S PMID: 31128858 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 29, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Update in severe asthma physiopathology and treatments].
Authors: Hassoun D, Moui A, Colas L, Blanc FX, Magnan A Abstract Asthma is an inflammatory airway disease which presentation is highly heterogeneous. Last two decades provided new clinical and basic data concerning asthma physiopathology that make global understanding much complex. Phenotypes based on clinical settings and paraclinical investigations from large cohorts confirm old paradigm (eosinophilic vs. non-eosinophilic asthma) but also introduce new concepts (obesity-related asthma, late onset asthma, etc.). Conversely, improvement of big data analytics allows to initiate new cohorts aiming at better understan...
Source: Revue de Medecine Interne - May 29, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A persistent acrocyanosis in a 55 year-old woman].
Authors: Humbert S, Razanamahery J, Payet-Revest C, Méaux-Ruault N, Gil H, Magy-Bertrand N, London J PMID: 31128860 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 29, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A microcytic sideroblastic anemia successfully treated with B6 vitamin].
CONCLUSION: Pyridoxine deficiency must be sought in sideroblastic anemia in patients at risk. PMID: 31133329 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 29, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Should we look for neoplasia in a patient with unexplained granulomatosis?]
Authors: Seve P, Jamilloux Y, Gerfaud-Valentin M, El-Jammal T, Pavic M PMID: 31133330 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 29, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Bilateral adrenal tumors].
Authors: Esnault H, Lahaye C, Girard L, Desoutter MA, Couvelard A, Alexandra JF, Faucher N, Raynaud-Simon A, Lilamand M, Sanchez M PMID: 31133331 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 29, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Undernutrition of the elderly].
Authors: Drevet S, Gavazzi G Abstract Malnutrition remains a particularly important issue in elderly. Physiological ageing induces many changes but ageing cannot entirely explain a Protein-Energy Malnutrition (PEM). Nutritionnal screening is indicated once a year in community medicine or in the first 48hours in case of an acute disease or of hospitalization. The Mini Nutritional Assessment is recommended for screening and for the diagnostic of malnutrition. Possible aetiologies are large and must be investigated in order to be careful not to dismiss curable disease and to be able to take corrective actions. PEM is ...
Source: Revue de Medecine Interne - May 24, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hemophagocytic lymphohistiocytosis with granulomatosis and diffuse T-cell infiltration associated with disseminated Nocardiosis and pulmonary infection due to Streptomyces spp].
CONCLUSION: Recent diagnosis of HLH without obvious etiology should lead to etiological investigation, including the search for infections with slow-growing bacteria such as Nocardia or Streptomyces spp. PMID: 31103241 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 21, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Facial redness and fainting after elevation of both arms in a 74 year-old man].
Authors: Baugé C, Strazzulla A, de Pontfarcy A, Flateau C, Diamantis S, Chakvetadze C PMID: 31103242 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 21, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Treatment of ITP and AIHA in CVID: A systematic literature review].
CONCLUSION: The presence of CVID does not mean that it is necessary to give up on corticosteroids as a first-line treatment and rituximab as a second-line treatment for AIHA and ITP, but it should be in addition to immunoglobulin replacement. A splenectomy should be reserved as a third-line treatment. PMID: 31101329 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 19, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A tetraparesis of unusual cause].
Authors: Ferrieres L, Catros F, Gache F PMID: 31101330 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 19, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hydrochlorothiazide use and risk of skin cancers: A systematic review].
Authors: Becquart O, Guillot B, Bourrain JL, Duflos C, Du-Thanh A Abstract The risk of skin cancer induced by photosensiting drugs is well known. An association between hydrochlorothiazide use and skin cancer has been recently published in some epidemiological studies. A systematic review of case-control or prospectives cohorts showed an increased risk of cutaneous squamous cell carcinoma even if some confusing factors such as tobacco smoking was not analysed. Results are more conflicting for basal cell carcinoma or melanoma. These results do not modify the benefit/risk ratio but should lead to propose preventive m...
Source: Revue de Medecine Interne - May 19, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Tumoral lesion of the face].
Authors: Frikha F, Boudaya S, Bahloul E, Mesrati H, Amouri M, Turki H PMID: 31092320 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 18, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A frontal sinus lesion].
Authors: Bilger L, Kauffmann P, Brunhuber C, Bilbault P, Le Borgne P PMID: 31060891 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 8, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Benefits and risks of oxygen therapy during acute medical illness: Just a matter of dose!
