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Critical Appraisal on the Role of Warfarin in the Current Era
J Assoc Physicians India. 2023 Oct;71(10):31-36. doi: 10.59556/japi.71.0378.ABSTRACTWarfarin has been the most extensively used oral anticoagulant (OAC) in medical settings for over 60 years. Its uses, potential adverse effects, and methods for reversing its effects have been firmly established, rendering it a routine medication in medical settings where most professionals feel at ease employing it. Compared to other vitamin K antagonists (VKAs), such as acenocoumarol, warfarin offers benefits like diminished prothrombin time (PT) assays leading to enhanced oral anticoagulation. Observations over the past few years have se...
Source: Journal of the Association of Physicians of India - May 8, 2024 Category: General Medicine Authors: Tiny Nair Source Type: research

 Streptomyces pyxinae sp. nov. and Streptomyces pyxinicus sp. nov. isolated from lichen Pyxine cocoes (Sw.) Nyl
Int J Syst Evol Microbiol. 2024 May;74(5). doi: 10.1099/ijsem.0.006364.ABSTRACTTwo novel actinobacteria, designated as LP05-1T and LP11T, were isolated from the lichen Pyxine cocoes (Sw.) Nyl. collected in Bangkok, Thailand. Genotypic and phenotypic analyses revealed that both strains represented members of the genus Streptomyces. The 16S rRNA gene of LP05-1T showed the highest similarity to the genome of Streptomyces gelaticus (98.41 %), while the 16S rRNA gene of LP11T was most similar to that of Streptomyces cinerochromogenes (98.93 %). The major menaquinones in LP05-1T were MK-9(H8), MK-9(H6), MK-9(H4) and MK-9(H2), an...
Source: International Journal of Systematic and Evolutionary Microbiology - May 7, 2024 Category: Microbiology Authors: Achiraya Somphong Wetchasart Polyiam Chanwit Suriyachadkun Paranee Sripreechasak Enjuro Harunari Yasuhiro Igarashi Somboon Tanasupawat Wongsakorn Phongsopitanun Source Type: research

Sa1577 THE ROLE OF INTRAVENOUS VITAMIN K IN THE CORRECTION OF CIRRHOSIS-ASSOCIATED COAGULOPATHY.
(Source: Gastroenterology)
Source: Gastroenterology - May 6, 2024 Category: Gastroenterology Authors: Hila Shaim, Kian Abdul-Baki, Jordan C. Malone, Anni Chowdhury, Edward Butt, Moe Ameri, Daniel Shofner, Marissa Lee, Milee Patel, Pooja Bhakta, Michael Antony, Peter McCaffrey, Sean Yates Tags: AASLD Abstracts Source Type: research

In older patients with AF and frailty, switching from VKA to NOAC therapy increased a composite of major or CRNM bleeding at 12 mo
Ann Intern Med. 2024 May 7. doi: 10.7326/J24-0024. Online ahead of print.ABSTRACTJoosten LP, van Doorn S, van de Ven PM, et al. Safety of switching from a vitamin K antagonist to a non-vitamin K antagonist oral anticoagulant in frail older patients with atrial fibrillation: results of the FRAIL-AF randomized controlled trial. Circulation. 2024;149:279-289. 37634130.PMID:38710082 | DOI:10.7326/J24-0024 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - May 6, 2024 Category: Internal Medicine Authors: Andrew Dunn Source Type: research

 Microbacterium salsuginis sp. nov., a halotolerant actinobacterium with antimicrobial activity
Int J Syst Evol Microbiol. 2024 May;74(5). doi: 10.1099/ijsem.0.006362.ABSTRACTA novel Gram-staining-positive actinobacterium with antimicrobial activity, designated CFH 90308T, was isolated from the sediment of a salt lake in Yuncheng, Shanxi, south-western China. The isolate exhibited the highest 16S rRNA gene sequence similarities to Microbacterium yannicii G72T, Microbacterium hominis NBRC 15708T and Microbacterium xylanilyticum S3-ET (98.5, 98.4 and 98.2 %, respectively), and formed a separate clade with M. xylanilyticum S3-ET in phylogenetic trees. The strain grew at 15-40 ºC, pH 6.0-8.0 and could tolerate NaCl up t...
Source: International Journal of Systematic and Evolutionary Microbiology - May 2, 2024 Category: Microbiology Authors: Qingyang Su Yuwei Liu Tingting Xia Shuanglong Wei Caixia Cui Zhao Zhang Xudong Liu Guoxing Nie Hong Ming Source Type: research

Jeotgalibacillus haloalkalitolerans sp. nov., a novel alkalitolerant and halotolerant bacterium, isolated from the confluence of the Fenhe River and the Yellow River
Antonie Van Leeuwenhoek. 2024 May 1;117(1):74. doi: 10.1007/s10482-024-01968-8.ABSTRACTA Gram-stain positive, aerobic, alkalitolerant and halotolerant bacterium, designated HH7-29 T, was isolated from the confluence of the Fenhe River and the Yellow River in Shanxi Province, PR China. Growth occurred at pH 6.0-12.0 (optimum, pH 8.0-8.5) and 15-40℃ (optimum, 32℃) with 0.5-24% NaCl (optimum, 2-9%). The predominant fatty acids (> 10.0%) were iso-C15:0 and anteiso-C15:0. The major menaquinones were MK-7 and MK-8. The polar lipids were phosphatidylglycerol, diphosphatidylglycerol and two unidentified phospholipids. Phylo...
Source: Antonie van Leeuwenhoek - May 1, 2024 Category: Microbiology Authors: Ya-Fei Zhang Yun-Lin Peng Yong-Hui Xiao Bing Yu Ming-Yue Cao Zhi-Ling Zhang Le-Qun Huang Yi Li Source Type: research