[Usefulness of nuclear medicine in Erdheim-Chester disease: A Lille experience].
CONCLUSION: Our retrospective study suggests that bone scintigraphy and 18F-FDG PET/CT could be useful in the initial assessment of Erdheim-Chester disease but also for the latter in the therapeutic evaluation. PMID: 28268124 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 9, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Management of mesenteric ischemia in the era of intestinal stroke centers: The gut and lifesaving strategy].
Authors: Nuzzo A, Corcos O Abstract Mesenteric ischemia is a gut and life-threatening, medical and surgical, digestive and vascular emergency. Mesenteric ischemia is the result of an arterial or venous occlusion, a vasospasm secondary to low-flow states in intensive care patients, aortic clamping during vascular surgery or intestinal transplantation. Progression towards mesenteric infarction and its complications is unpredictable and correlates with high rates of mortality or a high risk of short bowel syndrome in case of survival. Thus, mesenteric ischemia should be diagnosed and treated at an early stage, when gu...
Source: Revue de Medecine Interne - March 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Pulmonary nodules].
Authors: Prevel R, Receveur MC, Duvignaud A PMID: 28258864 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 5, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Sternal tumefaction].
Authors: Pamoukdjian F, Al Nawakil C, Bouzouina L, Landré T, Sebbane G, Taleb C PMID: 28258865 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 5, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Peripheral neuropathies: Diagnostic strategy].
Authors: Magy L Abstract Diagnosing a peripheral neuropathy is sometimes challenging, as the causes are diverse and the clinical pictures heterogeneous. Overall, diagnosing a patient with peripheral neuropathy will require some knowledge in almost every field of medicine. Therefore, it appears crucial to adopt a diagnostic strategy that is based on solid clinical and neurophysiological grounds. The present paper describes a three-step diagnostic strategy: (1) to delineate a clinico-pathologic entity from clinical and electrodiagnostic findings; (2) to propose a list of plausible causes based on step one, history an...
Source: Revue de Medecine Interne - March 5, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acrocyanosis: A common but poorly understood condition].
Authors: Miranda S, Lévesque H PMID: 28242038 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - March 2, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Streptococcus milleri: An unusual cause of skull extensive osteomyelitis in an immunocompetent patient].
CONCLUSION: It is necessary to discuss the differential diagnosis of giant cell arteritis particularly when symptoms are unusual. Even a short-term corticosteroid therapy may dramatically exacerbate an undetected infection. PMID: 28236536 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 27, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Prevalence and risk factors for sickle retinopathy in a sub-Saharan comprehensive Sickle Cell Center].
We report here the results of a routine screening for sickle retinopathy in a Comprehensive Sickle Cell Center in Sub-Saharan Africa. METHODS: Screening of sickle retinopathy was carried out in all sickle cell patients aged 10 and over, followed between 2010 and 2012. Retinopathy was screened by dilated indirect fundoscopic examination and retinal angiography, if necessary. The gender, age and hematological parameters of patients with sickle retinopathy were compared with those of controls randomly selected from the cohort of sickle cell patients without retinopathy followed during the same period. RESULTS: The ove...
Source: Revue de Medecine Interne - February 27, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Regulation of French research: How to use it?]
Authors: Mamzer MF PMID: 28215924 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 23, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Elderly patients and intensive care: Systematic review and geriatrician's point of view].
The objective of this review is to provide an overview of the literature about the management of elderly patients in intensive care unit and more specifically about epidemiology, admission criteria, mortality, functional prognosis and ethical aspects. We also discuss the data on cardiorespiratory arrest, shock, acute respiratory failure and delirium. The mortality rate of patients over 80 years old in intensive care unit can reach up to 70% at 1year, but is dependent on many factors, such as comorbidities or frailty. Above all, more than half of elderly patients recover their long-term autonomy. Their quality of life is co...
Source: Revue de Medecine Interne - February 23, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acute pancreatitis as the presenting feature of an IgA vasculitis: An unusual presentation].
