Eradication of hepatitis C virus infection disclosing a previously hidden, underlying autoimmune hepatitis: Autoimmune hepatitis and HCV.
This reports demonstrates that patients with features of auto-reactivity and HCV after DAA-induced viral clearance require careful follow-up. PMID: 32029393 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 9, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The effects of hyperthermia on human hepatocellular carcinoma stem and mature cancer cells.
CONCLUSIONS: These results suggest that human HCC CSCs are not more thermal resistant than MCCs and therefore, do not support the hypothesis that HCC recurrences following hyperthermic treatment reflect CSC thermal-resistance. PMID: 32005636 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 3, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Osteopontin - A potential biomarker of advanced liver disease.
Authors: Bruha R, Vitek L, Smid V Abstract Cirrhosis is a primary cause of liver-related mortality and morbidity. The basic process driving chronic liver disease to cirrhosis is accelerated fibrogenesis. Although the pathogenesis of liver cirrhosis is a multifactorial process, the essential step in the evolution of liver fibrosis is the activation of hepatic stellate cells, which are the main source of collagen produced in the extracellular matrix. This activation process is mediated by multiple growth factors, cytokines, and chemokines. One of the hepatic stellate cell-activating signaling molecules (and also one ...
Source: Annals of Hepatology - February 3, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Meta-analysis: The efficacy of metformin and other anti-hyperglycemic agents in prolonging the survival of hepatocellular carcinoma patients with type 2 diabetes.
This study aimed to compare the therapeutic efficacy of metformin and other anti-hyperglycemic agents in hepatocellular carcinoma (HCC) patients with type 2 diabetes (T2D). MATERIALS: A systematic electronic search on keywords including HCC and different anti-hyperglycemic agents was performed through electronic databases including Medline and EMBASE. The primary outcome was the overall survival (OS). The secondary outcomes were the recurrence-free survival (RFS) and progression-free survival (PFS). RESULTS: Six retrospective cohort studies were included for analysis: Four studies with curative treatment for HCC (6...
Source: Annals of Hepatology - January 27, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Requirement of cyclin-dependent kinase function for hepatitis B virus cccDNA synthesis as measured by digital PCR.
CONCLUSIONS: Dpcr greatly improved the sensitivity and specificity of cccDNA detection. Host CDK activities are likely required for cccDNA synthesis. dPCR can potentially be applied for drug screening for effective cccDNA inhibitors. PMID: 31964596 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 24, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

NRF-2 and nonalcoholic fatty liver disease.
Authors: Solano-Urrusquieta A, Morales-González JA, Castro-Narro GE, Cerda-Reyes E, Flores-Rangel PD, Fierros-Oceguera R Abstract Currently, chronic liver diseases have conditioned morbidity and mortality, many of these with a metabolic, toxicologic, immunologic, viral, or other etiology. Thus, a transcription factor that has been of huge importance for biomedical research is NRF-2. The latter is considered a principal component of the antioxidant mechanism, and it has been acknowledged that it impairs the function of NRF-2 in many liver diseases and that it forms an essential part of the pathologic changes ...
Source: Annals of Hepatology - January 23, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Advancements in genomic medicine and the need for updated regional clinical practice guidelines in the field of hepatology.
Authors: Panduro A, Roman S PMID: 31916948 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 10, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Ruptured hepatocellular carcinoma and non-alcoholic fatty liver disease, a potentially life-threatening complication in a population at increased risk.
Authors: Nuño-Guzmán CM, Marín-Contreras ME PMID: 31916949 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 10, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Ocular manifestations of liver disease in children: Clinical aspects and implications.
Authors: Prasad D, Bhriguvanshi A Abstract Liver and eyes are interlinked to each other in various medical conditions. There are certain ocular findings which directly indicate specific liver disorders. Thus, it becomes critical to identify disorders of liver and eyes early in the course of illness, so that prompt management may be initiated before the commencement of complications. It is highly advantageous in metabolic liver disorders as it offers prognostic value and spares the patient of unnecessary invasive and detailed work up. However, due to its silent and heterogeneous presentation, it is often unrecognize...
