Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: a multi-centre retrospective cohort study
CONCLUSIONS: Our results indicate that higher levels of LDH, CRP, and ALT are associated with higher in-hospital mortality risk in Mexican patients admitted with COVID-19.PMID:33647501 | PMC:PMC7908830 | DOI:10.1016/j.aohep.2021.100338 (Source: Annals of Hepatology)
Source: Annals of Hepatology - March 1, 2021 Category: Gastroenterology Authors: Paulina Vidal-Cevallos Fatima Higuera-De-La-Tijera Norberto C Ch ávez-Tapia Francisco Sanchez-Giron Eira Cerda Reyes Victor Hugo Rosales-Salyano Alfredo Servin-Caama ño Mart ín Uriel Vázquez Medina Nahum Mendez-Sanchez Source Type: research

The Presence of Diabetes Impacts Liver Fibrosis and Steatosis by Transient Elastography in a Primary Care Population
Ann Hepatol. 2021 Feb 26:100336. doi: 10.1016/j.aohep.2021.100336. Online ahead of print.ABSTRACTINTRODUCTION AND OBJECTIVES: Noninvasive liver assessment in type 2 diabetes (T2DM) in a primary care population identifies higher risk non-alcoholic fatty liver disease (NAFLD). We aimed to evaluate the association of T2DM with liver fibrosis and steatosis by transient elastography (TE).MATERIALS AND METHODS: This is a retrospective study of a TE referral program where primary care physicians were able to order TE. Patients with alcohol abuse were excluded. TE and Controlled Attenuation Parameter (CAP) scores were obtained. Mu...
Source: Annals of Hepatology - March 1, 2021 Category: Gastroenterology Authors: Hirsh D Trivedi Jaspreet Suri Daheun Oh Jeffrey Schwartz Daniela Goyes Rajab Idriss Michael P Curry Michelle Lai Source Type: research

Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: a multi-centre retrospective cohort study
CONCLUSIONS: Our results indicate that higher levels of LDH, CRP, and ALT are associated with higher in-hospital mortality risk in Mexican patients admitted with COVID-19.PMID:33647501 | PMC:PMC7908830 | DOI:10.1016/j.aohep.2021.100338 (Source: Annals of Hepatology)
Source: Annals of Hepatology - March 1, 2021 Category: Gastroenterology Authors: Paulina Vidal-Cevallos Fatima Higuera-De-La-Tijera Norberto C Ch ávez-Tapia Francisco Sanchez-Giron Eira Cerda Reyes Victor Hugo Rosales-Salyano Alfredo Servin-Caama ño Mart ín Uriel Vázquez Medina Nahum Mendez-Sanchez Source Type: research

The Presence of Diabetes Impacts Liver Fibrosis and Steatosis by Transient Elastography in a Primary Care Population
Ann Hepatol. 2021 Feb 26:100336. doi: 10.1016/j.aohep.2021.100336. Online ahead of print.ABSTRACTINTRODUCTION AND OBJECTIVES: Noninvasive liver assessment in type 2 diabetes (T2DM) in a primary care population identifies higher risk non-alcoholic fatty liver disease (NAFLD). We aimed to evaluate the association of T2DM with liver fibrosis and steatosis by transient elastography (TE).MATERIALS AND METHODS: This is a retrospective study of a TE referral program where primary care physicians were able to order TE. Patients with alcohol abuse were excluded. TE and Controlled Attenuation Parameter (CAP) scores were obtained. Mu...
Source: Annals of Hepatology - March 1, 2021 Category: Gastroenterology Authors: Hirsh D Trivedi Jaspreet Suri Daheun Oh Jeffrey Schwartz Daniela Goyes Rajab Idriss Michael P Curry Michelle Lai Source Type: research

Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: a multi-centre retrospective cohort study
CONCLUSIONS: Our results indicate that higher levels of LDH, CRP, and ALT are associated with higher in-hospital mortality risk in Mexican patients admitted with COVID-19.PMID:33647501 | PMC:PMC7908830 | DOI:10.1016/j.aohep.2021.100338 (Source: Annals of Hepatology)
Source: Annals of Hepatology - March 1, 2021 Category: Gastroenterology Authors: Paulina Vidal-Cevallos Fatima Higuera-De-La-Tijera Norberto C Ch ávez-Tapia Francisco Sanchez-Giron Eira Cerda Reyes Victor Hugo Rosales-Salyano Alfredo Servin-Caama ño Mart ín Uriel Vázquez Medina Nahum Mendez-Sanchez Source Type: research

The Presence of Diabetes Impacts Liver Fibrosis and Steatosis by Transient Elastography in a Primary Care Population
Ann Hepatol. 2021 Feb 26:100336. doi: 10.1016/j.aohep.2021.100336. Online ahead of print.ABSTRACTINTRODUCTION AND OBJECTIVES: Noninvasive liver assessment in type 2 diabetes (T2DM) in a primary care population identifies higher risk non-alcoholic fatty liver disease (NAFLD). We aimed to evaluate the association of T2DM with liver fibrosis and steatosis by transient elastography (TE).MATERIALS AND METHODS: This is a retrospective study of a TE referral program where primary care physicians were able to order TE. Patients with alcohol abuse were excluded. TE and Controlled Attenuation Parameter (CAP) scores were obtained. Mu...
Source: Annals of Hepatology - March 1, 2021 Category: Gastroenterology Authors: Hirsh D Trivedi Jaspreet Suri Daheun Oh Jeffrey Schwartz Daniela Goyes Rajab Idriss Michael P Curry Michelle Lai Source Type: research

In Reply
Ann Hepatol. 2021 Mar-Apr;21:100313. doi: 10.1016/j.aohep.2021.100313.NO ABSTRACTPMID:33640103 | DOI:10.1016/j.aohep.2021.100313 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 28, 2021 Category: Gastroenterology Authors: Ling-Ling He Jia-Li Ma Yu Jiang Jun-Ru Yang Ping Li Yao Zhang Hong-Shan Wei Source Type: research

Milestones in Hepatology
Ann Hepatol. 2021 Mar-Apr;21:100324. doi: 10.1016/j.aohep.2021.100324.NO ABSTRACTPMID:33640104 | DOI:10.1016/j.aohep.2021.100324 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 28, 2021 Category: Gastroenterology Authors: Octavio Campollo Source Type: research

In Reply
Ann Hepatol. 2021 Mar-Apr;21:100313. doi: 10.1016/j.aohep.2021.100313.NO ABSTRACTPMID:33640103 | DOI:10.1016/j.aohep.2021.100313 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 28, 2021 Category: Gastroenterology Authors: Ling-Ling He Jia-Li Ma Yu Jiang Jun-Ru Yang Ping Li Yao Zhang Hong-Shan Wei Source Type: research

Milestones in Hepatology
Ann Hepatol. 2021 Mar-Apr;21:100324. doi: 10.1016/j.aohep.2021.100324.NO ABSTRACTPMID:33640104 | DOI:10.1016/j.aohep.2021.100324 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 28, 2021 Category: Gastroenterology Authors: Octavio Campollo Source Type: research

Latin America and chronic diseases: A perfect storm during the COVID-19 pandemic
Ann Hepatol. 2021 Feb 22:100332. doi: 10.1016/j.aohep.2021.100332. Online ahead of print.NO ABSTRACTPMID:33631378 | PMC:PMC7899031 | DOI:10.1016/j.aohep.2021.100332 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 25, 2021 Category: Gastroenterology Authors: Antonio Pizuorno Nora A Fierro Source Type: research