CONCLUSION: Despite its rarity, pancreatitis is a potential life-threatening complication of IgA vasculitis in which the role of glucocorticoids and immunosuppressive drugs remains uncertain. A prompt elimination of other usual pancreatitis etiologies is mandatory to improve the management of the patients. PMID: 28215926 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 23, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[When and how prescribe antipsychotics?]
Authors: Tebeka S, Airagnes G, Limosin F Abstract Antipsychotics are commonly prescribed in the general population since they have many indications. They can be used in acute care such as agitation or behavior disorders, or to treat more characterized psychiatric disorders like psychotic or mood disorders. Consequently, any practitioner will have to prescribe or renew a prescription of antipsychotics. These treatments require a benefit/risk balance assessment taking into account the specific context of each patient. Indeed, antipsychotics have many side effects, mainly neurological (extrapyramidal syndrome, dyskine...
Source: Revue de Medecine Interne - February 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Sarcoidosis flare after autologous stem cell transplantation: An immune paradox?]
CONCLUSION: Sarcoidosis must be considered ahead of compatible clinicoradiological presentation occurring after HSCT. Sarcoidosis can mimic metastatic cancer or lymphatic relapse. Tissue biopsies and exclusion of differential diagnosis of granuloma diseases are warranted to confirm sarcoidosis diagnosis. PMID: 28196699 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Splenic abscesses: From diagnosis to therapy].
Authors: Davido B, Dinh A, Rouveix E, Crenn P, Hanslik T, Salomon J Abstract Splenic abscess is septic collection which occurs after haematogenous spread or local dissemination. Splenic abscess is an uncommon and rare condition, more frequently affecting male and immunocompromised patients. There are no guidelines regarding its diagnosis and management. Computed tomography (CT) scan is highly sensitive and specific (95% and 92%, respectively) in the diagnosis of splenic abscess. Diagnosis is based on blood cultures which are positive in 24 to 80% of cases. Bacterial growth culture of abscess after drainage is more ...
Source: Revue de Medecine Interne - February 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Adult immunisation: General points, hot topics and perspectives].
Authors: Loubet P, Launay O Abstract Vaccination in immunocompetent adult mainly concerns booster vaccination against diphtheria, tetanus, polio and pertussis. Some chronic diseases may also require the achievement of pneumococcal and influenza vaccines. In addition, from the age of 65, annual influenza vaccination as well as one dose of a live attenuated shingles vaccine between 64 and 75 years are recommended. Immunocompromised adults, due to the increased risk of serious infections responsible of significant morbidity and mortality, are particularly concerned by vaccination. Main issues in this population are th...
Source: Revue de Medecine Interne - February 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Opportunistic autoimmunity secondary to cancer immunotherapy (OASI): An emerging challenge.
Authors: Kostine M, Chiche L, Lazaro E, Halfon P, Charpin C, Arniaud D, Retornaz F, Blanco P, Jourde-Chiche N, Richez C, Stavris C Abstract With "checkpoint inhibitors" targeting PD1/PD-1-ligands or CTLA-4/CD28 pathways, immunotherapy has profoundly modified therapeutic strategies in oncology. First approved in refractory metastatic neoplasms (melanoma and lung adenocarcinoma), it is now being tested broadly in other cancers and/or as adjuvant treatment. For a significant proportion of patients, immunotherapy is responsible for "immunological" events, identified as Immune-Related Adverse Events ...
Source: Revue de Medecine Interne - February 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Misuse and dependence on prescription opioids: Prevention, identification and treatment].
Authors: Rolland B, Bouhassira D, Authier N, Auriacombe M, Martinez V, Polomeni P, Brousse G, Schwan R, Lack P, Bachellier J, Rostaing S, Bendimerad P, Vergne-Salle P, Dematteis M, Perrot S Abstract Since the 1990s, the use of prescription opioids has largely spread, which has brought a real progress in the treatment of pain. The long-term use of prescription opioid is sometimes required, and may lead to pharmacological tolerance and withdrawal symptoms, i.e. pharmacological dependence on prescription opioids. Occasionally, this may also lead to misuse of prescription opioids (MPO). MPO preferentially occurs in vul...
