Recent Progress in Modified Atmosphere Packaging and Biopolymeric Films and Coatings for Fresh Strawberry Shelf ‐Life Extension
Fresh strawberries (FS) have a limited shelf life. Modified atmosphere packaging has been used to extend FS' shelf life. Biopolymeric films and coatings are technologies used to extent FS' shelf life. Active molecules have been used to manufacture films and coatings. ABSTRACTStrawberry (Fragaria × ananassa) is a valuable crop cultivated worldwide. This fruit is mainly consumed fresh and is an important source of vitamin C, fat-soluble vitamins and carotenoids. However, fresh strawberries (FS) have a limited shelf life. Conventionally, the shelf life of FS has been extended using refrigeration coupled with modified atmosph...
Source: Packaging Technology and Science - April 24, 2024 Category: Food Science Authors: Erika Paulsen, Sof ía Barrios, Nicolas Bogdanoff, Gabriel Coelho Leandro, Germán Ayala Valencia Tags: REVIEW ARTICLE Source Type: research

Clinical Pathologic Conference Case #6: Oral and Cutaneous Findings in a 14-year-old Female
A 14-year-old female with a history of Kawasaki disease was referred to a university oral medicine clinic by her orthodontist due to swollen, hemorrhagic gingiva and tooth mobility. Scurvy was suspected by the patient's nurse practitioner and confirmed by a measure of ascorbic acid in plasma of less than 5 μmol per liter (0.1 mg per deciliter; reference range, 23 to 114 μmol per liter [0.4 to 2.0 mg per deciliter]). Laboratory testing also revealed vitamin D deficiency with a measured 25-hydroxyvitamin D level of less than 23.3 ng per milliliter (50 nmol per liter; reference range 32.0-100.0 ng per milliliter). (Source: ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 24, 2024 Category: ENT & OMF Authors: Sarah Glass, Mark Mintline Source Type: research

Serum vitamins and homocysteine levels in autoimmune liver disease: A systematic review and meta ‐analysis
ConclusionMost vitamins are deficient in AILD, so appropriate vitamin supplementation should be necessary. Further studies with larger sample sizes are needed to validate these findings. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 23, 2024 Category: Allergy & Immunology Authors: Jiahuan Li, Shan Tian, Bai Ci, Yuwen Xi, Xiaoling Deng Tags: REVIEW ARTICLE Source Type: research

Use of complementary and alternative medicine in vitiligo: a cross-sectional survey
AbstractVitiligo is characterized by skin depigmentation, which can lead to profound psychological effects and decreased quality of life, especially for those with skin of color. Individuals with vitiligo may utilize complementary and alternative medicine (CAM) due to limited treatment options with varying efficacy.An anonymous, multiple-choice, cross-sectional questionnaire was distributed to participants with vitiligo in the United States through online forums. Data on disease characteristics, use of prescription medications, use of topical therapies, supplements, and diets, and perceptions of CAM were collected.In total...
Source: Archives of Dermatological Research - April 23, 2024 Category: Dermatology Source Type: research

Ascorbic acid biosynthesis in Pacific abalone Haliotis discus hannai Ino and L-gulonolactone oxidase gene loss as an independent event
In conclusion, the present study provided direct evidence to prove that the GLO activity and the ability to synthesize AA exist in abalone. The AA synthesis ability in vertebrates might have originated from invertebrates dating back 930.31 million years.PMID:38649080 | DOI:10.1016/j.ijbiomac.2024.131733 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Kai Luo Xiaojun Yu Jia Wang Jiahuan Liu Xinxin Li Mingzhu Pan Dong Huang Kangsen Mai Wenbing Zhang Source Type: research