Source: Annals of Hepatology - January 7, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Serological and molecular study of Hepatitis E virus in pediatric patients in Mexico.
Authors: López-Santaella T, Álvarez Y Muñoz T, Medeiros-Domingo M, Moreno-Espinosa S, Consuelo-Sánchez A, Muñoz-Hernández O, Sarmiento-Silva RE, Sotomayor-González A, Trujillo-Ortega ME, García-Hernández ME, Taboada-Ramírez BI, Arenas-Huertero F Abstract INTRODUCTION AND OBJECTIVES: Cases of viral hepatitis reported in Mexico are typically identified as hepatitis A, B and C. However, unspecified cases are reported annually. Hepatitis E virus (HEV) is an emergent agent that causes a self-limiting infection that can evolve to chronic in immunosuppr...
Source: Annals of Hepatology - January 4, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Identification and study of differentially expressed miRNAs in aged NAFLD rats based on high-throughput sequencing.
CONCLUSIONS: A total of 10 DE-miRs identified in the aged NAFLD rats were involved in some certain insulin secretion and age-related functional pathways, which may serve as novel candidate targets for the diagnosis and treatment of aging-associated NAFLD. PMID: 31899128 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 4, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

48 weeks outcome after cessation of nucleos(t)ide analogue therapy in chronic hepatitis B patients.
Authors: Gao L, Hu Y, Shi X, Li X, Zhang D, Ren H Abstract INTRODUCTION AND OBJECTIVE: The aim of the present study was to investigate the significance of serum HBsAg levels in treatment cessation of nucleoside analogues (NAs) in patients with chronic hepatitis B (CHB) infection. METHODS: In 158 CHB patients with long-term NAs treatment, 74 patients were in HBeAg negative and had a HBsAg level
Source: Annals of Hepatology - December 31, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Comparing hepatic steatosis distribution patterns between non-alcoholic fatty liver disease and fatty liver disease with chronic hepatitis B by second-harmonic generation/two-photon excited fluorescence method.
Authors: Zhuang Z, Qu H, Yang W, Liu J, Wang F, Liu Y, Ding J, Shi J Abstract INTRODUCTION AND OBJECTIVES: Hepatitis B virus (HBV) might be an etiological factor modulating fat distribution in steatotic livers. We aim to compare hepatic steatosis distribution patterns between NAFLD and FL&CHB patients with second-harmonic generation (SHG)/two-photon excited fluorescence (TPEF) method. PATIENTS AND METHODS: 42 patients with NAFLD, 46 with FL&CHB and 55 without steatosis were enrolled in the study. Overall and regional steatosis in liver sections were quantified by SHG/TPEF method. The accuracy of which w...
Source: Annals of Hepatology - December 25, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Peroxisomal footprint in the pathogenesis of nonalcoholic steatohepatitis.
Authors: Islam SMT, Won J, Khan M, Chavin KD, Singh I Abstract Nonalcoholic steatohepatitis (NASH) is a form of fatty liver disease where benign hepatic steatosis leads to chronic inflammation in the steatotic liver of a patient without any history of alcohol abuse. Mechanisms underlying the progression of hepatic steatosis to NASH have long been investigated. This review outlines the potential role of peroxisomal dysfunctions in exacerbating the disease in NASH. Loss of peroxisomes as well as impaired peroxisomal functions have been demonstrated to occur in inflammatory conditions including NASH. Because peroxisom...
Source: Annals of Hepatology - December 25, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Tips for TIPS: A combined percutaneous and transjugular approach for intrahepatic portosystemic shunt placement after liver transplant.