Source: Revue de Medecine Interne - February 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Systemic lupus erythematosus and lymphopenia: Clinical and pathophysiological features].
Authors: Martin M, Guffroy A, Argemi X, Martin T Abstract Lymphopenia is frequent in systemic lupus erythematosus (SLE) and profound (
Source: Revue de Medecine Interne - February 20, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Long-term infectious risks after splenectomy: A retrospective cohort study with up to 10 years follow-up].
CONCLUSION: After splenectomy, the incidence of severe infection declined over time but can occur after 10 years. The onset of infection is linked to age and reason for splenectomy. PMID: 28190612 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 15, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Recurrent pericarditis.
Authors: Imazio M, Battaglia A, Gaido L, Gaita F Abstract Recurrent pericarditis is the most troublesome complication of pericarditis occurring in 15 to 30% of cases. The pathogenesis is often presumed to be immune-mediated although a specific rheumatologic diagnosis is commonly difficult to find. The clinical diagnosis is based on recurrent pericarditis chest pain and additional objective evidence of disease activity (e.g. pericardial rub, ECG changes, pericardial effusion, elevation of markers of inflammation, and/or imaging evidence of pericardial inflammation by CT or cardiac MR). The mainstay of medical therap...
Source: Revue de Medecine Interne - February 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Zika fever].
Authors: Eftekhari-Hassanlouie S, Le Guern A, Oehler E Abstract Zika virus infection is an emerging arboviral disease which presented as a mild flu-like or algo-eruptive syndrome with fever, arthralgia, myalgia and a maculopapulous eruption. Severe neurological and fetal complications have recently been highlighted. Diagnosis is established by detection of viral RNA by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). Many publications report on the progress of knowledge on zika and its complications. Treatment is symptomatic, mainly with analgesics. Prevention is essential through individual and collective...
Source: Revue de Medecine Interne - February 13, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Discontinuation or tapering strategies of biologics in rheumatoid arthritis in remission].
Authors: Mallick A, Fautrel B, Sagez F, Sordet C, Javier RM, Petit H, Chatelus E, Rahal N, Gottenberg JE, Sibilia J Abstract The arrival of new drugs and new therapeutic strategies allowed to reach sustained remission in an increasing number of patients with rheumatoid arthritis. The study of biologic disease-modifying anti-rheumatic drugs (bDMARDs) adaptation strategies is a need to optimize the benefit/risk balance and cost/effectiveness ratio of these molecules. Current recommendations such as EULAR 2016 propose tapering bDMARDs, especially when combined with a csDMARD, when the patient is in remission after sto...
Source: Revue de Medecine Interne - February 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Prevalence and risk factors of vitamin D deficiency in healthy adults aged 18-65  years in northern France].
[Prevalence and risk factors of vitamin D deficiency in healthy adults aged 18-65 years in northern France]. Rev Med Interne. 2017 Feb 01;: Authors: Deplanque X, Wullens A, Norberciak L Abstract INTRODUCTION: Screening and treatment of vitamin D deficiency are the subject of several publications. A lot of recognized risk factors have increased steadily, leading to the recognition of populations at risk. Despite their exposure to the same risk factors as other populations, there are no recommendations concerning healthy adults, a population rarely studied. To determine the prevalence of vitamin D d...
Source: Revue de Medecine Interne - February 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Systemic lupus erythematosus and contraception: A systematic literature review].
CONCLUSION: Use of oral combined hormonal contraceptives should be limited to patients with non-severe and stable disease, without thrombosis risk factors. PMID: 28161112 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Myocarditis].
