Imaging and quantifying drug delivery in skin - Part 1: Autoradiography and mass spectrometry imaging.
Evans CL Abstract In this two parts review we present an up-do-date description of different imaging methods available to map the localization of drugs on skin as a complement of established ex-vivo absorption studies. This first part deals with invasive methods and are grouped in two classes according to their underlying principles: i) methods using radioactivity such as autoradiography and ii) mass spectrometry methods such as MALDI and SIMS. For each method, a description of the principle is given along with example applications of imaging and quantifying drug delivery in human skin. Thanks to these techniques...
Source: Advanced Drug Delivery Reviews - November 25, 2019 Category: Drugs & Pharmacology Authors: Grégoire S, Luengo GS, Hallegot P, Pena AM, Chen X, Bornschlögl T, Chan KF, Pence I, Obeidy P, Feizpour A, Jeong S, Evans CL Tags: Adv Drug Deliv Rev Source Type: research

Rational designs of in vivo CRISPR-Cas delivery systems.
Abstract The CRISPR-Cas system initiated a revolution in genome editing when it was, for the first time, demonstrated success in the mammalian cells. Today, scientists are able to readily edit the genome, regulate gene transcription, engineer posttranscriptional events, and image nucleic acids using CRISPR-Cas-based tools. However, to efficiently transport CRISPR-Cas into target tissues/cells remains challenging due to many extra- and intra-cellular barriers, therefore largely limiting the applications of CRISPR-based therapeutics in vivo. In this review, we summarize the features of plasmid-, RNA- and ribonucleop...
Source: Advanced Drug Delivery Reviews - November 20, 2019 Category: Drugs & Pharmacology Authors: Xu CF, Chen GJ, Luo YL, Zhang Y, Zhao G, Lu ZD, Czarna A, Gu Z, Wang J Tags: Adv Drug Deliv Rev Source Type: research

Sequential drug delivery for liver diseases.
Abstract The liver performs critical physiological functions such as metabolism/detoxification and blood homeostasis/biliary excretion. A high degree of blood access means that a drug's resident time in any cell is relatively short. This short drug exposure to cells requires local sequential delivery of multiple drugs for optimal efficacy, potency, and safety. The high metabolism and excretion of drugs also impose both technical challenges and opportunities to sequential drug delivery. This review provides an overview of the sequential events in liver regeneration and the related liver diseases. Using selected exa...
Source: Advanced Drug Delivery Reviews - November 14, 2019 Category: Drugs & Pharmacology Authors: Huang X, Lee F, Teng Y, Lingam CB, Chen Z, Sun M, Song Z, Balachander GM, Leo HL, Guo Q, Shah I, Yu H Tags: Adv Drug Deliv Rev Source Type: research

Nanotechnology in regenerative ophthalmology.
Abstract In recent years, regenerative medicine is gaining momentum and is giving hopes for restoring function of diseased, damaged, and aged tissues and organs and nanotechnology is serving as a catalyst. In the ophthalmology field, various types of allogenic and autologous stem cells have been investigated to treat some ocular diseases due to age-related macular degeneration, glaucoma, retinitis pigmentosa, diabetic retinopathy, and corneal and lens traumas. Nanomaterials have been utilized directly as nanoscaffolds for these stem cells to promote their adhesion, proliferation and differentiation or indirectly a...
Source: Advanced Drug Delivery Reviews - November 7, 2019 Category: Drugs & Pharmacology Authors: Sahle FF, Kim S, Niloy KK, Tahia F, Fili CV, Cooper E, Hamilton DJ, Lowe TL Tags: Adv Drug Deliv Rev Source Type: research

Topical treatments for skin cancer.
Abstract Skin cancer is a broad term used to describe a number of different malignant indications of the skin. Skin cancers mostly comprise of the keratinocyte cancers [Basal Cell Carcinoma (BCC) and cutaneous Squamous Cell Carcinoma (SCC)], and melanoma. Surgical excision of these malignancies has been the preferred treatment of patients for decades. However, the decision to perform surgery can be affected by various considerations, including co-morbidities of the patient, the anatomical site of the lesion and potential intolerance for repeated excisions. Topical treatment of skin cancer may therefore be more app...
Source: Advanced Drug Delivery Reviews - November 6, 2019 Category: Drugs & Pharmacology Authors: Cullen JK, Simmons JL, Parsons PG, Boyle GM Tags: Adv Drug Deliv Rev Source Type: research

Advanced nanotherapies to promote neuroregeneration in the injured newborn brain.
Abstract Neonatal brain injury affects thousands of babies each year and may lead to long-term and permanent physical and neurological problems. Currently, therapeutic hypothermia is standard clinical care for term newborns with moderate to severe neonatal encephalopathy. Nevertheless, it is not completely protective, and additional strategies to restore and promote regeneration are urgently needed. One way to ensure recovery following injury to the immature brain is to augment endogenous regenerative pathways. However, novel strategies such as stem cell therapy, gene therapies and nanotechnology have not been ade...
Source: Advanced Drug Delivery Reviews - October 30, 2019 Category: Drugs & Pharmacology Authors: Cabeza OA, Mikrogeorgiou A, Kannan S, Ferriero DM Tags: Adv Drug Deliv Rev Source Type: research

