Venous thromboembolism - was is new in the revised AWMF guideline?
Dtsch Med Wochenschr. 2024 Mar;149(6):274-282. doi: 10.1055/a-2128-0005. Epub 2024 Feb 27.ABSTRACTFor the diagnosis of a lower-extremity deep vein thrombosis (LEDVT), venous duplex ultrasound is the method of first choice. If a qualified ultrasonography is not timely available, D-dimer testing, and limited ultrasound protocols (point-of-care ultrasound, POCUS) can contribute to therapeutic decision-making when clinical probability is low. A DOAC-based treatment regimen is preferable to a vitamin K antagonist for both acute therapy and secondary prophylaxis of venous thromboembolism (VTE). Treatment with DOACs is unproblema...
Source: Hamostaseologie - February 27, 2024 Category: Hematology Authors: Birgit Linnemann Katja Sibylle M ühlberg Robert Klamroth Source Type: research
Dietary macro and micronutrients associated with MASLD: Analysis of a national US cohort database
CONCLUSIONS: The deficiencies of micronutrients and excess of macronutrients point to oxidative stress, pro-inflammatory state, and lipotoxicity as pathways linking the US diet to MASLD. MASLD patients are more often on special diets, which may reflect prior provider counseling on diet changes to improve health.PMID:38412922 | DOI:10.1016/j.aohep.2024.101491 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 27, 2024 Category: Gastroenterology Authors: Mary Nemer Fauzia Osman Adnan Said Source Type: research
The Impact of Anticoagulant Medications on Fragility Femur Fracture Care: The Hip and Femoral Fracture Anticoagulation Surgical Timing Evaluation (Haste) Study
The benefits of expedited surgery to patients with fragility femoral fractures is established and underpins guidelines for their care [1,2]. Despite this, patients who take anticoagulant medications such as Vitamin K antagonists (VKA) and Direct Oral AntiCoagulants (DOAC) typically experience longer surgical delay greater than those that don't [3]. Anecdotally, delay is driven by concerns of complications despite the fact that prompt surgery is both safe and feasible [4 –9] and evidence for increased complications is scarce. (Source: Injury)
Source: Injury - February 27, 2024 Category: Orthopaedics Authors: MM Farhan-Alanie, R Chinweze, R Walker, WGP Eardley, HASTE collaborators Source Type: research
Vitamin K: Infection, Inflammation, and Auto-Immunity
J Inflamm Res. 2024 Feb 20;17:1147-1160. doi: 10.2147/JIR.S445806. eCollection 2024.ABSTRACTVitamin K (VK) comprises a group of substances with chlorophyll quinone bioactivity and exists in nature in the form of VK1 and VK2. As its initial recognition originated from the ability to promote blood coagulation, it is known as the coagulation vitamin. However, based on extensive research, VK has shown potential for the prevention and treatment of various diseases. Studies demonstrating the beneficial effects of VK on immunity, antioxidant capacity, intestinal microbiota regulation, epithelial development, and bone protection h...
Source: Atherosclerosis - February 26, 2024 Category: Cardiology Authors: Yuanyuan Xie Shifang Li Dinan Wu Yining Wang Jiepeng Chen Lili Duan Shuzhuang Li Yuyuan Li Source Type: research
Anticoagulation in atrial fibrillation and end-stage kidney disease on hemodialysis: a meta-analysis of randomized trials comparing direct oral anticoagulants with vitamin K antagonists
CONCLUSION: Orally administered activated factor X inhibitors carried a similar risk of bleeding and death when compared with VKAs in patients with NVAF undergoing chronic hemodialysis. Moreover, there was a trend towards a reduction of thromboembolic events or stroke in patients receiving DOACs.PMID:38404942 | PMC:PMC10885786 | DOI:10.1016/j.rpth.2024.102332 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 26, 2024 Category: Hematology Authors: Maximilian Tscharre Daniel Steiner David Mutschlechner Cihan Ay Thomas Gremmel Source Type: research
Vitamin K: Infection, Inflammation, and Auto-Immunity
J Inflamm Res. 2024 Feb 20;17:1147-1160. doi: 10.2147/JIR.S445806. eCollection 2024.ABSTRACTVitamin K (VK) comprises a group of substances with chlorophyll quinone bioactivity and exists in nature in the form of VK1 and VK2. As its initial recognition originated from the ability to promote blood coagulation, it is known as the coagulation vitamin. However, based on extensive research, VK has shown potential for the prevention and treatment of various diseases. Studies demonstrating the beneficial effects of VK on immunity, antioxidant capacity, intestinal microbiota regulation, epithelial development, and bone protection h...
