Treatment with Melatonin Improves Cognitive Behavior and Motor Skills in a Rat Model of Liver Fibrosis.
CONCLUSION: These findings suggest that MT improves cognition and motor skills in the LF model. PMID: 31113577 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Efficacy and Tolerability of Ombitasvir/Paritaprevir/Ritonavir in HCV Genotype 1-infected Elderly Japanese Patients.
CONCLUSION: Tolerability should be monitored in older patients for whom concomitant medications are discontinued or changed because of drug interactions. PMID: 31113578 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Feasibility of Hepatology-Directed Microwave Ablation in Management of Hepatocellular Carcinoma in North America: A Pilot Project.
Authors: Ansari MS, Tanaka T, Laroia ST, Sun S Abstract In North America, the role of Hepatologists in treatment of hepatocellular carcinoma is limited. We conducted a pilot project wherein a Hepatologist participated directly in microwave ablation of HCC at an academic center in the United States (n = 14). The pilot project shows promising outcomes, with complete remission rate of 93%. PMID: 31113579 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

miR-182-5p Attenuates High-Fat -Diet-Induced Nonalcoholic Steatohepatitis in Mice.
CONCLUSIONS: miR-182-5p ameliorated HFD-induced NASH by suppressing TLR4. PMID: 31113580 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

ALBI and PALBI Grades Are Associated with the Outcome of Patients with Stable Decompensated Cirrhosis.
Authors: Oikonomou T, Goulis L, Doumtsis P, Tzoumari T, Akriviadis E, Cholongitas E Abstract INTRODUCTION AND AIM: Studies carried out mainly in patients with hepatocellular carcinoma (HCC), have shown the prognostic significance of albumin-bilirubin (ALBI) grade. Recently, another predictive score incorporating platelet count into ALBI, PALBI grade, was introduced in patients with HCC. AIM: We evaluated the ability of ALBI and PALBI grades in predicting the outcome (mortality / liver transplantation) of patients with stable decompensated cirrhosis with various etiology of liver diseases. MATERIAL AND METHO...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Interferon-Free Regimen: Equally Effective in Treatment Naive and Experienced HCV Patients.
Conclusion An all-oral regimen of co-for-mulated OBT/PTV/r with DSV and RBV results in high rate of sustained virologic response at post-treatment week 12 among HCV GT1b infected patients associated with compensated cirrhosis, regardless of previous treatment experience with PegIFN/RBV. PMID: 31113582 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Challenges in Management of Hepatitis A Virus Epidemiological Transition in Mexico.
Authors: Trujillo-Ochoa JL, Viera-Segura O, Fierro NA Abstract Hepatitis A virus (HAV) is the most common cause of acute viral hepatitis worldwide. The virus is mainly transmitted via the fecaloral route and, the incidence of infection is closely related to low socioeconomic conditions and poor sanitation. Mexico, previously categorized an area of high endemicity for HAV infection, is undergoing epidemiological transition. However, a limited number of HAV-related scientific reports regarding to virus burden is available. According to the local government health agency (Secretarla de Salud, SSA in Spanish), from 199...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Metabolomics Discloses a New Non-invasive Method for the Diagnosis and Prognosis of Patients with Alcoholic Hepatitis.
CONCLUSIONS: Signatures based on metabolomics allowed an accurate non-invasive diagnosis and prognostic stratification of alcoholic hepatitis. The differences observed in the metabolic profile of the patients according to the presence and severity of alcoholic hepatitis are related with different mechanisms involved in the pathophysiology of alcoholic hepatitis such as peroxisomal activity, synthesis of inflammatory mediators or oxidation. This information could be useful for the development of novel targeted therapies. PMID: 31113584 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Serum NGAL Is Superior to Cystatin C in Predicting the Prognosis of Acute-on-Chronic Liver Failure.
This study aimed to compare the performance of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC) in predicting the 90-day mortality in patients with hepatitis B virus (HBV)-associated ACLF (HBV-ACLF). MATERIALS AND METHODS: This prospective, observational study enrolled 54 patients with HBV-ACLF. The serum NGAL and CysC levels were determined. A multivariate logistic regression analysis was used to analyze the independent risk factors of mortality. RESULTS: Serum NGAL, but not CysC, was found to significantly correlate with the total bilirubin, international normalized ratio, and model for end...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Choosing Wisely Canada-Top Five List in Hepatology: Official Position Statement of the Canadian Association for the Study of the Liver (CASL) and Choosing Wisely Canada (CWC).
