Development and validation of high-performance liquid chromatography-Orbitrap mass spectrometric method for quantification of NDMA in ranitidine drug products and evaluation of antioxidants as inhibitors of classical nitrosation reaction
CONCLUSIONS: This study compared the effectiveness of antioxidants as NDMA attenuators in ranitidine under storage conditions susceptible to NDMA generation. The study concluded that ascorbic acid and trolox are potent inhibitors of NDMA formation and nitrosation attenuators in ranitidine drug products.PMID:38600640 | DOI:10.1002/rcm.9747 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 11, 2024 Category: Chemistry Authors: Dande Aishwarya Pallaprolu Nikhil Subramanian Natesan Ravichandiran Velayutham Ramalingam Peraman Source Type: research
Development and validation of high-performance liquid chromatography-Orbitrap mass spectrometric method for quantification of NDMA in ranitidine drug products and evaluation of antioxidants as inhibitors of classical nitrosation reaction
CONCLUSIONS: This study compared the effectiveness of antioxidants as NDMA attenuators in ranitidine under storage conditions susceptible to NDMA generation. The study concluded that ascorbic acid and trolox are potent inhibitors of NDMA formation and nitrosation attenuators in ranitidine drug products.PMID:38600640 | DOI:10.1002/rcm.9747 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 11, 2024 Category: Chemistry Authors: Dande Aishwarya Pallaprolu Nikhil Subramanian Natesan Ravichandiran Velayutham Ramalingam Peraman Source Type: research
Antioxidants accelerate tendon-to-bone healing after rotator cuff repair surgery
This study aimed to investigate the effects of reduction of oxidative stress induced by antioxidants such as N-acetylcysteine (NAC) and vitamin C (VC) on rotator cuff repair in a rotator cuff repair model in rats. Infraspinatus tendon was ruptured in 48 rats and repaired 1 week later. Rats were divided into 3 groups: NAC group, VC group, or control group, and were administered NAC, VC, or distilled water respectively. The specimens were collected at 3, 6, and 12 weeks after repair. Histological evaluation was performed using hematoxylin/eosin and toluidine blue staining, and oxidative stress was evaluated using dihydroethi...
Source: Journal of Shoulder and Elbow Surgery - April 11, 2024 Category: Orthopaedics Authors: Hirohisa Uehara, Yoshiaki Itoigawa, Daichi Morikawa, Akihisa Koga, Hironori Tsurukami, Muneaki Ishijima Source Type: research
Molecules, Vol. 29, Pages 1732: Effect of the Drying Method and Storage Conditions on the Quality and Content of Selected Bioactive Compounds of Green Legume Vegetables
This study aimed to determine the effect of the drying method (freeze-drying, air-drying), storage period (12 months), and storage conditions (2–4 °C, 18–22 °C) applied to two legume species: green beans and green peas. The raw and dried materials were determined for selected physical parameters typical of dried vegetables, contents of bioactive components (vitamin C and E, total chlorophyll, total carotenoids, β-carotene, and total polyphenols), antioxidative activity against the DPPH radical, and sensory attributes (overall quality and profiles of color, te...
Source: Molecules - April 11, 2024 Category: Chemistry Authors: Piotr G ębczyński Ma łgorzata Tabaszewska Katarzyna Kur Maria Zbylut-G órska Jacek S łupski Tags: Article Source Type: research
Fruit and vegetable intake and risk of disabling dementia: JPHC Disabling Dementia Study
CONCLUSIONS: Fruit and vegetable intake and dietary intake of vitamin C may contribute to reducing the risk of disabling dementia among men and women.PMID:38599388 | DOI:10.1016/j.tjnut.2024.04.008 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Rie Kishida Kazumasa Yamagishi Hiroyasu Iso Junko Ishihara Nobufumi Yasuda Manami Inoue Shoichiro Tsugane Norie Sawada JPHC Study Group Source Type: research
Co-administration of "L-Lysine, Vitamin C, and Zinc" increased the antioxidant activity, decreased insulin resistance, and improved lipid profile in streptozotocin-induced diabetic rats
CONCLUSIONS: The results of this study indicated that co-administration of Lys, a chemical chaperone, with two antioxidants (VC and Zn) potentiates its antidiabetic effects and prevent diabetic complications in rat model of diabetes.PMID:38599057 | DOI:10.1016/j.biopha.2024.116525 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Mostafa Yousefian Saeid Abedimanesh Amirhossein Yadegar Manouchehr Nakhjavani S Zahra Bathaie Source Type: research
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance
In conclusion, our results demonstrate the potential of vitamin C as a potential therapeutic choice for RA.PMID:38599880 | DOI:10.5582/bst.2024.01037 (Source: BioScience Trends)
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Yanjie Zhang Sibin Zhen Hao Xu Songfang Sun Ziwei Wang Mian Li Liang Zou Yangyang Zhang Yan Zhao Yazhou Cui Jinxiang Han Source Type: research
Co-administration of "L-Lysine, Vitamin C, and Zinc" increased the antioxidant activity, decreased insulin resistance, and improved lipid profile in streptozotocin-induced diabetic rats