Authors: Lenci I, Neri B, Morosetti D, Milana M, Palmieri G, Tisone G, Orlacchio A, Angelico M, Baiocchi L Abstract A 39-year-old female, liver transplanted for Autosomic Dominant Polycystic Kidney Disease (ADPKD) developed refractory ascites early after surgery, with frequent need of large-volume paracentesis. This was associated with severe sarcopenia and kidney impairment. Liver biopsy showed a sinusoidal congestion with a significant enlargement of hepatic portal veins. This picture suggested the diagnosis of vascular obstructions. Due to an unfavorable passage through the piggy-back surgical anastomosis and th...
Source: Annals of Hepatology - December 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

50 years of Hepatology: The Royal Free Hospital School of Hepatology.
Authors: Campollo O Abstract Writing about the history of Hepatology would necessarily imply writing about the history of the Liver Unit and the School of Hepatology created by Dr. Sheila Scherlock at the Royal Free Hospital (London). On the 70th anniversary of the creation of the first liver unit (Hammersmith Hospital) this article presents a brief account of the history, organization, structure, educational program and contributions of perhaps the first and the most influential medical research models created for the study of liver diseases: the Royal Free Hospital Liver Unit. PMID: 31838027 [PubMed - as supp...
Source: Annals of Hepatology - December 17, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Laparoscopic repair of transected right hepatic artery during cholecystectomy: A report of two cases.
Authors: Bao-Qiang W, Jun H, Wen-Song L, Yong J, Xue-Min C, Dong-Lin S Abstract In laparoscopic cholecystectomy (LC), the treatment of iatrogenic biliary tract injury has been given much attention. However, most accidental right hepatic artery (RHA) injuries are treated with simple clipping. The reason is that the RHA has difficulty in revascularization, and it is generally considered that RHA injury does not cause serious consequences. However, some studies suggest that some cases of RHA ligation can cause a series of pathological changes correlated to arterial ischemia, such as liver abscess, bile tumor, liver at...
Source: Annals of Hepatology - December 15, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Metformin in the prevention of hepatocellular carcinoma in diabetic patients: A systematic review.
CONCLUSIONS: The use of metformin was associated with a reduced risk of HCC, and it may be a relevant factor for preventing HCC in diabetic patients. PMID: 31836424 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - December 15, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The preventive effect of liraglutide on the lipotoxic liver injury via increasing autophagy.
CONCLUSIONS: Liraglutide could upregulate autophagy to decrease lipid over-accumulation via the AMPK/mTOR pathway. PMID: 31787541 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - December 5, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Multiple therapeutic targets in rare cholestatic liver diseases: Time to redefine treatment strategies.
Authors: Gerussi A, D'Amato D, Cristoferi L, O'Donnell SE, Carbone M, Invernizzi P Abstract Primary biliary cholangitis and primary sclerosing cholangitis are rare diseases affecting the bile ducts and the liver. The limited knowledge of their pathogenesis leads to limited therapeutic options. Nevertheless, the landscape of novel therapies for these cholangiopathies is now rapidly changing, providing new treatment opportunities for patients and clinicians involved in their care. The aim of this review is to summarize the evidence of novel molecules under investigation for primary biliary cholangitis and primary scl...
Source: Annals of Hepatology - November 28, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Low prevalence of anti-hepatitis E virus IgG antibodies in Tepehuanos in Mexico.
This study aimed to determine the seroprevalence of and risk factors associated with HEV infection in Tepehuanos in Durango, Mexico, and to compare this seroprevalence with that in non-Tepehuanos. MATERIALS AND METHODS: Through a case-control seroprevalence study, we studied 146 Tepehuanos and 146 age- and gender-matched control subjects of the general population from rural settings. The frequency of anti-HEV IgG antibodies was determined using an enzyme-linked immunoassay. Bivariate and multivariate analyses were used to assess the association between seropositivity and socio-demographic, clinical and behavioral chara...
Source: Annals of Hepatology - November 28, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

ABCB4 disease: Many faces of one gene deficiency.