CONCLUSION: The Choosing Wisely recommendations will foster patient-physician discussions, reduce unnecessary treatment and testing, avert adverse effects from testing and treatment along with reducing medical expenditure in hepatology. PMID: 31113586 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Experience with Sorafenib in 3 Hospitals in Sao Paulo.
CONCLUSION: Our results suggest that, in experienced hands, sorafenib therapy may benefit carefully selected hepatocellular carcinoma patients for whom other therapies are initially contraindicated, including those patients with Child-Pugh B liver function and those patients who are subsequently treated with concomitant TACE. PMID: 31113587 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Hepatocellular Carcinoma and Associated Clinical Features in Latino and Caucasian Patients from a Single Center.
CONCLUSION: Latino and Caucasian patients with HCC present with a different profile of etiologies, but cancer features appear to be more severe in Latinos. PMID: 31113588 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Acute Liver Failure due to Wilson Disease: Eight Years of the National Liver Transplant Program in Uruguay.
Authors: Mainardi V, Rando K, Valverde M, Olivari D, Castelli J, Rey G, Gerona S Abstract INTRODUCTION AND AIM: Wilson's disease (WD) is an uncommon cause of acute liver failure (ALF). Our aim was to describe clinical features, diagnostic findings, treatments, and outcomes of patients with ALF due to WD. MATERIAL AND METHODS: Retrospective medical record reviews of all patients with ALF due to WD in eight years in Uruguay. RESULTS: WD was the cause of six (15%) of thirty-nine ALF cases. All patients were females, with a mean age of 18 years. Four patients presented with hyperacute liver failure and two with...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Effects of Age on Treatment of Chronic Hepatitis C with Direct Acting Antivirals.
CONCLUSIONS: The high efficacy and tolerance of interferon-free regimens is confirmed in elderly patients in real-life conditions. PMID: 31113590 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Impact of Sustained Viral Response in the Evolution of Minimal Hepatic Encephalopathy: a Prospective Pilot Study.
Authors: Hernández-Conde M, Fernández-Carrillo C, Llop E, Perelló C, López-Gómez M, Martínez-Porras JL, Fernández-Puga N, Calleja JL Abstract INTRODUCTION AND AIMS: To determine the prevalence of minimal hepatic encephalopathy (MHE) in patients with liver cirrhosis (LC) due to hepatitis C virus (HCV) infection and to evaluate the impact of sustained viral response (SVR) on MHE. MATERIAL AND METHODS: We performed a prospective study using MHE screening and follow-up on patients with HCV and LC. The patients were evaluated at the beginning of treatment and 24 weeks...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Primary Adenoid Cystic Carcinoma of the Liver: Case Report and Review of the Literature.
We described its histopathologic features and its immunohistochemical profile, and reviewed the literature. The surgical treatment and patient follow up information was also presented. PMID: 31113592 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Sclerosing Cholangitis Related to IgG4: Not Always a Curable Entity.
In conclusion, this clinical case highlights the importance of prompt diagnosis and therapeutics for sclerosing cholangitis secondary to IgG4-related disease in order to avoid progression of the disease and development of liver cirrhosis, as well as the refractory, aggressive nature of the disease in some cases as this one. PMID: 31113593 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Immune Reconstitution Syndrome with Initiation of Treatment of HBV/HIV Co-infection: Activity Flare associated with E antigen Seroconversion.
We present a case of highly active antiretroviral therapy initiation for HIV that led to a flare of HBV activity despite antiviral therapy directed towards both. Liver biopsy and longitudinal serologic evaluation lend support to the hypothesis that the flare in activity was representative of IRIS. Importantly, we document eAg/eAb seroconversion with the IRIS phenomenon. PMID: 31113594 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Clinical Presentation and Anatopathologic Finding of a Hepatic Vascular Hamartoma: a Case Report.
We describe the anatomo-pathologic findings focusing on the clinical and radiological presentation, the intraoperative characteristics and the differential diagnosis. PMID: 31113595 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Acoustic Radiation Force Impulse (ARFI) Elastography in Autoimmune and Cholestatic Liver Diseases.
CONCLUSION: ARFI elastography can evaluate fibrosis in AIH, PSC and PSC-/PBC-AIH-overlap syndrome with good accuracy for the detection of hepatic cirrhosis. Shear wave velocities in PBC should be interpreted with caution in early stages of fibrosis. PMID: 31113596 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Lysosomal Acid Lipase Deficiency Leading to Liver Cirrhosis: a Case Report of a Rare Variant Mutation.
