Hepatitis E Virus: Still an Enigma in Mexico.
Authors: Realpe-Quintero M, Viera-Segura O, Fierro NA Abstract Based on high seroprevalence, null surveillance, and lack of diagnostics, Mexico is a high-risk region for hepatitis E Virus (HEV) infection. However, few local news on infection are available. Clinicians and general population are in need of increasing awareness, and preventive measures should be emphasized. PMID: 29893694 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Relationship of Severity of Hepatitis A with Polymorphisms in Hepatitis A Virus Cellular Receptor 1 (HAVCR1) Gene.
DISCUSSION: In the study population, the 157insMTTTVP variant of HAVCR1 gene was not associated with more severe outcome of HAV infection. Further studies in other populations around the world are needed to assess the relation of this genetic variation with disease outcome. PMID: 29893695 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

New Insights About Albumin and Liver Disease.
Authors: Carvalho JR, Verdelho Machado M Abstract Decompensated liver cirrhosis has a dismal prognosis, with an overall survival of 2-4 years, which is worse than for many oncological diseases. Albumin is an important tool in the management of patients with cirrhosis, since it decreases for less than half the risk for post-paracentesis cardiocirculatory dysfunction and mortality associated with spontaneous bacterial infection, as well as, it triplicates the response to terlipressin in patients with hepatorenal syndrome. Recently, research on albumin has been a hot topic, with important new insights such as the char...
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Extracellular Matrix Proteins Substantiate IL-28B T allele Effect on Histological Outcome of Chronic Hepatitis C.
CONCLUSION: This study suggests that IL-28B T allele affects the natural course of CHC type 4 and also suggests that carriage of the IL-28B C allele protects from unfavorable clinical outcomes in CHC as coexistence of C allele with T allele reduced cirrhosis severity. PMID: 29893697 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Association Between Serum Hemoglobin Levels and Non Alcoholic Fatty Liver Disease in a Mexican Population.
CONCLUSION: Patients with non-alcoholic fatty liver disease showed elevated levels of circulating Hb, evidence that suggests that Hb exerts a protective role, as it may act as an antioxidant and may counteract the adverse effects of this disease. PMID: 29893698 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Impact of Diabetes Mellitus and Insulin on Nonalcoholic Fatty Liver Disease in the Morbidly Obese.
CONCLUSION: Type 2 diabetes mellitus plays an important role in the progression of non-alcoholic fatty liver disease as an independent risk factor for severe fibrosis. PMID: 29893699 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Correlation of APRI Index with Metavir Index in Children with Neonatal Cholestasis Without Biliary Atresia.
CONCLUSION: APRI is not an effective tool to measure fibrosis or cirrhosis in patients with non-BA neonatal cholestasis in Indian children. PMID: 29893700 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Frequency and Characteristics of Occult Hepatitis B Infection Among Hepatocellular Carcinoma Patients in Japan.
CONCLUSIONS: OBI was detected in 38% of cryptogenic and 25.6% of CHC patients. There was no correlation between OBI and anti-HBV antibodies, but fewer patients with OBI had high inflammatory activity, suggesting that factors other than inflammation may be involved in HCC carcinogenesis in patients with OBI. PMID: 29893701 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Racial, Ethnic, and Age Disparities in Incidence and Survival of Intrahepatic Cholangiocarcinoma in the United States; 1995-2014.
CONCLUSION: The results demonstrate ethnic, race, age and gender disparities in iCCA incidence and survival, and confirm continued increase in iCCA incidence in the United States. PMID: 29893702 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Urinary Neutrophil Gelatinase-Associated Lipocalin in Cirrhotic Patients with Acute Kidney Injury.
CONCLUSION: A single baseline measurement of uNGAL level has the ability to determine type of kidney dysfunction in cirrhotic patients, perhaps accelerating management decisions and improving outcomes. PMID: 29893703 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Association between Low Testosterone Levels and Sarcopenia in Cirrhosis: A Cross-sectional Study.
CONCLUSION: Low testosterone levels are associated with sarcopenia in male cirrhotic patients. The potential therapeutic effect of testosterone to reverse sarcopenia in these patients warrants evaluation in future trials. PMID: 29893704 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Pattern of Vascular Involvement in Egyptian Patients with Budd-Chiari Syndrome: Relation to Etiology and Impact on Clinical Presentation.
