Non-invasive diagnosis of non-alcoholic fatty liver disease using an algorithm combining clinical indexes and ultrasonographic measures.
CONCLUSION: The ultrasonography measure of right liver lobe diameter by itself can reliably identify patients with NAFLD with a good sensitivity and specificity, however, this can be improved by adding the LAP mathematical index in our population. PMID: 33031969 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 10, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Latin American Association for the Study of the Liver (ALEH) Practice Guidance for the Diagnosis and Treatment of Non-Alcoholic Fatty Liver Disease.
Authors: Arab JP, Dirchwolf M, Álvares-da-Silva MR, Barrera F, Benítez C, Castellanos-Fernandez M, Castro-Narro G, Chavez-Tapia N, Chiodi D, Cotrim H, Cusi K, de Oliveira CPMS, Díaz J, Fassio E, Gerona S, Girala M, Hernandez N, Marciano S, Masson W, Mendez-Sanchez N, Leite N, Lozano A, Padilla M, Panduro A, Paraná R, Parise E, Perez M, Poniachik J, Restrepo JC, Ruf A, Silva M, Tagle M, Tapias M, Torres K, Vilar-Gomez E, Costa Gil JE, Gadano A, Arrese M Abstract Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chr...
Source: Annals of Hepatology - October 10, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The Histone Variant H3.3 Regulates the Transcription of the Hepatitis B Virus.
CONCLUSIONS: We found that the histone variant H3.3 positively regulates HBV transcription. Importantly, the characterization of the viral chromatin dynamics might allow the discovery of new therapeutic targets to develop drugs for the treatment of chronically infected HBV patients. PMID: 33007428 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 4, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Temporal histopathological changes in biliary atresia: A perspective for rapid fibrosis progression.
CONCLUSIONS: Fibrosis in BA progresses rapidly and is significantly correlated with BDP. Assessment of targeting BDP as an adjuvant medical therapy is recommended. PMID: 33007429 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - October 4, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling.
CONCLUSIONS: Salvianolic acid B prevented LPS-induced HSC proliferation and activation by enhancing antifibrotic FGF19/FGFR4 signaling. PMID: 32980439 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 30, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Outcomes of Japanese patients with non-alcoholic fatty liver disease according to genetic background and lifestyle-related diseases.
CONCLUSIONS: Genetic background may affect NAFLD prognosis and ALDH2 SNP could predict the outcome. PMID: 32987175 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 30, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

LncRNA DDX11-AS1 accelerates hepatocellular carcinoma progression via the miR-195-5p/MACC1 pathway.
CONCLUSION: Our data revealed that DDX11-AS1 could act as an oncogenic regulator in HCC, providing a potential therapeutic target for HCC treatment. PMID: 32961346 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 24, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