We describe the case of a 53-year-old Brazilian man who was referred to our center due to the diagnosis of liver cirrhosis of unknown etiology. He was asymptomatic and had normal body mass index. He had dyslipidemia, and family history of myocardial infarction and stroke. Abdominal imaging tests showed liver cirrhosis features and the presence of intrahepatic calcifications. Initial investigation of the etiology of the liver disease was not elucidated, but liver biopsy showed microgoticular steatosis and cholesterol esters deposits in Kuppfer cells. The dosage of serum lysosomal acid lipase was undetectable and we found th...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done.
We present three case reports of retreatment with a new combination of Direct-acting antivirals (DAAs), Sofosbuvir, Elbasvir/Grazoprevir in patients with GT3 with a previous failure with Sofosbuvir/Ledipasvir. All the cases achieved sustained virologic response (SVR) at week +12 without adverse effects. In our experience, this combo may represent an effective and safe option for these patients. PMID: 31113598 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

A Duplicated Gallbladder in a Patient Presenting with Acute Cholangitis. A Case Study and a Literature Review.
In conclusion, gallbladder anomalies should be anticipated in the presence of a cystic lesion reported around the gallbladder when evaluating radiologic studies. In case of surgery, preoperative diagnosis is essential to prevent possible biliary injuries or reoperation if accessory gallbladder has been overlooked during initial surgery. Laparoscopic cholecystectomy remains feasible for intervention can be safely done and awareness is necessary to avoid complications or multiple procedures. PMID: 31113599 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Type II Abernethy Malformation in a Patient with Primary Budd-Chiari Syndrome.
We report here the first case of a patient with combined type II Abernethy malformation and BCS from China. The inferior vena cava obstruction was treated with percutaneous balloon angioplasty; close follow-up was elected for the Abernethy malformation. PMID: 31113600 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Case Series Regarding Parastomal Variceal Bleeding: Presentation and Management.
We present a case series with five different patients who had a PVB at our institution. The aim of this case series is to report our experience on the management of this infrequently reported but serious condition. We also conducted a systemic literature review focusing on the treatment modalities of 163 patients with parastomal variceal bleeds. In our series, patient 1 had embolization and sclerotherapy without control of bleed and expired on the day of intervention due to hemorrhagic shock. Patient 2 had TIPS in conjunction with embolization and sclerotherapy and had no instance of rebleed 441 days after therapy. Patient...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Biliary Paracoccidioidomycosis: An Unusual Infection Simulating Malignant Neoplasm.
Authors: Steinbrück K, Fernandes R Abstract Paracoccidioidomycosis is a systemic granulomatous disease caused by the dimorphic fungus Paracoccidioides brasiliensis and is restricted to Latin America. It normally affects lungs, skin and lymph nodes. Abdominal organs are usually not involved. In rare cases paracoccidioidomycosis may simulate neoplasm. Herein we describe our experience with four cases of paracoccidioidomycosis mimicking cholangiocarcinoma. To the best of our knowledge, this is the largest case series on this subject produced in English. Paracoccidioidomycosis must be considered as a differential ...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report.
Authors: De Vito C, Papathomas G T, Pedica F, Kane P, Amir A, Heaton N, Quaglia A Abstract Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3.4 cm arterialized hepatic lesion and a 7 cm paraduodenal mass. Surgical resection of both lesions and histological examination revealed an inflammatory hepatocellular adenoma and a unicentric plasma cell type of Castleman disease. Moreover, a diffuse AA amyloid deposition in the liver ...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Laparoscopic Partial ALPPS: Much Better Than ALPPS!
In conclusion, laparoscopic p-ALPPS is feasible and seems less aggressive than the original ALPPS technique with total transection. It may be an interesting alternative to the classical portal vein embolization (PVE) and two-stage hepatectomy strategy. PMID: 31113604 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Implications of Manganese in Chronic Acquired Hepatocerebral Degeneration.
In conclusion, CAHD is a rare condition occurring in liver cirrhosis that should always be considered in patients with neurological manifestations of chronic liver disease. PMID: 31113605 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Predictors of 1-month and 3-months Hospital Readmissions in Decompensated Cirrhosis: A Prospective Study in a Large Asian Cohort.
Authors: Patel R, Poddar P, Choksi D, Pandey V, Ingle M, Khairnar H, Sawant P Abstract INTRODUCTION AND AIM: Considered as a healthcare quality indicator, hospital readmissions in decompensated cirrhosis predispose the patients and the society to physical, social and economic distresses. Few studies involving North American cohorts have identified different predictors. The aim of this study was to determine and validate the predictors of 1-month and 3-months readmission in an Asian cohort. MATERIAL AND METHODS: We prospectively studied 281 hospitalised patients with decompensated cirrhosis at a large tertiary c...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Celastrol Attenuates Intrahepatic Cholestasis of Pregnancy by Inhibiting Matrix Metalloproteinases-2 and 9.