Authors: Sticova E, Jirsa M Abstract ATP-binding cassette (ABC) subfamily B member 4 (ABCB4), also known as multidrug resistance protein 3 (MDR3), encoded by ABCB4, is involved in biliary phospholipid secretion, protecting hepatobiliary system from deleterious detergent and lithogenic properties of the bile. ABCB4 mutations altering canalicular ABCB4 protein function and expression may have variable clinical presentation and predispose to several human liver diseases. Well-established phenotypes of ABCB4 deficit are: progressive familial intrahepatic cholestasis type 3, gallbladder disease 1 (syn. low phospholipid ...
Source: Annals of Hepatology - November 25, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Spleen Stiffness Probability Index (SSPI): A simple and accurate method to detect esophageal varices in patients with compensated liver cirrhosis.
Authors: Giuffrè M, Macor D, Masutti F, Abazia C, Tinè F, Bedogni G, Tiribelli C, Crocè LS Abstract BACKGROUND AND OBJECTIVES: Recent findings pointed out that even low-risk esophageal varices (EVs) are markers of severe prognosis. Accordingly, we analyzed spleen stiffness (SS) as a non-invasive method to predict EVs of any grade in a cohort of patients with compensated liver cirrhosis. METHOD: We measured SS and liver stiffness (LS) using point-Shear-Wave Elastography (pSWE) with Philips Affiniti 70 system in 210 cirrhotic patients who had undergone endoscopic screening for EVs. We compare...
Source: Annals of Hepatology - November 21, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The lack of guidelines and government policies for regulating nonprescription sale of antibiotics and its medical consequences.
Authors: Juárez-Hernández E, Uribe M PMID: 31735347 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - November 20, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Yellow Fever.
Authors: Ferreira MS PMID: 31735348 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - November 20, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Hepatotoxicity during TB treatment in people with HIV/AIDS related to NAT2 polymorphisms in Pernambuco, Northeast Brazil.
Authors: Araujo-Mariz C, Militão de Albuquerque MFP, Lopes EP, Ximenes RAA, Lacerda HR, Miranda-Filho DB, Lustosa-Martins BB, Pastor AFP, Acioli-Santos B Abstract INTRODUCTION AND OBJECTIVE: Hepatotoxicity during tuberculosis (TB) treatment is frequent and may be related to the Arylamine N-Acetyltransferase (NAT2) acetylator profile, in which allele frequencies differ according to the population. The aim of this study was to investigate functional polymorphisms in NAT2 associated with the development of hepatotoxicity after initiating treatment for TB in people living with HIV/AIDS (PLWHA) in Pernambuco, Nor...
Source: Annals of Hepatology - November 18, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

HEPLA: A multicenter study on demographic and disease characteristics of patients with hepatitis C in Latin America.
CONCLUSIONS: At the time the HEPLA study was carried out, the data from this cross-section of patients in Latin America showed that the CHC population has variation in disease and viral characteristics, with a minority of patients receiving treatment and many patients having advanced disease. Increased awareness and access to treatment are necessary in Latin America in order to meet the goal of hepatitis C virus elimination by 2030. PMID: 31718995 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - November 15, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Calling a stage-based treatment model for chronic liver diseases in China mainland.
This article aims to describe the current seek medical status of chronic liver diseases and discuss a stage-based consulting medical model for chronic liver diseases in China mainland, which would contribute to make rational use of limited medical resources and help to address National Health China 2030 strategy initiated by the Chinese government. PMID: 31711913 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - November 14, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Comparative study of impulsiveness and risk behaviors among infected individuals with hepatitis C virus and human T-cell lymphotropic virus type 1.
CONCLUSIONS: This study confirms the higher rate of risk behaviors and the levels of impulsiveness commonly observed in patients with HCV, along with comparisons to patients with HTLV-1. PMID: 31711914 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - November 14, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

EPA plus DHA improves survival related to a decrease of injury after extended liver ischemia in Sprague-Dawley rats.