CONCLUSION: Isolated HVs occlusion was the most common pattern of vascular involvement in Egyptian patients with primary BCS. Vascular pattern of involvement affected the clinical presentation and was related to the underlying thrombophilia in those patients. PMID: 29893705 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Hepatic Angiosarcoma with Kasabach-Merritt Phenomenon: A Case Report and Review of the Literature.
Authors: Fujii F, Kimura T, Tanaka N, Kubota D, Sugiura A, Umemura T, Wada S, Tanaka E Abstract A 76-year-old woman was referred to our hospital due to massive gingival bleeding following teeth extraction. Laboratory findings suggested disseminated intravascular coagulopathy (DIC). Enhanced computed tomography and magnetic resonance imaging disclosed multiple hypervascular liver masses of 2-6 cm in diameter, the largest of which displaying an irregular enhancement pattern. We considered that her DIC was caused by the multiple liver masses and commenced repeated erythrocyte/fresh frozen plasma infusión and ga...
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Undue Elevation of Procalcitonin in Pediatric Paracetamol Intoxication is Not Explained by Liver Cell Injury Alone.
CONCLUSION: The underlying mechanism is neither caused by infection nor fully explained by liver cell death alone and remains to be determined. PMID: 29893707 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Rapamycin Combi with TAE on the Growth, Metastasis, and Prognosis of Hepatocellular Carcinoma in Rat Models.
CONCLUSION: Rapamycin combined with TAE may effectively suppress the EMT formation and angiogenesis, thereby inhibiting the growth and lung metastasis of HCC rats, which provides a new idea for countering the recurrence and metastasis of HCC. PMID: 29893708 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

SVR 24 Achievement Two Weeks After a Tripled Dose of Daclatasvir in an HCV Genotype 3 Patient.
We describe a 51-year-old Pakistani man with a chronic HCV-genotype 3 (GT3a) infection with moderate liver fibrosis, who achieved sustained virological response (SVR) 24 after a tripled dose of Daclatasvir (DCV) taken erroneously associated to Sofosbuvir (SOF). The patient had a concomitant intestinal TB infection whose treatment had been delayed in order to firstly eradicate HCV to reduce the liver toxicity of anti-mycobacterial drugs. Thanks to the cultural mediator support, we explained to the patient the correct posology of each drug to take during the day consisting of 12 week SOF (400 mg daily) plus DCV (60 mg daily)...
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Renovation of Annals of Hepatology's Scientific Scope: Towards Preventing Rather Than Treating End-Stage Liver Disease.
Authors: Panduro A, Tiribelli C, Chávez-Tapia NC, Arrese M, Uribe M PMID: 29894288 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Occult Hepatitis B and Other Unexplored Risk Factors for Hepatocellular Carcinoma in Latin America.
In conclusion, OBI and other causes involved in the epidemiology of HCC in Latin America are unexplored risk factors. Genome-based research is required to decipher the role of gene-environmental interactions associated with chronic liver disease. Novel algorithms to detect OBI supported by basic/applied/clinical research are also needed. PMID: 29894289 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - June 13, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

An Overview of Liver Transplant Pathology: Data from a Tertiary Referral Centre in Western India.
CONCLUSION: 1. Alcohol- and hepatitis- virus related ESCLD, and biliary atresia are leading indications for liver transplantation in adults and children respectively. 2. Prevalence of 4.28% of moderate steatosis, is much lower than that documented in western literature. Only 5 cases of incidental granulomas is unexpectedly low in a country endemic for tuberculosis. 3. Most common diagnoses of post-transplant liver biopsies in adults has been acute rejection, which is similar to the findings from much larger published series. PMID: 29735782 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Antiproliferative Effects of Epigenetic Modifier Drugs Through E-cadherin Up-regulation in Liver Cancer Cell Lines.
CONCLUSION: We were able to demonstrate Wnt/ β-catenin pathway modulation through E-cadherin up-regulation induced by 5aza-dC and TSA treatments, under an activation-pathway background, like CTNNB1 and TP53 mutations. These findings provide evidences of the potential effect of epigenetic modifier drugs for liver cancer treatment. However, further research needs to be conducted, to determine the in vivo potential of this treatment regimen for the management of liver cancer. PMID: 29735783 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Sofosbuvir-Based Therapy in the Pre-Liver Transplant Setting: The Canadian National Experience.