COVID-19 and the liver: What do we know after six months of the pandemic?
Authors: Fierro NA Abstract Despite liver injury in patients infected with severe acute respiratory syndrome (SARS) coronavirus (CoV)-2 (SARS-CoV-2) is associated with prolonged hospitalization, and liver dysfunction is mainly described in patients with severe viral disease. How liver abnormalities may affect virus infection is still unknown. Improved understanding of host genetics, lifestyle, underlying comorbidities and adequate follow-up of patients with liver damage are critical in the new scenario of the pandemic virus. PMID: 32956871 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 23, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Usefulness of collagen type IV in the detection of significant liver fibrosis in Nonalcoholic Fatty Liver Disease.
CONCLUSION: Type 4 collagen could predict the presence of significant and advanced fibrosis in NAFLD patients and it would be a useful tool in routine clinical practice. PMID: 32949785 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 21, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Efficacy and Safety of Glecaprevir/Pibrentasvir in Treatment-Na ïve Adults with Chronic Hepatitis C Virus Genotypes 1-6 in Brazil.
CONCLUSIONS: Glecaprevir/pibrentasvir was effective and well tolerated in treatment-naïve Brazilian patients with hepatitis C infection without cirrhosis and with compensated cirrhosis. TRIAL REGISTRATION: ClinicalTrials.gov NCT03219216. PMID: 32949786 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 21, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Silymarin is an ally against insulin resistance: a review.
Authors: MacDonald-Ramos K, Michán L, Martínez-Ibarra A, Cerbón M Abstract Silymarin is obtained from the Milk thistle plant Silybum marianum and has been used over the centuries to treat principally liver disease, although it has also been studied for its beneficial effects in cardioprotection, neuroprotection, immune modulation, and cancer among others. Importantly, silymarin's active component silybin is a flavonolignan that exhibits different activities such as; scavenger, anti-oxidant, anti-inflammatory, and recently revealed, insulin-sensitizing properties which have been explored in clin...
Source: Annals of Hepatology - September 21, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Cost of illness of liver diseases in Japan.
CONCLUSIONS: The COI of liver diseases in Japan has been decreasing for the past 15 years. In the future, a further reduction in patients with hepatitis C is expected, and even if the incidence of NASH and alcoholic liver disease increases, that of cirrhosis and liver cancer will likely continue to decrease. PMID: 32942026 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 18, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The effect of liver test abnormalities on the prognosis of covid-19.
CONCLUSIONS: ALT-AST elevation and AST/ALT ratio>1 was associated with more severe course and increased mortality in COVID-19. PMID: 32920162 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 16, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: a meta-analysis of eleven epidemiological studies.
CONCLUSIONS: Regular coffee consumption is significantly associated with a reduced risk of NAFLD. It is also significantly associated with decreased risk of liver fibrosis development in already diagnosed NAFLD patients. Although coffee consumption may be considered an essential preventive measure for NAFLD, this subject needs further epidemiological studies. PMID: 32920163 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 16, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

An Outbreak Presents An Opportunity to Learn About A Rare Phenotype: Autoimmune Hepatitis After Acute Hepatitis A.
We describe the presenting features, diagnosis, treatment and long-term outcomes of these cases. This case series provides a insight into the clinical presentation and treatment of autoimmune hepatitis after hepatitis A infection with interesting take home points for clinical hepatologists. PMID: 32927125 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 16, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Diagnostic performance of three non-invasive fibrosis scores (Hepamet, FIB-4, NAFLD fibrosis score) in NAFLD patients from a mixed Latin American population.
CONCLUSION: Thresholds of non-invasive fibrosis scores (Hepamet, FIB-4 and NFS) can be modified to maximize diagnostic accuracy in Latin American patients with NAFLD. PMID: 32919087 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 14, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Usefulness of Neutrophil-to-Lymphocyte Ratio (NLR) as a prognostic predictor after treatment of hepatocellular carcinoma." Review article.
Usefulness of Neutrophil-to-Lymphocyte Ratio (NLR) as a prognostic predictor after treatment of hepatocellular carcinoma." Review article. Ann Hepatol. 2020 Sep 04;: Authors: Mouchli M, Reddy S, Gerrard M, Boardman L, Rubio M Abstract The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker which has been investigated as a prognostic indicator in post-therapeutic recurrence and survival of patients with HCC. Our aim was to review all studies that assessed the prognostic value of pre-treatment NLR in predicting patient survival, cancer recurrence, and graft survival in patients undergoing...
Source: Annals of Hepatology - September 10, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Hepatology and the "new reality" ushered in by the COVID-19 pandemic.
Hepatology and the "new reality" ushered in by the COVID-19 pandemic. Ann Hepatol. 2020 Sep - Oct;19(5):449-450 Authors: Uribe M, Aquino-Matus J PMID: 32891255 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 8, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