Authors: Allardet-Servent J, Sicard G, Metz V, Chiche L Abstract Oxygen therapy is used to reverse hypoxemia since more than a century. Current usage is broader and includes routine oxygen administration despite normoxemia which may result in prolonged periods of hyperoxemia. While systematic oxygen therapy was expected to be of benefit in some ischemic diseases such as stroke or acute myocardial infarction, recent randomised controlled trials (RCTs) have challenged this hypothesis by showing the absence of clinical improvement. Although oxygen is known to be toxic at high inspired oxygen fractions, a recent meta-a...
Source: Revue de Medecine Interne - May 7, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Management of myelodysplastic syndromes in 2019: An update].
This article aims to provide an update on the knowledge that an internist should know for the practical management of myelodysplastic syndromes in 2019. PMID: 31054780 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 7, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acute carpal tunnel syndrome caused by a thrombosis of a persistent median artery: 2 case reports].
We describe 2 cases of acute carpal tunnel syndrome due to thrombosed persistent median artery, including a case of thromboangiitis obliterans. These thrombosis might also be due to traumatic causes. No guidelines are currently available to help physicians for the management of carpal tunnel syndrome from thrombosed persistent median artery. Antiplatelet therapy, statin, anticoagulant might be helpful, and surgery has sometimes be reported as effective. PMID: 31040049 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - May 2, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Sj ögren's syndrome update: Clinical and therapeutic aspects].
[Sjögren's syndrome update: Clinical and therapeutic aspects]. Rev Med Interne. 2019 Apr 23;: Authors: Nocturne G Abstract Sjögren's syndrome (SS) is a systemic orphan disease. It is characterized by the involvement of epithelial tissues leading to the term of autoimmune epithelitis. New classification criteria have been developed in 2016. New scores have also been developed: a patient-reported outcome called ESSPRI and a score assessing systemic activity of the disease called ESSDAI. These new tools are very helpful to better stratify patients and to customize the management of this very het...
Source: Revue de Medecine Interne - April 28, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hepatitis B virus infection: Natural history, clinical manifestations and therapeutic approach].
Authors: Paccoud O, Surgers L, Lacombe K Abstract Chronic hepatitis B infection remains a major public-health problem, with approximately 260 million world-wide cases of infection. Recent advances in the understanding of the natural history of chronic hepatitis B infection have led to progress in the care of infected patients. Sustained viral suppression is now possible for a majority of treated patients and is associated with a decrease in the morbidity and mortality attributable to cirrhosis and hepatocellular carcinoma. Complete cure is however not yet possible, due to the long-term persistence of viral DNA in h...
Source: Revue de Medecine Interne - April 17, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Very early and early systemic sclerosis: An update].
Authors: Michaud M, Catros F, Ancellin S, Gaches F Abstract Classification criteria for systemic sclerosis evolved over the last three decades, allowing an earlier classification. In the late 2000s, the EULAR Scleroderma Trials and Research Group validated very early and early systemic sclerosis criteria. Raynaud phenomenon, anti-nuclear antibody positivity and the puffy fingers are "Red flags" that must lead to refer the patient to a specialist and benefit from a capillaroscopy and the specific autoantibodies. At the stage of very early systemic sclerosis, pulmonary, cardiac and digestive involvements ma...
Source: Revue de Medecine Interne - April 15, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Coronary involvement and nephrotic syndrome in systemic lupus: A case report].
CONCLUSION: Coronary artery disease should be systematically evoked in the presence of ventricular dysfunction in patients with systemic lupus, including when they are young and in the absence of chest pain. Nephrotic syndrome should be identified as a risk factor for arterial thrombosis. PMID: 30981562 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 15, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Use of biotherapy in the management of Beh çet's disease in a department of internal medicine].
CONCLUSION: Biotherapy is effective and represents a solution to the failures of conventional treatments in severe forms of Behçet's disease with ocular involvement. PMID: 30955904 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 10, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Primary prophylaxis of venous thromboembolism in ambulatory cancer patients treated with antineoplastic agents].
Authors: Debourdeau P, Simonin C, Carbasse C, Debourdeau T, Zammit C, Scotté F Abstract Apart from myeloma, primary prophylaxis of venous thromboembolism (VTE) in ambulatory cancer patients treated with chemotherapy is underused, despite its proven benefit for pancreatic cancer and to a lesser extent for lung cancer. This prophylaxis has been showed to be effective for myeloma, pancreas but in absolute numbers these cancers lead to a few venous thromboembolic events. Up to date, VTE risk scores cannot be used as a discriminatory criterion to select a high-risk population that could really benefit from this p...
Source: Revue de Medecine Interne - April 2, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A tool for knowledge transfer in internal medicine from Quebec: "BaladoCritique: Journal Club" podcast].