Authors: Hékimian G, Combes A Abstract Acute myocarditis must be considered in patients with recent onset of cardiac failure or arrhythmia. Fulminant myocarditis is a distinct entity characterized by sudden onset of severe congestive heart failure or cardiogenic shock, usually following a flu-like illness, parvovirus B19, human herpesvirus 6, coxsackie virus and adenovirus being the most frequently viruses responsible for the disease. In this setting, early recognition of patients rapidly progressing to refractory cardiac failure and their immediate transfer to a medical-surgical center experienced in mechan...
Source: Revue de Medecine Interne - February 7, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Autoinflammatory diseases].
Authors: Grateau G PMID: 28139336 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - February 2, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Artificial intelligence in the field of internal medicine].
Authors: Chiche L, Servy H PMID: 28131438 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 31, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Antineutrophil cytoplasmic antibodies associated with infective endocarditis: Literature review].
Authors: Langlois V, Marie I Abstract Antineutrophil cytoplasmic antibodies (ANCA) associated with infective endocarditis are a rare disorder. The condition can mimic primary systemic vasculitis (i.e. granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis). Thus, a wrong diagnosis of valvular involvement related to primary systemic vasculitis can be made in patients exhibiting ANCA associated with infective endocarditis. Because treatment of both conditions is different, this wrong diagnosis will lead to dramatic consequences in these latter patients. This revi...
Source: Revue de Medecine Interne - January 31, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Epidemiology and pharmacoepidemiology of immune thrombocytopenia].
Authors: Moulis G, Lapeyre-Mestre M, Adoue D, Sailler L Abstract During the last decade, the development of large clinical and population-based cohorts led to new findings in the epidemiology and the pharmacoepidemiology of immune thrombocytopenia (ITP). The incidence is estimated to 3-4 for 10(5) inhabitants/year, with a slight female predominance and peaks in children and patients after 60 years. The incidence rate is 9 for 10(5) inhabitants/year in males after 75 years. Variations across ethnic groups are discussed. In France, there is a North-South gradient and a peak of incidence during win...
Source: Revue de Medecine Interne - January 31, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[A rare complication of Paget's disease].
Authors: Jelin G, Grados F, Fardellone P, Goëb V PMID: 28131441 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 31, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Reactive arthritis due to Clostridium difficile: Report of two cases and literature review].
CONCLUSION: The increasing incidence of C. difficile infection makes more likely the occurrence of this related reactive arthritis. Therefore physicians should consider it in differential diagnosis of bacterial infections capable of causing reactive arthritis. PMID: 28129954 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 30, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Primary infection with cytomegalovirus: An infectious cause of splenic infarction].
CONCLUSION: A primary infection with CMV must be added to the diagnostic work-up in the presence of a febrile splenic infarction, especially when it is associated with a biological mononucleosis reaction. PMID: 28129955 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 30, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Medically unexplained symptoms' care in internal medicine: A paradigm of doctor-patient relationship in situation of uncertainty].
Authors: Ranque B, Nardon O Abstract Medically unexplained symptoms (MUS) are extremely common in general practice as in all medical specialties, but their designation is not unambiguous and the approaches to take care of the patients differ from conventional therapeutic approaches. The difficulty is not to confirm the diagnosis, which is rapidly obvious with some experience, but to establish a genuinely human therapeutic relationship, without any technical help, which pushes the doctor to the edge of his empathy and communication skills. The discomfort or even distress regularly encountered by physicians in front ...
Source: Revue de Medecine Interne - January 30, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acquired, non-amyloid related factor  X deficiency: A first case associated with atypical chronic lymphocytic leukemia and literature review].
CONCLUSION: DNAA-FX should be considered in case of bleeding events or coagulation disorders during low-grade hematological malignancies. Its occurrence can be considered as a treatment indication to prevent potentially fatal bleeding complications. PMID: 28110969 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 24, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Evolutionary medicine: A new look on health and disease].
