DOACs now recommended over warfarin to prevent blood clots in people with atrial fibrillation
For decades, warfarin (Coumadin) was the standard anticoagulant medication used to prevent blood clots, which can lead to stroke, in people with atrial fibrillation (afib). Direct oral anticoagulants (DOACs), sometimes called novel oral anticoagulants (NOACs), are a new type of anticoagulant medication that came on the market in 2010. In 2019, the American Heart Association/American College of Cardiology/Heart Rhythm Society (AHA/ACC/HRS) updated their afib guidelines to strongly recommend using DOACs over warfarin in people with afib. Warfarin is effective, but has downsides Afib is a condition in which the upper chambers...
Source: Harvard Health Blog - December 16, 2019 Category: Consumer Health News Authors: Peter Zimetbaum, MD Tags: Drugs and Supplements Heart Health Source Type: blogs
Pharmacogenomics: The Science of Personalizing Drugs Based On DNA
Individuals share about 99.97 percent of their DNA and only the remaining 0.03 percent is responsible for the differences in skin, hair or eye color, height, shoe size or sunspots. Scientists discovered somewhat recently that our bodies also metabolize drugs differently so it would make sense to prescribe medications based on the knowledge hidden in our DNA. In some cases, physicians already do that. Here’s what you need to know about pharmacogenomics and the future of prescription drugs. It’s all in your genes Why do some people eat creamy French cakes all the time, only do sports when they have to run after t...
Source: The Medical Futurist - November 27, 2018 Category: Information Technology Authors: nora Tags: Future of Pharma Genomics Medical Professionals Patients Researchers DNA dna testing drugs genetics Health Healthcare Innovation medication pharmacogenetics pharmacogenomics precision health precision medicine technology Source Type: blogs
The Starting Five: Vitamins for Improved Health
You're reading The Starting Five: Vitamins for Improved Health, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. “By the proper intakes of vitamins and other nutrients…you can, I believe, extend your life and years of well-being by twenty-five or even thirty-five years,” said Nobel Prize winning scientist Linus Pauling. Modern research has confirmed Pauling’s belief as it has identified five vitamins that may improve overall health. Vitamin D Vitamin D provides many important health benefits. It ...
Source: PickTheBrain | Motivation and Self Improvement - November 9, 2018 Category: Consumer Health News Authors: IndySummers Tags: featured health and fitness pickthebrain self improvement vitamins what vitamins should i take Source Type: blogs
Osteoporosis Linked with Increased Risk of Later Development of Dementia
This study is the first to address this question in a very large database enabling the case-control-comparison between patients with and without osteoporosis." This retrospective cohort study used data from the Disease Analyzer database (IQVIA), which compiles information on drug prescriptions, diagnoses, and demographic data obtained directly and in anonymous format from computer systems used by general practitioners and specialists. This database has already been used in several studies focusing on osteoporosis and dementia in recent years. The study included patients diagnosed with osteoporosis between Janua...
Source: Fight Aging! - September 19, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Anticoagulation for prosthetic valve in pregnancy – Cardiology MCQ – Answer
Anticoagulation for prosthetic valve in pregnancy – Cardiology MCQ – Answer Anticoagulation regimen in pregnancy with prosthetic valve associated with lowest rate of fetal or neonatal loss: Correct answer: d) Low molecular weight heparin Low molecular weight heparin is associated with lowest rate of fetal or neonatal loss in pregnancy with prosthetic valve, but has a higher risk of valve thrombosis . Though the often followed method is initial use of unfractionated heparin followed by warfarin in second trimester followed by unfractionated heparin in peripartum period, this approach has higher maternal...