Highly sensitive humidity sensor based on composite film of partially reduced graphene oxide and bacterial cellulose
In this study, a humidity sensing composite film with high sensitivity and short response time was made by using the mixture of graphene oxide (GO) and bacterial cellulose (BC) with simple dry film-forming method. L-ascorbic acid was used as reducing agent to reduce GO and improve the conductivity of GO/BC composite film (BG). The influence of different BC contents and the different reduction degree on the resistance change rate of composite film was investigated in details. The maximum resistance change rate of partially reduced BG humidity sensitive composite film reached up to 94%, and the response and recovery time wer...
Source: Biosensors and Bioelectronics - April 21, 2024 Category: Biotechnology Authors: Jingyi Song Mingshuai Fan Rui Zhang Meijie Qu Ping Tang Hai Wang Yuezhen Bin Source Type: research

High-dose Vitamin C injection ameliorates against sepsis induced myocardial injury by anti-apoptosis, anti-inflammatory and pro-autophagy through regulating MAPK, NF- κB and PI3K/AKT/mTOR signaling pathways in rats
This study aimed to evaluate the effects of VC on SIMI in rats.METHODS: In this study, the survival rate of high dose VC for SIMI was evaluated within 7 days. Rats were randomly assigned to three groups: Sham group, CLP group, and high dose VC (500 mg/kg i.v.) group. The animals in each group were treated with drugs for 1 day, 3 days or 5 days, respectively. Echocardiography, myocardial enzymes and HE were used to detect cardiac function. IL-1β, IL-6, IL-10 and TNF-α) in serum were measured using ELISA kits. Western blot was used to detect proteins related to apoptosis, inflammation, autophagy, MAPK, NF-κB and PI3K/Akt/...
Source: Aging - April 21, 2024 Category: Biomedical Science Authors: Ya-Nan Cui Na Tian Yan-Hai Luo Ji-Jun Zhao Cheng-Fei Bi Yi Gou Jia Liu Ke Feng Jun-Fei Zhang Source Type: research

Corneal fibrosis: From in vitro models to current and upcoming drug and gene medicines
Adv Drug Deliv Rev. 2024 Apr 18:115317. doi: 10.1016/j.addr.2024.115317. Online ahead of print.ABSTRACTFibrotic diseases are characterised by myofibroblast differentiation, uncontrolled pathological extracellular matrix accumulation, tissue contraction, scar formation and, ultimately tissue / organ dysfunction. The cornea, the transparent tissue located on the anterior chamber of the eye, is extremely susceptible to fibrotic diseases, which cause loss of corneal transparency and are often associated with blindness. Although topical corticosteroids and antimetabolites are extensively used in the management of corneal fibros...
Source: Advanced Drug Delivery Reviews - April 20, 2024 Category: Drugs & Pharmacology Authors: Laura Trujillo Cubillo Mehmet Gurdal Dimitrios I Zeugolis Source Type: research

Fabrication of Long-Range Film of Flower-Like Ag Nanoparticles for Highly Sensitive SERS Substrate
AbstractThe fabrication of sensitive and homogeneous surface-enhanced Raman scattering (SERS) substrates is the key to its practical application. In this paper, flower-like silver nanoparticles (Ag NPs) were successfully synthesized in water/ethanol/n-octanol emulsions by an assistant of citric acid and sodium citrate. The size and surface roughness of flower-like Ag NPs can be adjusted by changing the experimental parameters, such as the ratio of citric acid to sodium citrate, and the concentration of ascorbic acid. The resulting flower-like Ag NPs were constructed to form a homogeneous single-layer film by a three-phase ...
Source: Plasmonics - April 20, 2024 Category: Biomedical Science Source Type: research

Poly (aniline-co-aniline-2,5-disulfonic acid) / L-ascorbic acid / Ag@SiO2 / polysafranin nanocomposite: synthesis, characterization and anomalous electrical behaviour
We report the synthesis of sulfonated copolyaniline/polysafranin/L-ascorbic acid/Ag@SiO2 fine powdered nanocomposites and investigate the influence of incorporating the dye on their conductivity. The composite wa... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - April 20, 2024 Category: Chemistry Authors: Hammed H. A. M. Hassan, Marwa Abdel Fattah and Fatma Abdel Maged Tags: Research Source Type: research

Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway
In this study, we found that neutrophil extracellular traps (NETs) were present in the circulation and brain tissues of rats after SBI, which promoted neuroinflammation, cerebral edema, neuronal cell death, and aggravated neurological dysfunction. Inhibition of NETs formation by peptidylarginine deiminase (PAD) inhibitor or disruption of NETs with deoxyribonuclease I (DNase I) attenuated SBI-induced damages and improved the recovery of neurological function. We show that SBI triggered the activation of cyclic guanosine monophosphate-adenosine monophosphate synthase stimulator of interferon genes (cGAS-STING), and that inhi...
Source: Cellular and Molecular Neurobiology - April 18, 2024 Category: Cytology Authors: Bingbing Li Lixia Xu Zhengang Wang Qi Shi Yang Cui Weijia Fan Qiaoli Wu Xiaoguang Tong Hua Yan Source Type: research

Uremia Impedes Skeletal Myocyte Myomixer Expression and Fusogenic Activity: Implication for Uremic Sarcopenia
Am J Pathol. 2024 May;194(5):759-771. doi: 10.1016/j.ajpath.2024.01.005.ABSTRACTIn patients with chronic kidney disease (CKD), skeletal muscle mass and function are known to occasionally decline. However, the muscle regeneration and differentiation process in uremia has not been extensively studied. In mice with CKD induced by adenine-containing diet, the tibialis anterior muscle injured using a barium chloride injection method recovered poorly as compared to control mice. In the cultured murine skeletal myocytes, stimulation with indoxyl sulfate (IS), a representative uremic toxin, morphologically jeopardized the differen...
Source: The American Journal of Pathology - April 18, 2024 Category: Pathology Authors: Takaaki Higashihara Motoki Odawara Hiroshi Nishi Takehito Sugasawa Yumika Suzuki Satoshi Kametaka Reiko Inagi Masaomi Nangaku Source Type: research

Uremia Impedes Skeletal Myocyte Myomixer Expression and Fusogenic Activity: Implication for Uremic Sarcopenia
Am J Pathol. 2024 May;194(5):759-771. doi: 10.1016/j.ajpath.2024.01.005.ABSTRACTIn patients with chronic kidney disease (CKD), skeletal muscle mass and function are known to occasionally decline. However, the muscle regeneration and differentiation process in uremia has not been extensively studied. In mice with CKD induced by adenine-containing diet, the tibialis anterior muscle injured using a barium chloride injection method recovered poorly as compared to control mice. In the cultured murine skeletal myocytes, stimulation with indoxyl sulfate (IS), a representative uremic toxin, morphologically jeopardized the differen...
Source: Am J Pathol - April 18, 2024 Category: Pathology Authors: Takaaki Higashihara Motoki Odawara Hiroshi Nishi Takehito Sugasawa Yumika Suzuki Satoshi Kametaka Reiko Inagi Masaomi Nangaku Source Type: research

Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway
In this study, we found that neutrophil extracellular traps (NETs) were present in the circulation and brain tissues of rats after SBI, which promoted neuroinflammation, cerebral edema, neuronal cell death, and aggravated neurological dysfunction. Inhibition of NETs formation by peptidylarginine deiminase (PAD) inhibitor or disruption of NETs with deoxyribonuclease I (DNase I) attenuated SBI-induced damages and improved the recovery of neurological function. We show that SBI triggered the activation of cyclic guanosine monophosphate-adenosine monophosphate synthase stimulator of interferon genes (cGAS-STING), and that inhi...
Source: Cellular and Molecular Neurobiology - April 18, 2024 Category: Cytology Authors: Bingbing Li Lixia Xu Zhengang Wang Qi Shi Yang Cui Weijia Fan Qiaoli Wu Xiaoguang Tong Hua Yan Source Type: research