Exploring the impact of high-altitude de-acclimatization on renal function: The roles of oxidative and endoplasmic reticulum stress in rat models

CONCLUSION: This study elucidates the pivotal roles of oxidative and endoplasmic reticulum stress in the early-stage renal injury in rats undergoing HADA. Early intervention with the Vit C and TUDCA significantly mitigates renal damage caused by HADA. These findings provide insights into the pathophysiological mechanisms of HADA and suggest potential therapeutic strategies for its future management.PMID:38518722 | DOI:10.1016/j.bbrc.2024.149770

Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Dong-Xin Huang Xia Kang Li-Juan Jiang Dan-Ling Zhu Lin Yang Jing-Ya Luo Meng-Meng Yang Wei Li Guo-Ping Wang Yi Wen Zhu Huang Li-Jun Tang Source Type: research