Silk fibroin for skin injury repair: Where do things stand?
Abstract Several synthetic and natural materials are used in soft tissue engineering and regenerative medicine with varying degrees of success. Among them, silkworm silk protein fibroin, a naturally occurring protein-based biomaterial, exhibits many promising characteristics such as biocompatibility, controllable biodegradability, tunable mechanical properties, aqueous preparation, minimal inflammation in host tissue, low cost and ease of use. Silk fibroin is often used alone or in combination with other materials in various formats and is also a promising delivery system for bioactive compounds as part of such re...
Source: Advanced Drug Delivery Reviews - October 30, 2019 Category: Drugs & Pharmacology Authors: Gholipourmalekabadi M, Sapru S, Samadikuchaksaraei A, Reis RL, Kaplan DL, Kundu SC Tags: Adv Drug Deliv Rev Source Type: research

Intradermal and transdermal drug delivery using microneedles - Fabrication, performance evaluation and application to lymphatic delivery.
Abstract The progress in microneedle research is evidenced by the transition from simple 'poke and patch' solid microneedles fabricated from silicon and stainless steel to the development of bioresponsive systems such as hydrogel-forming and dissolving microneedles. In this review, we provide an outline on various microneedle fabrication techniques which are currently employed. As a range of factors, including materials, geometry and design of the microneedles, affect the performance, it is important to understand the relationships between them and the resulting delivery of therapeutics. Accordingly, there is a ne...
Source: Advanced Drug Delivery Reviews - October 18, 2019 Category: Drugs & Pharmacology Authors: Sabri AH, Kim Y, Marlow M, Scurr DJ, Segal J, Banga AK, Kagan L, Lee JB Tags: Adv Drug Deliv Rev Source Type: research

Fundamentals of fractional laser-assisted drug delivery: An in-depth guide to experimental methodology and data interpretation.
Abstract In the decade since their advent, ablative fractional lasers have emerged as powerful tools to enhance drug delivery to and through the skin. Effective and highly customizable, laser-assisted drug delivery (LADD) has led to improved therapeutic outcomes for several medical indications. However, for LADD to reach maturity as a standard treatment technique, a greater appreciation of its underlying science is needed. This work aims to provide an in-depth guide to the technology's fundamental principles, experimental methodology and unique aspects of LADD data interpretation. We show that drug's physicochemic...
Source: Advanced Drug Delivery Reviews - October 16, 2019 Category: Drugs & Pharmacology Authors: Wenande E, Anderson RR, Haedersdal M Tags: Adv Drug Deliv Rev Source Type: research

Physical and chemical profiles of nanoparticles for lymphatic targeting.
Abstract Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted...
Source: Advanced Drug Delivery Reviews - October 15, 2019 Category: Drugs & Pharmacology Authors: Ke X, Howard GP, Tang H, Cheng B, Saung MT, Santos JL, Mao HQ Tags: Adv Drug Deliv Rev Source Type: research

Nanostructured DNA for the delivery of therapeutic agents.
Abstract DNA and RNA, the nucleic acids found in every living organism, are quite crucial, because not only do they store the genetic information, but also they are used as signals through interaction with various molecules within the body. The nature of nucleic acids, especially DNA, to form double-helix makes it possible to design nucleic acid-based nanostructures with various shapes. Because the shapes as well as the physicochemical properties determine their interaction with proteins or cells, nanostructured DNAs will have different features in the interaction compared with single- or double-stranded DNA. Some...
Source: Advanced Drug Delivery Reviews - October 12, 2019 Category: Drugs & Pharmacology Authors: Nishikawa M, Tan M, Liao W, Kusamori K Tags: Adv Drug Deliv Rev Source Type: research

Modified nucleobase-specific gene regulation using engineered transcription activator-like effectors.
Abstract Epigenetic modification, as typified by cytosine methylation, is a key aspect of gene regulation that affects many biological processes. However, the biological roles of individual methylated cytosines are poorly understood. Sequence-specific DNA recognition tools can be used to investigate the roles of individual instances of DNA methylation. Transcription activator-like effectors (TALEs), which are DNA-binding proteins, are promising candidate tools with designable sequence specificity and sensitivity to DNA methylation. In this review, we describe the bases of DNA recognition of TALEs, including methyl...
Source: Advanced Drug Delivery Reviews - September 9, 2019 Category: Drugs & Pharmacology Authors: Tsuji S, Imanishi M Tags: Adv Drug Deliv Rev Source Type: research