A systematic review and meta-analysis of the COVID-19 associated liver injury.
CONCLUSION: COVID-19 associated liver injury is more common in severe COVID-19 than non-severe COVID-19. Physicians should be aware of possible progression to severe disease in subjects with COVID-19-associated liver injury. PMID: 32882393 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 7, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Clinical evaluation of modified ALPPS procedures based on risk-reduced strategy for staged hepatectomy.
CONCLUSIONS: ALPPS could be a feasible treatment for complex liver tumors by risk-reduced modification. It could be expected to provide long-term survival for patients without enough FLR. PMID: 32877762 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 4, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

PNPLA3 rs738409 associates with alcoholic liver cirrhosis but not with serum levels of IL6, IL10, IL8 or CCL2 in the Russian population.
CONCLUSION: Thus, in the Russian population heavy drinkers carrying PNPLA3 rs738409 G allele are at higher risk of ALC, however the presence of rs738409 allele does not influence the serum cytokine levels. PMID: 32871288 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 3, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Body mass index and alcohol consume are directly related with liver steatosis. Results from a prospective study of patients referred for hyperferritinemia.
Authors: Castiella A, Zapata E, Urreta I, Zubiaurre L, Alústiza JM, Otazua P, Emparanza JI, Burnia Group PMID: 32866690 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - September 1, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

SARS-CoV-2 another kind of liver aggressor, how does it do that?
Authors: Lozano-Sepulveda SA, Galan-Huerta K, Martínez-Acuña N, Arellanos-Soto D, Rivas-Estilla AM Abstract Clinical manifestations of SARS-CoV-2 infection include more frequently fever and cough, but complications (such as pneumonia, respiratory distress syndrome, and multiorgan failure) can occur in persons with additional comorbidities. Liver dysfunction is one of the most striking affections among patients suggesting that SARS-CoV-2 may represent a new king of liver aggressor. However, the molecular process underlying this phenomenon is still unclear. In this work, we overview the most recent find...
Source: Annals of Hepatology - August 29, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

An Integrated Review of the Hepatorenal Syndrome.
Authors: Ojeda-Yuren AS, Cerda-Reyes E, Herrero-Maceda MR, Castro-Narro G, Piano S Abstract Among the complications of cirrhosis, hepatorenal syndrome (HRS) is characterized by having the worst survival rate. HRS is a disorder that involves the deterioration of kidney function caused primarily by a systemic circulatory dysfunction, but in recent years, systemic inflammation and cirrhotic cardiomyopathy have been discovered to also play an important role. The diagnosis of HRS requires to meet the new International Club of Ascites-Acute Kidney Injury (ICA-AKI) and Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) cr...
Source: Annals of Hepatology - August 28, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