Non-invasive diagnosis of non-alcoholic fatty liver disease using an algorithm combining clinical indexes and ultrasonographic measures
Ann Hepatol. 2021 Feb 21:100335. doi: 10.1016/j.aohep.2021.100335. Online ahead of print.NO ABSTRACTPMID:33626411 | DOI:10.1016/j.aohep.2021.100335 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 24, 2021 Category: Gastroenterology Authors: Monica C Preciado-Puga Yeniley Ruiz-Noa Juana R Garcia-Ramirez Benjamin Jordan-Perez Serafin Garnelo-Caba ñas Maria L Lazo de la Vega-Monroy Karen I Gutierrez-Aguirre Lorena R Ibarra-Reynoso Source Type: research

Deep stool microbiome analysis in cirrhosis reveals an association between short-chain fatty acids and hepatic encephalopathy
CONCLUSIONS: We found 8 fecal species and 6 SCFAs linked to OHE. Many of the species inversely linked to OHE also have an association with SCFA production. Further work is needed to detail this relationship and to develop targeted interventions to treat HE.PMID:33621653 | DOI:10.1016/j.aohep.2021.100333 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2021 Category: Gastroenterology Authors: Patricia P Bloom Jes ús M Luévano Kelsey J Miller Raymond T Chung Source Type: research

Aminotransferases disorders associated with venous thromboembolic events in patients infected with COVID-19
Ann Hepatol. 2021 Feb 20:100334. doi: 10.1016/j.aohep.2021.100334. Online ahead of print.NO ABSTRACTPMID:33621654 | PMC:PMC7896488 | DOI:10.1016/j.aohep.2021.100334 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2021 Category: Gastroenterology Authors: Amer Hamad é Bastien Woehl Marjolaine Talbot Naouel Bensalah Pierre Michel Golnaz Obringer Mich èle Lehn-Hogg Nathalie Buschenrieder Mahdi Issa Jonathan Tousch Dominique Stephan Lucas Jambert Source Type: research

Deep stool microbiome analysis in cirrhosis reveals an association between short-chain fatty acids and hepatic encephalopathy
CONCLUSIONS: We found 8 fecal species and 6 SCFAs linked to OHE. Many of the species inversely linked to OHE also have an association with SCFA production. Further work is needed to detail this relationship and to develop targeted interventions to treat HE.PMID:33621653 | DOI:10.1016/j.aohep.2021.100333 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2021 Category: Gastroenterology Authors: Patricia P Bloom Jes ús M Luévano Kelsey J Miller Raymond T Chung Source Type: research

Aminotransferases disorders associated with venous thromboembolic events in patients infected with COVID-19
Ann Hepatol. 2021 Feb 20:100334. doi: 10.1016/j.aohep.2021.100334. Online ahead of print.NO ABSTRACTPMID:33621654 | DOI:10.1016/j.aohep.2021.100334 (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2021 Category: Gastroenterology Authors: Amer Hamad é Bastien Woehl Marjolaine Talbot Naouel Bensalah Pierre Michel Golnaz Obringer Mich èle Lehn-Hogg Nathalie Buschenrieder Mahdi Issa Jonathan Tousch Dominique Stephan Lucas Jambert Source Type: research