Carbohydrate-based nanocarriers and their application to target macrophages and deliver antimicrobial agents.
Abstract Many deadly infections are produced by microorganisms capable of sustained survival in macrophages. This reduces exposure to chemotherapy, prevents immune detection, and is akin to criminals hiding in police stations. Therefore, the use of glyco-nanoparticles (GNPs) as carriers of therapeutic agents is a burgeoning field. Such an approach can enhance the penetration of drugs into macrophages with specific carbohydrate targeting molecules on the nanocarrier to interact with macrophage lectins. Carbohydrates are natural biological molecules and the key constituents in a large variety of biological events su...
Source: Advanced Drug Delivery Reviews - September 9, 2019 Category: Drugs & Pharmacology Authors: Mosaiab T, Farr D, Kiefel MJ, Houston TA Tags: Adv Drug Deliv Rev Source Type: research

Pharmacokinetics of nanotechnology-based formulations in pediatric populations.
Abstract The development of therapeutics for pediatric use has advanced in the last few decades. However, off-label use of adult medications in pediatrics remains a significant clinical problem. Furthermore, the development of therapeutics for pediatrics is challenged by the lack of pharmacokinetic (PK) data in the pediatric population. To promote the development of therapeutics for pediatrics, the United States Pediatric Formulation Initiative recommended the investigation of nanotechnology-based delivery systems. Therefore, in this review, we provided comprehensive information on the PK of nanotechnology-based f...
Source: Advanced Drug Delivery Reviews - September 5, 2019 Category: Drugs & Pharmacology Authors: Yellepeddi V, Joseph A, Nance E Tags: Adv Drug Deliv Rev Source Type: research

Domesticating the foreign body response: Recent advances and applications.
Abstract The foreign body response is an immunological process that leads to the rejection of implanted devices and presents a fundamental challenge to their performance, durability, and therapeutic utility. Recent advances in materials development and device design are now providing strategies to overcome this immune-mediated reaction. Here, we briefly review our current mechanistic understanding of the foreign body response and highlight new anti-FBR technologies from this decade that have been applied successfully in biomedical applications relevant to implants, devices, and cell-based therapies. Further develo...
Source: Advanced Drug Delivery Reviews - September 3, 2019 Category: Drugs & Pharmacology Authors: Veiseh O, Vegas AJ Tags: Adv Drug Deliv Rev Source Type: research

Lymphatic changes in cancer and drug delivery to the lymphatics in solid tumors.
Abstract Although many solid tumors use the lymphatic system to metastasize, there are few treatment options that directly target cancer present in the lymphatic system, and those that do are highly invasive, uncomfortable, and/or have limitations. This review gives a brief overview of lymphatic function and anatomy, discusses changes that befall the lymphatics in cancer and the mechanisms by which these changes occur, and presents limitations for drug delivery to the lymphatic system. We then go on to summarize relevant techniques and new research for targeting cancer populations in the lymphatics and enhancing d...
Source: Advanced Drug Delivery Reviews - August 25, 2019 Category: Drugs & Pharmacology Authors: Cote B, Rao D, Alany RG, Kwon GS, Alani AWG Tags: Adv Drug Deliv Rev Source Type: research

Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors.
Abstract Intervertebral disc (IVD) degeneration has been associated with low back pain, which is a major musculoskeletal disorder and socio-economic problem that affects as many as 600 million patients worldwide. Here, we first review the current knowledge of IVD physiology and physiopathological processes in terms of homeostasis regulation and consecutive events that lead to tissue degeneration. Recent progress with IVD restoration by anti-catabolic or pro-anabolic approaches are then analyzed, as are the design of macro-, micro-, and nano-platforms to control the delivery of such therapeutic agents. Finally, we ...
Source: Advanced Drug Delivery Reviews - August 21, 2019 Category: Drugs & Pharmacology Authors: Frapin L, Clouet J, Delplace V, Fusellier M, Guicheux J, Le Visage C Tags: Adv Drug Deliv Rev Source Type: research

Hyaluronan as tunable drug delivery system.
Abstract The hyaluronan (HA) polymer is an important macromolecule of extracellular matrix with remarkable structure and functions: it is a linear and unbranched polymer without sulphate or phosphate groups and has key role in several biological processes in mammals. It is ubiquitous in mammalian tissues with several and specific functions, influencing cell proliferation and migration as well as angiogenesis and inflammation. To exert these important functions in tissues HA modifies the concentration and size. Considering this HA content in tissues is carefully controlled by different mechanisms including covalent...
Source: Advanced Drug Delivery Reviews - August 14, 2019 Category: Drugs & Pharmacology Authors: Passi A, Vigetti D Tags: Adv Drug Deliv Rev Source Type: research

Hydrogel vehicles for sequential delivery of protein drugs to promote vascular regeneration.
Abstract In recent years, as the mechanisms of vasculogenesis and angiogenesis have been uncovered, the functions of various pro-angiogenic growth factors (GFs) and cytokines have been identified. Therefore, therapeutic angiogenesis, by delivery of GFs, has been sought as a treatment for many vascular diseases. However, direct injection of these protein drugs has proven to have limited clinical success due to their short half-lives and systemic off-target effects. To overcome this, hydrogel carriers have been developed to conjugate single or multiple GFs with controllable, sustained, and localized delivery. Howeve...
Source: Advanced Drug Delivery Reviews - August 14, 2019 Category: Drugs & Pharmacology Authors: Wei Z, Volkova E, Blatchley MR, Gerecht S Tags: Adv Drug Deliv Rev Source Type: research