CONCLUSIONS: SOF-based therapy for patients progressing to liver transplantation leads to high SVR rates, short term stability in liver function, and deactivation from the transplant list . PMID: 29735784 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Alcohol Consumption Influences Clinical Outcome in Patients Admitted to a Referral Center for Liver Disease.
CONCLUSION: On the present study, the prevalence of heavy use of alcohol was high and associated with a poorer prognosis in hospitalized cirrhotic patients, increasing the risk of infection and death. PMID: 29735785 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Prognostic Significance of The New Criteria for Acute Kidney Injury in Cirrhosis.
CONCLUSIONS: Early AKI was frequent and associated with 90-day mortality or transplantation only when the final Cr level was ≥ 1.5 mg/dL. Distinct approaches are needed for patients with AKI1 according to final Cr. PMID: 29735786 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

A Dynamic Model for Predicting Outcome in Patients with HBV Related Acute-On-Chronic Liver Failure.
CONCLUSION: In conclusion, the model was superior to the conventional methods in predicting the outcomes of patients with HBV related ACLF treated with NA. It is the first description of a novel prognostic model using consecutive data in patients with HBV-induced acute-on-chronic liver failure (ACLF) treated by nucleoside analogs. PMID: 29735787 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Association Between Hepatitis C Virus and Chronic Kidney Disease: A Systematic Review and Meta-Analysis.
CONCLUSION: An association between HCV infection and increased risk of chronic kidney disease in the general population exists. The mechanisms underlying such association are currently under active investigation. PMID: 29735788 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Direct Acting Antivirals Improve HCV Treatment Initiation and Adherence Among Underserved African Americans.
CONCLUSION: Availability of DAA is associated with increased treatment eligibility, initiation, adherence to HCV care, and cure in HCV-infected underserved AAs; highlighting the critical role of access to DAA in this population. PMID: 29735789 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Comparison of Dynamic Changes Among Various Prognostic Scores in Viral Hepatitis-Related Acute Liver Failure.
CONCLUSIONS: Dynamic assessment of prognostic scores better predicts outcome. ALFED model performs better than MELD, MELD, MELD-Na, CLIF-C ACLF scores and KCH criteria for predicting outcome in viral hepatitis- related ALF. PMID: 29735790 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Vitamin D Deficiency is not Associated with Fatty Liver in a Mexican Population.
CONCLUSIONS: In Mexican adults, deficient VD concentration and FL were not independently associated of caloric consumption and physical activity. PMID: 29735791 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

A New Stage in Annals of Hepatology.
Authors: Panduro A, Tiribelli C, Chávez-Tapia NC, Uribe M PMID: 29735792 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Viewpoint: "Alcohol Consumption in Late Adolescence is Associated with an Increased Risk of Severe Liver Disease Later in Life".
Viewpoint: "Alcohol Consumption in Late Adolescence is Associated with an Increased Risk of Severe Liver Disease Later in Life". Ann Hepatol. 2018 Apr 09;17(3):343-344 Authors: Tamburello A, Marando M, Bellentani S Abstract Drinking alcohol during adolescence predispose to severe liver disease in the adult phase. This is the main message of this prospective study. Each daily gram of alcohol men consumed in their youth was linked with a two percent increase in the risk of severe liver disease. No threshold level emerged for liver damage and this is a warning for all the sociologists and politi...
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The Presence and Severity of Nonalcoholic Steatohepatitis Is Associated with Specific Changes in Circulating Bile Acids.
Authors: Gottlieb A, Bechmann L, Canbay A Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease nowadays with currently no approved therapies for the disease. The liver plays a pivotal role in lipid and glucose metabolism. The interactions of molecular mechanisms on the gut for example influences the development still needs to be understood. Bile acids (BA) have been shown to impact metabolic homeostasis and insulin sensitivity. Here, we comment on a study analyzing BA profiles in NAFLD patients addressing novel pathways involved in NAFLD progression. PMID: 2973579...
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

LncRNA-Regulated Autophagy and its Potential Role in Drug-Induced Liver Injury.