CONCLUSION: Our findings described for the first time the effects of celastrol to attenuate ICP symptoms through an inhibition of both MMP-2 and -9, providing evidence for a potential role of celastrol as a new drug for the treatment of ICP. PMID: 31113607 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The Role of the CLIF-C OF and the 2016 MELD in Prognosis of Cirrhosis with and without Acute-on-Chronic Liver Failure.
This study aimed to identify and characterize this condition and to test the CLIF-C OF score comparing it to the 2016-MELD (with sodium) and the Child-Pugh. MATERIAL AND METHODS: 18-month prospective observational study with systematic inclusion of admitted patients with CLD decompensation. RESULTS: 39 patients had ACLF (33.1%). These patients experienced higher 28-day and 90-day mortality, when compared to patients without ACLF (43.6% and 64.1% vs. 2.5% and 7.6% respectively, p
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The Painstaking Job of Making Editorial Decisions for Biomedical Journals.
Authors: Panduro A PMID: 31113609 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Performance of Serum Glypican 3 in Diagnosis of Hepatocellular Carcinoma: A meta-analysis.
CONCLUSION: Serum GPC3 is inferior to AFP in the differential diagnosis between HCC and LC. However, the combination of GPC3 and AFP exhibited a much better performance. PMID: 31113610 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Alcohol and the Liver: The Return of the Prodigal Son.
Authors: Campollo O Abstract With the discovery of direct-acting antivirals and the prospective of viral hepatitis becoming curable, alcohol liver disease (ALD) is back to primetime. In the last 20 years, there have been many advances in the understanding of the biology, the psychology and the social and environmental factors associated with this long-known medical problem. Recent information about regional, ethnic, cultural and genetic factors seem to be relevant for the Latin American (LA) population. New approaches based on the new concepts and current information will render better results in the overall manage...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

HLA Class II-DRB1 Alleles with Hepatitis C Virus Infection Outcome in Egypt: A Multicentre Family-based Study.
CONCLUSIONS: It was concluded that among the Egyptian families, HLA-DRB1*030101, and DRB1*130101 alleles associated with the risk of progression to CHC infection, while DRB1*040101, DRB1*040501, DRB1*7:01:01and DRB1*110101 act as protective alleles against HCV infection. PMID: 31113612 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Lysosomal Acid Lipase: Can it be a New Non-Invasive Serum Biomarker of Cryptogenic Liver Fibrosis and Cirrhosis?
Authors: Gravito-Soares M, Gravito-Soares E, Gomes D, Tome L Abstract INTRODUCTION AND AIM: The association between lysosomal acid lipase (LAL) activity and liver steatosis or fibrosis is poorly studied. The aim of our study was to determine the predictive power of LAL for cryptogenic liver steatosis and cryptogenic significant fibrosis/cirrhosis. MATERIAL AND METHODS: Cross-sectional observational study of 101 adult patients with unexplained elevated liver enzymes/hepatomegaly with or without dyslipidemia submitted to the determination of LAL activity and LIPA gene (E8SJM-C.894G^A) mutation. Seventy-one patien...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Effect of Portal Vein Ligation Plus Venous Congestion on Liver Regeneration in Rats.
Authors: Kawaguchi D, Hiroshima Y, Kumamoto T, Mori R, Matsuyama R, Ichikawa Y, Inayama Y, Endo I Abstract INTRODUCTION AND AIM: We developed a rat model of portal vein ligation (PVL) with venous congestion (PVL+C) to investigate beneficial effect PVL plus congestion for regeneration of intact liver segments. MATERIALS AND METHODS: In the PVL group, portal vein branches were ligated except the caudate lobe (CL). In the PVL + C group, the left lateral hepatic vein was ligated in addition to PVL. Chronological changes in the following variables were compared among the groups: CL weight to body weight ratio (CL/BW...
Source: Annals of Hepatology - May 24, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The Editorial Challenges Faced by International Medical Journals in Latin America.
Authors: Panduro A PMID: 31104786 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Adherence to Appropriate Nutrition in Acute Alcoholic Hepatitis is Low.
In conclusion, our compliance of appropriate nutrition in AAH is low. Our initial investigation suggests that hepatology and nutrition consultation improved compliance with appropriate nutrition. The next step will be to implement protocolized care for appropriate nutrition in AAH by incorporating consultation of hepatology and nutrition services, assess the effect on adherence to appropriate nutrition, and determine the impact on patient outcomes. PMID: 31104787 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Interferon-based Simeprevir Therapy for Pediatric Patients with Chronic Hepatitis C Viral Infection.