For fatty liver diseases, it is time to utilize non-invasive fibrosis tests to predict liver related events rather than just histological stages of hepatic fibrosis!
Authors: Peltekian KM PMID: 32853777 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - August 28, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Carcinoembryonic antigen, α-fetoprotein, and Ki67 as biomarkers and prognostic factors in intrahepatic cholangiocarcinoma: A retrospective cohort study.
Carcinoembryonic antigen, α-fetoprotein, and Ki67 as biomarkers and prognostic factors in intrahepatic cholangiocarcinoma: A retrospective cohort study. Ann Hepatol. 2020 Aug 22;: Authors: Qiang ZY, Zhang WH, Jin S, Dai KF, He YT, Tao LY, Yu HB Abstract INTRODUCTION AND OBJECTIVE: The purpose of this study was to investigate the expression levels and prognostic roles of α-fetoprotein (AFP), carcinoembryonic antigen (CEA), and Ki67 in tumor tissues of intrahepatic cholangiocarcinoma (ICC) patients. PATIENTS OR MATERIALS AND METHODS: The study involved ninety-two ICC patients with complet...
Source: Annals of Hepatology - August 27, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Spleen stiffness can be employed to assess the efficacy of spontaneous portosystemic shunts in relieving portal hypertension.
Authors: Giuffrè M, Bedogni G, Abazia C, Masutti F, Tiribelli C, Crocè LS Abstract INTRODUCTION: Spleen stiffness (SS) has been found to mirror dynamic changes in portal pressure after transjugular intrahepatic portosystemic shunt (TIPS) placement. However, there is no data available regarding SS in patients with spontaneous portosystemic shunting (SPSS), especially in decompensation prediction. METHODS: We retrospectively selected patients with confirmed SPSS and EVs at endoscopic examination, and recorded any decompensating event (i.e., variceal hemorrhage, overt hepatic encephalopathy, refracto...
Source: Annals of Hepatology - August 25, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Infected Hepatic Echinococcosis. Clinical, Therapeutic, and Prognostic Aspects. A Systematic Review.
Authors: Castillo S, Manterola C, Grande L, Rojas C Abstract Infected hepatic echinococcosis (IHE), defined as a cystic infection, and the development of a liver abscess may be a complication in the natural history of hepatic echinococcosis. The aim of this study was to review the evidence available related to the clinical, therapeutic, and prognostic aspects of IHE. We conducted a systematic review. DATA SOURCES: Trip Database, BIREME-BVS, SciELO, LILACS, IBECS, PAHO-WHO; WoS, EMBASE, SCOPUS and PubMed. STUDY PARTICIPANTS: Studies related to IHE in human populations, without language restriction, published...
Source: Annals of Hepatology - August 25, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Outbreak of hepatitis A in a post-vaccination era: high rate of co-infection with sexually transmitted diseases.
CONCLUSIONS: Our study describes that during the study period, HAV infection affected predominantly young adults, particularly men who have sex with men. An elevated proportion of them was diagnosed with a concomitant sexually transmitted disease, and several patients had a severe presentation of the disease. PMID: 32835862 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - August 25, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Preoperative evaluation and prediction of clinical scores for hepatocellular carcinoma microvascular invasion: a single-center retrospective analysis.
Authors: He YZ, He K, Huang RQ, Wang ZL, Ye SW, Liu LW, Luo QJ, Hu ZM Abstract INTRODUCTION: Microvascular invasion (MVI) of is generally considered to be an important prognostic factor for hepatocellular carcinoma(HCC) after operation, An accurate prediction of MVI before operation is helpful for clinical decision-making before operation. MATERIAL AND METHODS: A retrospective analysis of 227 cases of hepatocellular carcinoma patients after hepatectomy has been confirmed the pathological result whether there was MVI, and has been determined the independent risk factors of MVI. Based on these independent risk fa...
Source: Annals of Hepatology - August 14, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Efficacy and Safety of Basiliximab as Initial Immunosuppression in Liver Transplantation: A Single Center Study.
CONCLUSION: Basiliximab-induced IS protocol is a safe regimen that reduces medium-term renal dysfunction and achieves similar survival without increasing the acute rejection or infection rate in liver transplantation recipients. PMID: 32768592 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - August 14, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Accuracy of non-invasive methods/models for predicting esophageal varices in patients with compensated advanced chronic liver disease secondary to nonalcoholic fatty liver disease.
CONCLUSION: LSPS and VRS performed excellently in both predicting VNT and sparing EGD, and Expanded Baveno VI showed good performance in sparing EGDs, with acceptable risk of missing VNT. An LSM cutoff point was established and had good performance. PMID: 32745630 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - August 5, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Differential capacity of CD90+ cells in autophagy activation following chemotherapy in hepatocellular carcinoma.
Authors: Do HQ, Luong AB, Bonazza D, Bottin C, Doan TP, Tran LD, Truong NH, Tell G, Pham HL, Tiribelli C, Sukowati CH Abstract INTRODUCTION AND OBJECTIVES: Analysis of cancer biomarkers is an important tool in developing targeted-therapy and in modulating chemoresistance. Here, we analyze the relevance of CD90, a marker of cancer stem cells (CSC) in hepatocellular carcinoma (HCC) and its correlation with autophagy. MATERIALS AND METHODS: For in vivo study, 86 specimens were collected from 43 patients undergoing liver resections. In each patient, HCC nodule (HCC) and surrounding non-tumor (SNT) were collected. F...
Source: Annals of Hepatology - August 5, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Increased Serum Selenium Levels Are Associated with Reduced Risk of Advanced Liver Fibrosis and All-Cause Mortality in NAFLD Patients: National Health and Nutrition Examination Survey (NHANES) III.
CONCLUSIONS: The risk of advanced liver fibrosis is inversely associated with serum selenium levels, particularly in older patients, Caucasians, and females. All-cause mortality decreased with increased selenium levels. Selenium may play a role in the prevention of liver fibrosis in NAFLD. PMID: 32745632 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - August 5, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Dietary consumption and serum pattern of bioactive fatty acids in NAFLD patients.
CONCLUSION: Dietary consumption of bioactive fatty acids is different according to NAFLD severity. Individualized diets according to NAFLD severity could be successful in order to prevent liver injury-related outcomes. PMID: 32717363 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - July 29, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Enriched MACK-3 following CHAI and MACK-3 for the noninvasive diagnosis of nonalcoholic steatohepatitis.
Authors: Polyzos SA, Kountouras J Abstract Not required for letters to the Editor. PMID: 32702498 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - July 25, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