Authors: Bauduer F Abstract Evolutionary medicine represents an innovative approach deriving from evolutionary biology. It includes the initial Darwin's view, its actualization in the light of progresses in genetics and also dissident theories (i.e. non gene-based) particularly epigenetics. This approach enables us to reconsider the pathophysiology of numerous diseases, as for instance, infection, and our so-called diseases of civilization especially obesity, type 2 diabetes, allergy or cancer. Evolutionary medicine may also improve our knowledge regarding inter-individual variation in susceptibility to disease or ...
Source: Revue de Medecine Interne - January 21, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

Five cases of acute Zika virus infection in French women of reproductive age returning from Central and South America.
CONCLUSION: As the duration of potential materno-foetal infectivity is still unknown, we were unable to answer with certitude to the patients' questions about the time interval to respect before attempting a pregnancy: one of them became pregnant one month after the diagnosis. PMID: 28104381 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 21, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Large vessel vasculitis with myelodysplastic syndrome: A rare association].
CONCLUSION: Myelodysplastic syndrome and large vessels vasculitis is a rare but serious association disease. The lack of efficiency of corticosteroids seems to be common. Prognosis depends on the haematological treatment effectiveness. PMID: 28094068 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 18, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Renal abnormalities].
Authors: Messika J, Nahmani Y, Aouad P, Berquier G, Roux D, Delahousse M PMID: 28081902 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - January 14, 2017 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Alzheimer's disease cerebro-spinal fluid biomarkers: A clinical research tool sometimes useful in daily clinical practice of memory clinics for the diagnosis of complex cases].
Authors: Magnin E, Dumurgier J, Bouaziz-Amar E, Bombois S, Wallon D, Gabelle A, Lehmann S, Blanc F, Bousiges O, Hannequin D, Jung B, Miguet-Alfonsi C, Quillard M, Pasquier F, Peoc'h K, Laplanche JL, Hugon J, Paquet C, pour le groupe ePLM (étude des biomarqueurs de la Ponction Lombaire Multicentrique) Abstract The role of biomarkers in clinical research was recently highlighted in the new criteria for the diagnosis of Alzheimer's disease. Cerebro-spinal fluid (CSF) biomarkers (total Tau protein, threonine 181 phosphorylated Tau protein and amyloid Aβ1-42 peptide) are associated with cerebral ne...
Source: Revue de Medecine Interne - November 29, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Autoimmune and inflammatory disorders associated with lymphoid hematological malignancies].
Authors: Grignano E, Mekinian A, Jachiet V, Coppo P, Fain O Abstract In this literature review, we reported autoimmune and inflammatory disorders associated with lymphoid hematological malignancies, including non-Hodgkin's lymphoma, Hodgkin's lymphoma and chronic lymphocytic leukemia. The different types of systemic involvement are classified by affected organ. We listed in this review the joint diseases, skin, neurologic, hematologic, renal, and vasculitis. We tried to determine whether there is a correlation between each autoimmune manifestation and a specific type of lymphoma or a particular feature that may sup...
Source: Revue de Medecine Interne - November 29, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Primary immunodeficiency and autoimmunity].
Authors: Guffroy A, Gies V, Martin M, Korganow AS Abstract Many evidences highlight that immunodeficiency and autoimmunity are two sides of a same coin. Primary immune deficiencies (PIDs), which are rare mono- or multigenic defects of innate or adaptative immunity, frequently associate with autoimmunity. Analyses of single-gene defects in immune pathways of families with PIDs, by new tools of molecular biology (next genome sequencing technologies), allowed a better understanding of the ways that could both drive immune defect with immune deficiency and autoimmunity. Moreover, genes implicated in rare single-gene de...
Source: Revue de Medecine Interne - November 28, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[An abnormal tongue].
Authors: Mouelhi B, Jean E, Ernest V, Mouyon R, Bessai S, Rossi P, Granel B PMID: 27889324 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 28, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Langerhans cell histiocytosis and Erdheim-Chester disease, a continuity?]
CONCLUSION: The literature review finds forty observations linking the two diseases that may suggest a pathophysiological link, especially with the hematopoietic myeloid stem cell CD34+. The term inflammatory myeloid neoplasm was advanced. PMID: 27889325 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 28, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Inventory of training of internal medicine in France: Results of a national survey].