Source: Atherosclerosis - February 26, 2024 Category: Cardiology Authors: Yuanyuan Xie Shifang Li Dinan Wu Yining Wang Jiepeng Chen Lili Duan Shuzhuang Li Yuyuan Li Source Type: research
Anticoagulation in atrial fibrillation and end-stage kidney disease on hemodialysis: a meta-analysis of randomized trials comparing direct oral anticoagulants with vitamin K antagonists
CONCLUSION: Orally administered activated factor X inhibitors carried a similar risk of bleeding and death when compared with VKAs in patients with NVAF undergoing chronic hemodialysis. Moreover, there was a trend towards a reduction of thromboembolic events or stroke in patients receiving DOACs.PMID:38404942 | PMC:PMC10885786 | DOI:10.1016/j.rpth.2024.102332 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 26, 2024 Category: Hematology Authors: Maximilian Tscharre Daniel Steiner David Mutschlechner Cihan Ay Thomas Gremmel Source Type: research
Anticoagulation in atrial fibrillation and end-stage kidney disease on hemodialysis: a meta-analysis of randomized trials comparing direct oral anticoagulants with vitamin K antagonists
CONCLUSION: Orally administered activated factor X inhibitors carried a similar risk of bleeding and death when compared with VKAs in patients with NVAF undergoing chronic hemodialysis. Moreover, there was a trend towards a reduction of thromboembolic events or stroke in patients receiving DOACs.PMID:38404942 | PMC:PMC10885786 | DOI:10.1016/j.rpth.2024.102332 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 26, 2024 Category: Hematology Authors: Maximilian Tscharre Daniel Steiner David Mutschlechner Cihan Ay Thomas Gremmel Source Type: research
Protocol for a randomised controlled trial comparing warfarin with no oral anticoagulation in patients with atrial fibrillation on chronic dialysis: the Danish Warfarin-Dialysis (DANWARD) trial
Introduction
Atrial fibrillation is highly prevalent in patients on chronic dialysis. It is unclear whether anticoagulant therapy for stroke prevention is beneficial in these patients. Vitamin K-antagonists (VKA) remain the predominant anticoagulant choice. Importantly, anticoagulation remains inconsistently used and a possible benefit remains untested in randomised clinical trials comparing oral anticoagulation with no treatment in patients on chronic dialysis. The Danish Warfarin-Dialysis (DANWARD) trial aims to investigate the safety and efficacy of VKAs in patients with atrial fibrillation on chronic dialysis. The hypo...
Source: BMJ Open - February 26, 2024 Category: General Medicine Authors: Ballegaard, E. L. F., Lindhard, K., Lindhardt, M., Peters, C. D., Thomsen Nielsen, F., Tietze, I. N., Borg, R., Boesby, L., Bertelsen, M. C., Brosen, J. M. B., Cibulskyte-Ninkovic, D., Rantanen, J. M., Mose, F. H., Kampmann, J. D., Nielsen, A. S., Breinho Tags: Open access, Cardiovascular medicine Source Type: research
Kidney Transplant Recipient With Cerebral Paradoxical Embolism Following Recurrent Idiopathic Deep Vein Thrombosis and Pulmonary Embolism: Case Report and Review of the Literature
Exp Clin Transplant. 2024 Jan;22(Suppl 1):348-353. doi: 10.6002/ect.MESOT2023.P38.ABSTRACTParadoxical embolism occurs when a thrombus crosses an intracardiac defect into the systemic circulation. Here, we present the case of a 35-yearold male kidney transplant recipient with a cerebral paradoxical embolism associated with a spontaneous venous thromboembolism. This patient had recurrent deep venous thrombosis and showering emboli to the lung and paradoxically to the brain through patent foramen ovale, and we treated him successfully. The role of bubble echocardiography was essential in diagnosis to avoid contrast-induced ne...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Osama Gheith Hassanen Abo Atya Ayman Maher Nagib Ahmed Sami Prasad Nair Medhat Alawady Khaja M Sharfuddin Ahmed Fathy Wesam Mattar Ahmed Abass Abdulwahab Mahmoud Mohamed Al Ajmi Torki Al Otaibi Source Type: research
Kidney Transplant Recipient With Cerebral Paradoxical Embolism Following Recurrent Idiopathic Deep Vein Thrombosis and Pulmonary Embolism: Case Report and Review of the Literature
Exp Clin Transplant. 2024 Jan;22(Suppl 1):348-353. doi: 10.6002/ect.MESOT2023.P38.ABSTRACTParadoxical embolism occurs when a thrombus crosses an intracardiac defect into the systemic circulation. Here, we present the case of a 35-yearold male kidney transplant recipient with a cerebral paradoxical embolism associated with a spontaneous venous thromboembolism. This patient had recurrent deep venous thrombosis and showering emboli to the lung and paradoxically to the brain through patent foramen ovale, and we treated him successfully. The role of bubble echocardiography was essential in diagnosis to avoid contrast-induced ne...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Osama Gheith Hassanen Abo Atya Ayman Maher Nagib Ahmed Sami Prasad Nair Medhat Alawady Khaja M Sharfuddin Ahmed Fathy Wesam Mattar Ahmed Abass Abdulwahab Mahmoud Mohamed Al Ajmi Torki Al Otaibi Source Type: research