Drug-induced liver injury: A management position paper from the Latin American Association for Study of the liver.
Authors: Bessone F, Hernandez N, Tagle M, Arrese M, Parana R, Mendez N, Ridruejo E, Mendizabal M, Dagher L, Contreras F, Fassio E, Pesoa M, Brahm J, Silva M Abstract Idiosyncratic drug-induced liver injury (DILI) caused by xenobiotics (drugs, herbals and dietary supplements) is an uncommon cause of liver disease presenting with a wide range of phenotypes and disease severity, acute hepatitis mimicking viral hepatitis to autoimmune hepatitis, steatosis, fibrosis or rare chronic vascular syndromes. Disease severity ranges from asymptomatic liver test abnormalities to acute liver failure. DILI has been traditionally c...
Source: Annals of Hepatology - February 21, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Frailty and reduced gait speed are independently related to mortality of cirrhotic patients in long-term follow-up.
Authors: Soto R, Díaz LA, Rivas V, Fuentes-López E, Zalaquett M, Bruera MJ, González C, Mezzano G, Benítez C Abstract INTRODUCTION AND OBJECTIVES: Frailty is characterized by a poor restoration of homeostasis after a stressor event. Although it is not usually diagnosed, it has been associated with decreased survival in cirrhotic patients. We aimed to evaluate the impact of frailty and decreased gait speed over survival in cirrhotic patients at long-term follow-up. MATERIALS AND METHODS: We included stable cirrhotic patients Child-Pugh B-C or MELD≥12, ≥50 years old. We performed...
Source: Annals of Hepatology - February 18, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Reply to: Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19).
Authors: López-Mendez I, Castro-Narro G PMID: 33582320 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 17, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Effect of bile acids on the MRP3 and MRP4 expression: in vitro study on HepG2 cells.
CONCLUSION: Primary bile acids (CDCA and CA) induce overexpression of the MRP4 and MRP3 transporters in the HepG2 cell line. PMID: 33582321 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 17, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The impact electronic medical record system implementation on HCV screening and continuum of care: A systematic review.
CONCLUSIONS: EMR system utilization had a positive impact on increasing HCV screening. However, the clinical effectiveness of utilizing an EMR system to help eliminate transmission and increase HCV treatment cure rates requires further study. PMID: 33549734 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 10, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Hepatic steatosis and respiratory diseases a new panorama.
This article aims to understand the liver and chronic obstructive pulmonary disease mechanisms, obstructive sleep apnea syndrome, asthma, and lung cancer. Given that non-alcoholic fatty liver disease has a considerable impact on the patient's well-being and life quality, as well as on the costs they generate for the country's health services, it is essential to continue research, especially in areas such as the respiratory tract, as there is much misinformation about it. PMID: 33549735 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 10, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The changing impact of pre-liver transplant renal dysfunction on post-transplant survival: Results of 2 decades from a single center.
Authors: Wadei HM, Taner CB, Keaveny AP, Mai ML, Hodge DO, White LJ, Harnois DM, Mao SA, Jarmi T, Croome KP Abstract INTRODUCTION AND OBJECTIVES: Renal dysfunction before liver transplantation (LT) is associated with higher post-LT mortality. We aimed to study if this association still persisted in the contemporary transplant era. MATERIALS AND METHODS: We retrospectively reviewed data on 2,871 primary LT performed at our center from 1998 to 2018. All patients were listed for LT alone and were not considered to be simultaneous liver-kidney (SLK) transplant candidates. SLK recipients and those with previous LT w...
Source: Annals of Hepatology - February 7, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Reply to: Platelets level variability during the first year after liver transplantation in the risk prediction model for recipients mortality.
Authors: Ciszek M PMID: 33545404 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 7, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Roles of diencephalon/mesencephalon homeobox 1 in the development and prognosis of hepatocellular carcinoma.
Authors: Huang X, Xiang L, Liu W, Li M, Ren A, Chen Z, Zheng C, Chengcong C, Liu J, Yuan Y Abstract INTRODUCTION AND OBJECTIVES: The oncogene diencephalon/mesencephalon homeobox 1 (DMBX1) is widely overexpressed in a variety of human cancers. The present study aimed to analyze the expression and clinical importance of DMBX1 in nonneoplastic tissues and tumor tissues from patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: DMBX1 expression in HCC and adjacent nontumor tissues was analyzed using immunohistochemical staining. Chi-square tests were applied to compare DMBX1 expression between the tu...
Source: Annals of Hepatology - February 3, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Horizon scanning of therapeutic modalities for nonalcoholic steatohepatitis.
In conclusion, some therapeutic modalities showed promising benefits, but further studies are warranted to find a definite treatment of NASH which prevents progression to cirrhosis and adverse liver outcomes. PMID: 33515800 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 1, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Outcomes of Hepatitis C Virus Seropositive Donors to Hepatitis C Virus Seronegative Liver Recipients: A Large Single Center Analysis.
CONCLUSIONS: HCV-seropositive organs can be safely transplanted into HCV-seronegative patients with minimal complications post-transplant. PMID: 33515801 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 1, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Reply to: Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease.
Authors: de Oliveira CPMS PMID: 33515802 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 1, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Effects of chronic HBV infection on lipid metabolism in non-alcoholic fatty liver disease: A lipidomic analysis.
Authors: Li H, Xu QY, Xie Y, Luo JJ, Cao HX, Pan Q Abstract INTRODUCTION AND OBJECTIVES: Chronic hepatitis B virus (HBV) infection exerts an impact on lipid metabolism, but its interaction with dysmetabolism-based non-alcoholic fatty liver disease (NAFLD) remains uncertain. Purpose of the study is to investigate the effects of HBV infection on lipid metabolism, hepatic steatosis and related impairments of NAFLD patients. METHODS: Biopsy-proven Chinese NAFLD patients with (NAFLD-HBV group, n = 21) or without chronic HBV infection (NAFLD group, n = 41) were enrolled in the case-control...
Source: Annals of Hepatology - February 1, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Evaluation of drug-induced liver injury as etiology for acute liver failure in Brazil.
CONCLUSIONS: Undetermined etiology and DILI are the main causes of ALF in Brazil. However, APAP toxicity and DILI due to HDS are mostly uncommon. PMID: 33508520 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 29, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Cumulative incidence of solid and hematological De novo malignancy after liver transplantation in a multicentre cohort.
CONCLUSIONS: Lung tumors and head & neck tumors are the most frequently observed SOT after LT. PMID: 33482364 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 24, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Post-liver transplant outcomes in patients with major psychiatric diagnosis in the United States.
CONCLUSIONS: The Cox proportional hazard regression analysis of censored data at 1 and 5 year indicate higher allograft loss and all-cause mortality among LT patients with psychiatric diagnosis. Patients with well-controlled psychiatric disorders who undergo LT need close monitoring and medication adherence. PMID: 33482365 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 24, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit.
Authors: Torre A PMID: 33454389 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 21, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Waitlist mortality and transplant free survival in Hispanic patients listed for liver transplant using the UNOS database.
Authors: Goyes D, Danford CJ, Nsubuga JP, Bonder A Abstract INTRODUCTION AND OBJECTIVES: After the implementation of "Share 35", several concerns arose such as the potential to increase travel distance, costs, and decreased liver availability. These elements could have a negative impact on waitlist outcomes among ethnic minorities. We aimed to determine waitlist survival after the implementation of the Share 35 policy in non-Hispanic white and Hispanic patients. MATERIALS AND METHODS: We identified non-Hispanic whites and Hispanics who were listed for liver transplantation from June 18th, 2013 to June...
Source: Annals of Hepatology - January 15, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Ras related GTP binding D promotes aerobic glycolysis of hepatocellular carcinoma.
CONCLUSION: This study highlights RRAGD as an important cancer-promoting factor for cancer progression and aerobic glycolysis, and thereby it is a potential therapeutic target for HCC intervention. PMID: 33434687 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 14, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Aminotransferases disorders associated with venous thromboembolic events in patients infected with COVID-19.
Authors: Zhu X, Li X PMID: 33434688 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 14, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