This study was conducted between May and September 2015 with coordinators (interviews of 45minutes) of local Internal Medicine training and fellows (online questionnaire). RESULTS: All coordinators (n=28) responded to the interviews. Local training of Internal Medicine exists in 86% of regions (3.1±3.1hours/month) and an interregional training in all interregions (34.7±13.9hours/year). When excluding Île-de-France, no correlation between the number of teachers and the amount of lessons was noted (P=0.61). Of the 550 fellows in Internal Medicine in 2014-2015, 223 (41%) responded to the online questio...
Source: Revue de Medecine Interne - November 28, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Management of adverse effects related to human immunoglobulin therapy: Recommendations for clinical practice].
Authors: Marie I, Chérin P, Michallet M, Pelus E, Dantal J, Crave JC, Delain JC, Viallard JF Abstract Both intravenous and subcutaneous immunoglobulins are therapeutic modalities approved in various conditions, including primary and secondary immune deficiencies and autoimmune disorders. To date, immunoglobulins have more often been considered as a safe medication, with minor adverse effects such as hypertension, fever and chills, nausea, myalgia or headache. However, with the wider use of immunoglobulins in the treatment of autoimmune diseases, severe side effects have also been reported to occur in immunog...
Source: Revue de Medecine Interne - November 27, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Acid sphingomyelinase deficiency (Niemann-Pick disease type B) in adulthood: A retrospective multicentric study of 28  adult cases].
[Acid sphingomyelinase deficiency (Niemann-Pick disease type B) in adulthood: A retrospective multicentric study of 28 adult cases]. Rev Med Interne. 2016 Nov 22;: Authors: Lidove O, Belmatoug N, Froissart R, Lavigne C, Durieu I, Mazodier K, Serratrice C, Douillard C, Goizet C, Cathebras P, Besson G, Amoura Z, Tazi A, Gatfossé M, Rivière S, Sené T, Vanier MT, Ziza JM Abstract INTRODUCTION: Acid sphingomyelinase deficiency (ASMD) is an autosomal recessive disease with a clinical spectrum ranging from a neurovisceral infantile form (Niemann-Pick disease type A) to a chronic visc...
Source: Revue de Medecine Interne - November 27, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Neurosarcoidosis: Diagnosis and therapeutic issues].
Authors: Cohen Aubart F, Galanaud D, Haroche J, Psimaras D, Mathian A, Hié M, Le-Thi Huong Boutin D, Charlotte F, Maillart E, Maisonobe T, Amoura Z Abstract Neurological localizations of sarcoidosis are heterogeneous and may affect virtually every part of the central or peripheral nervous system. They are often the inaugural manifestation of sarcoidosis. The diagnosis may be difficult due to the lack of extra-neurological localization. Diagnosis may be discussed in the presence of an inflammatory neurological disease, in particular in case of suggestive radiological or biological pattern. Cerebrospinal fluid...
Source: Revue de Medecine Interne - November 27, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Abdominal pain and vomiting in a 66-year-old man].
Authors: Girszyn N, Hellouin L, Sauvêtre G, Ngo S, Lévesque H, Masseau A PMID: 27884457 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 27, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[Anti-HMG-CoA reductase necrotizing myopathy: A report of 4 cases].
CONCLUSION: An early diagnosis of this myopathy is necessary in order to introduce an immunotherapy associated with a close monitoring. The therapeutic strategy (within which the stead of intravenous immunoglobulin seems increased) remains to be defined and long-term prospective studies are thus needed. PMID: 27876175 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 25, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research

[An aortic abnormality].
Authors: Levasseur T, N'Guyen Y, Aludaat C, Espinosa M, Metz D PMID: 27876176 [PubMed - as supplied by publisher] (Source: Revue de Medecine Interne)
Source: Revue de Medecine Interne - November 25, 2016 Category: Internal Medicine Tags: Rev Med Interne Source Type: research