CONCLUSIONS: This review described the recent findings on autophagy and its possible lncRNA-miRNA-associated pathways, thereby providing new insights for further studies on the pathogenesis of DILI. PMID: 29735795 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Non-Alcoholic Fatty Liver Disease in Children and Adolescents: Lifestyle Change - a Systematic Review and Meta-Analysis.
CONCLUSIONS: Lifestyle changes lead to significant improvements in BMI, aminotransferase levels and hepatic steatosis in children and adolescents with NAFLD. PMID: 29735796 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Modulatory Effect of Dietary Inclusion of Aegle marmelos Fruits against Cisplatin - Induced Hepatotoxicity In Wistar Rats.
CONCLUSIONS: We can conclude that the hepatoprotective activity of Aegle marmelos was due to its antioxidant effect as evidenced by increasing activity of antioxidant enzymes with enhanced hepatic function and significantly changed the physiological parameters. PMID: 29735797 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Thrombosis of the Portal Venous System in Cirrhotic vs. Non-Cirrhotic Patients.
CONCLUSIONS: In cirrhotic patients, hepatocellular carcinoma and cirrhosis were the strongest risk factors to develop portal venous system thrombosis. In contrast, extrahepatic inflammatory conditions were main risk factors associated in non-cirrhotics. Moreover, the portal vein was the most frequent site of thrombosis in both groups. PMID: 29735798 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Therapeutic Effect of HGF on NASH Mice Through HGF/c-Met and JAK2-STAT3 Signalling Pathway.
CONCLUSIONS: Excess HGF highly probable improved NASH liver function. Combined with its ligand, c-Met, HGF may promote the phosphorylation of JAK2-STAT3 and inhibit inflammation in NASH. Therefore, it may be potentially useful treatment for NASH. PMID: 29735799 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Potential Molecular Targets of Statins in the Prevention of Hepatocarcinogenesis.
CONCLUSION: Statins can prevent the proliferative HCB effects on Hep-G2 cells. TGF-β1, c-Src and TH may be the statins molecular targets in hepatocarcinogenesis. PMID: 29735800 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Mucinous Cystic Neoplasm of the Liver or Intraductal Papillary Mucinous Neoplasm of the Bile Duct? A Case Report and a Review of Literature.
We present the case of a 33-year-old woman with a rapid progression of a cystic tumor of the liver. In 2 years, the lesion increased from 27 to 64 mm and a dilation of the left hepatic duct appeared. Percutaneous transhepatic drainage with a biopsy was performed. No malignant cells were found on biopsy. Because of the rapid progression of the cystic tumor and unclear malignant potential, left hemihepatectomy was performed. Even though tumor masses were present in the biliary duct, on the basis of the presence of OLS, histology finally confirmed MCN-L with intermediate-grade intraepithelial dysplasia to high-grade intraepit...
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

HCBP6 Is Involved in the Development of Hepatic Steatosis Induced by High-Fat Diet and CCL4 in Rats.
CONCLUSION: HCBP6 is involved in the development of high-fat diet- and CCL4-induced hepatic steatosis and related negatively with SREBP-1c. PMID: 29735802 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The Observed Effect of Gastric Bypass Surgery on Direct-acting Antiviral Treatment: a Case Report.
Authors: Smolders EJ, Willemse SB, El-Sherif O, Khoo S, Burger DM Abstract Chronic hepatitis C virus (HCV) infection can be cured with treatment using direct-acting antivirals (DAAs). Although these drugs have been widely studied, information about certain special populations is missing. In this case report we describe a treatment-experienced patient with chronic HCV infection genotype 1b, treated with 150 mg/day simeprevir, 400 mg/day sofosbuvir, and 1,000 mg/ day ribavirin for 24 weeks, after a Roux-and-Y gastric bypass. At steady-state a pharmacokinetic curve was recorded of sofosbuvir, GS-331007, and simeprevir...
Source: Annals of Hepatology - May 9, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Early Successes in an Open Access, Provincially Funded Hepatitis C Treatment Program in Prince Edward Island.
CONCLUSION: In conclusion, results from the first 12 months of this multi-phase hepatitis C elimination strategy demonstrate improved access to treatment, and high rates of safe engagement and cure for patients living with chronic hepatitis C genotype 1 infections. PMID: 29469034 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Antifibrotic Mechanism of Pinocembrin: Impact on Oxidative Stress, Inflammation and TGF- β /Smad Inhibition in Rats.