CONCLUSIONS: The results of this study indicated that co-administration of Lys, a chemical chaperone, with two antioxidants (VC and Zn) potentiates its antidiabetic effects and prevent diabetic complications in rat model of diabetes.PMID:38599057 | DOI:10.1016/j.biopha.2024.116525 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: Mostafa Yousefian Saeid Abedimanesh Amirhossein Yadegar Manouchehr Nakhjavani S Zahra Bathaie Source Type: research
Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance
In conclusion, our results demonstrate the potential of vitamin C as a potential therapeutic choice for RA.PMID:38599880 | DOI:10.5582/bst.2024.01037 (Source: BioScience Trends)
Source: BioScience Trends - April 10, 2024 Category: Biomedical Science Authors: Yanjie Zhang Sibin Zhen Hao Xu Songfang Sun Ziwei Wang Mian Li Liang Zou Yangyang Zhang Yan Zhao Yazhou Cui Jinxiang Han Source Type: research
GSE171850 Global change of microRNA expression induced by vitamin C treatment on immature boar Sertoli cells
Contributors : Cai-Xia Yang ; Zhi-Qiang DUSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofaSertoli cells (SCs), the only somatic constituent of the testicular seminiferous epithelium, are vital to spermatogenesis. We previously found that vitamin C (ascorbic acid, AA) can reprogram the transcriptome, and promote the proliferation and reproductive function of pig immature SCs (iSCs). However, the global change of microRNAs (miRNA) expression and its effect on pig iSCs as induced by vitamin C treatment is still unknown. Here, we performed small RNA sequencing on pig iSCs after 250 μM AA...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Sus scrofa Source Type: research
Antidiabetic effectiveness of < em > Phyllanthus niruri < /em > bioactive compounds < em > via < /em > targeting DPP-IV
This study aimed to evaluate the P. niruri L. whole plant extract (PNE) for secondary metabolite assay (total phenolic and terpenoid content) followed by the potential antioxidant activity (ABTS diammonium salt radical assay, DPPH· activity, superoxide anion (O2-) radicals' assay, and nitric oxide (NO) radical generation) and antidiabetic activity in vivo and in vitro in streptozotocin (STZ) induced albino mice. PNE showed good scavenging activity with a value of 286.45 ± 6.55 mg TE/g and 194.54 ± 4.64 mg TE/g in ABTS and DPPH assays respectively. In the superoxide anion assay, the PNE caused a dose-dependent inhibition...
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Vinay Bhushan Sudhanshu Kumar Bharti Supriya Krishnan Amit Kumar Awanish Kumar Source Type: research
Antidiabetic effectiveness of < em > Phyllanthus niruri < /em > bioactive compounds < em > via < /em > targeting DPP-IV
This study aimed to evaluate the P. niruri L. whole plant extract (PNE) for secondary metabolite assay (total phenolic and terpenoid content) followed by the potential antioxidant activity (ABTS diammonium salt radical assay, DPPH· activity, superoxide anion (O2-) radicals' assay, and nitric oxide (NO) radical generation) and antidiabetic activity in vivo and in vitro in streptozotocin (STZ) induced albino mice. PNE showed good scavenging activity with a value of 286.45 ± 6.55 mg TE/g and 194.54 ± 4.64 mg TE/g in ABTS and DPPH assays respectively. In the superoxide anion assay, the PNE caused a dose-dependent inhibition...
Source: Natural Product Research - April 9, 2024 Category: Biochemistry Authors: Vinay Bhushan Sudhanshu Kumar Bharti Supriya Krishnan Amit Kumar Awanish Kumar Source Type: research
Probiotics Pediococcus acidilactici GR-1 promotes the functional strains and remodels gut microbiota to reduce the Cr(VI) toxicity in a dual-chamber simulated intestinal system
Chemosphere. 2024 Apr 7:141927. doi: 10.1016/j.chemosphere.2024.141927. Online ahead of print.ABSTRACTNumerous animal studies have demonstrated the toxicity of hexavalent chromium [Cr(VI)] and the bioremediative effects of probiotics on the composition and functions of gut microbiota. Since the precise mechanisms of Cr(VI) detoxification and its interactions with human gut microbiota were unknown, a novel dual-chamber simulated intestinal (DCSI) system was developed to maintain both the stability of the simulated system and the composition of the gut microbiota. Probiotic GR-1 was found to regulate intestinal gut microbiot...
Source: Chemosphere - April 9, 2024 Category: Chemistry Authors: Xing Wang Zemin Wang Shaochen Su Ying Wu Jingjing Fan Xiaoxiao Hou Kunyue Zhang El-Sayed Salama Saurabh Kulshrestha Zhenmin Ling Pu Liu Xiangkai Li Source Type: research
Probiotics Pediococcus acidilactici GR-1 promotes the functional strains and remodels gut microbiota to reduce the Cr(VI) toxicity in a dual-chamber simulated intestinal system
Chemosphere. 2024 Apr 7:141927. doi: 10.1016/j.chemosphere.2024.141927. Online ahead of print.ABSTRACTNumerous animal studies have demonstrated the toxicity of hexavalent chromium [Cr(VI)] and the bioremediative effects of probiotics on the composition and functions of gut microbiota. Since the precise mechanisms of Cr(VI) detoxification and its interactions with human gut microbiota were unknown, a novel dual-chamber simulated intestinal (DCSI) system was developed to maintain both the stability of the simulated system and the composition of the gut microbiota. Probiotic GR-1 was found to regulate intestinal gut microbiot...
Source: Chemosphere - April 9, 2024 Category: Chemistry Authors: Xing Wang Zemin Wang Shaochen Su Ying Wu Jingjing Fan Xiaoxiao Hou Kunyue Zhang El-Sayed Salama Saurabh Kulshrestha Zhenmin Ling Pu Liu Xiangkai Li Source Type: research
