Vitamin C Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Vitamin deficiencies in children: Lessons from clinical and neuroimaging findings
CONCLUSIONS: Acquired vitamin deficiencies may display reversible clinical symptoms mimicking inherited metabolic disorders. Some situations raise suspicion for diagnosis: concordant clinical presentation, suggestive neuroimaging findings, and/or biochemical evidence. Any acute neurological condition should be treated without waiting for definitive biochemical confirmation.PMID:38520815 | DOI:10.1016/j.ejpn.2024.02.013 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - March 23, 2024 Category: Neurology Authors: Gabrielle Dupuy Charles-Joris Roux R émi Barrois Apolline Imbard Cl ément Pontoizeau Marie Th érèse Dangles M élodie Aubart Jean-Baptiste Arnoux Diane Margoses Ana ïs Brassier Clothilde Marbach Claire-Marine B érat Eug énie Sarda Cyril Gitiaux Pas Source Type: research

Antioxidant Activities of Stem, Leaves and Fruits Extracts of Pepino ( < em > Solanum muricatum < /em > Aiton)
Conclusion:</b> The DPPH and CUPRAC assays demonstrated that pepino exhibits potential as a source of natural antioxidants, especially in its fruit part.PMID:38516748 | DOI:10.3923/pjbs.2024.69.79 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - March 22, 2024 Category: Biomedical Science Authors: Rika Hartati Nethania Alysia Febiana Hegar Pramastya Irda Fidrianny Source Type: research

SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxidation
J Cell Mol Med. 2024 Apr;28(7):e18212. doi: 10.1111/jcmm.18212.ABSTRACTSBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis of tumour cells. However, the underlying mechanism by which SBFI26 induces ferroptosis in breast cancer cells remains largely unknown. Three breast cancer cell lines were treated with SBFI26 and CCK-8 assessed cytotoxicity. Transcriptome was performed on the Illumina platform and verified by qPCR. Western blot evaluated protein levels. Malondialdehyde (MDA), total superoxide dismutase (T-SOD), Fe, glutathione (GSH) and oxidized glutathione (GSSG) were measured. SB...
Source: J Cell Mol Med - March 22, 2024 Category: Molecular Biology Authors: Gang He Yiyuan Zhang Yanjiao Feng Tangcong Chen Mei Liu Yue Zeng Xiaojing Yin Shaokui Qu Lifen Huang Youqiang Ke Li Liang Jun Yan Wei Liu Source Type: research

SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxidation
J Cell Mol Med. 2024 Apr;28(7):e18212. doi: 10.1111/jcmm.18212.ABSTRACTSBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis of tumour cells. However, the underlying mechanism by which SBFI26 induces ferroptosis in breast cancer cells remains largely unknown. Three breast cancer cell lines were treated with SBFI26 and CCK-8 assessed cytotoxicity. Transcriptome was performed on the Illumina platform and verified by qPCR. Western blot evaluated protein levels. Malondialdehyde (MDA), total superoxide dismutase (T-SOD), Fe, glutathione (GSH) and oxidized glutathione (GSSG) were measured. SB...
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Gang He Yiyuan Zhang Yanjiao Feng Tangcong Chen Mei Liu Yue Zeng Xiaojing Yin Shaokui Qu Lifen Huang Youqiang Ke Li Liang Jun Yan Wei Liu Source Type: research

Ultrasensitive detection of tyrosinase with click reaction-combined dark-field imaging platform
In this study, we developed an ingenious and powerful method for the ultrasensitive detection of TYR by click reaction-combined dark-field microscopy. This method begins with the formation of cuprous ions (Cu+) based on the reduction of copper ions (Cu2+) by ascorbic acid (AA). Subsequently, the formed Cu+ can catalyze the crosslinking between azide- and alkyne-functionalized gold nanoparticles, causing a significant red-shift in the scattering spectrum. However, AA can chelate with TYR, which inhibits the generation of Cu+ and subsequent click reaction, thus achieving TYR-controlled scattering spectral shift. The proposed...
Source: Talanta - March 22, 2024 Category: Chemistry Authors: Zi-Yue Jin Cai-Hong He Cheng-Ye Xi Yi Wang Eshtiag Abdalla Bin-Bin Chen Da-Wei Li Source Type: research

Exploring the impact of high-altitude de-acclimatization on renal function: The roles of oxidative and endoplasmic reticulum stress in rat models
CONCLUSION: This study elucidates the pivotal roles of oxidative and endoplasmic reticulum stress in the early-stage renal injury in rats undergoing HADA. Early intervention with the Vit C and TUDCA significantly mitigates renal damage caused by HADA. These findings provide insights into the pathophysiological mechanisms of HADA and suggest potential therapeutic strategies for its future management.PMID:38518722 | DOI:10.1016/j.bbrc.2024.149770 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Dong-Xin Huang Xia Kang Li-Juan Jiang Dan-Ling Zhu Lin Yang Jing-Ya Luo Meng-Meng Yang Wei Li Guo-Ping Wang Yi Wen Zhu Huang Li-Jun Tang Source Type: research

SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxidation
J Cell Mol Med. 2024 Apr;28(7):e18212. doi: 10.1111/jcmm.18212.ABSTRACTSBFI26, an inhibitor of FABP5, has been shown to suppress the proliferation and metastasis of tumour cells. However, the underlying mechanism by which SBFI26 induces ferroptosis in breast cancer cells remains largely unknown. Three breast cancer cell lines were treated with SBFI26 and CCK-8 assessed cytotoxicity. Transcriptome was performed on the Illumina platform and verified by qPCR. Western blot evaluated protein levels. Malondialdehyde (MDA), total superoxide dismutase (T-SOD), Fe, glutathione (GSH) and oxidized glutathione (GSSG) were measured. SB...
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Gang He Yiyuan Zhang Yanjiao Feng Tangcong Chen Mei Liu Yue Zeng Xiaojing Yin Shaokui Qu Lifen Huang Youqiang Ke Li Liang Jun Yan Wei Liu Source Type: research