MicroRNA-494-3p prevents liver fibrosis and attenuates hepatic stellate cell activation by inhibiting proliferation and inducing apoptosis through targeting TRAF3.
CONCLUSIONS: This study provided a novel mechanistic comprehension of the anti-fibrotic effect of miR-494-3p. PMID: 33434689 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 14, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Mediterranean diet or genome-based nutrition diets in Latin America's clinical practice guidelines for managing chronic liver diseases?
Authors: Ojeda-Granados C, Roman S PMID: 33388121 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 5, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Viruses and the Liver 2020: Before COVID-19 and the beginning of a new age in medicine.
Authors: Panduro A PMID: 33388122 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 5, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease.
Authors: Chen C, Li X, Guolin W PMID: 33385572 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 2, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Non-invasive diagnosis of non-alcoholic fatty liver disease using an algorithm combining clinical indexes and ultrasonographic measures.
Authors: Jin L, Li X PMID: 33385573 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 2, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Progression of Intraductal Papillary Neoplasm of the Bile Duct (IPNB): A proposed model through the observation of patients with non-resected tumors.
Authors: Luvira V PMID: 33378705 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - January 1, 2021 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission.
Authors: Mendizabal M, Piñero F, Ridruejo E, Anders M, Silveyra MD, Torre A, Montes P, Urzúa A, Pages J, Toro LG, Díaz J, Ballerga EG, Miranda-Zazueta G, Peralta M, Gutiérrez I, Michelato D, Venturelli MG, Varón A, Pozo EV, Tagle M, García M, Tassara A, Brutti J, García SR, Bustios C, Escajadillo N, Macias Y, la Tijera FH, Gómez AJ, Dominguez A, Barradas MC, Contreras F, Scarpin A, Schinoni MI, Toledo C, Girala M, Mainardi V, Sanchez A, Bessone F, Rubinstein F, O Silva M Abstract INTRODUCTION & OBJECTIVES: The independent effect of liver biochemistries as ...
Source: Annals of Hepatology - December 29, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