Source: Cardiophile MD - September 16, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Uncategorized Source Type: blogs
Anticoagulation for prosthetic valve in pregnancy – Cardiology MCQ
Anticoagulation for prosthetic valve in pregnancy – Cardiology MCQ Anticoagulation regimen in pregnancy with prosthetic valve associated with lowest rate of fetal or neonatal loss: a) Vitamin K Antagonist b) Direct acting oral anticoagulants c) Heparin followed by vitamin K antagonist d) Low molecular weight heparin Click here for the correct answer (Source: Cardiophile MD)
Source: Cardiophile MD - September 16, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Uncategorized Source Type: blogs
Limitations of warfarin
Warfarin is very useful to prevent stroke in patients with atrial fibrillation and maintenance of function of a mechanical prosthetic valve. At the same time it has several limitations: Unpredictable response: Same dose produces different responses in terms of elevation of prothrombin time international normalized ratio (PT-INR) in different persons and in same person at different times. Narrow therapeutic window: Difference between toxic dose and ineffective dose is narrow. A mild increase in dose can produce a disproportionate rise in INR. Slow onset and offset of action: On the average it takes about 4 days for a stea...
Source: Cardiophile MD - September 15, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Uncategorized Source Type: blogs
MKSAP: 77-year-old woman with frequently fluctuating INRs
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 77-year-old woman is evaluated for frequently fluctuating INRs (3.5) while taking warfarin therapy. She has undergone INR testing every 1 to 2 weeks and frequent warfarin dose adjustments. She reports a consistent dietary intake. Medical history is notable only for recurrent deep venous thrombosis. She takes no other medications. On physical examination, vital signs are normal, as is the remainder of the examination. Which of the following is the most appropriate next step in management? A. Daily low-d...
Source: Kevin, M.D. - Medical Weblog - August 18, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Oncology/Hematology Source Type: blogs
No Scientific Proof That Multivitamins Promote Heart Health
https://www.medscape.com/viewarticle/899130No Scientific Proof That Multivitamins Promote Heart HealthTaking multivitamin/mineral (MVM) supplements does not prevent myocardial infarction, stroke, or death from a cardiovascular cause, according to a comprehensive meta-analytic review of relevant research." The take-home message is simple: there is no scientific evidence that MVM supplements promote cardiovascular health. We hope that our paper helps to settle the controversy on MVM use for CVD prevention, " lead author Joonseok Kim, MD, University of Alabama at Birmingham, toldtheheart.org | Medscape Cardiology.Th...
Source: Dr Portnay - July 25, 2018 Category: Cardiology Authors: Dr Portnay Source Type: blogs
‘Rats! I’m High’
A 24-year-old man presented with uncontrollable epistaxis. He said he had been bleeding "a ton" from his nose continuously for four hours. He denied recent trauma, and explained that this epistaxis was sudden onset. He had no past medical history, and denied previous episodes of excessive bleeding. An examination demonstrated no signs of trauma and was unremarkable aside from the epistaxis. His nostrils revealed no obvious bleeding vessels for cauterization. His social history was remarkable for occasional drinking, marijuana use, and recent use of synthetic marijuana.His vital signs were a heart rate of 85 bp...
Source: The Tox Cave - July 2, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
NOAC – Cardiology MCQ – Answer
In which of the following conditions non-vitamin K antagonist oral anticoagulants (NOACs) should not be used: Correct answer: c) Mechanical prosthetic valve with atrial fibrillation Subgroup analysis of certain clinical trials support the use of rivaroxaban, apixaban, dabigatran and edoxaban in patients with aortic stenosis, aortic regurgitation or mitral regurgitation patients having atrial fibrillation. NOACs can also be used in aortic bioprosthesis with atrial fibrillation if the valve was implanted more than 3 months back. NOACs are better avoided in those with moderate or severe mitral stenosis and atrial fibrillation...
