Inconclusive Findings in Non-Vitamin K Antagonist Oral Anticoagulants Study — In Reply
In Reply We appreciate the insights provided by Khan et al and Tzeng and Tsai regarding our study. As noted in the study limitations, although the use of prescription data from the claims database is superior to self-reported medication use, this method may not fully capture patient nonadherence, which could be a potential risk for misclassification. The best pragmatic approach to verify the time elapsed since the most recent dose of non −vitamin K antagonist oral anticoagulants (NOACs) is to use medication adherence monitoring devices (eg, ingestible electronic sensor) or noninvasive medication compliance monitoring sys...
Source: JAMA Internal Medicine - March 11, 2024 Category: Internal Medicine Source Type: research
Inconclusive Findings in Non-Vitamin K Antagonist Oral Anticoagulants Study
To the Editor We read with interest the nationwide population-based cohort study with meta-analysis by Tsai et al. The study findings showed that patients who received non-vitamin K antagonist oral anticoagulants (NOACs) before a stroke, compared with those receiving warfarin and those without oral anticoagulant treatment (non-OAC), did not experience a higher risk of intracranial hemorrhage (ICH), major bleeding events, or mortality when treated with intravenous alteplase for acute ischemic stroke. In comparison with the active comparator (warfarin group), the odds ratios (ORs) were 0.88 (95% CI, 0.32-2.40) for ICH, 0.82 ...
Source: JAMA Internal Medicine - March 11, 2024 Category: Internal Medicine Source Type: research
Inconclusive Findings in Non-Vitamin K Antagonist Oral Anticoagulants Study
To the Editor In their population-based cohort study using Taiwan ’s National Health Insurance Research Database, Tsai et al report no excess risk of intracranial hemorrhage (ICH) associated with treatment compared with no treatment with non-vitamin K antagonist oral anticoagulants (NOACs) in patients with acute ischemic stroke receiving intravenous alteplase. W e applaud the authors’ efforts to build on the evidence on the safety of thrombolysis in patients receiving NOACs; however, we wonder about potential issues of exposure and outcome misclassification producing results that are biased toward the null hypothesis. ...
Source: JAMA Internal Medicine - March 11, 2024 Category: Internal Medicine Source Type: research
Incidence and predictors of left atrial thrombus in patients with atrial fibrillation under anticoagulation therapy
ConclusionsLAT was present in a considerable number of patients who were already receiving anticoagulation therapy. A prediction model that combines clinical and echocardiographic predictors could be useful in distinguishing patients who require imaging evaluations before left atrial intervention.Graphical abstractIncidnece and predictors of LAT in patients with AF under anticoagulation therapy. AF, atrial fibrillation; CVS, CHA2DS2-VASc score; LA, left atrium; LAA, left atrial appendage; LAE, left atrial enlargement; LVEF, left ventricular ejection fraction; MR, mitral regurgitation; OAC, oral anticoagulant; PeAF, persist...
Source: Clinical Research in Cardiology - March 6, 2024 Category: Cardiology Source Type: research
Atrial Thrombosis Prevalence before Cardioversion or Catheter Ablation of Atrial Fibrillation: An Update Systematic Review and Meta-Analysis of Direct Oral Anticoagulants Versus Vitamin K Antagonists
The presence of left atrial or left atrial appendage thrombosis (LAT) is a contraindication to catheter ablation (CA) and cardioversion (CV), procedures commonly used to restore sinus rhythm in symptomatic atrial fibrillation (AF) patients [1,2]. Transesophageal echocardiography (TEE) is useful to identify LAT and avoid the risk of thrombosis systemic or cerebral embolization due to restoration of sinus rhythm leading to either stroke or asymptomatic cerebral emboli [1,2]. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - March 6, 2024 Category: Cardiology Authors: Federica Troisi, Pietro Guida, Nicola Vitulano, Federico Quadrini, Antonio Di Monaco, Giuseppe Patti, Massimo Grimaldi Source Type: research
Incidence and predictors of left atrial thrombus in patients with atrial fibrillation under anticoagulation therapy
ConclusionsLAT was present in a considerable number of patients who were already receiving anticoagulation therapy. A prediction model that combines clinical and echocardiographic predictors could be useful in distinguishing patients who require imaging evaluations before left atrial intervention.Graphical abstractIncidnece and predictors of LAT in patients with AF under anticoagulation therapy. AF, atrial fibrillation; CVS, CHA2DS2-VASc score; LA, left atrium; LAA, left atrial appendage; LAE, left atrial enlargement; LVEF, left ventricular ejection fraction; MR, mitral regurgitation; OAC, oral anticoagulant; PeAF, persist...
Source: Clinical Research in Cardiology - March 6, 2024 Category: Cardiology Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | DOI:10.3346/jkms.2024.39.e72 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 5, 2024 Category: Biomedical Science Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | DOI:10.3346/jkms.2024.39.e72 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 5, 2024 Category: General Medicine Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Effect of non-vitamin K oral anticoagulants for thrombosis prophylaxis in pediatric heart diseases
Eur J Intern Med. 2024 Mar 4:S0953-6205(24)00090-6. doi: 10.1016/j.ejim.2024.02.032. Online ahead of print.NO ABSTRACTPMID:38443264 | DOI:10.1016/j.ejim.2024.02.032 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - March 5, 2024 Category: Internal Medicine Authors: Hong Hong Wengen Zhu Zhongli Xie Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | PMC:PMC10911935 | DOI:10.3346/jkms.2024.39.e72 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 5, 2024 Category: Biomedical Science Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | PMC:PMC10911935 | DOI:10.3346/jkms.2024.39.e72 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 5, 2024 Category: General Medicine Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Effect of non-vitamin K oral anticoagulants for thrombosis prophylaxis in pediatric heart diseases
Eur J Intern Med. 2024 Mar 4:S0953-6205(24)00090-6. doi: 10.1016/j.ejim.2024.02.032. Online ahead of print.NO ABSTRACTPMID:38443264 | DOI:10.1016/j.ejim.2024.02.032 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - March 5, 2024 Category: Internal Medicine Authors: Hong Hong Wengen Zhu Zhongli Xie Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | PMC:PMC10911935 | DOI:10.3346/jkms.2024.39.e72 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 5, 2024 Category: Biomedical Science Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | PMC:PMC10911935 | DOI:10.3346/jkms.2024.39.e72 (Source: J Korean Med Sci)
Source: J Korean Med Sci - March 5, 2024 Category: General Medicine Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation
CONCLUSION: This study revealed the safety and effectiveness of either dose regimen of rivaroxaban in an Asian population for stroke prevention of AF. Considerable numbers of patients are receiving LDRR therapy in real-world practice in Asia. Both regimens were safe and effective for these patients.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04096547.PMID:38442717 | PMC:PMC10911935 | DOI:10.3346/jkms.2024.39.e72 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - March 5, 2024 Category: Biomedical Science Authors: Ju Youn Kim Juwon Kim Seung-Jung Park Kyoung-Min Park June Soo Kim Sung-Hwan Kim Jaemin Shim Eue Keun Choi Dae-Hyeok Kim Il-Young Oh Young Keun On XAIENT Study Group Source Type: research