Kidney Transplant Recipient With Cerebral Paradoxical Embolism Following Recurrent Idiopathic Deep Vein Thrombosis and Pulmonary Embolism: Case Report and Review of the Literature
Exp Clin Transplant. 2024 Jan;22(Suppl 1):348-353. doi: 10.6002/ect.MESOT2023.P38.ABSTRACTParadoxical embolism occurs when a thrombus crosses an intracardiac defect into the systemic circulation. Here, we present the case of a 35-yearold male kidney transplant recipient with a cerebral paradoxical embolism associated with a spontaneous venous thromboembolism. This patient had recurrent deep venous thrombosis and showering emboli to the lung and paradoxically to the brain through patent foramen ovale, and we treated him successfully. The role of bubble echocardiography was essential in diagnosis to avoid contrast-induced ne...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Osama Gheith Hassanen Abo Atya Ayman Maher Nagib Ahmed Sami Prasad Nair Medhat Alawady Khaja M Sharfuddin Ahmed Fathy Wesam Mattar Ahmed Abass Abdulwahab Mahmoud Mohamed Al Ajmi Torki Al Otaibi Source Type: research
Kidney Transplant Recipient With Cerebral Paradoxical Embolism Following Recurrent Idiopathic Deep Vein Thrombosis and Pulmonary Embolism: Case Report and Review of the Literature
Exp Clin Transplant. 2024 Jan;22(Suppl 1):348-353. doi: 10.6002/ect.MESOT2023.P38.ABSTRACTParadoxical embolism occurs when a thrombus crosses an intracardiac defect into the systemic circulation. Here, we present the case of a 35-yearold male kidney transplant recipient with a cerebral paradoxical embolism associated with a spontaneous venous thromboembolism. This patient had recurrent deep venous thrombosis and showering emboli to the lung and paradoxically to the brain through patent foramen ovale, and we treated him successfully. The role of bubble echocardiography was essential in diagnosis to avoid contrast-induced ne...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Osama Gheith Hassanen Abo Atya Ayman Maher Nagib Ahmed Sami Prasad Nair Medhat Alawady Khaja M Sharfuddin Ahmed Fathy Wesam Mattar Ahmed Abass Abdulwahab Mahmoud Mohamed Al Ajmi Torki Al Otaibi Source Type: research
Kidney Transplant Recipient With Cerebral Paradoxical Embolism Following Recurrent Idiopathic Deep Vein Thrombosis and Pulmonary Embolism: Case Report and Review of the Literature
Exp Clin Transplant. 2024 Jan;22(Suppl 1):348-353. doi: 10.6002/ect.MESOT2023.P38.ABSTRACTParadoxical embolism occurs when a thrombus crosses an intracardiac defect into the systemic circulation. Here, we present the case of a 35-yearold male kidney transplant recipient with a cerebral paradoxical embolism associated with a spontaneous venous thromboembolism. This patient had recurrent deep venous thrombosis and showering emboli to the lung and paradoxically to the brain through patent foramen ovale, and we treated him successfully. The role of bubble echocardiography was essential in diagnosis to avoid contrast-induced ne...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Osama Gheith Hassanen Abo Atya Ayman Maher Nagib Ahmed Sami Prasad Nair Medhat Alawady Khaja M Sharfuddin Ahmed Fathy Wesam Mattar Ahmed Abass Abdulwahab Mahmoud Mohamed Al Ajmi Torki Al Otaibi Source Type: research
Kidney Transplant Recipient With Cerebral Paradoxical Embolism Following Recurrent Idiopathic Deep Vein Thrombosis and Pulmonary Embolism: Case Report and Review of the Literature
Exp Clin Transplant. 2024 Jan;22(Suppl 1):348-353. doi: 10.6002/ect.MESOT2023.P38.ABSTRACTParadoxical embolism occurs when a thrombus crosses an intracardiac defect into the systemic circulation. Here, we present the case of a 35-yearold male kidney transplant recipient with a cerebral paradoxical embolism associated with a spontaneous venous thromboembolism. This patient had recurrent deep venous thrombosis and showering emboli to the lung and paradoxically to the brain through patent foramen ovale, and we treated him successfully. The role of bubble echocardiography was essential in diagnosis to avoid contrast-induced ne...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Osama Gheith Hassanen Abo Atya Ayman Maher Nagib Ahmed Sami Prasad Nair Medhat Alawady Khaja M Sharfuddin Ahmed Fathy Wesam Mattar Ahmed Abass Abdulwahab Mahmoud Mohamed Al Ajmi Torki Al Otaibi Source Type: research