Source: Cardiophile MD - June 13, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
NOAC – Cardiology MCQ
In which of the following conditions non-vitamin K antagonist oral anticoagulants (NOACs) should not be used: a) Aortic regurgitation with atrial fibrillation b) Aortic bioprosthesis implanted 6 months back, with atrial fibrillation c) Mechanical prosthetic valve with atrial fibrillation d) Mitral regurgitation with atrial fibrillation Please post your answer as a comment below. Correct answer will be published on: Jun 13, 2018 @ 18:00 (Source: Cardiophile MD)
Source: Cardiophile MD - June 11, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
The reasons why parents refuse vitamin K for their little ones
You're reading The reasons why parents refuse vitamin K for their little ones, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. There is an alarming trend that has been witnessed by doctors in recent times. More parents refusing vitamin K for newborn. It would lead to an increase in bleeding of the intestines or brains in the little ones. Vitamin K is one of the essential components that do help the body in blood clot formation. You can find them in the digestive system of adults or old people. It has been also observed t...
Source: PickTheBrain | Motivation and Self Improvement - June 8, 2018 Category: Consumer Health News Authors: Harris Tags: health and fitness newborn baby Vitamin K Source Type: blogs
A Tale of 2 FDAs
By ANISH KOKA Frances Oldham Kelsey by all accounts was not mean to have a consequential life. She was born in Canada in 1914, at a time women were meant to be seen and not heard. Nonetheless, an affinity for science eventually lead to a masters in pharmacology from the prestigious McGill University. Her first real break came after she was accepted for PhD level work in the pharmacology lab of a professor at the University of Chicago. An esteemed professor was starting a pharmacology lab and needed assistants, and the man from Canada seemed to have a perfect resume to fit. That’s right, ...
Source: The Health Care Blog - June 4, 2018 Category: Consumer Health News Authors: anish_koka Tags: Uncategorized Source Type: blogs
Tropical Travel Trouble 007 Mega Malaria Extravaganza
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 007 When you think tropical medicine, malaria has to be near the top. It can be fairly complex and fortunately treatment has become a lot simpler. This post is designed to walk you through the basic principals with links to more in depth teaching if your niche is travel medicine, laboratory diagnostics or management of severe or cerebral malaria. If you stubbled on this post while drinking a cup of tea or sitting on the throne and want a fe...
Source: Life in the Fast Lane - April 5, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Clinical Cases Tropical Medicine malaria Plasmodium plasmodium falciparum plasmodium knowles plasmodium malariae plasmodium ovale plasmodium vivax Source Type: blogs
Eat these foods daily (or at least often)
Improving your diet can seem like a lofty goal, one that people often think requires rigid self-discipline and sacrifice. Cupcakes out, pizza out, treats out, sigh. But it doesn’t really have to be that way. Sometimes making better decisions for your body can be about adding — not taking away. This may create a more palatable option for those looking for a health boost that feels like a bonus, not a burden. But what to add? I asked Teresa Fung, adjunct professor in the department of nutrition at the Harvard T.H. Chan School of Public Health for her advice on what foods pack the biggest nutritional punch to a da...
Source: Harvard Health Blog - April 5, 2018 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Diet and Weight Loss Health Healthy Eating Source Type: blogs
Reclaiming Ancient Wisdom
This article originally appeared in the Q3 2017 Regenerate Magazine. Photo Credit VacTruth.com (Source: vactruth.com)
Source: vactruth.com - November 22, 2017 Category: Allergy & Immunology Authors: Phil Silberman Tags: Logical Phil Silberman Top Stories health Skeptics vaccine choice Source Type: blogs
Taking an anticlotting drug? If you need a procedure, be prepared
Millions of people with cardiovascular disease take drugs that help prevent blood clots, which can lodge in a vessel and choke off the blood supply to part of a leg, lung, or the brain. These potentially lifesaving medications include warfarin (Coumadin) and a class of drugs called non-vitamin K antagonist oral anticoagulants or NOACs. Examples include dabigatran (Pradaxa) and rivaroxaban (Xarelto). However, if you’re taking one of these drugs and need an invasive procedure — anything from a tooth extraction to a hip replacement — managing the risks can be tricky, says cardiologist Dr. Gregory Piazza, ass...