CONCLUSIONS: The ω3 supplementation could prevent and promote the restoration of the liver tissue and significantly improve the survival rate in rats at 48h. PMID: 31711915 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - November 14, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Aggressive recurrence of Non-Hodgkin's Lymphoma after successful clearance of hepatitis C virus with direct acting antivirals.
We present a patient with DLBCL, in remission after appropriate treatment, HCV cirrhosis that was cured with the new antivirals and shortly after SVR, he experienced a lethal lymphoma recurrence. PMID: 31694799 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - November 8, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

A combination of α-fetoprotein, midkine, thioredoxin and a metabolite for predicting hepatocellular carcinoma.
This study examined 196 patients for an estimation study (104 patients with HCC, 52 with liver cirrhosis and 40 with liver fibrosis) and 122 patients for the validation study (80 patients with HCC, 42 with liver cirrhosis). All patients were positive for hepatitis C virus. Four markers were measured: Midkine and thioredoxin using ELISA, 1-methyladenosine and 1-methylguanosine using a gas chromatography-mass spectrometry (GC-MS). The results were compared with alpha-fetoprotein (AFP). The performance of the model was estimated in BCLC, CLIP and Okuda staging systems of HCC. RESULTS: The model yielded high performance wi...
Source: Annals of Hepatology - October 29, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Infection in cirrhosis: A prospective study.
Authors: Bhattacharya C, Das-Mondal M, Gupta D, Sarkar AK, Kar-Purkayastha S, Konar A Abstract INTRODUCTION AND OBJECTIVES: Multidrug-resistant (MDR) infections in cirrhosis are associated with poor outcomes. We attempted a prospective study on infections in patients with cirrhosis evaluating microbiology of these infections and how outcomes depended on factors like bacterial resistance, appropriate antibiotics, stage of liver disease and whether outcomes were significantly different from patients who did not have infections. MATERIALS AND METHODS: This was a prospective evaluation involving one hundred and fif...
Source: Annals of Hepatology - October 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Diagnosis, surgical treatment and postoperative outcomes of hepatic endometriosis: A systematic review.
CONCLUSIONS: Preoperative diagnosis of HE is challenging due to variable radiologic features and clinical symptomatology. Nonetheless, it should be considered in the differential diagnosis of a liver mass especially in premenopausal women with a history of endometriosis. The type of resection of the endometriotic lesion is based on the extent and the location of the disease and presented with favourable outcomes concerning morbidity, symptom relief and recurrence. PMID: 31630985 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 22, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

MicroRNA-124a contributes to glucocorticoid resistance in acute-on-chronic liver failure by negatively regulating glucocorticoid receptor alpha.
CONCLUSIONS: This study provides evidence that GRα expression was negatively regulated by miR-124a, which primarily determines the extent of acquired glucocorticoid resistance in ACLF. PMID: 31628069 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 21, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The relative expression of hepatocellular and cholestatic liver enzymes in adult patients with liver disease.
CONCLUSIONS: These data provide health care providers with predicted ranges of liver enzymes in patients with hepatocellular or cholestatic liver disease and may thereby help to identify patients with concurrent forms of liver disease. PMID: 31628070 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 21, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Liver transplantation in acute liver failure due to Hepatitis B. Two clinical cases.
Authors: Sedano R, Castro L, Venegas M, Miranda J, Hurtado C, Poniachik J, Brahm J Abstract Hepatitis B virus (HBV) related acute liver failure (ALF) is uncommon in our region, and there is limited HBV literature regarding the optimal management of these cases. In this article, we report two clinical cases of young men who have sex with men (MSM), both developed severe acute hepatitis caused by HBV, progressed to ALF and afterward required liver transplantation. Antiviral post-transplant treatment included entecavir without Hepatitis B Immunoglobulin (HBIG), and immunosuppression therapy with steroids, tacrolimus, ...