Brief update on endocytosis of nanomedicines.
Abstract The complexity of nanoscale interactions between biomaterials and cells has limited the realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such, significant effort has been devoted to advancing our understanding of the biophysical interactions of the myriad nanoparticles. Endocytosis of nanomedicine has drawn tremendous interest in the last decade. Here, we highlight the ever-present barriers to efficient intracellular delivery of nanoparticles as well as the current advances and strategies deployed to breach these barriers. We also introduce new barriers that have be...
Source: Advanced Drug Delivery Reviews - August 13, 2019 Category: Drugs & Pharmacology Authors: Patel S, Kim J, Herrera M, Mukherjee A, Kabanov A, Sahay G Tags: Adv Drug Deliv Rev Source Type: research

Nanocarrier-based systems for targeted and site specific therapeutic delivery.
Abstract Systemic drug delivery methods such as oral or parenteral administration of free drugs possess relatively low treatment efficiency and marked adverse side effects. The use of nanoparticles for drug delivery in most cases substantially enhances drug efficacy, improves pharmacokinetics and drug release and limits their side effects. However, further enhancement in drug efficacy and significant limitation of adverse side effects can be achieved by specific targeting of nanocarrier-based delivery systems especially in combination with local administration. The present review describes major advantages and lim...
Source: Advanced Drug Delivery Reviews - August 7, 2019 Category: Drugs & Pharmacology Authors: Majumder J, Taratula O, Minko T Tags: Adv Drug Deliv Rev Source Type: research

RNA imaging by chemical probes.
Abstract Sequence-specific detection of intracellular RNA is one of the most important approaches to understand life phenomena. However, it is difficult to detect RNA in living cells because of its variety and scarcity. In the last three decades, several chemical probes have been developed for RNA detection in living cells. These probes are composed of DNA or artificial nucleic acid and hybridize with the target RNA in a sequence-specific manner. This hybridization triggers a change of fluorescence or a chemical reaction. In this review, we classify the probes according to the associated fluorogenic mechanism, tha...
Source: Advanced Drug Delivery Reviews - August 6, 2019 Category: Drugs & Pharmacology Authors: Tomoike F, Abe H Tags: Adv Drug Deliv Rev Source Type: research

Biologically Targeted Photo-Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion.
Abstract Cancer immunotherapy is one of the fastest growing and most promising fields in clinical oncology. T-cell checkpoint inhibitors are revolutionizing the management of advanced cancers including non-small cell lung cancer and melanoma. Unfortunately, many common cancers are not responsive to these drugs and resistance remains problematic. A growing number of novel cancer immunotherapies have been discovered but their clinical translation has been limited by shortcomings of conventional drug delivery. Immune signaling is tightly-regulated and often requires simultaneous or near-simultaneous activation of mul...
Source: Advanced Drug Delivery Reviews - July 19, 2019 Category: Drugs & Pharmacology Authors: Mi Y, Yang F, Bloomquist C, Xia Y, Sun B, Qi Y, Wagner K, Montgomery S, Zhang T, Wang AZ Tags: Adv Drug Deliv Rev Source Type: research

A toll-like receptor 3 (TLR3) agonist ARNAX for therapeutic immunotherapy.
Abstract Vaccine immunotherapy consisting of tumor antigens combined with an immune-enhancing adjuvant fosters cytotoxic T cell (CTL) proliferation. Clinically, polyI:C has been used as an adjuvant to enhance cancer vaccine protocols. However, according to its long history, polyI:C promotes inflammation that causes cytokine toxicity. Although checkpoint inhibitor immunotherapy has improved the prognoses of patients with progressive cancer, over 75% of patients continue to experience resistance to antibody (Ab) against anti-programmed cell death-protein 1 (PD-1) or its ligand, PD-L1 therapy. In most cases, patients...
Source: Advanced Drug Delivery Reviews - July 11, 2019 Category: Drugs & Pharmacology Authors: Seya T, Takeda Y, Matsumoto M Tags: Adv Drug Deliv Rev Source Type: research

Subchronic and Chronic Toxicity Evaluation of Inorganic Nanoparticles for Delivery Applications.
Abstract Inorganic nanoparticles provide the opportunity to localize bioactive agents to the target sites and protect them from degradation. In many cases, acute toxicities of inorganic nanoparticles used for delivery applications have been investigated. However, little information is available regarding the long-term toxicity of such materials. This review focuses on the importance of subchronic and chronic toxicity assessment of inorganic nanoparticles investigated for delivery applications. We have attempted to provide a comprehensive review of the available literature for chronic toxicity assessment of inorgan...
Source: Advanced Drug Delivery Reviews - July 8, 2019 Category: Drugs & Pharmacology Authors: Mohammadpour R, Dobrovolskaia MA, Cheney DL, Greish KF, Ghandehari H Tags: Adv Drug Deliv Rev Source Type: research

Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging.
Abstract The preclinical landscape of photoacoustic imaging has experienced tremendous growth in the past decade. This non-invasive imaging modality augments the spatiotemporal capabilities of ultrasound with optical contrast. While it has principally been investigated for diagnostic applications, many recent reports have described theranostic delivery systems and drug monitoring strategies using photoacoustics. Here, we provide an overview of the of the progress to date while highlighting work in three specific areas: theranostic nanoparticles, real-time drug monitoring, and stem cell ("living drug") tr...
Source: Advanced Drug Delivery Reviews - July 8, 2019 Category: Drugs & Pharmacology Authors: Moore C, Chen F, Wang J, Jokerst JV Tags: Adv Drug Deliv Rev Source Type: research

Fibrosis in tissue engineering and regenerative medicine: treat or trigger?
ela P Abstract Fibrosis is a life-threatening pathological condition resulting from a dysfunctional tissue repair process. There is no efficient treatment and organ transplantation is in many cases the only therapeutic option. Here we review tissue engineering and regenerative medicine (TERM) approaches to address fibrosis in the cardiovascular system, the kidney, the lung and the liver. These strategies have great potential to achieve repair or replacement of diseased organs by cell- and material-based therapies. However, paradoxically, they might also trigger fibrosis. Cases of TERM interventions with adverse ou...
Source: Advanced Drug Delivery Reviews - July 8, 2019 Category: Drugs & Pharmacology Authors: Fernández-Colino A, Iop L, Ventura Ferreira MS, Mela P Tags: Adv Drug Deliv Rev Source Type: research

Integrating nanomedicine into clinical radiotherapy regimens.
Abstract While the advancement of clinical radiotherapy was driven by technological innovations throughout the 20th century, continued improvement relies on rational combination therapies derived from biological insights. In this review, we highlight the importance of combination radiotherapy in the era of precision medicine. Specifically, we survey and summarize the areas of research where improved understanding in cancer biology will propel the field of radiotherapy forward by allowing integration of novel nanotechnology-based treatments. PMID: 31279729 [PubMed - as supplied by publisher] (Source: Advanced ...
Source: Advanced Drug Delivery Reviews - July 4, 2019 Category: Drugs & Pharmacology Authors: DuRoss AN, Neufeld MJ, Rana S, Thomas CR, Sun C Tags: Adv Drug Deliv Rev Source Type: research

Reprogramming lymphocytes for the treatment of melanoma: From biology to therapy.
Abstract This decade has introduced drastic changes in melanoma therapy, predominantly due to the materialization of the long promise of immunotherapy. Cytotoxic T cells are the chief component of the immune system, which are targeted by different strategies aimed to increase their capacity against melanoma cells. To this end, reprogramming of T cells occurs by T cell centered manipulation, targeting the immunosuppressive tumor microenvironment or altering the whole patient. These are enabled by delivery of small molecules, functional monoclonal antibodies, different subunit vaccines, as well as living lymphocytes...
Source: Advanced Drug Delivery Reviews - July 2, 2019 Category: Drugs & Pharmacology Authors: Margolis N, Markovits E, Markel G Tags: Adv Drug Deliv Rev Source Type: research

Intratumoral fate of functional nanoparticles in response to microenvironment factor: Implications on cancer diagnosis and therapy.
Abstract The extraordinary growth and progression of tumor require enormous nutrient and energy. Unregulated behaviors of cancer cell progressing and persistently change of tumor microenvironment (TME) which acts as the soil for cancer growth and metastasis are the ubiquitous features. The tumor microenvironment exhibits some unique features which differ with the normal tissues. While the nanoparticles get through the blood vessel leakage, they encounter immediately and interact directly with these microenvironment factors. These factors may inhibit the diffusion of nanoparticles from penetrating through the tumor...
Source: Advanced Drug Delivery Reviews - July 2, 2019 Category: Drugs & Pharmacology Authors: Peng J, Yang Q, Shi K, Xiao Y, Wei X, Qian Z Tags: Adv Drug Deliv Rev Source Type: research

In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends.
z A Abstract During the past two decades, a range of in vitro models simulating the digestion processes occurring in the stomach and small intestine have been developed to characterize lipid based drug delivery systems (LbDDSs). This review describes the presently existing range of in vitro digestion models and their use in the field of oral drug delivery. The models are evaluated in terms of their suitability to assess LbDDSs, and their ability to produce in vitro - in vivo correlations (IVIVCs). While the pH-stat lipolysis model is by far the most commonly utilized in vitro digestion model in relation to charact...
Source: Advanced Drug Delivery Reviews - June 29, 2019 Category: Drugs & Pharmacology Authors: Berthelsen R, Klitgaard M, Rades T, Müllertz A Tags: Adv Drug Deliv Rev Source Type: research