CONCLUSION: These results suggest that PIN possess potent antifibrotic effects that can be explained on its antioxidant properties. It ameliorates oxidative stress and inflammation during induction of fibrogenesis via its ability to augment celular antioxidant defenses, activating Nrf2-mediated HO-1 expression and modulating NF-κB and TGF-β1/Smad signaling pathway. PMID: 29469035 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Incomplete Kawasaki Disease in an Infant with Cholangitis Post Kasai Surgery for Biliary Atresia.
Authors: Shetty NS, Shah I Abstract Kawasaki's disease (KD) is a systemic vasculitis often seen with viral and bacterial infections. Cholangitis is a known complication in biliary atresia patients post Kasai Portoenterostomy (KP). However KD, in a biliary atresia patient post KP has not been previously reported. A 1 years old girl who had previously undergone a KP for BA, presented with cholangitis which was presumed to be caused by a previous enterobacter infection that she had 2 months ago. However, on treating the cholangitis, the patient developed fever again after ten days which persisted even after c...
Source: Annals of Hepatology - February 23, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Hepatitis E Virus Genotype 1 Cases Imported to Portugal from India, 2016.
Authors: Mesquita JR, Almeida-Santos M, Fernandes M, Maltez F, Lino S, Alves L, Abreu-Silva J, Oliveira RMS, Curran MD, Nascimento MSJ Abstract Hepatitis E in industrialized countries is mainly associated with genotype 3 hepatitis E virus (HEV) and normally causes a sporadic self-limiting disease in immunocompetent individuals. Unlike genotype 3, genotypes 1 and 2 circulate in developing countries, produce severe disease and occur in the epidemic form. Hepatitis E occurring in travellers returning from endemic areas in developing countries is not a novel epidemiological occurrence, however the vast majority of case...
Source: Annals of Hepatology - February 23, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Bacterial Translocation Is Linked to Increased Intestinal IFN- γ, IL-4, IL-17, and mucin-2 in Cholestatic Rats.
In conclusion, bacterial overgrowth associated with bacterial translocation is linked to the over-expression of IFN-γ, IL-4, IL-17 and mucin-2. These molecules might facilitate the intestinal permeability through exacerbating the inflammatory process and disturbing tight junctions, leading to the perpetuation of the liver damage. PMID: 29469038 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Impact of Cholangioscopy: Diagnosing Sclerosing Cholangitis-Associated Biliary Calculi not Detected Using MRI and Endoscopic Ultrasound.
Authors: Fateen W, Taylor N, James MW PMID: 29469039 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Long-Term Follow-up and Quantitative Hepatitis B Surface Antigen Monitoring in North American Chronic HBV Carriers.
CONCLUSION: qHBsAg titers were associated with CHB phase and remained stable in those on long-term NA. A significant number of treated patients had low-level qHBsAg, of which some may be eligible for treatment discontinuation without risk of flare. PMID: 29469040 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype.
CONCLUSIONS: Quercetin and the aqueous extracts decrease intracellular lipid accumulation by down-regulation of lipogenesis and up-regulation of lipolysis. PMID: 29469041 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

More Evidence for the Genetic Susceptibility of Mexican Population to Nonalcoholic Fatty Liver Disease through PNPLA3.
CONCLUSIONS: The PNPLA3 gene is associated with NAFLD in Mexican population. More studies are required to explain the high prevalence of PNPLA3 polymorphism in Mexican-Americans, Mexican-Indians, and Mexican-Mestizos. PMID: 29469042 [PubMed - in process] (Source: Annals of Hepatology)
Source: Annals of Hepatology - February 23, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Viscoelastic Testing in Liver Disease.
We describe the technique and interpretation of commercially available VET and assess the application of VET in both transplant and non-transplant cirrhosis populations. VET largely correlates well with traditional testing including platelet count and fibrinogen level, however, is potentially less accurate in patients with low fibrinogen levels. VET may be useful in identifying patients at higher risk of hypercoagulable complications post-transplant and reflects changes in hemostasis in decompensated patients. While VET has been associated with decreased transfusión support in multiple studies, the lack of bleeding ...
Source: Annals of Hepatology - February 23, 2018 Category: Gastroenterology Tags: Ann Hepatol Source Type: research