[A tool for knowledge transfer in internal medicine from Quebec: "BaladoCritique: Journal Club" podcast]. Rev Med Interne. 2019 Mar 27;: Authors: Lanthier L, Plourde MÉ, Huard G, Cauchon M PMID: 30928245 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - April 2, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Analysis of the discrimination of the final marks after the first computerized national ranking exam in Medicine in June 2016 in France].
CONCLUSION: The cNRE reduced equally-ranked students compared to 2015, with a mean deviation between two papers of 0.28 in 2016 vs 0.04 in 2015. Despite the new format introduced by the cNRE, 75% of students are still ranked in a low proportion of points that is equivalent to previous NRE in 2015 (between 15 et 20% of points). PMID: 30902508 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 26, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acquired autoimmune haemophilia: Where is the place of rituximab in the treatment strategy? Reflection from a monocentric series of 8 patients and literature review].
CONCLUSIONS: Rituximab appears to be an effective and well-tolerated treatment for autoimmune acquired haemophilia. However, its place remains to be specified. PMID: 30904179 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 26, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Which place of antiphosphatidylethanolamine antibodies research in seronegative antiphospholipid syndrome suspicion?]
CONCLUSION: These results suggest the implication of aPE in SNAPS. PMID: 30905593 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 26, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[One or more functional somatic syndromes? Comparison of the health status of fibromyalgia and electro-hypersensitive people].
CONCLUSION: The health status of fibromyalgia persons is overall worse than the health status of electro-hypersensitive individuals in this small sample. Despite the overlap in symptoms and a similar impact on daily functioning, this exploratory study suggests that heterogeneous mechanisms of "somatization" may be at stake in functional somatic syndromes. PMID: 30885414 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 21, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Reliability and validity of a workbook for assessment of professional competencies of internal medicine residents].
CONCLUSION: This study suggest that it would be difficult to ensure a sufficient reliability for professional skills assessment using these tools given our available current human and material resources. However, these assessment forms could be added to the resident portfolio as supports for the debriefing in order to document their progression during their formation. PMID: 30871866 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 16, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Free light chains assay: Indications and methods].
Authors: Martellosio JP, Leleu X, Roblot P, Martin M, Puyade M Abstract Serum free light chains (sFLC) assay is an important marker in plasma cell dyscrasia. It is thus recommended for the diagnosis of monoclonal gammopathy, together with serum protein electrophoresis and immunofixation. sFLC assay has also a prognostic value and is a criterion for treatment response and relapse of some monoclonal gammopathies. Three assays are currently available in France, the gold standard being the Freelite® assay, the two others requiring further validation. These three assays are not interchangeable during patient's follo...
Source: Revue de Medecine Interne - March 15, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Azithromycine and chronic bronchial diseases: For which patients? For which benefits? With what modalities?]
Authors: Pronost P, Tromeur C Abstract Azithromycin is a macrolide widely used in chronic bronchial diseases due to its anti-inflammatory properties. This treatment is prescribed to patients with bronchiectasis, asthma and severe chronic obstructive pulmonary disease who present more than 3 exacerbations per year or a deterioration of respiratory function despite an optimal treatment. Macrolides decrease the number of exacerbation but azythromycine must be prescribed carefully. Indeed, it involves potential cardiovascular and otological toxicities and the emergence of resistant bacteria. In addition, studies r...
Source: Revue de Medecine Interne - March 13, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A rash of the face].
Authors: Chaabouni R, Bahloul E, Boudaya S, Frikha F, Amouri M, Turki H PMID: 30857824 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 13, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Unusual cause of upper extremity edema].
Authors: Quentric P, Michelin P, Lévesque H, Miranda S PMID: 30853379 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 12, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Alcohol withdrawal syndrome management: Is there anything new?
Authors: Airagnes G, Ducoutumany G, Laffy-Beaufils B, Le Faou AL, Limosin F Abstract Patients with alcohol use disorder experience frequently alcohol withdrawal syndrome (AWS), which is a potentially life-threatening condition mainly caused by glutamate overactivity. The aim of therapeutic alcohol withdrawal is the entry into a process of complete and lasting abstinence. Therefore preparing withdrawal is crucial to optimize compliance and efficacy of aftercare. Indeed, performing repeated withdrawal per se without any project of subsequent abstinence may be deleterious, at least because of repeated exposure to glut...
Source: Revue de Medecine Interne - March 12, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Chronic metabolic and renal disorders related to lithium salts treatment].