Careers in nanomedicine and drug delivery.
Abstract Nanomedicine continues to be a rapidly growing and increasingly interdisciplinary field. The career opportunities available in nanomedicine are also numerous, yet not always obvious to the early-career scientist determining their individual track for maximal impact. This perspective provides a brief overview of the field of nanomedicine, then delves into the many career trajectories one could take in this field. The article concludes with thoughts on how to provide diverse training to increase supply for the variety of career paths, and the role that mentors can play in young scientists' development and e...
Source: Advanced Drug Delivery Reviews - June 28, 2019 Category: Drugs & Pharmacology Authors: Nance E Tags: Adv Drug Deliv Rev Source Type: research

Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems.
Abstract Nanocarriers (NCs) are a type of drug delivery system commonly used to regulate the pharmacokinetic and pharmacodynamic properties of drugs. Although a wide variety of NCs has been developed, relatively few have been registered for clinical trials and even fewer are clinically approved. Overt or potential toxicity, indistinct mechanisms of drug release and unsatisfactory pharmacokinetic behavior all contribute to their high failure rate during preclinical and clinical testing. These negative characteristics are not only due to the NCs themselves but also to the materials of the drug nanocarrier system (MD...
Source: Advanced Drug Delivery Reviews - June 27, 2019 Category: Drugs & Pharmacology Authors: Su C, Liu Y, Li R, Wu W, Fawcett JP, Gu J Tags: Adv Drug Deliv Rev Source Type: research

Hybrid drug nanocrystals.
Abstract Nanocrystals show promise to deliver poorly water-soluble drugs to yield systemic exposure. However, our knowledge regarding the in vivo fate of nanocrystals is in its infancy, as nanocrystallization is simply viewed as an approach to enhance the dissolution of drug crystals. The dying crystal phenomenon inspired the development of hybrid nanocrystals by physically embedding fluorophores into the crystal lattice. This approach achieved concurrent therapy and bioimaging and is well-established to study pharmacokinetics and nanocrystal dissolution in vivo. Nanocrystals also offer the advantage of long-term ...
Source: Advanced Drug Delivery Reviews - June 26, 2019 Category: Drugs & Pharmacology Authors: Lu Y, Lv Y, Li T Tags: Adv Drug Deliv Rev Source Type: research

Enabling biodegradable functional biomaterials for the management of neurological disorders.
Abstract An increasing number of patients are being diagnosed with neurological diseases, but are rarely cured because of the lack of curative therapeutic approaches. This situation creates an urgent clinical need to develop effective diagnosis and treatment strategies for repair and regeneration of injured or diseased neural tissues. In this regard, biodegradable functional biomaterials provide promising solutions to meet this demand owing to their unique responsiveness to external stimulation fields, which enable neuro-imaging, neuro-sensing, specific targeting, hyperthermia treatment, controlled drug delivery, ...
Source: Advanced Drug Delivery Reviews - June 19, 2019 Category: Drugs & Pharmacology Authors: Shan D, Ma C, Yang J Tags: Adv Drug Deliv Rev Source Type: research

Nanomedicines - Tiny particles and big challenges.
Abstract After decades of research, nanotechnology has been used in a broad array of biomedical products including medical devices, drug products, drug substances, and pharmaceutical-grade excipients. But like many great achievements in science, there is a fine balance between the risks and opportunities of this new technology. Some materials and surface structures in the nanosize range can exert unexpected toxicities and merit a more detailed safety assessment. Regulatory agencies such as the United States Food and Drug Administration or the European Medicines Agency have started dealing with the potential risks ...
Source: Advanced Drug Delivery Reviews - June 18, 2019 Category: Drugs & Pharmacology Authors: Marques MRC, Choo Q, Ashtikar M, Rocha TC, Bremer-Hoffmann S, Wacker MG Tags: Adv Drug Deliv Rev Source Type: research

Local pharmacological induction of angiogenesis: Drugs for cells and cells as drugs.
Abstract The past decades have seen significant advances in pro-angiogenic strategies based on delivery of molecules and cells for conditions such as coronary artery disease, critical limb ischemia and stroke. Currently, three major strategies are evolving. Firstly, various pharmacological agents (growth factors, interleukins, small molecules, DNA/RNA) are locally applied at the ischemic region. Secondly, preparations of living cells with considerable bandwidth of tissue origin, differentiation state and preconditioning are delivered locally, rarely systemically. Thirdly, based on the notion, that cellular effects...
Source: Advanced Drug Delivery Reviews - June 18, 2019 Category: Drugs & Pharmacology Authors: Gaspar D, Peixoto R, De Pieri A, Striegl B, Zeugolis DI, Raghunath M Tags: Adv Drug Deliv Rev Source Type: research

Application of F örster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines.
Application of Förster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines. Adv Drug Deliv Rev. 2019 Jun 12;: Authors: Chen T, He B, Tao J, He Y, Deng H, Wang X, Zheng Y Abstract Extensive studies on nanomedicines have been conducted for drug delivery and disease diagnosis (especially for cancer therapy). However, the intracellular and in vivo biofate of nanomedicines, which is significantly associated with their clinical therapeutic effect, is poorly understood at present. This is because of the technical challenges to quantify the disassemb...
Source: Advanced Drug Delivery Reviews - June 12, 2019 Category: Drugs & Pharmacology Authors: Chen T, He B, Tao J, He Y, Deng H, Wang X, Zheng Y Tags: Adv Drug Deliv Rev Source Type: research