Authors: Suzuki M, Minowa K, Tajiri H Abstract Interferon-based simeprevir therapy showed high efficacy and tolerability in children with genotype 1 hepatitis C virus infection. While direct-acting antivirals (DAAs) therapy are undergoing study in children, this regimen is considered an available therapeutic option for selected patients in countries where DAAs have not yet been approved. PMID: 31104788 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Controversies in Early Liver Transplantation for Severe Alcoholic Hepatitis.
Authors: Wu T, Morgan TR, Klein AS, Volk ML, Saab S, Sundaram V Abstract Alcoholic hepatitis (AH) is a condition of acute liver inflammation in the setting of heavy alcohol use that is often managed with corticosteroids in severe cases. Among non-responders to steroids, however, prognosis is poor with up to 75% mortality within 6 months after treatment failure. Early liver transplantation (LT) can achieve an acceptable short-term survival, and initial studies have demonstrated 3-year survival rates of up to 84%. However, the practice of early LT in severe AH remains controversial with concerns over the 6-month rule...
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Salidroside and Curcumin Formula Prevents Liver Injury in Nonalcoholic Fatty Liver Disease in Rats.
CONCLUSION: SC formula could ameliorate the injury caused by high fat diet. The effect was likely mediated via its influence on insulin resistance, lipid peroxidation injury and AMPK signaling pathway. PMID: 31104790 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Thyroid Function and Risk of Non-Alcoholic Fatty Liver Disease in Euthyroid Subjects.
CONCLUSION: Among the euthyroid population, FT3 and TSH levels were positively associated with the risk of NAFLD. PMID: 31104791 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Acoustic Radiation Force Impulse Elastography with APRI and FIB-4 to Identify Significant Liver Fibrosis in Chronic Hepatitis B Patients.
CONCLUSIONS: A combination of ARFI, APRI, and FIB-4 may spare some CHB patients with equivocal indication for antiviral treatment a liver biopsy. PMID: 31104792 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Chronic Hepatitis C Patients with Obesity: Do We Need Two Operators for Accurate Evaluation of Liver Stiffness?
Authors: Shiha GE, El-Etreby S, Bahgat M, Hamed M, Sherbini ME, Ghoneem EA, Zalata K, Soliman RE, ElBasiouny MA, Mikhail NN Abstract INTRODUCTION AND AIM: Transient elastography is gaining popularity as a non-invasive method for predicting liver fibrosis, but inter observer agreement and factors influencing reproducibility have not been adequately assessed. MATERIAL AND METHODS: This cross-sectional study was conducted at Specialized Medical Hospital and the Egyptian Liver Foundation, Mansoura, Egypt. The inclusion criteria were: age older than 18 years and chronic infection by hepatitis C. The exclusion criter...
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Association between Repeated Praziquantel treatment and Papillary, and Intrahepatic Cholangiocarcinoma.
CONCLUSION: The current study found an association between papillary and intrahepatic CCA and repeated use of PZQ treatment. We suggest further study on the risk factors for papillary and tubular CCA should be performed separately. PMID: 31104794 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

A Head CT is Unnecessary in the Initial Evaluation of A Cirrhotic Patient with Recurrent Hepatic Encephalopathy.
CONCLUSION: In conclusion, the yield of a head CT in determining the cause of change in mental status is extremely low in patients with cirrhosis who present with recurrent hepatic encephalopathy. PMID: 31104795 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Multicenter Experience using Ledipasvir/Sofosbuvir ± RBV to Treat HCV GT 1 Relapsers after Simeprevir and Sofosbuvir Treatment.
CONCLUSIONS: Treatment with LDV/SOF with/without RBV for 12-24 weeks was very well tolerated and resulted in high SVR 12 rates (96%) in HCV GT1 relapsers to SMV + SOF treatment. PMID: 31104796 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Olfactory Function is Affected in Patients with Cirrhosis Depending on the Severity of Hepatic Encephalopathy.
Authors: Heiser C, Haller B, Sohn M, Hofauer B, Knopf A, Mühling T, Freiherr J, Bender M, Tiller M, Schmidt A, Schepp W, Gundling F Abstract INTRODUCTION AND AIM: Olfactory functions are altered to a variable degree by chronic liver disease. Few studies including only small populations of patients emphasized the possibility of hepatic encephalopathy (HE) influencing olfactory nervous tasks. So far, no study has explicitly focused on olfactory function depending on the severity of HE as assessed by objective diagnostic procedures. Thus we performed a study using the "Sniffin' Sticks" test system, crit...
Source: Annals of Hepatology - May 23, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research