STAT3, a key regulator in liver fibrosis.
This article reviewed the recent studies on STAT3 in the development of various liver fibrosis to find a more effective method to relieve and cure liver diseases, such as hepatitis B virus (HBV), non-alcoholic fatty liver disease (NAFLD), schistosomiasis, and chemical liver injury. PMID: 32702499 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - July 25, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Is hepatitis C direct-acting antiviral therapy a risk factor for the development and recurrence of hepatocellular carcinoma? Narrative literature review and clinical practice recommendations.
Authors: Delgado-Martínez C, Gómez-Rubio M, Gómez-Domínguez C Abstract The development of direct-acting antivirals (DAAs) has been a turning point in chronic hepatitis C treatment. With an efficacy rate on viral eradication close to 100% and an excellent safety profile, they have replaced interferon-based treatments as first-line therapy for hepatitis C virus (HCV). Following the encouraging results observed during the first years with these treatments, new publications suggested an unexpectedly high incidence of hepatocellular carcinoma (HCC) in patients previously treated with DAAs as ...
Source: Annals of Hepatology - July 22, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Cerebral Hemodynamics in the Non-Alcoholic Fatty Liver.
CONCLUSIONS: This study demonstrates a subclinical process of the middle cerebral artery in subjects with NAFLD, which suggests it may be involved in the disease development and points the need to make decisions for this liver manifestation prevention and treatment. PMID: 32683094 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - July 21, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

LI-RADS 4 or 5 categorization may not be clinically relevant for decision-making processes: a prospective cohort study.
CONCLUSIONS: LI-RADS was useful to standardize reports; however, no significant differences were observed between LR-4 and 5 HCC probability when compared to explant pathology. PMID: 32683095 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - July 21, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Hepatic transcriptome signature correlated with HOMA-IR explains early Nonalcoholic Fatty Liver Disease pathogenesis.
CONCLUSIONS: Hepatic expression of genes associated with insulin resistance may drive NAFLD development and progression. PMID: 32682086 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - July 19, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Curcumin downregulates Smad pathways and reduces hepatic stellate cells activation in experimental fibrosis.
CONCLUSIONS: Curcumin reduced liver damage, oxidative stress, fibrosis, and restored normal activity of MMP-9 and MMP-2. Besides, curcumin restored NF-κB, IL-1, IL-10, TGF-β, CTGF, Col-I, MMP-13, and Smad7 protein levels. On the other hand, curcumin decreased JNK and Smad3 phosphorylation. Furthermore, curcumin treatment decreased α-SMA and Smad3 protein and mRNA levels. Curcumin normalized GSH, and NF-κB, JNK-Smad3, and TGF-β-Smad3 pathways, leading to a decrement in activated hepatic stellate cells, thereby producing its antifibrotic effects. PMID: 32673649 [PubMed - as supplied by publish...
Source: Annals of Hepatology - July 18, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Mediterranean-like mix of fatty acids induces cellular protection on lipid-overloaded hepatocytes from western diet fed mice.
In conclusion, our results show that Mediterranean-like mix of fatty acids exerts cellular protection in steatosis by decreasing triglycerides, cholesterol, ROS content and oxidative damage. PMID: 32663612 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - July 16, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