Electrically conductive nanomaterials for cardiac tissue engineering.
Abstract Patient deaths resulting from cardiovascular diseases are increasing across the globe, posing the greatest risk to patients in developed countries. Myocardial infarction, as a result of inadequate blood flow to the myocardium, results in irreversible loss of cardiomyocytes which can lead to heart failure. A sequela of myocardial infarction is scar formation that can alter the normal myocardial architecture and result in arrhythmias. Over the past decade, a myriad of tissue engineering approaches has been developed to fabricate engineered scaffolds for repairing cardiac tissue. This paper highlights the re...
Source: Advanced Drug Delivery Reviews - June 6, 2019 Category: Drugs & Pharmacology Authors: Ashtari K, Nazari H, Ko H, Tebon P, Akhshik M, Akbari M, Alhosseini SN, Mozafari M, Mehravi B, Soleimani M, Ardehali R, Warkiani ME, Ahadian S, Khademhosseini A Tags: Adv Drug Deliv Rev Source Type: research

Nuclear imaging of liposomal drug delivery systems: A critical review of radiolabelling methods and applications in nanomedicine.
Abstract The integration of nuclear imaging with nanomedicine is a powerful tool for efficient development and clinical translation of liposomal drug delivery systems. Furthermore, it may allow highly efficient imaging-guided personalised treatments. In this article, we critically review methods available for radiolabelling liposomes. We discuss the influence that the radiolabelling methods can have on their biodistribution and highlight the often-overlooked possibility of misinterpretation of results due to decomposition in vivo. We stress the need for knowing the biodistribution/pharmacokinetics of both the radi...
Source: Advanced Drug Delivery Reviews - June 3, 2019 Category: Drugs & Pharmacology Authors: Man F, Gawne PJ, de Rosales RTM Tags: Adv Drug Deliv Rev Source Type: research

Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool.
Abstract One of the current challenges in the monitoring of drug nanocarriers lies in the difficulties in discriminating the carrier-bound signals from the bulk signals of probes. Environment-responsive probes that enable signal switching are making steps towards a solution to this problem. Aggregation-caused quenching (ACQ), a phenomenon generally regarded as unfavorable in bioimaging, has turned out to be a promising characteristic for achieving environment-responsiveness and eliminating free-probe interference. So-called ACQ probes emit fluorescence when dispersed molecularly within the carrier matrix but quenc...
Source: Advanced Drug Delivery Reviews - May 31, 2019 Category: Drugs & Pharmacology Authors: Qi J, Hu X, Dong X, Lu Y, Lu H, Zhao W, Wu W Tags: Adv Drug Deliv Rev Source Type: research

Ligand density on nanoparticles: A parameter with critical impact on nanomedicine.
Abstract Nanoparticles modified with ligands for specific targeting towards receptors expressed on the surface of target cells are discussed in literature towards improved delivery strategies. In such concepts the ligand density on the surface of the nanoparticles plays an important role. How many ligands per nanoparticle are best for the most efficient delivery?. Importantly, this number may be different for in vitro and in vivo scenarios. In this review first viruses as "biological" nanoparticles are analyzed towards their ligand density, which is then compared to the ligand density of engineered nanop...
Source: Advanced Drug Delivery Reviews - May 31, 2019 Category: Drugs & Pharmacology Authors: Alkilany AM, Zhu L, Weller H, Mews A, Parak W, Barz M, Feliu N Tags: Adv Drug Deliv Rev Source Type: research

Cardiac fibrosis - A short review of causes and therapeutic strategies.
Abstract Fibrotic diseases cause annually more than 800,000 deaths worldwide, whereof the majority accounts for lung and cardiac fibrosis. A pathological remodeling of the extracellular matrix either due to ageing or as a result of an injury or disease leads to fibrotic scars. In the heart, these scars cause several cardiac dysfunctions either by reducing the ejection fraction due to a stiffened myocardial matrix, or by impairing electric conductance, or they can even lead to death. Today it is known that there are several different types of cardiac scars depending on the underlying cause of fibrosis. In this revi...
Source: Advanced Drug Delivery Reviews - May 31, 2019 Category: Drugs & Pharmacology Authors: Hinderer S, Schenke-Layland K Tags: Adv Drug Deliv Rev Source Type: research

Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms.
Abstract Lipid-based formulations (LBF) are widely used by industry and accepted by the regulatory authorities for oral drug delivery in the pharmaceutical and consumer healthcare market. Innovation in the LBF field is however needed in order to meet the demands of modern drugs, their more challenging problem statements and growing needs for achieving optimal pharmacokinetics (i.e., no food-effects, low variability) on approval. This review describes a new lipophilic salt / ionic liquid approach in combination with LBF, and how this salt strategy can be used to better tailor the properties of a drug to LBFs. The p...
Source: Advanced Drug Delivery Reviews - May 28, 2019 Category: Drugs & Pharmacology Authors: Williams HD, Ford L, Igonin A, Shan Z, Botti P, Morgen MM, Hu G, Pouton CW, Scammells PJ, Porter CJH, Benameur H Tags: Adv Drug Deliv Rev Source Type: research

