Inconclusive Findings in Non-Vitamin K Antagonist Oral Anticoagulants Study — In Reply

In Reply We appreciate the insights provided by Khan et al and Tzeng and Tsai regarding our study. As noted in the study limitations, although the use of prescription data from the claims database is superior to self-reported medication use, this method may not fully capture patient nonadherence, which could be a potential risk for misclassification. The best pragmatic approach to verify the time elapsed since the most recent dose of non −vitamin K antagonist oral anticoagulants (NOACs) is to use medication adherence monitoring devices (eg, ingestible electronic sensor) or noninvasive medication compliance monitoring systems (eg, pill bottle−mounted wireless sensor). We are pleased to see future studies using these technologies to investigate this important issue.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research