Minimally Modified Human Blood Coagulation Factor X to Bypass Direct Factor Xa Inhibitors

CONCLUSIONS: These human factor X variants have the potential to serve as a rescue reversal strategy to overcome the effect of direct factor Xa inhibitors in case of life-threatening bleeding events or emergency surgical interventions.PMID:38729577 | DOI:10.1016/j.jtha.2024.04.022

Source: Thrombosis and Haemostasis - May 10, 2024 Category: Hematology Authors: Mark Schreuder Georges Jourdi Dejvid Veizaj David A Poole Ka Lei Cheung G éraldine Poenou Dani ël Verhoef Stella Thomassen Laura F H Janssen Alain Stepanian Tilman M Hackeng Pascale Gaussem Pieter H Reitsma Daan P Geerke Virginie Siguret Mettine H A Bos Source Type: research