Source: Harvard Health Blog - November 1, 2017 Category: Consumer Health News Authors: Julie Corliss Tags: Drugs and Supplements Health Heart Health Surgery anticlotting drug anticlotting drugs Source Type: blogs
Baby Foreskin Is Being Used To Make Vaccines
Conclusion Vaccine companies have regularly used blood and body parts from killed cows, dogs, worms, mice, chickens, human babies, monkeys, guinea pigs, rabbits, hamsters, rats, etc., to make these vaccines, so using foreskin from newborn babies may not surprise some. For many, it is appalling.  Circumcisions fuel multi-billion dollar industries. If you see neonatal foreskin for sale, which is very easy to find on the internet, remember that these newborn children didn’t consent to being circumcised and they didn’t consent for their foreskin to be sold, used for research purposes, or to be injected into the...
Source: vactruth.com - September 28, 2017 Category: Allergy & Immunology Authors: Augustina Ursino Tags: Augustina Ursino Top Stories circumcision truth about vaccines Source Type: blogs
Blueberry, Carrot, and Greens Prebiotic Shake
Another delicious recipe from my new Undoctored book. If you are into getting more greens and other nutritious foods through a shake or smoothie, here is one way to combine them with prebiotic fibers. The spinach is interchangeable with your choice of greens, such as kale or collard greens— great sources of vitamin K1. Makes 1 1 peeled green banana or peeled raw white potato, coarsely chopped 1 cucumber, coarsely sliced 1 cup fresh spinach 1 carrot, coarsely sliced 1⁄2 cup fresh or frozen blueberries cup water Sweetener equivalent to 1 tablespoon sugar 1 teaspoon inulin or FOS powder (optional) In a ble...
Source: Wheat Belly Blog - August 1, 2017 Category: Cardiology Authors: Dr. Davis Tags: Recipes Undoctored Vitamin K Wheat Belly Lifestyle Source Type: blogs
Vitamin K and Osteoporosis — What ’ s the connection?
Before you are prescribed bisphosphonates: Fosamax, Actonel, Boniva, Reclast or Zometa, maybe you should consider the Undoctored strategy. The grain-free diet, vitamin D, and magnesium protocols in the core Undoctored program provide the bulk of bone health benefits through a variety of mechanisms, including increased intestinal calcium absorption, reduced urinary calcium loss, and reduced levels of the parathyroid hormone that weakens bones. You should also avoid calcium supplements, as the effects of vitamin D and the increased intestinal calcium absorption that develops after eliminating calcium-binding phytates from gr...
Source: Wheat Belly Blog - August 1, 2017 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Vitamin K Wheat Belly Lifestyle anti-aging bowel flora Dr. Davis gluten-free grain-free health osteopenia osteoporosis Wheat Belly Total Health Source Type: blogs
Can probiotics help treat depression and anxiety?
There is a lot of interest right now in the human microbiome (the populations of bacteria that live in various parts of the body, including the intestine, skin, and lungs). We now know that there are approximately 10 times as many bacterial cells as human cells in the body. The vast majority of these bacterial cells are in the intestinal tract, and they serve many purposes, including digesting foods, manufacturing certain vitamins (for example, vitamin K), and regulating our immune system. Researchers are actively studying whether changes in intestinal bacteria can increase the risk of chronic illnesses, such as obesity or...
Source: Harvard Health Blog - July 26, 2017 Category: Consumer Health News Authors: Athos Bousvaros, MD Tags: Anxiety and Depression Behavioral Health Brain and cognitive health Digestive Disorders Mental Health Source Type: blogs
Funtabulously Frivolous Friday Five 170 Christmas Edition
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 170 Christmas Edition Question 1 Why is Christmas disease so named? + Reveal the Funtabulous Answer expand(document.getElementById('ddet1725772665'));expand(document.getElementById('ddetlink1725772665')) Haemophilia B was first recognized as a different kind of haemophilia in 1952, named after Stephen Christmas, the first patient described with this disease. If that was not festive enough for you then...