LncRNA CASC9 promotes proliferation, migration and apoptosis of hepatocellular carcinoma cells by down-regulating miR-424-5p.
CONCLUSION: CASC9 reduced proliferation, invasion and migration and induced apoptosis in HCC cells by inhibiting miR-424-5p. LncRNAs, long non-coding RNAs; HCC, hepatocellular carcinoma; AFP, alpha-fetoprotein; CASC9, cancer sensitivity 9; ESCC, esophageal squamous cell carcinoma; qRT-PCR, quantitative reverse transcription polymerase chain reaction; ATCC, American Type Culture Collection; DMEM, Dulbecco's Modified Eagle Medium; CCK-8, cell counting kit-8; RIPA, radio-immunoprecipitation assay; SDS-PAGE, sodium dodecylsulphate polyacrylamide gel electrophoresis; PVDF, polyvinylidene fluoride; GAPDH, glyceraldehyde-3-phosph...
Source: Annals of Hepatology - December 23, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit.
Authors: Ying S, Li X PMID: 33346095 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)
Source: Annals of Hepatology - December 23, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Professor Emeritus Neil McIntyre, BSc, M.D., F.R.C.P. (1934-2020).
Authors: Campollo O, McCormick A PMID: 33272446 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - December 6, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Impact of Brazilian expanded criteria for liver transplantation in patients with hepatocellular carcinoma: a multicenter study.
Authors: Chagas AL, Mattos AA, Diniz MA, Felga GEG, Boin IFSF, Silva RCMA, Silva RF, Garcia JHP, Lima AS, Coelho JCU, Bittencourt PL, Alves VAF, D'Albuquerque LAC, Carrilho FJ, Brazilian HCC Study Group Abstract INTRODUCTION AND OBJECTIVES: Hepatocellular carcinoma (HCC) is one of the main indications for orthotopic liver transplantation (OLT). In Brazil, selection criteria for HCC is an expanded version of the Milan Criteria (MC), the so-called "Brazilian Milan Criteria" (BMC). Our aims were to evaluate post-OLT outcomes in patients with HCC and analyze the BMC performance. MATERIALS AND METHODS: We ...
Source: Annals of Hepatology - December 6, 2020 Category: Gastroenterology Tags: Ann Hepatol Source Type: research