Source: Annals of Hepatology - October 19, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Elevation of hepatic autophagy and antioxidative capacity by endurance exercise is associated with suppression of apoptosis in mice.
CONCLUSIONS: Our findings indicate that improved autophagy and antioxidant capacity, and potentiated anabolic signaling may be a potent non-pharmacological therapeutic strategy against diverse liver diseases. PMID: 31611063 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 17, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Role of zinc supplementation in the management of chronic liver diseases: A systematic review and meta-analysis.
CONCLUSIONS: Clinical trials assessing zinc supplementation in liver diseases do not show benefits in terms of clinical improvement or disease halting. There are possible benefits of zinc supplementation on hepatic encephalopathy, however, this is based on limited evidence. This research question is still open for evaluation in larger, well-designed, clinical trials. PMID: 31611064 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 17, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Evaluation of prophylactic antibiotic regimens on recurrence and mortality in spontaneous bacterial peritonitis.
CONCLUSIONS: In patients with a history of SBP, our data indicate similar outcomes with daily, intermittent, or no secondary antibiotic prophylaxis. With available data, including ours, demonstrating a changing epidemiology for SBP pathogens, further data is required to determine if traditional approaches to secondary SBP prophylaxis remain appropriate. PMID: 31611065 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 17, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Chronic kidney disease in patients with non-alcoholic fatty liver disease: What the Hepatologist should know?
Authors: Kiapidou S, Liava C, Kalogirou M, Akriviadis E, Sinakos E Abstract The association of non-alcoholic fatty liver disease (NAFLD) with several other diseases has gained increased interest during the recent years. Among them, the association with chronic kidney disease (CKD) has emerged as an important one regarding both its prevalence and significance. The early recognition of this association is important for the prognosis of patients with NAFLD and CKD. Apart from early diagnosis, the accurate assessment of renal function is also crucial in the clinical practice of hepatologists. Several methods have been ...
Source: Annals of Hepatology - October 15, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Sinusoidal obstruction syndrome secondary the intake of Senecio brasiliensis: A case report.
Authors: Barcelos STA, Dall'Oglio VM, de Araújo A, Cerski CTS, Álvares-da-Silva MR Abstract Hepatic sinusoidal obstruction syndrome (HSOS) is a hepatic vascular disease histologically characterized by edema, necrosis, detachment of endothelial cells in small sinusoidal hepatic and interlobular veins and intrahepatic congestion, which leads to portal hypertension and liver dysfunction. In the Western world, most HSOS cases are associated with myeloablative pretreatment in a hematopoietic stem cell transplantation setting. Here we report a case of a 54 years old female patient, otherwise healthy, with n...
Source: Annals of Hepatology - October 15, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Oxidative stress in hepatitis C virus-human immunodeficiency virus co-infected patients.
Authors: Gravier-Hernández R, Gil-Del Valle L, Valdes-Alonso L, Hernández-Ayala N, Bermúdez-Alfonso Y, Hernández-Requejo D, Rosell-Guerra T, Hernández-González-Abreu MC Abstract INTRODUCTION AND OBJECTIVES: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) co-infection generates sustained inflammation with increased reactive oxygen species production. The pathogenic impact of systemic oxidative stress is known to influence drug treatment and follow-up. The aim of this case-control study was to compare the redox status in HCV-HIV co-infected with respect to HIV-...
Source: Annals of Hepatology - October 15, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Validation of original, expanded Baveno VI, and stepwise & platelet-MELD criteria to rule out varices needing treatment in compensated cirrhosis from various etiologies.
CONCLUSIONS: All 3 criteria showed satisfactorily high NPVs in ruling out VNT in compensated cirrhosis from various causes. The expanded Baveno VI and the platelet-MELD criteria could spare more endoscopies than the original Baveno VI criteria. From a public health standpoint, the platelet-MELD criteria might be useful in a resource-limited setting where TE is not widely available. PMID: 31607647 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 15, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Hyperdynamic circulatory syndrome in a mouse model transgenic for SerpinB3.