Authors: Tabibzadeh N, Vrtovsnik F, Serrano F, Vidal-Petiot E, Flamant M Abstract Lithium salts are the main treatment of bipolar disorder, which is characterized by potentially life-threatening maniac and/or depressive episodes. They have proven efficient in the prevention and treatment of acute episodes as well as in the prevention of suicidal risk. However, this efficacy is counterbalanced by a narrow therapeutic range that can lead to potentially harmful overdose, and by adverse long-term events. Nevertheless, they remain first-line treatment, notwithstanding therapeutic alternatives. In this review, we will de...
Source: Revue de Medecine Interne - March 6, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hemolytic disorders and venous thrombosis: An update].
Authors: Lecouffe-Desprets M, Graveleau J, Artifoni M, Connault J, Agard C, Pottier P, Hamidou M, Néel A Abstract Many factors can contribute to the risk of venous thrombosis observed in hemolytic diseases. Some mechanisms are related to hemolysis by itself, while others seem more specific to each disease. Despite recent advances in the quantification of this risk and in understanding its physiopathology, the association of hemolysis with venous thrombosis is often unknown. The purpose of this general review is to clarify the main pro-thrombotic mechanisms during hemolysis and to synthesize the clinical data...
Source: Revue de Medecine Interne - February 20, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hypertrophic cardiomyopathies].
Authors: Lairez O Abstract Hypertrophic cardiomyopathies represent a heterogeneous group of pathophysiological mechanisms and etiologies (genetic or not), which lead to the development of left ventricular hypertrophy. Left ventricular hypertrophy, when not explained by a significant and prolonged increase in post-load (such as severe poorly controlled arterial hypertension or severe aortic stenosis) justifies etiological exploration. The etiology may range from physiological adaptation in the athlete to myocardial involvement, isolated or integrated as part of a global neuromuscular involvement; metabolic or mitoch...
Source: Revue de Medecine Interne - February 13, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Diagnosis of pulmonary embolism].
Authors: Righini M, Robert-Ebadi H, Le Gal G Abstract The diagnosis of pulmonary embolism (PE) is nowadays based on the sequential use of several diagnostic tests rather than on a single test. These diagnostic strategies are safe and have been prospectively validated. The first step after identifying patients with suspicion of PE is to establish the pre-test clinical probability. Several scores are available in order to make a standardised and reproducible assessment of the clinical probability, and therefore represent precious diagnostic tools. Indeed, clinical probability guides further investigations. Indeed, in...
Source: Revue de Medecine Interne - February 13, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Chronic disease and empathy: Psychotherapy or placebotherapy?]
Authors: Braillon A, Grenon Q, Taiebi F PMID: 30711359 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 5, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[CAR-T cells: Lymphocytes that express a chimeric antigen receptor].
Authors: Chabannon C, Bouabdallah R, Fürst S, Granata A, Saillard C, Vey N, Mokart D, Fougereau E, Lemarie C, Mfarrej B, Blaise D, Calmels B Abstract CAR-T cells are genetically modified human lymphocytes and gene therapy medicinal products. They are developed to treat cancers that express a membrane antigen targeted by the CAR. The FDA approved the two first-in-class medicinal products in 2017 and EMA in August 2018; both are autologous CAR-T cells targeting CD19 that is expressed at the surface of normal B-cells throughout their differentiation, and on B-cell lymphoid malignancies. Clinical efficacy was demo...
Source: Revue de Medecine Interne - January 30, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Association between prescription of long-term systemic glucocorticoid therapy associated measures and prescriber's medical speciality].
CONCLUSION: Adjuvant measures to long-term glucocorticoid therapy are heterogeneously prescribed. The prescriptions depend largely on the medical specialty of the prescribing physician. PMID: 30683427 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 29, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Headaches of unusual cause].
Authors: Rougelot A, Beaumel A, Luyton C, Coury F PMID: 30638701 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 16, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Hepatitis C virus infection, 1989-2019: From discovery to eradication].
Authors: Cacoub P, Halfon P PMID: 30638702 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 16, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Metabolic encephalopathies].
Authors: Marois C, Quirins M, Hermann B, Mouri S, Bouzbib C, Rudler M, Thabut D, Weiss N Abstract Metabolic encephalopathies (ME) are a common cause of admission to emergency rooms, to hospitalization wards or to intensive care units. They could account for 10 to 20% of causes of comatose states in ICU and could be associated to a poor outcome especially in older patients. Nevertheless, they are often reversible and are associated with a favorable outcome when diagnosed and rapidly treated. They correspond to an altered brain functioning secondary to the deficiency of a substance that is mandatory for the normal br...
Source: Revue de Medecine Interne - January 16, 2019 Category: Internal Medicine Tags: Rev Med Interne Source Type: research