MH Newsletter.
Authors: PMID: 32616196 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - July 5, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma.
Authors: Piñero F, Tanno M, Soteras GA, Baña MT, Dirchwolf M, Fassio E, Ruf A, Mengarelli S, Borzi S, Fernández N, Ridruejo E, Descalzi V, Anders M, Mazzolini G, Reggiardo V, Marciano S, Perazzo F, Spina JC, McCormack L, Maraschio M, Lagues C, Gadano A, Villamil F, Silva M, Cairo F, Ameigeiras B, Argentinean Association for the Study of Liver Diseases (A.A.E.E.H) Abstract The A.A.E.E.H has developed this guideline for the best care of patients with hepatocellular carcinoma (HCC) from Argentina. It was done from May 2018 to March 2020. Specific clinical research questions were systematically sea...
Source: Annals of Hepatology - July 2, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Identification of mutations in the S gene of Hepatitis B Virus in HIV positive Mexican patients with occult Hepatitis B virus infection.
CONCLUSIONS: In this study, we report the presence of OBI in a cohort of Mexican HIV-infected patients with an overall prevalence of 36%. Mutational analyses revealed that four non-silent mutations were frequent in different regions of the HBsAg gene, suggesting that they might be associated to the development of OBI in this population, nevertheless, further studies are required to determine their role in the pathogenesis of OBI. PMID: 32592870 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 29, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Hepatic autophagy fluctuates during the development of non-alcoholic fatty liver disease.
CONCLUSIONS: Hepatic autophagy fluctuates during the development of NAFLD in which mTORC1 signalling plays a critical regulatory role, suggesting a therapeutic potential of autophagy modulation by targeting the mTORC1 signalling pathway in NAFLD. PMID: 32553647 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 21, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

LncRNA MAGI2-AS3 is downregulated in the distant recurrence of hepatocellular carcinoma after surgical resection and affects migration and invasion via ROCK2.
CONCLUSION: Our study indicated that MAGI2-AS3 was downregulated in the distant recurrence of HCC after surgical resection and affected the invasion and migration of HCC cells via ROCK2. PMID: 32546442 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 19, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Performing thermal ablations for hepatomas - is it a worthy skill for hepatologists?
CONCLUSIONS: Hepatologists can play a key role in the management of HCC in the current era of multidisciplinary team approach. Training fellows in performing ultrasound guided thermal ablation techniques would be one step forward in this direction. PMID: 32546443 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 19, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Inhibition of fatty acid synthase (FASN) affects the proliferation and apoptosis of HepG2 hepatoma carcinoma cells via the β-catenin/C-myc signaling pathway.
This study aims to explore the effect of fatty acid synthase knockdown on the apoptosis and proliferation of HepG2 cells. MATERIALS AND METHODS: The human liver cancer cell line HepG2 was cultured and then transfected with FASN-specific siRNA and negative control RNAi. After 48h, cells and protein lysates were used for western blotting, CCK-8 (cell counting kit-8) assays, flow cytometry and other tests. To assess cell apoptosis, Bax, Bcl-2 and caspase-3 were detected; to assess proliferation, CDK4 (cyclin-dependent kinases 4) and P21 were detected; and to determine the signaling pathway involved, β-catenin and C-m...
Source: Annals of Hepatology - June 18, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research