Source: Life in the Fast Lane - December 23, 2016 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five bowel perforation brussel sprouts Christmas accidents christmas cake decoration Christmas disease Christmas pudding Haemophilia B stephen christmas vitamin k warfarin Source Type: blogs
Direct thrombin inhibitor – Cardiology MCQ
Which of the following is a direct thrombin inhibitor? a) Apixaban b) Rivaroxaban c) Dabigatran d) Acenocoumarol Correct answer: c) Dabigatran Apixaban and rivaroxaban are direct factor Xa inhibitors, while acenocoumarol is a vitamin K antagonist. First three are newer oral anticoagulants while acenocoumarol has been in use for decades. Therapeutic effect of acenocoumarol can be monitored with prothrombin time while those of the newer anticoagulants cannot be monitored using widely available tests. Similarly effect of acenocoumarol can be reversed by vitamin K while a direct antidote is not available for the newer ora...
Source: Cardiophile MD - May 27, 2015 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
4 Reasons Why Kale is a True Superfood
By: Austin Perlmutter, Medical Student, Miller School of Medicine When it comes to healthy vegetables, kale may be among the best. Packing a powerful punch of antioxidants, nutrients and excellent digestive support, its role in optimal wellness is tough to dispute. For anyone still undecided, here are the top 4 reasons to make kale a part of your life. Kale is jam-packed with vitamins. Eating one cup of chopped kale gets you over 200% of your daily value of vitamin A, 134% of your daily value for vitamin C, and almost 700% of your daily value for vitamin K! In addition, kale contains important minerals like mang...
Source: Renegade Neurologist - A Blog by David Perlmutter, MD, FACN - August 14, 2014 Category: Neurologists Authors: gbadmin Tags: Nutrition antioxidants fiber kale Omega-3 Pesto vitamin a vitamin c vitamin k Source Type: blogs
Refusal of neonatal vitamin K injections: antivaccine déjà vu all over again
As prolific as I am, I have actually slowed down. Long time readers know this, as I used to have a post up seven days a week and sometimes two or more in a day. These days, I’ve made it a rule that I don’t post on weekends (except if something really catches my eye… (Source: Respectful Insolence)
Source: Respectful Insolence - August 5, 2014 Category: Surgery Authors: Orac Tags: Complementary and alternative medicine Quackery antivaccine chris mooney Clay Jones LivingWhole.org pediatrics vaccines vitamin K Source Type: blogs
Healthcare Update Satellite — 11-20-2013
This report says that mental health patients make up almost half of the emergency department patients at Denver Health every weekend. When you cut funding for psychiatric care by 20% and cut the number of psychiatric beds by 30%, the patients with psychiatric problems don’t just disappear. When they can’t get help, they end up in the emergency department, in jail, or even worse. Could the Columbine or Aurora shootings have been prevented by expanding psychiatric care? Probably not. But one emergency department physician noted that for every “high-profile event that everybody knows about, there’s a h...
Source: WhiteCoat's Call Room - November 20, 2013 Category: Emergency Medicine Doctors Authors: WhiteCoat Tags: Healthcare Update Source Type: blogs
Does taking supplements help IVF patients ?
Practically all women doing IVF are taking supplements of one sort or another ! These are supposed to improve egg yield, egg quality and embryo implantation , thus helping to improve IVF pregnancy rates. I have come across women who take over 10 different supplements daily – and I wonder how they manage to swallow so many different tablets, syrups and capsules in a day ! On second thoughts thought, it is not surprising , because the craving for a baby can make a woman move heaven and earth; which means taking umpteen supplements is not such a difficult task to accomplish. I have heard the followin...
Source: The Patient's Doctor - January 14, 2013 Category: Obstetricians and Gynecologists Tags: Food and Drug Administration Vitamin B In vitro fertilisation Aspirin Polycystic ovary syndrome Vitamin C Antioxidant Vitamin D Source Type: blogs