Intrinsic cancer vaccination.
Abstract Immunotherapy is revolutionizing the treatment of cancer, and the current immunotherapeutics have remarkably improved the outcomes for some cancer patients. However, we still need answers for patients with immunologically cold tumors that do not benefit from the current immunotherapy treatments. Here, we suggest a novel strategy that is based on using a very old and sophisticated system for cancer immunotherapy, namely "intrinsic cancer vaccination", which seeks to awaken our own immune system to activate tumor-specific T cells. To do this, we must take advantage of the genetic instability of ca...
Source: Advanced Drug Delivery Reviews - May 24, 2019 Category: Drugs & Pharmacology Authors: Yang Y, Nam GH, Kim GB, Kim YK, Kim IS Tags: Adv Drug Deliv Rev Source Type: research

Corrigendum to "Overcoming ocular drug delivery barriers through the use of physical forces" [Advanced Drug Delivery Reviews 126 (2018) 96-112].
Corrigendum to "Overcoming ocular drug delivery barriers through the use of physical forces" [Advanced Drug Delivery Reviews 126 (2018) 96-112]. Adv Drug Deliv Rev. 2019 May 24;: Authors: Huang D, Chen YS, Rupenthal ID PMID: 31133328 [PubMed - as supplied by publisher] (Source: Advanced Drug Delivery Reviews)
Source: Advanced Drug Delivery Reviews - May 24, 2019 Category: Drugs & Pharmacology Authors: Huang D, Chen YS, Rupenthal ID Tags: Adv Drug Deliv Rev Source Type: research

Sequential drug delivery to modulate macrophage behavior and enhance implant integration.
Abstract Macrophages are major upstream regulators of the inflammatory response to implanted biomaterials. Sequential functions of distinct macrophage phenotypes are essential to the normal tissue repair process, which ideally results in vascularization and integration of implants. Improper timing of M1 or M2 macrophage activation results in dysfunctional healing in the form of chronic inflammation or fibrous encapsulation of the implant. Thus, biphasic drug delivery systems that modulate macrophage behavior are an appealing approach to promoting implant integration. In this review, we describe the timing and role...
Source: Advanced Drug Delivery Reviews - May 16, 2019 Category: Drugs & Pharmacology Authors: O'Brien EM, Risser GE, Spiller KL Tags: Adv Drug Deliv Rev Source Type: research

Strategies, design, and chemistry in siRNA delivery systems.
Abstract Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad classes of diseases due to their ability to reversibly silence target genes. In August 2018, the FDA approved the first siRNA therapeutic, called ONPATTRO™ (Patisiran), for the treatment of transthyretin-mediated amyloidosis. This was an important milestone for the field of siRNA delivery that opens the door for additional siRNA drugs. Currently,>20 small interfering RNA (siRNA)-based therapies are in clinical trials for a wide variety of diseases including cancers, genetic disorders, and viral infections...
Source: Advanced Drug Delivery Reviews - May 15, 2019 Category: Drugs & Pharmacology Authors: Dong Y, Siegwart DJ, Anderson DG Tags: Adv Drug Deliv Rev Source Type: research

Translational challenges in advancing regenerative therapy for treating neurological disorders using nanotechnology.
Abstract The focus of regenerative therapies is to replace or enrich diseased or injured cells and tissue in an attempt to replenish the local environment and function, while slowing or halting further degeneration. Targeting neurological diseases specifically is difficult, due to the complex nature of the central nervous system, including the difficulty of bypassing the brain's natural defense systems. While cell-based regenerative therapies show promise in select tissues, preclinical and clinical studies have been largely unable to transfer these successes to the brain. Advancements in nanotechnologies have prov...
Source: Advanced Drug Delivery Reviews - May 14, 2019 Category: Drugs & Pharmacology Authors: Nemeth CL, Fine AS, Fatemi A Tags: Adv Drug Deliv Rev Source Type: research

Oxygenation strategies for encapsulated islet and beta cell transplants.
Abstract Human allogeneic islet transplantation (ITx) is emerging as a promising treatment option for qualified patients with T1D. However, widespread clinical application of allogeneic ITx is hindered by two critical barriers: the need for systemic immunosuppression and the limited supply of human islet tissue. Biocompatible, retrievable immunoisolation devices containing glucose-responsive insulin-secreting tissue may address both critical barriers by enabling the more effective and efficient use of allogeneic islets without immunosuppression in the near-term, and ultimately the use of a cell source with a virtu...
Source: Advanced Drug Delivery Reviews - May 8, 2019 Category: Drugs & Pharmacology Authors: Papas KK, De Leon H, Suszynski TM, Johnson RC Tags: Adv Drug Deliv Rev Source Type: research