Authors: Villano G, Verardo A, Martini A, Brocco S, Pesce P, Novo E, Parola M, Sacerdoti D, Di Pascoli M, Fedrigo M, Castellani C, Angelini A, Pontisso P, Bolognesi M Abstract INTRODUCTION AND OBJECTIVES: SerpinB3 is a cysteine protease inhibitor involved in several biological activities. It is progressively expressed in chronic liver disease, but not in normal liver. The role in vascular reactivity of this serpin, belonging to the same family of Angiotensin II, is still unknown. Our aim was to evaluate the in vivo and in vitro effects of SerpinB3 on systemic and splanchnic hemodynamics. MATERIAL AND METHODS: D...
Source: Annals of Hepatology - October 15, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Sofosbuvir inhibits yellow fever virus in vitro and in patients with acute liver failure.
CONCLUSIONS: Sofosbuvir may be used as an option for treatment against YFV until other drugs are identified and approved for human use. These results offer insights into the role of nonstructural protein 5 (NS5) in YFV inhibition and suggest that nonstructural proteins may be explored as drug targets for YFV treatment. PMID: 31594756 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 9, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Liver transplantation in the setting of a spontaneous shunt between superior mesenteric vein and right renal vein.
Authors: Chedid MF, Zahler S, Chedid AD, Leipnitz I, Prediger JE, Giampaoli AZD, Lopes BB, Kruel CRP, Grezzana-Filho TJM Abstract Shunts between the superior mesenteric vein (SMV) and the right renal vein (RRV) are very rare. Here, we describe and depict the rare case of a liver transplant (LT) in the setting of shunt between SMV and RRV. A 67-year-old white man presenting with Child C cirrhosis secondary to hemochromatosis and persistent encephalopathy was listed for LT. Preoperative abdominal angiotomography revealed the presence of a large spontaneous shunt between the SMV and the RRV. The patient underwent LT b...
Source: Annals of Hepatology - October 9, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Mechanisms of kidney dysfunction in the cirrhotic patient: Non-hepatorenal acute-on-chronic kidney damage considerations.
Authors: Muciño-Bermejo MJ Abstract Renal dysfunction is a common finding in cirrhotic patients and has a great physiologic, and therefore, prognostic relevance. The combination of liver disease and renal dysfunction can occur as a result of systemic conditions that affect both the liver and the kidney, although primary disorders of the liver complicated by renal dysfunction are much more common. As most of the renal dysfunction scenarios in cirrhotic patients correspond to either prerenal azotemia or hepatorenal syndrome (HRS), physicians tend to conceive renal dysfunction in cirrhotic patients as mainly HR...
Source: Annals of Hepatology - October 9, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Effects of hepatitis B virus infection, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase on prediabetes and diabetes mellitus: A cohort study.
Authors: Gan T, Cheng N, Ding J, Cheng Z, Zhang D, Li H, Li J, Li N, Yang A, Ren X, Shi D, Pu H, Shen X, Ren X, Hu X, Zheng T, Bai Y Abstract INTRODUCTION AND OBJECTIVES: The purpose of this study was to confirm whether hepatitis B virus (HBV) infection and the levels of liver enzymes would increase the risk of prediabetes and diabetes mellitus (DM) in China. MATERIALS AND METHODS: A total of 10,741 individuals was enrolled in this prospective cohort study. Cox regression analysis was used to calculate the Hazard ratios (HRs) to evaluate the relationships between HBV infection and the risk of DM and prediabetes...
Source: Annals of Hepatology - October 8, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Liver iron concentration in dysmetabolic hyperferritinemia: Results from a prospective cohort of 276 patients.
CONCLUSIONS: Patients with hyperferritinemia and metabolic syndrome presented a mildly increased mean liver iron concentration that was not significantly different to that of patients with hyperferritinemia and non-metabolic syndrome. PMID: 31587985 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 8, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research